PharmaceuticsPharmaceutics, Vol. 11, Pages 687: An Inhalable Theranostic System for Local Tuberculosis Treatment Containing an Isoniazid Loaded Metal Organic Framework Fe-MIL-101-NH2—From Raw MOF to Drug Delivery SystemPharmaceutics, Vol. 11, Pages 687: An Inhalable Theranostic System for Local Tuberculosis Treatment Containing an Isoniazid Loaded Metal Organic Framework Fe-MIL-101-NH2—From Raw MOF to Drug Delivery System Pharmaceutics doi: 10.3390/pharmaceutics11120687 Authors: Gabriela Wyszogrodzka-Gaweł...
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Microorganisms, Vol. 7, Pages 712: Identification of Insect-Deterrent Metabolites from Acremonium masseei strain CICY026, a Saprophytic Fungus from a Sinkhole in YucatánMicroorganisms, Vol. 7, Pages 712: Identification of Insect-Deterrent Metabolites from Acremonium masseei strain CICY026, a Saprophytic Fungus from a Sinkhole in Yucatán Microorganisms doi: 10.3390/microorganisms7120712 Authors: Ana L. Ruiz-Jiménez Esaú Ruiz-Sánchez Gabriela Heredia Raúl Tapia-Tussell Azucena González-Coloma Karla...
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International Journal of Environmental Research and Public HealthIJERPH, Vol. 16, Pages 5156: Rainfall Trends and Malaria Occurrences in Limpopo Province, South AfricaIJERPH, Vol. 16, Pages 5156: Rainfall Trends and Malaria Occurrences in Limpopo Province, South Africa International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16245156 Authors: Abiodun Adeola Katlego Ncongwane Gbenga Abiodun Thabo Makgoale Hannes Rautenbach Joel Botai Omolola Adisa Christina Botai This...
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Cells, Vol. 8, Pages 1658: CD47-SIRPα Signaling Induces Epithelial-Mesenchymal Transition and Cancer Stemness and Links to a Poor Prognosis in Patients with Oral Squamous Cell CarcinomaCells, Vol. 8, Pages 1658: CD47-SIRPα Signaling Induces Epithelial-Mesenchymal Transition and Cancer Stemness and Links to a Poor Prognosis in Patients with Oral Squamous Cell Carcinoma Cells doi: 10.3390/cells8121658 Authors: Pai Bamodu Lin Lin Chu Chien Wang Hsiao Yeh Tsai Background: Oral squamous cell carcinoma...
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Antibiotics, Vol. 8, Pages 270: The Role of Drug Repurposing in the Development of Novel Antimicrobial Drugs: Non-Antibiotic Pharmacological Agents as Quorum Sensing-InhibitorsAntibiotics, Vol. 8, Pages 270: The Role of Drug Repurposing in the Development of Novel Antimicrobial Drugs: Non-Antibiotic Pharmacological Agents as Quorum Sensing-Inhibitors Antibiotics doi: 10.3390/antibiotics8040270 Authors: Gajdács Spengler Background: The emergence of multidrug-resistant organisms (MDROs) is a global...
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Biomolecules, Vol. 10, Pages 3: Thrombolytic Potential of Novel Thiol-Dependent Fibrinolytic Protease from Bacillus cereus RSA1: Biomolecules, Vol. 10, Pages 3: Thrombolytic Potential of Novel Thiol-Dependent Fibrinolytic Protease from Bacillus cereus RSA1Biomolecules doi: 10.3390/biom10010003Authors: Sharma Salem Sharma Gautam Singh The present study demonstrates the production and thrombolytic potential of a novel thermostable thiol-dependent fibrinolytic protease by Bacillus cereus...
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Biomolecules, Vol. 10, Pages 2: High Levels of Glutaminase II Pathway Enzymes in Normal and Cancerous Prostate Suggest a Role in 'Glutamine Addiction': Biomolecules, Vol. 10, Pages 2: High Levels of Glutaminase II Pathway Enzymes in Normal and Cancerous Prostate Suggest a Role in 'Glutamine Addiction'Biomolecules doi: 10.3390/biom10010002Authors: Dorai Dorai Pinto Grasso Cooper Abstract: Many tumors readily convert l-glutamine to α-ketoglutarate. This conversion is almost invariably...
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Increased Expression of Gankyrin and Stemness Factor Oct-4 are Associated with Unfavorable Clinical Outcomes and Poor Benefit of Tamoxifen in Breast Carcinoma Patients: AbstractTamoxifen is the most important treatment component in estrogen receptor positive (ER+) breast carcinoma patients. Tamoxifen resistance incidence presents an important obstacle in clinical treatment. Mechanisms underlying tamoxifen refractory are not completely understood. Although elevated expression of Gankyrin (P28GANK)...
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A case of large intra‐esophageal bronchogenic cyst treated with lauromacrogol ablation: AbstractA 23‐year‐old man was referred to our hospital because of mild dysphagia to solid food. Computed tomography showed an obvious mass arising from the lower esophagus. In the esophagogastroduodenoscopy examination, a bulging lesion was observed adjacent to the cardia. Endoscopic ultrasound revealed a 4.5x3.8cm hypoechoic cystic lesion without blood flow signal, which affected most of the muscularis propria...
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No effect of tDCS of the primary motor cortex on isometric exercise performance or perceived fatigue
No effect of tDCS of the primary motor cortex on isometric exercise performance or perceived fatigue: AbstractAnodal transcranial direct current stimulation (tDCS) of the primary motor cortex has been reported to improve isometric exercise performance without changing corticospinal excitability. One possible cause for this may be the previous use of relatively high (2 mA) current intensities, which have inconsistent effects on corticospinal excitability. The present pre‐registered study aimed to...
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Motor Skill Acquisition during a Balance Task as a Process of Optimization of Motor Primitives: AbstractIt has been argued that the central nervous system relies on combining simple movement elements (i.e. motor primitives) to generate complex motor outputs. However, how movement elements are generated and combined during the acquisition of new motor skills is still a source of debate. Herein, we present results providing new insights into the role of movement elements in the acquisition of motor...
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Out-of-School Use of Time and Its Association with Gender Differences in Educational Outcomes: AbstractRecent gender literature has highlighted that boys and girls devote their out-of-school time in dissimilar ways, which may differentially influence their academic achievement. Furthermore, this literature indicates that these gender differences may be rooted in society's gender stereotypes when using this time. To analyse this issue we employ longitudinal and census data for the Spanish region of...
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Clinical Applications of 68 Ga-PSMA PET/CT on Residual Disease Assessment of Juvenile Nasopharyngeal Angiofibroma (JNA): AbstractWe present a case of a 16-year-old boy who underwent 68Ga-PSMA PET/CT for residual disease assessment of juvenile nasal angiofibroma. Positive uptake was noted in residual tumor on PET/CT imaging. However, there was no abnormal uptake in surrounding scar tissues as compared with contrast-enhanced magnetic resonance imaging. These findings were confirmed by biopsy from the...
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Evaluation of periostin level for predicting severity and chronicity of childhood atopic dermatitis.
Postepy Dermatol Alergol. 2019 Oct;36(5):616-619. doi: 10.5114/ada.2018.79728. Epub 2019 Nov 12.Ozceker D1, Yucel E1, Sipahi S2, Dilek F3, Ozkaya E3, Guler EM4, Kocyigit A4, Guler N2, Tamay Z2.Author information1Department of Pediatric Allergy and Immunology, Okmeydanı Education and Resarch Hospital, Saglik Bilimleri University, Istanbul, Turkey.2Department of Pediatric Allergy and Immunology, Istanbul Medical Faculty, Istanbul, Turkey.3Department of Pediatric Allergy and Immunology, Bezmi Alem University,...
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Postepy Dermatol Alergol. 2019 Oct;36(5):620-625. doi: 10.5114/ada.2018.77497. Epub 2018 Aug 6.Pastuszczak M1, Kotnis-Gąska A2, Jakubowicz B3, Wojas-Pelc A1.Author information1Department of Dermatology, Jagiellonian University Medical College, Krakow, Poland.2Department of Laboratory Diagnostics, John Paul 2 Hospital, Krakow, Poland.3Department of Microbiology, University Hospital, Krakow, Poland.AbstractINTRODUCTION:Approximately 15% of appropriately treated patients with early syphilis remain serofast....
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Postepy Dermatol Alergol. 2019 Oct;36(5):626-634. doi: 10.5114/ada.2018.77502. Epub 2018 Aug 16.Ambroziak M1, Noszczyk B2, Pietruski P2, Guz W3, Paluch Ł4.Author information1Ambroziak Clinic, Warsaw, Poland.2Department of Plastic Surgery, Orlowski Memorial Hospital, Medical Centre of Postgraduate Education, Warsaw, Poland.3Department of Electroradiology, Institute of Nursing and Health Sciences, Faculty of Medicine, University of Rzeszow, Poland.4Department of Radiology, Gruca Orthopedic and Trauma...
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Increased Expression of Gankyrin and Stemness Factor Oct-4 are Associated with Unfavorable Clinical Outcomes and Poor Benefit of Tamoxifen in Breast Carcinoma Patients: AbstractTamoxifen is the most important treatment component in estrogen receptor positive (ER+) breast carcinoma patients. Tamoxifen resistance incidence presents an important obstacle in clinical treatment. Mechanisms underlying tamoxifen refractory are not completely understood. Although elevated expression of Gankyrin (P28GANK)...
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Weight Regain and Diabetes Evolution After Sleeve Gastrectomy: a Cohort Study with over 5 Years of Follow-Up: AbstractBackgroundA number of meta-analyses have demonstrated the effectiveness of bariatric surgery in improving morbid obesity and its associated co-morbidities. The aim of the study was to evaluate at long term a cohort of obese patients with type 2 diabetes (T2DM) submitted to laparoscopic sleeve gastrectomy (LSG) analyzing the incidence of weight regain (WR) and the impact of the WR...
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Children with epilepsy demonstrate macro- and microstructural changes in the thalamus, putamen, and amygdala: AbstractPurposeDespite evidence for macrostructural alteration in epilepsy patients later in life, little is known about the underlying pathological or compensatory mechanisms at younger ages causing these alterations. The aim of this work was to investigate the impact of pediatric epilepsy on the central nervous system, including gray matter volume, cerebral blood flow, and water diffusion,...
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Hippocampal Volume Loss, Brain Amyloid Accumulation, and APOE Status in Cognitively Intact Elderly Subjects: Background: Hippocampal volume loss (HVL), PET-documented brain amyloid accumulation, and APOE-ε4 status are predictive biomarkers of the transition from mild cognitive impairment to Alzheimer disease (AD). In asymptomatic cases, the role of these biomarkers remains ambiguous. In contrast to the idea that HVL occurs in late phases of neurodegeneration, recent contributions indicate that it...
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IJERPH, Vol. 17, Pages 4: Analysis of Factors Affecting Quality of Life in Patients Treated for Maxillofacial Fractures: IJERPH, Vol. 17, Pages 4: Analysis of Factors Affecting Quality of Life in Patients Treated for Maxillofacial FracturesInternational Journal of Environmental Research and Public Health doi: 10.3390/ijerph17010004Authors: Sikora Chlubek Grochans Jurczak Safranow Chlubek Maxillofacial fractures (MFF) belong to the major modern medicine and public health concerns....
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IJERPH, Vol. 17, Pages 3: Internet Gaming Disorder: Exploring Its Impact on Satisfaction in Life in PELLEAS Adolescent Sample: IJERPH, Vol. 17, Pages 3: Internet Gaming Disorder: Exploring Its Impact on Satisfaction in Life in PELLEAS Adolescent SampleInternational Journal of Environmental Research and Public Health doi: 10.3390/ijerph17010003Authors: Olivier Phan Constance Prieur Céline Bonnaire Ivana Obradovic Among adolescents, heavy video game use and socializing online may be valued...
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Effects of a probiotic intervention on Escherichia coli and high-fat diet-induced intestinal microbiota imbalance: AbstractObesity is often associated with intestinal microbiota imbalance and increased Gram-negative bacteria characterized by higher endotoxin levels. Therefore, a study on the joint effects of a high-fat diet and Gram-negative bacteria prechallenge might provide further information on the interactive effects of intestinal microbiota and obesity as well as the effects of a probiotic...
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Sulfur-containing amino acid supplementation to gilts from late pregnancy to lactation altered offspring's intestinal microbiota and plasma metabolites: AbstractMaternal nutrition during late pregnancy and lactation is highly involved with the offspring's health status. The study was carried out to evaluate the effects of different ratios of methionine and cysteine (Met/Cys: 46% Met, 51% Met, 56% Met, and 62% Met; maintained with 0.78% of total sulfur-containing amino acids; details in "Materials...
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Construction and application of a "superplasmid" for enhanced production of antibiotics: AbstractMore than two-third of known antibiotics are produced by actinomycetes of the genus Streptomyces. Unfortunately, the production rate from Streptomyces natural antibiotic is extremely slow and thus cannot satisfy industrial demand. In this study, the production of antibiotics by Streptomyces is enhanced by a "superplasmid" which including global regulatory factors afsR, cyclic adenosine receptor protein...
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Modulation effect of tea consumption on gut microbiota: AbstractTea is one of the most popular beverages in the world and possesses a wide range of beneficial effects for human health. The modulation of tea on gut microbiota has gained much interest in recent years. The present study discussed the modulation effect of various types of tea on gut microbiota, which plays crucial roles in human health, as investigated by in vitro animal and human studies. The currently available findings from a total...
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Calanus oil in the treatment of obesity-related low-grade inflammation, insulin resistance, and atherosclerosis: AbstractCalanus oil (COil) is a natural product extracted from marine zooplankton Calanus finmarchicus found in the North Atlantic Ocean. This oil is rich in wax esters of polyunsaturated fatty acids (PUFAs) and has been projected as the best alternative to fish oil because its production cannot keep pace with the demands from the growing markets. The COil is the only commercially available...
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Inotersen preserves or improves quality of life in hereditary transthyretin amyloidosis: AbstractObjectiveTo examine the impact on quality of life (QOL) of patients with hATTR amyloidosis with polyneuropathy treated with inotersen (Tegsedi™) versus placebo.MethodsData were from the NEURO-TTR trial (ClinicalTrials.gov Identifier: NCT01737398), a phase 3, multinational, randomized, double-blind, placebo-controlled study of inotersen in patients with hATTR amyloidosis with polyneuropathy. At baseline...
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A Massive Extradural Hematoma in Sickle Cell Disease and the Importance of Rapid Neuroimaging: Sickle cell disease (SCD) is an inherited hemoglobinopathy leading to several serious organ complications and early death. It is mostly found in equatorial countries like Tanzania. Extradural hematoma (EDH) is a rare, but serious complication to SCD and may have debilitating consequences. Hitherto, there is no report of EDH in SCD where neuroimaging has been available before, during, and after such an event....
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Subchronic Exposure to Cadmium Causes Persistent Changes in the Reproductive System in Female Wistar Rats: Cadmium (Cd) is an environmental toxicant and endocrine disruptor in humans and animals, and recent studies have illustrated that the uterus is exceedingly sensitive to Cd toxicity. The aim of the study was to investigate the influence of subchronic (90 days) oral Cd exposure in daily doses of 0.09-4.5 mg/kg b.w. on the balance of sex hormones by estimating estradiol (E2) and progesterone (P)...
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The effect of canal diameter on audiologic results in patients with cochlear implantation with large vestibular aqueduct syndrome: AbstractPurposeTo compare audiologic results according to vestibular aqueduct (VA) diameter in patients who have undergone cochlear implantation and were diagnosed with LVAS.MethodsThis was a retrospective study detailing the outcomes of 18 patients with LVAS and 18 patients undergone cochlear implants. VA diameter was assessed by magnetic resonance imaging and computed...
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Bacterial colonization of Montgomery salivary bypass tubes after hypopharyngeal reconstruction in head and neck cancer patients: AbstractBackgroundHypopharyngeal reconstruction after salvage pharyngolaryngectomy results in high postoperative morbidity. The use of salivary bypass tubes can reduce pharyngocutaneous fistula (PCF) formation. The influence of bacterial colonization has not been described in literature.MethodsBacterial swipes from 26 consecutive patients reconstructed after laryngopharyngectomy...
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Sample collection for laboratory‐based study of the nasal airway and sinuses: a research compendium: BackgroundCollection of biologic samples from the nasal cavity and paranasal sinuses is of critical importance to the study of infectious or inflammatory conditions that affect both upper and lower airways. Numerous techniques for the study of ex‐vivo samples exist, with specific applications, strengths, and weaknesses associated with each of them. In this compendium we summarize the available methods...
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Vascularized lymph node transfer with submental free flap: Publication date: Available online 16 December 2019Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): P. Mazerolle, T. Meresse, D. Gangloff, K. Kolsi, A. Dupret-BoriesAbstractLimb lymphoedema is common in patients who have undergone inguinal or axillary lymph node dissection. Lymphoedema seriously impacts the patient's quality of life by inducing adipogenesis, fibrosis and repeated episodes of lymphangitis and...
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Optico-carotid recess and anterior clinoid process pneumatization â€" proposal for a novel classiï¬cation and uniï¬ed terminology: an anatomic and radiologic study.: Related ArticlesOptico-carotid recess and anterior clinoid process pneumatization â€" proposal for a novel classiï¬cation and uniï¬ed terminology: an anatomic and radiologic study.Rhinology. 2019 Dec 01;57(6):444-450Authors: Andrianakis A, Tomazic PV, Wolf A, Anderhuber F, Gerstenberger C, Pilsl U, Stammberger HAbstract BACKGROUND:...
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5-aminolevulinic acid-mediated photodynamic diagnosis using fluorescence ureterorenoscopy for urinary upper tract urothelial carcinoma ∼Preliminary prospective single centre trial∼: Publication date: Available online 16 December 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Hideo Fukuhara, Atsushi Kurabayashi, Mutsuo Furihata, Shouhei Setuda, Kiwamu Takahashi, Kiyotaka Murakami, Toru Tanaka, Keiji InoueAbstractObjectiveTo investigate the diagnostic accuracy of 5- aminolevulinic acid-mediated...
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Mothers' emotional experiences related to their child's diagnosis of deafness and cochlear implant surgery: Parenting stress and child's language development.: Related ArticlesMothers' emotional experiences related to their child's diagnosis of deafness and cochlear implant surgery: Parenting stress and child's language development.Int J Pediatr Otorhinolaryngol. 2019 Dec 06;130:109812Authors: Majorano M, Guerzoni L, Cuda D, Morelli MAbstract OBJECTIVES: The present study aims to assess the...
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Novel <em>OTOF</em> pathogenic variant segregating with non-syndromic hearing loss in a consanguineous family from tribal Rajouri in Jammu and Kashmir: Publication date: Available online 16 December 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Raja A.H. Kuchay, Yaser Rafiq Mir, Xue Zeng, Asima Hassan, Kazunori Namba, Mustafa TekinAbstractBackgroundHereditary hearing loss is characterized by a very high genetic heterogeneity. The OTOF gene (Locus: DFNB9),...
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No Bull: A Case of Alpha-Gal Syndrome Associated With Buffalo Meat Sensitivity.: Related ArticlesNo Bull: A Case of Alpha-Gal Syndrome Associated With Buffalo Meat Sensitivity.Allergy Rhinol (Providence). 2019 Jan-Dec;10:2152656719893366Authors: Rowane M, Valencia R, Stewart-Bates B, Casselman J, Hostoffer RAbstract Introduction: Alpha (⍺)-gal syndrome (AGS) is an immunoglobulin E (IgE) antibody response against the glycoprotein carbohydrate galactose-⍺-1,3-galactose-β-1-(3)4-N-acetylglucosamine-R...
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Malignant Chondroid Syringoma With Nose and Paranasal Sinus Extension: A Case Report.: Related ArticlesMalignant Chondroid Syringoma With Nose and Paranasal Sinus Extension: A Case Report.Allergy Rhinol (Providence). 2019 Jan-Dec;10:2152656719893367Authors: Sekar R, Kalaiarasi R, Ganesan S, Alexander A, Saxena SKAbstract Chondroid syringoma is a rare, skin appendageal tumor. It is also known as mixed tumor of skin, as it histologically resembles mixed tumor of salivary gland (pleomorphic...
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Complications of bone-conduction hearing implants implantation surgery: Publication date: Available online 16 December 2019Source: American Journal of OtolaryngologyAuthor(s): Timothy Shun Man Chu, Michael Mather, Anirvan BanerjeeAbstractPurposeBone-conduction Hearing Implants (BCHIs) are surgically implanted hearing devices. As the implantation surgery involves soft tissue dissection through periosteum and drilling of skull, complications related to the skin and soft tissue remain common despite...
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Sunscreen: FDA regulation, and environmental and health impact: Photochem. Photobiol. Sci., 2020, Advance ArticleDOI: 10.1039/C9PP00366E, PaperShanthi Narla, Henry W. LimDespite the concern for potential environmental and health effects, the FDA still considers organic UVR filters safe for use. For those who are concerned, inorganic UVR filter (namely, zinc oxide and titanium dioxide)-based sunscreens can be used.To cite this article before page numbers are assigned, use the DOI form of citation...
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The effect of anatomic variations and maxillary sinus volume in antrochoanal polyp formation: AbstractPurposeThe antrochoanal polyp (ACP), otherwise known as the Killain polyp, is a benign lesion that originates from maxillary sinus mucosa, extending from the accessory ostium towards the middle meatus, and later tends to protrude posteriorly towards the choana and nasopharynx. Many studies have emphasized that its etiopathogenesis is unclear. Research suggests that chronic sinusitis and allergic...
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Appropriate medical management of chronic rhinosinusitis reduces use of antibiotics and oral corticosteroids: Objectives/HypothesisAntibiotics and oral corticosteroids are used in the treatment of acute exacerbations of chronic rhinosinusitis (AECRS) and reflect poor disease control. We sought to characterize utilization of these systemic medications after appropriate medical management of chronic rhinosinusitis (CRS).Study DesignProspective observational study.MethodsOne hundred fifty patients undergoing...
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Health utility of rhinectomy, surgical nasal reconstruction, and prosthetic rehabilitation: ObjectivesAdvanced nasal malignancies may require rhinectomy, which can have profound psychosocial impacts. Rhinectomy defects can be rehabilitated through surgery or prosthetics. We seek to understand the health utility of the rhinectomy defect, surgical, and prosthetic reconstruction, which have not been previously studied.Study DesignProspective clinical studyMethodsAdult naïve observers (n = 273) ranked...
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Oxytocin receptor gene loss influences expression of the oxytocin gene in C57BL/6j mice in a sex‐ and age‐dependent manner: AbstractParental care and sensory stimulation are critical environmental factors that influence oxytocin (OXT) and its receptor (OXTR). Because developmental Oxt mRNA expression is enhanced by sensory‐rich early life experience, and reduced by sensory deprivation, we predicted that compared to wild‐type (WT) littermates, mice with congenital loss of OXTR (OXTR KO), as a genetically‐induced...
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Non-invasive and real-time proliferative activity estimation based on a quantitative radiomics approach for patients with acromegaly: a multicenter study: AbstractBackgroundProliferative activity prediction is important for determining individual treatment strategies for patients with acromegaly, and tumor proliferative activity is usually measured by the expression of Ki-67.ObjectiveThis study aimed to assess the value of a magnetic resonance imaging (MRI)-based radiomics approach in predicting...
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Calcitriol Elevation is Associated with a Higher Risk of Refractory Hypercalcemia of Malignancy in Solid Tumors.: Related ArticlesCalcitriol Elevation is Associated with a Higher Risk of Refractory Hypercalcemia of Malignancy in Solid Tumors.J Clin Endocrinol Metab. 2019 Dec 16;:Authors: Chukir T, Liu Y, Hoffman K, Bilezikian JP, Farooki AAbstract BACKGROUND: Hypercalcemia of malignancy (HCM) is a common complication of advanced cancer. Parathyroid hormone (PTH)-independent HCM may be mediated...
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The melanocortin 4 receptor p.Ile269Asn mutation is associated with childhood and adult obesity in Mexicans.: Related ArticlesThe melanocortin 4 receptor p.Ile269Asn mutation is associated with childhood and adult obesity in Mexicans.J Clin Endocrinol Metab. 2019 Dec 16;:Authors: Vázquez-Moreno M, Zeng H, Locia-Morales D, Peralta-Romero J, Asif H, Maharaj A, Tam V, Romero-Figueroa MDS, Sosa-Bustamante GP, Méndez-Martínez S, Mejía-Benítez A, Valladares-Salgado A, Wacher-Rodarte N, National Obesity...
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Clinicopathologic overlap of psoriasis, eczema, and psoriasiform dermatoses: A retrospective study of T helper type 2 and 17 subsets, interleukin 36, and β-defensin 2 in spongiotic psoriasiform dermatitis, sebopsoriasis, and tumor necrosis factor α inhibitor–associated dermatitis: Publication date: Available online 16 December 2019Source: Journal of the American Academy of DermatologyAuthor(s): Jarish N. Cohen, Sarah Bowman, Zoltan G. Laszik, Jeffrey P. NorthBackgroundT helper (Th) type 17 and Th2...
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Serial biologic therapies in psoriasis patients: A 12-year, single-center, retrospective observational study: Publication date: January 2020Source: Journal of the American Academy of Dermatology, Volume 82, Issue 1Author(s): Emanuele Cozzani, Yiran Wei, Martina Burlando, Alessio Signori, Aurora ParodiBackgroundBiologic therapy for psoriasis is effective but not always long-lasting and sometimes needs to be switched.ObjectiveWe aimed to evaluate the drug survival (ie, the time from initiation to discontinuation)...
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Exploring changes in placebo treatment arms in hidradenitis suppurativa randomized clinical trials: A systematic review: Publication date: January 2020Source: Journal of the American Academy of Dermatology, Volume 82, Issue 1Author(s): Asma Amir Ali, Elizabeth K. Seng, Afsaneh Alavi, Michelle A. LowesBackgroundHidradenitis suppurativa (HS) is characterized by recurrent, painful nodules in flexural areas.ObjectiveThe objective of this study was to explore the placebo response in HS randomized clinical...
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Measuring psoriatic arthritis symptoms: A core domain in psoriasis clinical trials: Publication date: January 2020Source: Journal of the American Academy of Dermatology, Volume 82, Issue 1Author(s): Lourdes Maria Perez-Chada, Alice Bendix Gottlieb, Jeffrey Cohen, Philip Mease, Kristina Callis Duffin, Amit Garg, John Latella, April Wang Armstrong, Alexis Ogdie, Joseph Frank MerolaBackgroundThe International Dermatology Outcome Measures established a set of core domains to be measured in all psoriasis...
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Topical cholesterol/lovastatin for the treatment of porokeratosis: A pathogenesis-directed therapy: Publication date: January 2020Source: Journal of the American Academy of Dermatology, Volume 82, Issue 1Author(s): Lihi Atzmony, Young H. Lim, Claire Hamilton, Jonathan S. Leventhal, Annette Wagner, Amy S. Paller, Keith A. ChoateBackgroundPorokeratosis is associated with mevalonate pathway gene mutations. Therapeutic options are few and often limited in efficacy. We hypothesized that topical therapy...
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The impact of dupilumab on patch testing and the prevalence of comorbid allergic contact dermatitis in recalcitrant atopic dermatitis: A retrospective chart review: Publication date: January 2020Source: Journal of the American Academy of Dermatology, Volume 82, Issue 1Author(s): Jodie Raffi, Raagini Suresh, Nina Botto, Jenny E. MuraseBackgroundIt is unclear whether the type 2 T helper cell–specific immunosuppressive action of dupilumab interferes with patch testing.ObjectivesWe sought to evaluate...
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Improved overall survival of melanoma of the head and neck treated with Mohs micrographic surgery versus wide local excision: Publication date: January 2020Source: Journal of the American Academy of Dermatology, Volume 82, Issue 1Author(s): Jamie Hanson, Addison Demer, Walter Liszewski, Neal Foman, Ian MaherBackgroundOptimal surgical management for melanoma of the head and neck remains controversial.ObjectiveAssess outcomes for melanomas of the head and neck treated with Mohs micrographic surgery...
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Histopathologic features distinguishing secondary syphilis from its mimickers: Publication date: January 2020Source: Journal of the American Academy of Dermatology, Volume 82, Issue 1Author(s): Alexandra Flamm, Veronica Merelo Alcocer, Viktoryia Kazlouskaya, Eun Ji Kwon, Dirk ElstonBackgroundSyphilis is often misdiagnosed clinically, and biopsies might be required.ObjectiveTo determine histopathologic features that distinguish secondary syphilis from pityriasis lichenoides (PL), pityriasis rosea...
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Management of pediatric plaque psoriasis using biologics: Publication date: January 2020Source: Journal of the American Academy of Dermatology, Volume 82, Issue 1Author(s): Perla Lansang, James N. Bergman, Loretta Fiorillo, Marissa Joseph, Irene Lara-Corrales, Danielle Marcoux, Catherine McCuaig, Elena Pope, Vimal H. Prajapati, Sue Z.J. Li, Ian LandellsBackgroundPsoriasis is a chronic inflammatory disease with clinical manifestations of the skin that affect adults and children. In adults, biologics...
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The emerging utility of the cutaneous microbiome in the treatment of acne and atopic dermatitis: Publication date: January 2020Source: Journal of the American Academy of Dermatology, Volume 82, Issue 1Author(s): Taylor E. Woo, Christopher D. SibleyThe cutaneous microbiome has potential for therapeutic intervention in inflammatory-driven skin disease. Research into atopic dermatitis and acne vulgaris has highlighted the importance of the skin microbiota in disease pathogenesis, prognostication, and...
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Lactobacillus Endocarditis-Associated Glomerulonephritis Complicated by anti-Coagulant Nephropathy and Renal Amyloidosis: Kidney injury is a well-known sequelae of infectious endocarditis. Various types of kidney injury can be seen, including endocarditis-associated glomerulonephritis, and may affect nearly half of the patients with infectious endocarditis. Lactobacillus species are an infrequently documented cause of endocarditis. We present a case of Lactobacillus endocarditis-associated glomerulonephritis...
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Labial Adhesions Causing Recurrent Urinary-Tract Infections in an Elderly Woman: A 91-year-old postmenopausal woman with a prior history of two labial-adhesion separations suffered from recurrent urinary-tract infections. We were able to successfully treat her labial adhesions using surgery.
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Optic Nerve Hypoplasia, Corpus Callosum Agenesis, Cataract, and Lissencephaly in a Neonate with a Novel <b><i>COL4A1</i></b> Mutation: We report the case of a girl with a novel mutation of the COL4A gene (c.2716+2T#x3e;C) presenting microcephaly, parenchymal hemorrhages, lissencephaly, and bilateral cataracts, associated with agenesis of the corpus callosum and hypoplasia of the optic nerve. COL4A1, located on chromosome 13, encodes the α1 chain of type IV collagen, a key...
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Double-Needle Yamane Repositioning of a Previous Yamane Fixation: We describe a case of anteriorly dislocated, Yamane-fixated secondary intraocular lens (IOLs) with pigmentary dispersion syndrome. The patient presented with significant visual impairment and elevated intraocular pressure despite being maximally treated with all topical antihypertensive medications. The iris-IOL touch was confirmed by ultrasound biomicroscopy, and fundus examination revealed evidence of pigment granules on the optic...
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Penile reconstruction using scrotal flap after usage of monopolar electrocautery in a 2-month-old Syrian child: a case report: AbstractCircumcision is regarded as one of the most common procedures in pediatrics. We present a case of a newborn, who has undergone circumcision using monopolar electrocautery. He admitted to the hospital with glans necrosis and was treated with antibiotics and surgical debridement. Four months later, phalloplasty was performed for the newborn using scrotal flap. The result...
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Mechanical intestinal obstruction following laparoscopic inguinal hernia repair in a patient with abdominal cocoon syndrome: AbstractAbdominal cocoon syndrome (ACS) is a rare condition characterized by partial or complete encasement of small intestine by a thick fibro-collagenous membrane. A 65-year-old man presented to the surgical department with left inguinal. He underwent laparoscopic transabdominal preperitoneal inguinal hernia. When we inserted a trocar into the peritoneal cavity, the small...
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Pararectal angiomyxoma: a diagnostic dilemma: AbstractClinical diagnosis of pararectal masses remains a challenge to this day. Despite the availability of advanced imaging facilities, we often fail to reach a definitive diagnosis and have to resort to surgery. We describe a case of a 60-year-old female with a painless perianal swelling gradually increasing in size for 6 months with spontaneous reduction on assuming a supine position. Clinical examination of this patient was suggestive of a pelvic...
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A case of sigmoid colon perforation presenting with pneumomediastinum: AbstractA 62-year-old woman had developed polymyositis 12 years previously and had taken oral steroids. Chest and abdominal computed tomography showed pneumomediastinum and free air in the abdominal cavity. Although a colon perforation was suspected, the perforation site could not be identified on the image. In addition, a diagnosis of oesophageal rupture could not be excluded from the findings of pneumomediastinum. After general...
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Pancreatic solid serous cystadenoma: a rare entity that can lead to a futile surgery: AbstractAlthough many types of pancreatic tumors exist, pancreatic solid serous cystadenoma stand as the most rare. Despite advances in medical imaging, definitive diagnosis remains complex. Here, we report a case of a 63-year-old man with a suspicious lesion of the pancreas discovered during a positron emission tomography–computed tomography. Despite an echo-endoscopy being performed, no biopsies were contributive....
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Septo-optic dysplasia with amniotic band syndrome sequence: a case report: Insiyah A. Amiji, Ummulkheir H. Mohamed, Adelina G. Rutashobya, Mariam Mngoya, Nicole Schoenmann, Helga E. Naburi & Karim P. Manji Journal of Medical Case Reports volume 13, Article number: 370 (2019) Cite this article48 Accesses1 AltmetricMetricsdetailsAbstractIntroductionDe Morsier syndrome, or septo-optic dysplasia, is a rare, heterogeneous, complex condition with a highly variable phenotype. It is characterized by...
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Continuous intravenous low-dose diclofenac sodium to control a central fever after ischemic stroke in the intensive care unit: a case report and review of the literature: AbstractIntroductionElevation in body temperature within the first 24 hours of ischemic stroke is fairly common and known to be associated with worse outcomes. Only after thoroughly ruling out infection and the noninfectious etiologies and in the appropriate clinical setting should the diagnosis of central fever be made. Acetaminophen...
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Pneumothorax associated with giant bullous emphysema and mediastinum deviation:
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Successful emergency management of a bleeding tracheoinnominate fistula: In this case, we describe a novel approach to achieving temporary haemostasis in acute massive haemorrhage from a bleeding tracheoinnominate fistula. We report the case of a 42-year-old man admitted to hospital after suffering 80% body surface area burns. Thirty days following the percutaneous insertion of a tracheostomy, spontaneous massive haemorrhage occurred via the tracheostomy stoma, the tracheostomy tube and the mouth....
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Oral focal mucinosis of the mandible in an adolescent patient: Oral focal mucinosis (OFM) is the rare oral manifestation of cutaneous focal mucinosis. It is a diagnosis made histopathologically, as OFM remains clinically similar to other more common oral lesions, and radiographs do not provide any diagnostic information. This case is a report of a teenage female with left mandibular involvement of an elevated, rounded, asymptomatic, mucosa-coloured lesion in the facial and lingual gingiva between...
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Impact of radiological diagnostics in the survivor of disseminated Fournier gangrene patient with septic pulmonary embolism: A 51-year-old diabetic man diagnosed with prostatic abscess underwent its drainage twice. Following surgery he developed fever and right-sided painless visual loss due to endophthalmitis. To rule out its endogenous source CT scan was done which showed multisystem aetiology and complications. His pelvic CT and CT cystogram revealed postsurgical urethral injury along with urinary...
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Use of home telemedicine for critical illness rehabilitation: an Indian success story.: Unnikrishnan et al. Present a case report of a 26 year old male with Duchenne Muscular Dystrophy who benefited from the use of Telemedicine in the setting post-ICU rehabilitation. The Who defines Telemedicine as follows: "the delivery of healthcare services, where distance is a critical factor, by all healthcare professionals using information and communication technologies for the exchange of valid information...
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Antioxidants, Vol. 8, Pages 650: Acute Intake of a Grape and Blueberry Polyphenol-Rich Extract Ameliorates Cognitive Performance in Healthy Young Adults During a Sustained Cognitive Effort: Antioxidants, Vol. 8, Pages 650: Acute Intake of a Grape and Blueberry Polyphenol-Rich Extract Ameliorates Cognitive Performance in Healthy Young Adults During a Sustained Cognitive EffortAntioxidants doi: 10.3390/antiox8120650Authors: Pierre Philip Patricia Sagaspe Jacques Taillard Claire Mandon Joël...
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Elevated activity levels do not influence extrinsic fiber attachment morphology on the surface of muscle‐attachment sites: This study adapts surface metrological techniques to the automated, quantitative and non‐destructive analysis of bone surface histology. Although extrinsic fiber (EF) presence does indicate muscle attachment, activity does not have an observable effect on EF morphology.AbstractExtrinsic fibers (EFs) are a type of penetrating collagenous fiber, closely related to the periodontal...
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Developmental studies on the acquisition of perception conducting pathways via TRP channels in rat molar odontoblasts using immunohistochemistry and RT-qPCR: AbstractOdontoblasts act as dentin formation and sensory receptors. Recently, it was reported that transient receptor potential ankyrin (TRPA) 1, TRP vanilloid (TRPV) 4 and pannexin 1 (PANX-1) play important roles in odontoblast sensory reception. However, it is not known when odontoblasts begin to possess a sense reception function. The aim...
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The impact of cirrhosis in patients undergoing cardiac surgery: a retrospective observational cohort study: AbstractPurposePatients with cirrhosis and concomitant coronary/valvular heart disease present a clinical dilemma. The therapeutic outcome of major cardiac surgery is significantly poorer in patients with cirrhosis compared with patients without cirrhosis. To address this, we aimed to identify associations between the severity of cirrhosis and post-cardiac surgical outcomes.MethodsA historical...
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Knowledge and perceptions about perioperative stroke: a cross-sectional survey of patients scheduled for non-neurologic and non-cardiac surgery: AbstractPurposePerioperative stroke is associated with significant morbidity and mortality yet patients may not be aware of their risk or receive appropriate counselling. Our objectives were to 1) compare patient's perceived vs calculated risk of stroke; 2) determine level of worry; and 3) assess prior discussion about perioperative stroke risk amongst elective...
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Risk factors for reintubation after anterior cervical discectomy and fusion surgery: evaluation of three observational data sets: AbstractPurposePostoperative loss of airway requiring reintubation is a rare but potentially catastrophic complication following anterior cervical discectomy and fusion (ACDF). We sought to identify risk factors asscociated with reintubation within one day following ACDF. Attention was focused on patient demographics, comorbidities, and factors potentially linked to soft...
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Managing and securing the bleeding upper airway: a narrative review: AbstractFailure to manage bleeding in the airway is an important cause of airway-related death. The purpose of this narrative review is to identify techniques and strategies that can be employed when severe bleeding in the upper airway may render traditional airway management (e.g., facemask ventilation, intubation via direct/video laryngoscopy, flexible bronchoscopy) impossible because of impeded vision. An extensive literature...
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Rate, Rhythm, and Risk: Perioperative New-Onset Atrial Fibrillation: FEATURED ARTICLESAtrial Fibrillation: Current Evidence and Management Strategies During the Perioperative PeriodKaramchandani, Kunal MD, FCCP*; Khanna, Ashish K. MD, FCCP, FCCM†,‡; Bose, Somnath MD§; Fernando, Rohesh J. MD, FASE‖; Walkey, Allan J. MD, MSc¶,#Author InformationFrom the *Department of Anesthesiology & Perioperative Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania†Department of...
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Atrial Fibrillation: Current Evidence and Management Strategies During the Perioperative Period: Atrial fibrillation (AF) is the most common arrhythmia in the perioperative period. Previously considered a benign and self-limited entity, recent data suggest that perioperative AF is associated with considerable morbidity and mortality and may predict long-term AF and stroke risk in some patients. Despite known risk factors, AF remains largely unpredictable, especially after noncardiac surgery. As a...
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Comparison of general anesthesia with endotracheal intubation, combined spinal-epidural anesthesia, and general anesthesia with laryngeal mask airway and nerve block for intertrochanteric fracture surgeries in elderly patients: a retrospective cohort study: AbstractBackgroundThere is no consensus on the optimal anesthesia method for intertrochanteric fracture surgeries in elderly patients. Our study aimed to compare the hemodynamics and perioperative outcomes of general anesthesia with endotracheal...
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Anxiety and food allergy: AbstractBackgroundFood allergy (FA) is recognized as a growing public health burden affecting 5 to 10% of children worldwide. Several unique features specific to FA elicit high levels of emotional distress and anxiety in patients and caregivers, the first among all the possibility of a life‐threatening reaction. Anxiety disorders are highly prevalent in patients with chronic disease, but remain undertreated despite significant negative consequences on patient health.ObjectiveThis...
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Modulation of allergic inflammation in the lung by a peptide derived from mycobacteria tuberculosis chaperonin 60.1: AbstractBackgroundWe have previously demonstrated that M. tuberculosis chaperonin 60.1 inhibits leukocyte diapedesis and bronchial hyperresponsiveness in a murine model of allergic lung inflammation.MethodsIn the present study we have investigated the effect of a shorter peptide sequence derived from Cpn 60.1, named IRL201104, on allergic lung inflammation induced by ovalbumin (OVA)...
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Maternal psychological distress before birth influences gut immunity in mid‐infancy: AbstractBackgroundMaternal pre‐postnatal psychosocial distress increases the risk for childhood allergic disease. This may occur through a host immunity pathway that involves intestinal secretory Immuno‐globulin A (sIgA). Experimental animal models show changes in the gut microbiome and immunity of offspring when exposed to direct or prenatal maternal stress, but little is known in humans.ObjectiveWe determined the...
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Late-onset interstitial nephritis in a patient with drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms.: Related ArticlesLate-onset interstitial nephritis in a patient with drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms.J Dermatol. 2019 Dec 16;:Authors: Higashi Y, Baba N, Yoshimine H, Sakaguchi I, Kanekura TAbstract Drug-induced hypersensitivity syndrome (DIHS), also referred to as drug reaction with eosinophilia...
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Non-canonical autophagy in dermal dendritic cells mediates immunosuppressive effects of UV exposure: Publication date: Available online 16 December 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Payel Sil, Jutamas Suwanpradid, Ginger Muse, Artiom Gruzdev, Liwen Liu, David L. Corcoran, Cynthia J. Willson, Kyathanahalli Janardhan, Sara Grimm, Page Myers, Laura Miller Degraff, Amanda S. MacLeod, Jennifer MartinezAbstractBackgroundControl of the inflammatory response is critical to...
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Comparative study of food allergies in children from China, India and Russia: The EuroPrevall-INCO surveys: Publication date: Available online 16 December 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Jing Li, Ludmila M. Ogorodova, Padukudru Anand Mahesh, Maggie Haitian Wang, Olga Sergeevna Fedorova, Ting Fan Leung, Montserrat Fernandez-Rivas, EN Clare Mills, James Potts, Ischa Kummeling, Serge A. Versteeg, Ronald van Ree, Maria Yazdanbakhsh, Peter GJ. Burney,...
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Long-term combinations and updosing of second-generation H<sub>1</sub>-antihistamines show efficacy and safety in the treatment of chronic spontaneous urticaria: a multi-center real-life pilot study: Publication date: Available online 16 December 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Liming Zhang, Jian Wu, Yumeng Qi, Hong Zhu, Xu Yao, Mengmeng Li, Jingyi Li, Zaipei Guo, Xiangyang Su, Wei Lai, Siyu Hao, Yuzhen Li, Yang Li, Chunli Yao, Fuqiu Li,...
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Structural non-infectious manifestations of the central nervous system in common variable immunodeficiency disorders: Publication date: Available online 16 December 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Annick van de Ven, Irina Mader, Daniel Wolff, Sigune Goldacker, Hannah Fuhrer, Sebastian Rauer, Bodo Grimbacher, Klaus WarnatzAbstractBackgroundCentral nervous system (CNS) disease in adult common variable immunodeficiency (CVID) is rare and therefore diagnostic...
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Natural Language Processing Combined with ICD-9-CM Codes as a Novel Method to Study the Epidemiology of Allergic Drug Reactions: Publication date: Available online 16 December 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Aleena Banerji, Kenneth H. Lai, Yu Li, Rebecca R. Saff, Carlos A. Camargo, Kimberly G. Blumenthal, Li ZhouAbstractBackgroundAllergic drug reaction epidemiologic data are sparse because it remains difficult to identify true cases in large datasets...
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Trajectory analyses of adherence patterns in a real-life moderate to severe asthma population: Publication date: Available online 16 December 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Job FM. van Boven, Marjaana Koponen, Samanta Lalic, Johnson George, J. Simon Bell, Mark Hew, Jenni IlomakiAbstractBackgroundGlobal Initiative for Asthma step 5 therapies (GINA-5), other than inhaled corticosteroids and long-acting beta agonists in fixed dose combinations (ICS/LABA...
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CARsomes inhibit airway allergic inflammation in mice by inducing antigen specific Th2 cell apoptosis: AbstractBackgroundSkewed T helper (Th)2 response plays a crucial role in the pathogenesis of allergic diseases. The therapeutic efficacy for allergic diseases is unsatisfactory currently. This study aims to regulate the skewed Th2 response with CARsomes.MethodsThe CARsome consisted of an epitope of Dermatophagoides farina‐1 (Derf1), a segment of the anti‐DEC205 antibody, the scFv, and an open reading...
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Clinical utility of the Quantra® point‐of‐care haemostasis analyser during urgent cardiac surgery: SummaryCoagulopathic bleeding during and after cardiac surgery is associated with increased morbidity and mortality. Viscoelastic testing is increasingly used instead of laboratory testing. Our aim was to compare a new viscoelastic point‐of‐care device, the Quantra® System, with thromboelastography and standard laboratory testing. After ethical approval and with written informed consent, we prospectively...
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Immediate Plastic Surgery Closure at Index Spinal Surgery Minimizes Complications Compared to Delayed Reconstruction: A Retrospective Cohort Review: Complex spine surgery in patients with major comorbidities leads to increased need for midline back wound reconstruction by plastic surgeons. Literature suggests back wound reconstruction concurrent with high-risk immediate/index spine surgery may lead to fewer complication. This study aimed to validate this claim in a large cohort treated at a tertiary...
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Increasing Abdominal Wall Thickness Predicts Complications in Abdominally-Based Breast Reconstruction: A Review of 106 Consecutive Patients: Body mass index (BMI) has long been the proxy for patient selection in obese patients presenting for abdominally based breast reconstruction. Body mass index, however, fails to accurately reflect the distribution of abdominal adipose tissue. This study aims to quantify the effect of abdominal wall thickness on the incidence of post-operative complications and...
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Biportal Transparotid Dissection in the Retromandibular Approach for Condylar Fracture Osteosynthesis: Efficacy of a Novel Technique: : Facial nerve injury is a primary complication of open surgical management of condylar fractures. A new modification of the retromandibular transparotid approach, the "biportal transparotid dissection" (BTD), was developed to reduce these injuries in accidental nerve exposure.AbstractObjective: Facial nerve injury is a primary complication of open surgical management...
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The effect of intrathecal bupivacaine/morphine on quality of recovery in robot‐assisted radical prostatectomy: a randomised controlled trial: SummaryRobot‐assisted radical prostatectomy causes discomfort in the immediate postoperative period. This randomised controlled trial investigated if intrathecal bupivacaine/morphine, in addition to general anaesthesia, could be beneficial for the postoperative quality of recovery. One hundred and fifty‐five patients were randomly allocated to an intervention...
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2′-Hydroxychalcones as an alternative treatment for trichomoniasis in association with metronidazole
2′-Hydroxychalcones as an alternative treatment for trichomoniasis in association with metronidazole: AbstractThe treatment for trichomoniasis, based on 5′-nitroimidazol agents, has been presenting failures related to allergic reactions, side effects, and the emergence of resistant isolates. There are no alternative drugs approved for the treatment of these cases; thus, the search for new active molecules is necessary. In this scenario, chalcones have been extensively studied for their promising...
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Different prognostic significance of examined lymph node count for patients with non-small-cell lung cancer ≤1 cm or >1–2 cm: a population-based study: Future Oncology, Ahead of Print. Aim: This study aimed to investigate the impact of examined lymph node (ELN) count on survival of resected pT1a-1bN0M0 non-small-cell lung cancer (NSCLC). Materials & methods: Data were extracted from the US Surveillance, Epidemiology and End Results database. The association between ELN count and overall survival...
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Severe hyperandrogenism due to ovarian hyperthecosis in a young woman: Hyperandrogenism is a relatively common clinical problem. However, severe hyperandrogenism causing virilisation is rare. A 27-year-old woman presented with generalised hirsutism, clitoromegaly, breast atrophy and secondary amenorrhoea. She had serum testosterone levels elevated to the adult male range. Administration of gonadotropin-releasing hormone (GnRH) analogue resulted in >50% suppression of serum testosterone which was...
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Late ventricular standstill following an elective TAVI: Transcatheter aortic valve implantations (TAVIs) may be complicated by a need for permanent pacemaker implantation post procedure, usually due to local trauma or compression on the conduction system. There are some features that might help predict that a patient is high risk for developing conduction disease following TAVI, for example, underlying right bundle branch block or use of certain types of TAVI. It might also become apparent during...
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Isolated CNS leukaemic relapse in acute myeloid leukaemia: DescriptionA 61-year-old woman with acute myeloid leukaemia (AML) without maturation (M1) with trisomy 13 who achieved complete remission after her initial diagnosis with cytarabine and idarubicin. Two years later, she relapsed and underwent successful haematopoietic stem cell transplantation afterwards, and she entered complete remission. Sixteen months later, she presented to our emergency department with a 2-week history of worsening fatigue,...
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Primary seminal vesicle adenocarcinoma: a lethal yet cryptic malignancy with review of literature: The rarity of primary seminal vesical adenocarcinoma (PSVA) coupled with mostly late and advanced presentation with high mortality makes it an unanticipated malignancy with poor prognosis. Although there has been sporadic reporting of cases, the dearth of literature makes standardised care a challenge. The detection has incorporated immunohistochemistry for establishing the site of origin as well as...
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Somatosensory changes in Chinese patients after coronectomy vs. total extraction of mandibular third molar: a prospective study: AbstractObjectivesThis study aimed to quantitatively compare the somatosensory function changes of inferior alveolar nerve (IAN) after mandibular third molar extraction with a surgery protocol of coronectomy, as opposed to the conventional method.Materials and methodsPatients with a lower third molar directly contacting IAN were recruited and assigned either to a test group...
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Removing arsenic from water with an original and modified natural manganese oxide ore: batch kinetic and equilibrium adsorption studies: AbstractArsenic contamination of drinking water is a serious water quality problem in many parts of the world. In this study, a low-cost manganese oxide ore from Vietnam (Vietnamese manganese oxide (VMO)) was firstly evaluated for its performance in arsenate (As(V)) removal from water. This material contains both Mn (25.6%) and Fe (16.1%) mainly in the form of cryptomelane...
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Automatic detection of reverse-triggering related asynchronies during mechanical ventilation in ARDS patients using flow and pressure signals: AbstractAsynchrony due to reverse-triggering (RT) may appear in ARDS patients. The objective of this study is to validate an algorithm developed to detect these alterations in patient–ventilator interaction. We developed an algorithm that uses flow and airway pressure signals to classify breaths as normal, RT with or without breath stacking (BS) and patient...
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JCM, Vol. 9, Pages 1: Obstructive Sleep Apnea as a Predictor of Abnormal Heart Rate Turbulence: JCM, Vol. 9, Pages 1: Obstructive Sleep Apnea as a Predictor of Abnormal Heart Rate TurbulenceJournal of Clinical Medicine doi: 10.3390/jcm9010001Authors: Urbanik Gać Martynowicz Poręba Podgórski Negrusz-Kawecka Mazur Sobieszczańska Poręba Obstructive sleep apnea (OSA) causes dysfunction of the autonomic nervous system, but the exact mechanism has not been fully understood. The...
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Updates in Novel Therapies for Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN): AbstractPurpose of ReviewBlastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, clinically aggressive hematologic malignancy that has heterogeneous presentation and can involve the skin, lymph nodes, and bone marrow. Recent advancements in our patho-biologic understanding of the disease have led to the development of new targeted therapies for BPDCN. In this review, we aimed to describe some of the novel...
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Impact of peripheral neuropathy induced by platinum in first-line chemotherapy on second-line chemotherapy with paclitaxel for advanced gastric cancer: AbstractBackgroundFluoropyrimidine plus platinum, followed by paclitaxel (PTX) plus ramucirumab is a recommended treatment strategy for advanced gastric cancer (AGC). We investigated how peripheral neuropathy (PN), induced by platinum in first-line chemotherapy, affected the tolerability of second-line chemotherapy with PTX (2nd-PTX).MethodsThe subjects...
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