Journal of Clinical MedicineJCM, Vol. 9, Pages 185: Characterization and Analysis of the Skin Microbiota in Rosacea: Impact of Systemic AntibioticsJCM, Vol. 9, Pages 185: Characterization and Analysis of the Skin Microbiota in Rosacea: Impact of Systemic Antibiotics Journal of Clinical Medicine doi: 10.3390/jcm9010185 Authors: Woo Lee Cho Lee Kim Systemic antibiotics are extensively used to control the papules and pustules of rosacea. Hence, it is crucial to understand their impact on the rosacea...
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ClimateClimate, Vol. 8, Pages 10: Integrating Agriculture and Ecosystems to Find Suitable Adaptations to Climate ChangeClimate, Vol. 8, Pages 10: Integrating Agriculture and Ecosystems to Find Suitable Adaptations to Climate Change Climate doi: 10.3390/cli8010010 Authors: Thayer Vargas Castellanos Lafon McCarl Roelke Winemiller Lacher Climate change is altering agricultural production and ecosystems around the world. Future projections indicate that additional change is expected in the coming decades,...
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AntioxidantsAntioxidants, Vol. 9, Pages 60: ABTS On-Line Antioxidant, α-Amylase, α-Glucosidase, Pancreatic Lipase, Acetyl- and Butyrylcholinesterase Inhibition Activity of Chaenomeles Fruits Determined by Polyphenols and other Chemical CompoundsAntioxidants, Vol. 9, Pages 60: ABTS On-Line Antioxidant, α-Amylase, α-Glucosidase, Pancreatic Lipase, Acetyl- and Butyrylcholinesterase Inhibition Activity of Chaenomeles Fruits Determined by Polyphenols and other Chemical Compounds Antioxidants doi: 10.3390/antiox9010060...
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1a96tk-qj7wv.html[Biomedicines] Quarterly Newsletter, January 2020.eml 2akmpb-ujw2q.htmlActa Histochemica _ Volume 122, Issue 1.eml 3apt3g-qlvik.htmlActa Neuropathologica Communications, Vol. 7, Issue 1 - New Issue Alert.eml 4a5wcs-25va2.htmlAmerican Journal of Epidemiology Advance articles.eml 5aat2u-7bqqb.htmlAmerican Literary History Advance articles.eml 6au64f-azcab.htmlAnnals of Pediatric Surgery, Vol. 15, Issue 1 - New Issue Alert.eml 7aa287-srr3f.htmlArchives of Oral Biology _ Volume 110.eml 8ao1cd-jaxex.htmlArticles...
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Routine Surveillance Imaging is Associated with Improved Postrelapse Survival in Patients with Ewing Sarcoma: Journal of Adolescent and Young Adult Oncology, Ahead of Print. AbstractPurpose: Children with Ewing sarcoma (ES) routinely undergo surveillance imaging after completion of therapy; however, the medical benefit of this imaging remains unclear. We aimed to determine whether there is a difference in survival between patients whose relapse was detected based on development of new symptoms or...
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Alterations in Parafoveal and Optic Disc Vessel Densities in Patients with Obstructive Sleep Apnea Syndrome: Purpose. To analyze the effects of obstructive sleep apnea syndrome (OSAS) on ocular parameters and determine the alterations in macular vasculature by optical coherence tomography-angiography (OCT-A) in patients with different stages of OSAS. Methods. All the participants underwent a full ophthalmological examination. Using the macular OCT-A scans, the retinal peripapillary capillary plexus...
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Toll-Like Receptor-Mediated Cardiac Injury during Experimental Sepsis: Sepsis is associated with global cardiac dysfunction and with high mortality rate. The development of septic cardiomyopathy is due to complex interactions of damage-associated molecular patters, cytokines, and complement activation products. The aim of this study was to define the effects of sepsis on cardiac structure, gap junction, and tight junction (TJ) proteins. Sepsis was induced by cecal ligation and puncture in male C57BL/6...
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The association of trauma center transport and long‐term functional outcomes in head‐injured older adults transported by EMS: AbstractObjectiveIt is unclear if trauma center care is associated with improved outcomes in older adults with traumatic brain injury (TBI) compared to management at non‐trauma centers. Our primary objectives were to describe the long‐term outcomes of older adults with TBI and to evaluate the association of trauma center transport with long‐term functional outcome.MethodsThis...
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Therapeutic effects of AdipoRon on liver inflammation and fibrosis induced by CCl4 in mice.: CONCLUSIONS: AdipoRon demonstrates a remedial capacity against hepatitis and fibrosis induced by CCl4, potentially by inflammation restraint and HSC deactivation, which might pave the way for its therapeutical application in hepatic fibrosis. PMID: 31911372 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
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The Identification of Intraoperative Risk Factors Can Reduce, but Not Exclude, the Need for Completion Thyroidectomy in Low-Risk Papillary Thyroid Cancer Patients: Thyroid, Ahead of Print. AbstractBackground: The extent of initial surgical resection for low-risk papillary thyroid cancer (PTC) remains debatable. Since the 2015 American Thyroid Association (ATA) guidelines, several retrospective studies have reported that 40–60% of patients initially treated with lobectomy would require a completion...
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Diabetic amyotrophy, not your typical back pain: A 49-year-old man presented to the hospital for spinal cord decompression surgery with left buttock and left leg pain. The patient described an acute burning pain radiating down from his left buttock to left lateral leg. He also noted a 13.6 kg weight loss in recent months. Physical examination showed decreased muscle bulk of the left thigh, decreased strength of the left hip, left knee flexors and extensors. Recent MRI spine showed mild canal narrowing...
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Yolk sac tumour of ovary with fever and overt hypothyroidism: rare clinical presentation: Yolk sac tumours of the ovary are rare and highly malignant germ cell tumours, which comprise of only 10%–15% of all malignant germ cell tumours. They have various clinical presentations most common being subacute pelvic pain and feeling of lump but sometimes high-grade fever can be one of the rare presentations. Here, we present a case report of a 26-year-old nulliparous woman with 36 weeks gravid uterus size...
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Tuberculous arthritis in a patient with rheumatoid arthritis treated with methotrexate alone:
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Use of 3D modelling and 3D printing for the diagnostic process, decision making and preoperative planning of periprosthetic acetabular fractures: Periprosthetic acetabular fractures represent an uncommon but challenging complication of total hip arthroplasty (THA), mostly related to low-energy trauma and pathological conditions that reduce bone quality. Therefore, particularly in elderly patients, these fractures are associated with periprosthetic osteolysis and bone loss. CT scan is considered the...
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Desquamative interstitial pneumonia in a non-smoker with neurofibromatosis type 1 (Von Recklinghausen syndrome): Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder with multiple systemic manifestations. Pulmonary involvement has been reported in the form of interstitial fibrosis, emphysema, pulmonary hypertension and thoracic neoplasm. We report a case of desquamative interstitial pneumonia in a non-smoker with NF1.
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Primary clear cell sarcoma in the lung apex with spinal metastasis: a fatal outcome: Clear cell sarcoma (CCS) is a rare tumour that manifests in tendons and aponeuroses of the distal extremities and comprises roughly 1% of all soft tissue cancers. Only two cases of a primary CCS arising in the lung have been reported in the literature, and neither were located in the lung apex. We report a case of a primary CCS located in the lung apex that originally presented as ptosis, as well as arm pain and...
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"Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"[jour]; +55 new citations: 55 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"[jour]These pubmed results were generated on 2020/01/09PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed...
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An overview of yeast probiotics as cancer biotherapeutics: possible clinical application in colorectal cancer: AbstractThe previous reports have established a strong link between diet, lifestyle, and gut microbiota population with the onset of the colorectal cancer (CRC). Administration of probiotics has become a particular interest in prevention and treatment of CRC. As potential dietary complements, probiotics might be able to lower the risk of CRC and manage the safety of traditional cancer therapies...
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Optimizing Patient Selection for Endovascular Treatment in Acute Ischemic Stroke (SELECT): A Prospective Multicenter Cohort Study of Imaging Selection: AbstractObjectiveThe primary imaging modalities used to select patients for endovascular thrombectomy (EVT) are non‐contrast CT(CT) and CT‐perfusion(CTP). However, their relative utility is uncertain. We prospectively assessed CT and CTP concordance/discordance and correlated the imaging profiles on both with EVT treatment decisions and clinical outcomes.MethodsA...
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Impairment of glymphatic pathway and putative meningeal lymphatic vessels in aging human: ABSTRACTObjectiveAging is a major risk factor for numerous neurological disorders and the mechanisms underlying brain aging remain elusive. Recent animal studies demonstrated tight relationship between impairment of glymphatic pathway, meningeal lymphatic vessels and aging. However, the relationship in human brain remains uncertain.MethodsIn this observational cohort study, patients underwent MRI before and...
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Life course adiposity and amyotrophic lateral sclerosis: a Mendelian randomization study: AbstractObjectivesObservational studies have indicated that life course adiposity is associated with amyotrophic lateral sclerosis (ALS). However, whether such an association reflects causality remains unclear. We aimed to determine whether life course adiposity, such as birth weight (BW), childhood body mass index (BMI), adult BMI, body fat percentage (BF%), and waist‐to‐hip ratio (WHR), have causal effects...
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Brittle Stars Can 'See' Without Eyes: The starfish relatives can recognize patterns using photoreceptors on their arms—and their color-changing abilities could have something to do with it. Christopher Intagliata reports.-- Read more on ScientificAmerican.com Original enclosures: podcast.mp3 » Play • Play in background player • Enqueue
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Targeting hypoxia in tumor: a new promising therapeutic strategy: AbstractLow oxygen condition (hypoxia) is considered a hallmark of rapidly growing solid tumors. The presence of hypoxia renders tumor cells resistant to conventional chemo- and radio-therapy selecting a more malignant and invasive phenotype, and playing a negative role in patient prognosis. This commentary wishes to recognize the 2019 Nobel Prize in Medicine awarded to three physicians-scientists, Prof. William G. Kaelin Jr., Prof....
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JCM, Vol. 9, Pages 189: Sensitivity of Viscoelastic Tests to Platelet Function: JCM, Vol. 9, Pages 189: Sensitivity of Viscoelastic Tests to Platelet FunctionJournal of Clinical Medicine doi: 10.3390/jcm9010189Authors: Marco Ranucci Ekaterina Baryshnikova Viscoelastic tests provide a dynamic assessment of coagulation, by exploring the time to clot formation and the clot strength. Using specific activators or inhibitors, additional factors can be explored, like the fibrinogen contribution to clot...
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Development and evaluation of the Cancer Symptom Management System: Symptom Management Improves your LifE (SMILE)—a randomized controlled trial: AbstractPurposeTo develop a Cancer Symptom Management System: Symptom Management Improves your LifE (SMILE) and evaluate the effect and feasibility of the system in cancer symptom management.MethodsThe Cancer Symptom Management System: SMILE was developed, and a nonblinded, randomized controlled trial was conducted. Cancer patients starting adjuvant or palliative...
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An in-hospital clinical care pathway with integrated decision support for cancer pain management reduced pain intensity and needs for hospital stay: AbstractPurposeA clinical care pathway for pain management in a palliative care unit was studied with outcomes related to patients, physicians, and health care service. Mandatory use of patient-reported outcome measures (PROMs) and physician-directed decision support (DS) were integrated parts of the pathway.MethodsAdult cancer patients with pain intensity...
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Island NLF or Island FAMM Flap in Reconstruction of Oral Malignancy Defects?: AbstractFree tissue transfer is the reconstructive option of choice in oral defects of onco-resections. Local flaps like nasolabial flap and FAMM flaps need to be in the armamentarium of surgeons to use when need arises. The aim of this study is to assess utility of island FAMM or nasolabial flap in oral reconstruction, in an oncological setting. Patients with oral cancers, irrespective of nodal status, were included in...
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Serum VEGF: Diagnostic Value of Acute Coronary Syndrome from Stable Angina Pectoris and Prognostic Value of Coronary Artery Disease: Background. Although the level of serum vascular endothelial growth factor (VEGF) is elevated in coronary artery disease (CAD) patients, its potential role in acute coronary syndrome (ACS) or stable angina pectoris (SAP) patients remains unclear. Objectives. To evaluate diagnostic accuracy of serum VEGF in determining ACS patients from SAP and analyze the association...
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Circulating levels of vascular endothelial growth factor and post‐stroke long‐term functional outcome: AbstractObjectivesVascular endothelial growth factor (VEGF) acts in angiogenesis and neuroprotection, although the beneficial effects on experimental ischemic stroke (IS) have not been replicated in clinical studies. We investigated serum VEGF (s‐VEGF) in the acute stage (baseline) and 3 months post‐stroke in relation to stroke severity and functional outcome.MethodsThe s‐VEGF and serum high‐sensitivity...
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Human Atrial Fibroblast Adaptation to Heterogeneities in Substrate Stiffness: Fibrosis is associated with aging and many cardiac pathologies. It is characterized both by myofibroblast differentiation and by excessive accumulation of extracellular matrix proteins. Fibrosis-related tissue remodeling results in significant changes in tissue structure and function, including passive mechanical properties. This research area has gained significant momentum with the recent development of new tools and...
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Effect of a 12-Week Pilates Pelvic Floor-Strengthening Program on Short-Term Measures of Stress Urinary Incontinence in Women: A Pilot Study: The Journal of Alternative and Complementary Medicine, Ahead of Print.
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In Vivo Evaluation of Three-Dimensional Printed, Keratin-Based Hydrogels in a Porcine Thermal Burn Model: Tissue Engineering Part A, Ahead of Print. AbstractKeratin is a natural material that can be derived from the cortex of human hair. Our group had previously presented a method for the printed, sequential production of three-dimensional (3D) keratin scaffolds. Using a riboflavin–sodium persulfate–hydroquinone (initiator–catalyst–inhibitor) photosensitive solution, we produced 3D keratin-based...
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Treatment for Mycobacterium abscessus Infection Associated with Fat Grafting: Surgical Infections, Ahead of Print. AbstractBackground: Fat grafting is a standard method for soft augmentation. However, occasionally Mycobacterium abscessus infection can be seen secondary to fat grafting. The aim of this study was to report experience with and propose standard treatment.Patients and Methods: From 2006 to 2018, 12 women who had received fat grafting for facial soft augmentation in different Chinese private...
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Long-acting somatostatin analogue treatments in autosomal dominant polycystic kidney disease and polycystic liver disease: a systematic review and meta-analysis: ObjectivesA number of randomised control trials (RCTs) investigating the effects of long-acting somatostatin analogues in autosomal dominant polycystic kidney disease (ADPKD) and polycystic liver disease (PLD) have been recently reported. We sought to evaluate all available RCTs investigating the efficacy of somatostatin analogues treatment...
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Protocol for a prospective evaluation of postpartum engagement in HIV care among women living with HIV in South Africa: IntroductionKwaZulu-Natal (KZN), South Africa (SA) has the highest prevalence of pregnant women living with HIV in the world. Pregnancy and the postpartum period offer opportunities to engage women in HIV care, to prevent perinatal transmission and to optimise maternal and infant well-being. However, research suggests that remaining engaged in HIV care during this time can be challenging.Methods...
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Bowel movement frequency and risks of major vascular and non-vascular diseases: a population-based cohort study among Chinese adults: ObjectiveThe application of bowel movement frequency (BMF) in primary care is limited by the lack of solid evidence about the associations of BMF with health outcomes apart from Parkinson's disease and colorectal cancer. We examined the prospective associations of BMF with major vascular and non-vascular diseases outside the digestive system.DesignPopulation-based...
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Enablers and barriers to the implementation of socially assistive humanoid robots in health and social care: a systematic review: ObjectivesSocially assistive humanoid robots are considered a promising technology to tackle the challenges in health and social care posed by the growth of the ageing population. The purpose of our study was to explore the current evidence on barriers and enablers for the implementation of humanoid robots in health and social care.DesignSystematic review of studies entailing...
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Postoperative intravenous parecoxib sodium followed by oral celecoxib post total knee arthroplasty in osteoarthritis patients (PIPFORCE): a multicentre, double-blind, randomised, placebo-controlled trial: ObjectivesTo evaluate the morphine-sparing effects of the sequential treatment versus placebo in subjects undergoing total knee arthroplasty (TKA), the effects on pain relief, inflammation control and functional rehabilitation after TKA and safety.DesignDouble-blind, pragmatic, randomised, placebo-controlled...
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Association between muscle strength and health-related quality of life in a Chinese rural elderly population: a cross-sectional study: ObjectiveTo investigate the relationship between upper and lower limb muscle strength and the health-related quality of life (HRQoL) of a Chinese rural, elderly population.DesignA population-based, cross-sectional study.SettingMiyun, Beijing, China.ParticipantsThe participants of this study were 2083 (834 men and 1249 women) older adults from a rural area, (average...
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Worldwide prevalence of obesity among firefighters: a systematic review protocol: IntroductionObesity may interfere with job performance and increase the risk of injury during firefighting activity. Obesity also has many deleterious effects on health indices and is associated with higher all-cause mortality. Studies report a high prevalence of obesity in the fire service. Also, firefighters' work schedule (12-hour to 24-hour shifts) and food availability during night shifts may be related to weight...
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Retrospective cohort study of the association between maternal employment precarity and infant low birth weight in women in the USA: ObjectivesTo investigate the association between maternal employment precarity and infant low birth weight (LBW), and to assess if this association differs by race/ethnicity.MethodsData were collected from 2871 women enrolled in the National Longitudinal Survey of Youth 1979 and the National Longitudinal Survey of Youth 1979 Children and Young Adult Cohort. Employment...
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Evaluation of community pharmacists readiness to implement the Falsified Medicines Directive (Directive 2011/62/EC): an English cross-sectional survey with geospatial analysis: ObjectivesTo evaluate the readiness to implement the Falsified Medicines Directive (FMD) by community pharmacies in England. Eight secondary objectives were assessed.SettingCommunity/retail pharmacies.ParticipantsWe invited pharmacists from 501 pharmacies to complete a survey. Non-contractors, non-pharmacists or pharmacists...
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Evaluation of the WHO/CDC Syphilis Serology Proficiency Programme to support the global elimination of mother-to-child transmission of syphilis: an observational cross-sectional study, 2008-2015: ObjectivesSyphilis morbidity is high among pregnant women in lower income countries with limited laboratory capacity. We evaluated a long-standing global Syphilis Serology Proficiency Programme (SSPP) that supports testing quality in national reference laboratories to determine if participation affects congenital...
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Association between H. pylori infection and health Outcomes: an umbrella review of systematic reviews and meta-analyses: ObjectiveSystematic reviews and meta-analyses have revealed the associations between H. pylori infection and various health outcomes. We aimed to evaluate the strength and breadth of evidence on the associations.DesignUmbrella review of systematic reviews and meta-analyses.SettingNo settings.ParticipantsNo patients involved.Data sourcesEmbase, PubMed, Web of Science, Cochrane Library...
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Effectiveness of interventions targeting antibiotic use in long-term aged care facilities: a systematic review and meta-analysis: ObjectivesThere are high levels of inappropriate antibiotic use in long-term care facilities (LTCFs). Our objective was to examine evidence of the effectiveness of interventions designed to reduce antibiotic use and/or inappropriate use in LTCFs.DesignSystematic review and meta-analysis.Data sourcesMEDLINE, Embase and CINAHL from 1997 until November 2018.Eligibility criteriaControlled...
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A town level comprehensive intervention study to reduce salt intake in China: protocol for a cluster randomised controlled trial: IntroductionSalt intake in China (12 g/day) is more than twice the upper limit recommended by the WHO (5 g/day). To reduce salt intake, Action on Salt China (ASC) was launched in 2017. As one of four randomised controlled trials (RCTs) in the ASC programme, a comprehensive intervention study was designed to test whether all the components of the interventions adopted by...
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Epidemiology of at-risk alcohol use and associated comorbidities of interest among community-dwelling older adults: a protocol for a systematic review: IntroductionThere is little epidemiological evidence and knowledge about at-risk alcohol use among community-dwelling older adults and their chronic and acute alcohol-related comorbidities of interest. This systematic review will summarise and examine relevant studies about the epidemiology of at-risk alcohol use and associated comorbidities of interest...
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Glomangioma of Uncertain Malignant Potential: A Case Report: Glomus tumors are rare benign tumors which commonly affect the hand but are seldom seen extradigitally. Less commonly seen is the glomangioma, a variant of benign glomus tumor, and even rarer is the glomangiosarcoma, a malignant variant. Determining malignancy can be difficult and an intermediate diagnosis, glomus tumor of uncertain malignant potential, has been proposed. We present a case of a 56-year-old male with a recurrent forearm...
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Microscopic Positive Tumor Margin Increases Risk for Disease Persistence but Not Recurrence in Patients with Stage T1-T2 Differentiated Thyroid Cancer: Introduction. Differentiated thyroid cancer (DTC) has an overall excellent prognosis. Patients who develop recurrent disease have a more unfavorable disease course than those with no recurrence. Higher recurrence rates are seen with incomplete surgical resection and gross positive margins. It is unclear whether microscopic positive margin affects...
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A 22‐year Follow Up of Immediate Implant placement without Bone Augmentation: A Case Series Study: AbstractPurposeTo retrospectively evaluate the treatment outcome of immediate implants placed in fresh extraction sockets without bone augmentation after 22 years of function.Materials and MethodsThe study group received implant therapy in 1997 including surgical placement and prosthodontic rehabilitation. The mean age of the subjects at the time of implant placement was 40 ±5.54 years. A total of 35...
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Thyroid Cartilage Cysts, A Rare Entity Causing Dysphonia: Five cases are presented with a strained voice quality due to a unique underlying cause: thyroid cartilage cysts. Laryngoscopy and radiological images show antero‐medial displacement of both vestibular and vocal fold(s). Swelling in the ala of the thyroid cartilage results in a pear‐shaped lumen. These cysts were marsupialized with CO2 laser, fluid emerged, and histological biopsies confirmed cartilaginous cysts. Postoperatively, all cases...
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M2 macrophage immunotherapy abolishes glucose intolerance by increasing IL-10 expression and AKT activation: Immunotherapy, Ahead of Print. Aim: Glucose intolerance associates with M1/M2 macrophage unbalance. We thus wanted to examine the effect of M2 macrophage administration on mouse model of glucose intolerance. Materials & methods: C57BL/6 mice fed a high-fat diet (HFD) for 12 weeks and then received thrice 20 mg/kg streptozotocin (HFD-GI). Bone marrow-derived stem cells were collected from...
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5 years of clinical DC-CIK/NK cells immunotherapy for acute myeloid leukemia – a summary: Immunotherapy, Ahead of Print. Aim: To assess the efficacy of dendritic cells-cytokine induced killer (DC-CIK) and natural killer (NK) cell-based immunotherapy in treating the low- and intermediate-risk acute myeloid leukemia. Patients & methods: DC-CIK or NK cells were infused once every 3 months for 2–4 cycles to 85 patients. Results & conclusion: The 5-year overall survival (OS) and relapse-free survival...
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CD3D is associated with immune checkpoints and predicts favorable clinical outcome in colon cancer: Immunotherapy, Ahead of Print. Aim: The T cell receptor–CD3 complex has shown great potential in tumor therapy. However, there is currently no research on CD3D in tumors. Materials & methods: Correlation between CD3D expression and clinical parameters and immune checkpoints of of colon adenocarcinoma (COAD) were analyzed. Results: CD3D decreased with increasing clinical stage and microsatellite...
08:42
In Vivo Evaluation of Three-Dimensional Printed, Keratin-Based Hydrogels in a Porcine Thermal Burn Model: Tissue Engineering Part A, Ahead of Print.AbstractKeratin is a natural material that can be derived from the cortex of human hair. Our group had previously presented a method for the printed, sequential production of three-dimensional (3D) keratin scaffolds. Using a riboflavin–sodium persulfate–hydroquinone (initiator–catalyst–inhibitor) photosensitive solution, we produced 3D keratin-based constructs...
08:40
Identification of Distinct Immune Subtypes in Colorectal Cancer Based on the Stromal Compartment: The tumor environment is of vital importance for the incidence and development of colorectal cancer. Increasing evidence in recent years has elaborated the vital role of the tumor environment in cancer subtype classification and patient prognosis, but a comprehensive understanding of the colorectal tumor environment that is purely dependent on the stromal compartment is lacking. To decipher the tumor...
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Genomic Signatures of Immune Activation Predict Outcome in Advanced Stages of Ovarian Cancer and Basal-Like Breast Tumors: There is an unmet need for new therapies in metastatic ovarian cancer and basal-like breast cancer since no curative therapies are currently available. Immunotherapy has shown to be active in several solid tumors, but particularly more in those where a pre-activated immune state does exist. In this work, we aim to identify biomarkers that could distinguish immune-activated tumors...
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High-Dose Ipilimumab and High-Dose Interleukin-2 for Patients With Advanced Melanoma: High-dose ipilimumab (IPI) and high-dose interleukin-2 (IL-2) are approved agents for metastatic melanoma, but the efficacy and safety of the combination are unknown. The objective of this study was to evaluate the feasibility, safety, and efficacy of combination high-dose IPI and high-dose IL-2 in patients with histologically confirmed advanced unresectable stage III and IV melanoma. This Phase II, multicenter,...
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Intraoperative Molecular Imaging for ex vivo Assessment of Peripheral Margins in Oral Squamous Cell Carcinoma: Objective: Complete surgical resection is the standard of care for treatment of oral cancer although the positive margin rate remains 15–30%. Tissue sampling from the resected specimen and from the wound bed for frozen section analysis (FSA) remains the mainstay for intraoperative margin assessment but is subject to sampling error and can require the processing of multiple samples. We sought...
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Diagnostic Performance of PET/CT Using 18F-FACBC in Prostate Cancer: A Meta-Analysis: Background: Diagnostic performance of PET/CT using 18F-fluciclovine (18F-FACBC) in patients with prostate cancer (PCa) has been evaluated in only a few studies. There is no consensus on the diagnostic value of 18F-FACBC PET/CT in PCa recurrence or metastasis (except for bone metastasis), the primary diagnosis of the lesion. Hence, a meta-analysis was conducted to evaluate the performance of 18F-FACBC PET/CT.Methods:...
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Personalized Treatment of H3K27M-Mutant Pediatric Diffuse Gliomas Provides Improved Therapeutic Opportunities: Diffuse gliomas with K27M histone mutations (H3K27M glioma) are generally characterized by a fatal prognosis, particularly affecting the pediatric population. Based on the molecular heterogeneity observed in this tumor type, personalized treatment is considered to substantially improve therapeutic options. Therefore, clinical evidence for therapy, guided by comprehensive molecular profiling,...
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Bioprospecting Psychrotrophic Bacteria for Serine-Type Proteases from the Cold Areas of Western Himalayas: AbstractThe aim of present study was to analyze the prevalence of protease diversity among psychrotrophic bacteria in Lahaul and Spiti of the Western Himalayas. A total of 459 bacteria were screened and protease activity was observed in 150 isolates at 5 °C. Furthermore, 55 isolates showed protease activity up to pH 10 at 5 °C. Based on the hydrolytic zone, 22 isolates were selected for protease...
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An overview of yeast probiotics as cancer biotherapeutics: possible clinical application in colorectal cancer: AbstractThe previous reports have established a strong link between diet, lifestyle, and gut microbiota population with the onset of the colorectal cancer (CRC). Administration of probiotics has become a particular interest in prevention and treatment of CRC. As potential dietary complements, probiotics might be able to lower the risk of CRC and manage the safety of traditional cancer therapies...
08:38
Circ_0014130 Participates in the Proliferation and Apoptosis of Nonsmall Cell Lung Cancer Cells via miR-142-5p/IGF-1 Axis: Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print. AbstractBackground: Abnormal expression of circular RNA (circRNA) has been shown to play an important role in the progression of cancer. However, the role of circRNAs on nonsmall cell lung cancer (NSCLC) remains largely unknown. This study aims to reveal the effects and potential mechanisms of circRNA on NSCLC cell proliferation...
08:38
Knockdown of NRAGE Impairs Homologous Recombination Repair and Sensitizes Hepatoblastoma Cells to Ionizing Radiation: Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print. AbstractBackground: NRAGE (neurotrophin receptor-interacting melanoma antigen-encoding gene homolog) has a complex role and regulates cell growth in different tumor cells. Although NRAGE has been discovered for more than 10 years, the function of NRAGE in hepatoblastoma (HB) cells is currently unknown.Materials and Methods: The...
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Sphingosine Kinases Protect Murine ESCs from Sphingosine‐induced Cell Cycle Arrest: To test the function of the S1P signaling pathway in ESCs, conditional sphingosine kinase null mouse ESC lines were created. Sphk1 fl/fl ; Sphk2 −/− mice were crossed, and embryonic blastocysts used to derive mouse embryonic stem cell lines. Expression of Cre recombinase allows for excision of Sphk1 and produces sphingosine kinase null cells, which become blocked at G2/M due to excessive sphingosine. AbstractSphingosine‐1‐phosphate...
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Comprehensive Functional Echocardiographic Assessment of Transposition of the Great Arteries: From Fetus to Newborn: AbstractTo improve the understanding of the pathophysiology of transposition of the great arteries with intact ventricular septum (TGA/IVS) and the cardiac remodeling occurring from fetal to neonatal life, we performed a morphometric and functional echocardiographic assessment in fetuses and newborns. This was a prospective case–control study performed in a tertiary referral center,...
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Bioaccumulation And Toxicity Of Cadmium, Copper, Nickel, And Zinc And Their Mixtures To Aquatic Insect Communities: AbstractWe describe two artificial stream experiments that exposed aquatic insect communities to Zn, Cu, and Cd (year 2014) and to Zn, Cu, and Ni (year 2015). The testing strategy was to concurrently expose insect communities to single metals and mixtures. Single metals tests were repeated to evaluate reproducibility of the methods and year‐to‐year variability. Metals were strongly...
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GSE143404 The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids [Rh123hi-lo RNA-Seq]Contributors : M Chen ; M S SundrudSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCD4+ T cells are tightly regulated by microbiota in the intestine, but whether intestinal T cells interface with host-derived metabolites is less clear. Here, we show that CD4+ T effector (Teff) cells upregulated the xenobiotic transporter, Mdr1, in...
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Endoscopic Treatment of Idiopathic Subglottic Stenosis: A Systematic Review: Purpose: To identify different endoscopic techniques for treatment of idiopathic subglottic stenosis (iSGS) and evaluate treatment results.Methods: Embase and Cochrane Library were searched for publications on endoscopically treated iSGS. Identified interventions included procedures with cold knife, dilation (rigid or balloon), or laser (CO2 or Nd:YAG), used in several combinations and supplemented with mitomycin C and/or...
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JCM, Vol. 9, Pages 188: Sequential Circulating Tumor Cell Counts in Patients with Locally Advanced or Metastatic Hepatocellular Carcinoma: Monitoring the Treatment Response: JCM, Vol. 9, Pages 188: Sequential Circulating Tumor Cell Counts in Patients with Locally Advanced or Metastatic Hepatocellular Carcinoma: Monitoring the Treatment ResponseJournal of Clinical Medicine doi: 10.3390/jcm9010188Authors: Kun-Ming Rau Chien-Ting Liu Yu-Chiao Hsiao Kai-Yin Hsiao Tzu-Min Wang Wei-Shan Hung...
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Lung cancer and family-centered concerns: AbstractBackgroundGenetic and environmental interactions predispose certain groups to lung cancer, including families. Families or caregiving units experience the disease interdependently. We have previously evaluated the concerns and preferences of patients in addressing the lung cancer experience and cancer risks in their families. This qualitative study evaluates the concerns and preferences of family members and caregivers of patients with lung cancer...
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Development and evaluation of the Cancer Symptom Management System: Symptom Management Improves your LifE (SMILE)—a randomized controlled trial: AbstractPurposeTo develop a Cancer Symptom Management System: Symptom Management Improves your LifE (SMILE) and evaluate the effect and feasibility of the system in cancer symptom management.MethodsThe Cancer Symptom Management System: SMILE was developed, and a nonblinded, randomized controlled trial was conducted. Cancer patients starting adjuvant or palliative...
08:33
An in-hospital clinical care pathway with integrated decision support for cancer pain management reduced pain intensity and needs for hospital stay: AbstractPurposeA clinical care pathway for pain management in a palliative care unit was studied with outcomes related to patients, physicians, and health care service. Mandatory use of patient-reported outcome measures (PROMs) and physician-directed decision support (DS) were integrated parts of the pathway.MethodsAdult cancer patients with pain intensity...
08:33
Profile of anemia in acute lymphoblastic leukemia patients on maintenance therapy and the effect of micronutrient supplementation: AbstractBackgroundAnemia is a common finding and important cause of morbidity in patients with acute lymphoblastic leukemia (ALL) at diagnosis or during the course of its protracted treatment. We studied profile of anemia in ALL patients on maintenance therapy and evaluated specific micronutrients as cause of this anemia.Patients and methodsALL patients who were on maintenance...
08:32
An immunotherapy survivor population: health-related quality of life and toxicity in patients with metastatic melanoma treated with immune checkpoint inhibitors: AbstractPurposeThe immune checkpoint inhibitors (ICIs) have resulted in subgroups of patients with metastatic melanoma achieving high-quality durable responses. Metastatic melanoma survivors are a new population in the era of cancer survivorship. The aim of this study was to evaluate metastatic melanoma survivors in terms of health-related...
08:32
Educational video intervention improves knowledge and self-efficacy in identifying malnutrition among healthcare providers in a cancer center: a pilot study: AbstractPurposeCancer is the second leading cause of death in the USA, and malnutrition secondary to cancer progression and treatment side effects is common. While abundant evidence indicates that nutrition support improves patient outcomes, it is estimated that up to half of malnutrition cases are misclassified or undiagnosed. The use of a...
08:32
Religion as a determining factor for invasive care among physicians in end-of-life patients: AbstractObjectiveDescribe the knowledge of physicians in an Oncology Clinic and a school hospital, of both the private health network, located in Manaus-AM about palliative care (PC), and define the role of religion in medical care of patients with advanced severe illness, with no disease modifying therapy.MethodThis is a cross-sectional, descriptive, and observational study. After signing the Free and Informed...
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Risk assessment of febrile neutropenia and evaluation of G-CSF use in patients with cancer: a real-life study: AbstractPurposeThe guidelines suggest using granulocyte-colony stimulating factor (G-CSF) for febrile neutropenia (FN) as prophylaxis in chemotherapy protocols with the risk of 10–20% after assessment of patient's risk factors. Therefore, the aim of this study is to assess the risk of FN by using the Patient Risk Score (PRS) and evaluating G-CSF use and its side effects by a clinical pharmacist...
08:31
Dressings for the central venous catheter to prevent infection in patients undergoing hematopoietic stem cell transplantation: a systematic review and meta-analysis: AbstractPurposeTo identify the most effective dressing for covering long-term central venous catheter exit site to prevent catheter-related infections and skin irritation in patients undergoing hematopoietic stem cell transplantation.MethodsSystematic Review. The search was performed in the following electronic databases: CINAHL, Cochrane...
08:31
A pilot survey of ventilated cancer patients' perspectives and recollections of early mobility in the intensive care unit: AbstractPurposeTo determine the level of recall, satisfaction, and perceived benefits of early mobility (EM) among ventilated cancer patients after extubation in the intensive care unit (ICU).MethodsA survey of patients' perceptions and recollections of EM was administered within 72 h of extubation. Data on recall of EM participation, activities achieved, adequacy of staffing...
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GSE141387 O-glycan initiation directs distinct biological pathways and controls epithelial differentiationContributors : Emil H Pallesen ; Ieva Bagdonaite ; Hiren J JoshiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe used RNA_Seq to quantify cellular transcripts in human spontaneously immortalized HaCaT keratinocytes upon knock out of GALNT1, GALNT2, or GALNT3 - most abundantly expressed enzyme isoforms initiating mucin-type O-linked glycosylation.New GEO...
08:30
Exploring the Mechanism of Skeletal Muscle in a Tacrolimus-Induced Posttransplantation Diabetes Mellitus Model on Gene Expression Profiles: Objective. Posttransplantation diabetes mellitus (PTDM) is a known complication of transplantation that affects the prognosis. Tacrolimus (Tac or FK506) is a widely used immunosuppressant that has been reported to be a risk factor for PTDM and to further induce complications in heart and skeletal muscles, but the mechanism is still largely unknown. In our preliminary...
08:28
The Safety and Tolerability of Statin Therapy in Primary Prevention in Older Adults: A Systematic Review and Meta-analysis: AbstractPurposeThe use of statins in the primary prevention of cardiovascular disease (CVD) is increasing in older adults. Nonetheless, good clinical evidence for the safety and tolerability of statins in this population is limited.ObjectiveWe aimed to evaluate the safety and tolerability of statins in older adults without overt CVD, focusing on statin-related muscle symptoms.MethodsDouble-blinded...
08:28
Utilization Patterns of Amantadine in Parkinson's Disease Patients Enrolled in the French COPARK Study: AbstractIntroductionImmediate-release (IR) amantadine has been marketed for Parkinson's disease (PD) therapy for 50 years, while two novel extended-release formulations have only recently reached the market in the US.ObjectivesThe aim of this study was to describe amantadine IR utilization patterns in the French COPARK cohort, at baseline and after 2 years of follow-up.MethodsOverall, 683 PD patients...
08:28
Clinical Pharmacy Services in Older Inpatients: An Evidence-Based Review: AbstractBackgroundHospital admissions in older adults are frequently drug related and avoidable. Clinical pharmacy interventions during hospital stay might reduce drug-related harm and reduce hospital visits. Moreover, several recent positive clinical pharmacy investigations incorporated a transitional care component to further improve medication use after discharge. It is currently unclear what the strength of evidence is...
08:27
The Association Between Drug Burden Index (DBI) and Health-Related Outcomes: A Longitudinal Study of the 'Oldest Old' (LiLACS NZ): AbstractBackgroundThe prescribing of medications with anticholinergic and/or sedative properties is considered potentially inappropriate in older people (due to their side-effect profile), and the Drug Burden Index (DBI) is an evidence-based tool which measures exposure to these medications. Life and Living in Advanced Age: a Cohort Study in New Zealand (LiLACS NZ) is...
08:27
Interventions to Reduce Adverse Drug Event-Related Outcomes in Older Adults: A Systematic Review and Meta-analysis: AbstractBackgroundMany studies focus on interventions that reduce the processes that lead to adverse drug events (ADEs), such as inappropriate or high-risk prescribing, without assessing whether they result in a reduction in ADEs or associated adverse health outcomes.ObjectivesOur objective was to systematically review interventions to reduce the incidence of ADEs measured by health...
08:27
Microglia and macrophage phenotypes in intracerebral haemorrhage injury: therapeutic opportunities: AbstractThe prognosis of intracerebral haemorrhage continues to be devastating despite much research into this condition. A prominent feature of intracerebral haemorrhage is neuroinflammation, particularly the excessive representation of pro-inflammatory CNS-intrinsic microglia and monocyte-derived macrophages that infiltrate from the circulation. The pro-inflammatory microglia/macrophages produce...
08:26
Mapping migraine to a common brain network: AbstractInconsistent findings from migraine neuroimaging studies have limited attempts to localize migraine symptomatology. Novel brain network mapping techniques offer a new approach for linking neuroimaging findings to a common neuroanatomical substrate and localizing therapeutic targets. In this study, we attempted to determine whether neuroanatomically heterogeneous neuroimaging findings of migraine localize to a common brain network. We used meta-analytic...
08:26
Exploring Novel Biologically-Relevant Chemical Space Through Artificial Intelligence: The NCATS ASPIRE Program: In recent years, artificial intelligence (AI)/machine learning (ML; a subset of AI) have become increasingly important to the biomedical research community. These technologies, coupled to big data and cheminformatics, have tremendous potential to improve the design of novel therapeutics and to provide safe and effective drugs to patients. A National Center for Advancing Translational Sciences...
08:26
Evaluation of the effect of optic zone diameter selection on high-order aberrations in photorefractive keratectomy excimer laser treatment: AbstractTo evaluate the postoperative higher-order aberration (HOA) differences and visual quality outcomes of wavefront-optimised photorefractive keratectomy (PRK) surgery in 6.5-mm and 7.0-mm optic zones. The study included 136 eyes of 68 patients who underwent wavefront-optimised PRK surgery for myopia or myopia with astigmatism. Q values, third-order coma...
08:25
Microscopic Positive Tumor Margin Increases Risk for Disease Persistence but Not Recurrence in Patients with Stage T1-T2 Differentiated Thyroid Cancer: Introduction. Differentiated thyroid cancer (DTC) has an overall excellent prognosis. Patients who develop recurrent disease have a more unfavorable disease course than those with no recurrence. Higher recurrence rates are seen with incomplete surgical resection and gross positive margins. It is unclear whether microscopic positive margin affects...
08:25
Is there an intermuscular relationship in voluntary activation capacities and contractile kinetics?: AbstractPurposeThe force-generating capacities of human skeletal muscles are interrelated, highlighting a common construct of limb strength. This study aimed to further determine whether there is an intermuscular relationship in maximal voluntary activation capacities and contractile kinetics of human muscles.MethodsTwenty-six young healthy individuals participated in this study. Isometric maximal...
08:24
Potential role of the PD-L1 expression and tumor-infiltrating lymphocytes on neuroblastoma: AbstractPurposeThe programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) pathway has garnered much attention for its roles in clinical oncology. The aim of this study was to examine the clinical impact of the PD-L1 expression and tumor-infiltrating lymphocytes (TILs) on neuroblastoma.MethodsWe evaluated the PD-L1 expression and TIL status in 31 patients with neuroblastoma who underwent a biopsy or resection...
08:24
Could Heat Therapy Be an Effective Treatment for Alzheimer's and Parkinson's Diseases? A Narrative Review: Neurodegenerative diseases involve the progressive deterioration of structures within the central nervous system responsible for motor control, cognition, and autonomic function. Alzheimer's disease and Parkinson's disease are among the most common neurodegenerative disease and have an increasing prevalence over the age of 50. Central in the pathophysiology of these neurodegenerative diseases...
08:24
de Souza interprofessional practice cancer competency framework: AbstractPurposeAs the demand in cancer care continues to increase, health systems require a workforce of highly educated specialists and generalists to provide continuity of care across settings.ObjectivesLed by de Souza Institute in Canada, an interdisciplinary working group was formed to develop a competency framework with relevance across regulated health professionals involved in cancer care.MethodsThe working group was presented...
08:23
Labeled as lucky: contradictions between what women and healthcare professionals experience regarding the need for help after the early stages of gynecological cancer: AbstractPurposeTo explore how participants perceived a nurse-led, person-centered intervention, Guided Self-Determination Gynecological Cancer (GSD-GYN-C) and how participants felt it influenced the challenges they faced and their rehabilitation after gynecological cancer surgery.MethodsParticipants were invited from a previously conducted...
08:22
Sleep disturbance and cancer-related fatigue symptom cluster in breast cancer patients undergoing chemotherapy: AbstractPurposeSleep disturbance and cancer-related fatigue (CRF) are among the most commonly reported symptoms associated with breast cancer and its treatment. This study identified symptom cluster groups of breast cancer patients based on multidimensional assessment of sleep disturbance and CRF prior to and during chemotherapy.MethodsParticipants were 152 women with stage I–IIIA breast...
08:22
Profile of anemia in acute lymphoblastic leukemia patients on maintenance therapy and the effect of micronutrient supplementation: AbstractBackgroundAnemia is a common finding and important cause of morbidity in patients with acute lymphoblastic leukemia (ALL) at diagnosis or during the course of its protracted treatment. We studied profile of anemia in ALL patients on maintenance therapy and evaluated specific micronutrients as cause of this anemia.Patients and methodsALL patients who were on maintenance...
08:22
Chemotherapy-induced nausea and vomiting control in pediatric patients receiving ifosfamide plus etoposide: a prospective, observational study: AbstractPurposeLittle evidence exists regarding the emetogenicity of chemotherapy in pediatric patients. This study describes the prevalence of chemotherapy-induced nausea and vomiting (CINV) in pediatric patients receiving etoposide plus ifosfamide over 5 days, a common pediatric regimen.MethodsEnglish-speaking, non-chemotherapy-naïve patients aged 4 to...
08:22
Usefulness of Kinect sensor–based reachable workspace system for assessing upper extremity dysfunction in breast cancer patients: AbstractPurposeRecently, the utility of the Kinect sensor–based reachable workspace analysis system for measuring upper extremity outcomes of neuromuscular and musculoskeletal diseases has been demonstrated. Here, we investigated its usefulness for assessing upper extremity dysfunction in breast cancer patients.MethodsTwenty unilateral breast cancer patients were enrolled....
08:21
Using experience-based co-design to improve the pre-treatment care pathway for people diagnosed with head and neck cancer: AbstractBackgroundRecent studies have highlighted that people diagnosed with head and neck cancer (HNC) have complex information needs. They are subject to multiple clinical appointments with numerous healthcare professionals in preparation for their treatment. Speech and language therapists (SLTs) are core members of the HNC multidisciplinary team, providing assessment, prehabilitation...
08:21
Health-related quality of life in adult patients with brain metastases after stereotactic radiosurgery: a systematic, narrative review: AbstractPurposeA growing number of patients with brain metastases (BM) are being treated with stereotactic radiosurgery (SRS), and the importance of evaluating the impact of SRS on the health-related quality of life (HRQoL) in these patients has been increasingly acknowledged. This systematic review summarizes the current knowledge about the HRQoL of patients with...
08:20
Comparison of photobiomodulation using either an intraoral or an extraoral laser on oral mucositis induced by chemotherapy in rats: AbstractPurposeThe aim of the present study was to compare the effect of intraoral (IO) and extraoral (EO) diode laser irradiation on oral mucositis (OM) induced by 5-fluorouracil (5-FU) in rats.MethodsAnimals (n = 78) were divided into the following groups: negative control (NC), positive control (PC), IO 6 J/cm2, EO with 6 J/cm2 (EO 6 J/cm2), and 12 J/cm2 (EO 12 J/cm2)....
08:20
Influence of health insurance status on childhood cancer treatment outcomes in Kenya: AbstractBackgroundSurvival of childhood cancer in high-income countries is approximately 80%, whereas in low-income countries, it is less than 10%. Limited access to health insurance in low-income settings may contribute to poor survival rates. This study evaluates the influence of health insurance status on childhood cancer treatment in a Kenyan academic hospital.MethodsThis was a retrospective study. All children...
08:19
Improving information to caregivers of cancer patients: the Herlev Hospital Empowerment of Relatives through More and Earlier information Supply (HERMES) randomized controlled trial: AbstractPurposeThe newly developed "Herlev Hospital Empowerment of Relatives through More and Earlier information Supply" (HERMES) intervention systematically identifies cancer caregivers' unmet needs for information from health care professionals (HCPs) and offers them the information they lack. The aim of this study...
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Relative dose intensity of first-line chemotherapy and overall survival in patients with advanced non-small-cell lung cancer: AbstractPurposeThe effects of chemotherapy dose intensity on survival in patients with advanced non-small-cell lung cancer (NSCLC) are poorly understood. We retrospectively analyzed dose delays/reduction, relative dose intensity (RDI), and the association between chemotherapy intensity and survival in advanced NSCLC.MethodsThis retrospective cohort study included adults with...
08:19
Glycemic Index, Starch, and Protein Digestibility in Tempeh Gembus Cookies: Diabetes mellitus is directly related to diet and lifestyle. Control of blood glucose levels is needed to reduce the risk of complications, and one way is to choose foods with a low glycemic index. Cookies made from tempeh gembus/tempeh gembus flour are expected to be eaten as a snack and are safe for people with diabetes. The aim of this research was to analyze glycemic index (GI), glycemic load (GL), dietary fiber, in vitro...
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Practical lessons in implementing frailty assessments for hospitalised patients with COPD: IntroductionFrailty is a comprehensive health measure characterised by an individual's vulnerability and diminished reserve when faced with health stressors.1–3 As one becomes increasingly frail, the ability to recover from acute illnesses is impaired, leading to progressive disability, increased risk of hospitalisation, need for supportive living environments and death.1 4–6Current estimates suggest that 40%...
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First-line trifluridine/tipiracil plus bevacizumab for unresectable metastatic colorectal cancer: SOLSTICE study design: Future Oncology, Ahead of Print. Trifluridine/tipiracil (TT) is an orally administered combination of the thymidine-based nucleoside analogue trifluridine and the thymidine phosphorylase inhibitor tipiracil hydrochloride, which increases the bioavailability of cytotoxic trifluridine. Encouraging antitumor activity of first-line TT + bevacizumab (TT-B) has been observed in a Phase...
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VATS-US1: Thoracoscopic ultrasonography for the identification of nodules during lung metastasectomy
VATS-US1: Thoracoscopic ultrasonography for the identification of nodules during lung metastasectomy: Future Oncology, Ahead of Print. Open thoracotomy during pulmonary metastasectomy allows lung palpation and may discover unexpected further nodules. We assess the validity of intraoperative lung ultrasonography via thoracoscopy in identifying lung nodules. A first surgeon will perform an ultrasonographic investigation on the deflated lung by thoracoscopy. A second surgeon will then perform a manual...
08:16
Germline and somatic mutations in prostate cancer: focus on defective DNA repair, PARP inhibitors and immunotherapy: Future Oncology, Ahead of Print.
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Delayed use of eribulin in a heavily pretreated liposarcoma patient, previously misdiagnosed as leiomyosarcoma: Future Oncology, Ahead of Print. Due to its low incidence, liposarcoma displays a limited number of therapeutic options. However, eribulin recently received approval for the treatment of advanced liposarcoma patients, progressing to at least two chemotherapy lines. We report herein the case of a man initially diagnosed with a leyomiosarcoma, subsequently reclassified as a dedifferentiated...
08:15
The emerging role of cellular senescence in renal diseases: AbstractCellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence prevention, but it is also involved in many cardiovascular, renal and liver diseases through the senescence‐associated secretory phenotype (SASP). This review summarizes the molecular...
08:15
Flavonoids compounds from Tridax procumbens inhibit osteoclast differentiation by down‐regulating c‐Fos activation: AbstractThe total flavonoids from Tridax procumbens (TPFs) have been reported significantly to suppress on RANKL‐induced osteoclast differentiation and bone resorption in mouse primary cultured osteoclasts. However, the effects of ethyl ether fraction of Tridax procumbens flavonoids (TPF) on osteoclastogenesis remain unknown. In this study, we investigated the effects of TPF on lipopolysaccharides...
08:14
Analgesic Impact of Single-Shot Versus Continuous Femoral Nerve Block After Total Knee Arthroplasty: A Systematic Review and Meta-Analysis: AbstractIntroductionEfficient pain management after total knee arthroplasty will accelerate functional recovery and reduce the length of hospital stay. The femoral nerve block is increasingly used in clinical practice owing to its favorable analgesic efficacy. However, the effect of continuous femoral nerve block compared to single-shot femoral nerve block remains...
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Intra-articular Injection Administration in UK Ex-professional Footballers During Their Playing Careers and the Association with Post-career Knee Osteoarthritis: AbstractBackgroundThe long-term risk from knee intra-articular (KIA) injections in professional athletes such as ex-footballers remains unknown. The use of KIA injections is controversial and remains anecdotally prolific as it is perceived as being safe/beneficial. The aim of this study was to determine the number, type and frequency KIA...
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Batch-to-Batch Consistency of SB4 and SB2, Etanercept and Infliximab Biosimilars: AbstractBackgroundBiosimilars must meet stringent regulatory requirements, both at the time of authorization and during their lifecycle. Yet it has been suggested that divergence in quality attributes over time may lead to clinically meaningful differences between two versions of a biologic. Therefore, this study investigated the batch-to-batch consistency across a range of parameters for released batches of the etanercept...
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Validation of the HADS and PSS‐10 and a cross‐sectional study of psychological status in patients with recurrent aphthous stomatitis: AbstractObjectivesTo validate the Hospital Anxiety and Depression Scale (HADS) and the 10‐item Perceived Stress Scale (PSS‐10) for use in clinical studies of recurrent aphthous stomatitis (RAS) and to provide cross‐sectional assessment of anxiety, depressive, distress symptoms and perceived stress in patients with RAS.MethodsValidity and reliability of the HADS and...
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