International Journal of Molecular SciencesIJMS, Vol. 20, Pages 6279: Structural Insights into the Intracellular Region of the Human Magnesium Transport Mediator CNNM4IJMS, Vol. 20, Pages 6279: Structural Insights into the Intracellular Region of the Human Magnesium Transport Mediator CNNM4 International Journal of Molecular Sciences doi: 10.3390/ijms20246279 Authors: Paula Giménez-Mascarell Iker Oyenarte Irene González-Recio Carmen Fernández-Rodríguez María Ángeles Corral-Rodríguez Igone Campos-Zarraga...
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International Journal of Molecular SciencesIJMS, Vol. 20, Pages 6317: Comparative Proteomic Analysis of Pleurotus ostreatus Reveals Great Metabolic Differences in the Cap and Stipe Development and the Potential Role of Ca2+ in the Primordium DifferentiationIJMS, Vol. 20, Pages 6317: Comparative Proteomic Analysis of Pleurotus ostreatus Reveals Great Metabolic Differences in the Cap and Stipe Development and the Potential Role of Ca2+ in the Primordium Differentiation International Journal of Molecular...
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Chemosensors, Vol. 7, Pages 65: Electrochemical Sensing of Caffeic Acid Using Gold Nanoparticles Embedded in Poly(3,4-ethylenedioxythiophene) Layer by Sinusoidal Voltage ProcedureChemosensors, Vol. 7, Pages 65: Electrochemical Sensing of Caffeic Acid Using Gold Nanoparticles Embedded in Poly(3,4-ethylenedioxythiophene) Layer by Sinusoidal Voltage Procedure Chemosensors doi: 10.3390/chemosensors7040065 Authors: Bottari Pigani Zanardi Terzi Paţurcă Grigorescu Matei Lete Lupu The increasing demand for...
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Brain Sciences, Vol. 9, Pages 376: A Hybrid Feature Pool-Based Emotional Stress State Detection Algorithm Using EEG SignalsBrain Sciences, Vol. 9, Pages 376: A Hybrid Feature Pool-Based Emotional Stress State Detection Algorithm Using EEG Signals Brain Sciences doi: 10.3390/brainsci9120376 Authors: Hasan Kim Human stress analysis using electroencephalogram (EEG) signals requires a detailed and domain-specific information pool to develop an effective machine learning model. In this study, a multi-domain...
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Antibiotics, Vol. 8, Pages 268: Development, Validation, and Stability Assessment Application of RP-HPLC-DAD Method for Quantification of Ampicillin in Total Parenteral Nutrition AdmixturesAntibiotics, Vol. 8, Pages 268: Development, Validation, and Stability Assessment Application of RP-HPLC-DAD Method for Quantification of Ampicillin in Total Parenteral Nutrition Admixtures Antibiotics doi: 10.3390/antibiotics8040268 Authors: Maciej Stawny Aleksandra Gostyńska Katarzyna Dettlaff Anna Jelińska Marta...
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Protective effects of a polyphenol-enriched fraction of the fruit peel of Annona crassiflora Mart. on acute and persistent inflammatory pain: AbstractDifferent parts of Annona crassiflora Mart., a native species from Brazilian savanna, were traditionally used for the treatment of a wide variety of ailments including arthritis. Thus, this study aimed to investigate the possible antinociceptive and anti-inflammatory properties of a polyphenol-enriched fraction of the fruit peel of A. crassiflora, named...
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Sleep Quality and Health Related Problems of Shift Work Among Resident Physicians: A Cross-sectional Study: Publication date: Available online 15 December 2019Source: Sleep MedicineAuthor(s): Roa'a Jaradat, Amro Lahlouh, Mohamed MustafaAbstractObjectivesShift work is defined as any irregular work schedule that extends beyond the usual 9 am to 5 pm time frame. Evidence from outside medicine suggests that it may be related to detrimental health outcomes. Our objective from this study is to evaluate...
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Neuroprotection by insulin-like growth factor-1 in rats with ischemic stroke is associated with microglial changes and a reduction in neuroinflammation: Publication date: Available online 14 December 2019Source: NeuroscienceAuthor(s): Ahmad Serhan, Joeri L. Aerts, EWGM Boddeke, Ron KooijmanAbstractWe and others have shown that insulin-like growth factor-1 (IGF-1) is neuroprotective when administered systemically shortly following stroke. In the current study, we addressed the hypothesis that microglia...
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Effects of chronic dim-light-at-night exposure on sleep in young and aged mice: Publication date: Available online 14 December 2019Source: NeuroscienceAuthor(s): M. Panagiotou, T. DeboerAbstractDim-light-at-night (DLAN) exposure is associated with health problems, such as metabolic disruptions, immunological modulations, oxidative stress, sleep problems, and altered circadian timing. Neurophysiological parameters, including sleep patterns, are altered in the course of aging in a similar way. Here,...
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The Use of Inhaled <em>N</em>-Acetylcysteine for Laryngopharyngeal Reflux Disease: A Randomized Controlled Trial: Publication date: Available online 14 December 2019Source: Journal of VoiceAuthor(s): Yong Seok Jo, Ick Soo Choi, Yoon Kyoung SoSummaryObjectivesProton pump inhibitors (PPIs) are the mainstay of the medical treatment for laryngopharyngeal reflux disease (LPRD). However, extraesophageal symptoms of LPRD, such as globus, are often refractory to PPI treatment. Many kinds of adjunctive...
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Effect of Phonation on Perception of Femininity/Masculinity in Transgender and Cisgender Speakers: Publication date: Available online 15 December 2019Source: Journal of VoiceAuthor(s): Nichole Houle, Susannah V. LeviAbstractMany transwomen seek voice and communication therapy to support their transition from their gender assigned at birth to their gender identity. This has led to an increased need to examine the perception of gender and femininity/masculinity to develop evidence-based intervention...
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Does the Reflux Symptom Index Predict Increased Pharyngeal Events on HEMII-pH Testing and Correlate with General Quality of Life?: Publication date: Available online 14 December 2019Source: Journal of VoiceAuthor(s): Elliana Kirsh DeVore, Walter W. Chan, Jennifer J. Shin, Thomas L. CarrollSummaryObjectivesTo determine the ability of the reflux symptom index (RSI) to predict objective impedance and pH-probe testing, and to examine the relationship between disease-specific and general health status...
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Novel therapy brings hope in neuroendocrine tumors: Award-winning researchers from a top London facility have demonstrated how...Read more on AuntMinnieEurope.comRelated Reading:FDA approves new radionuclide therapy by AAAFDG-PET adds to gallium-68 scans for neuroendocrine tumorsFirst choice for neuroendocrine tumors: Ga-68 DOTATATEGa-68 DOTATATE PET/CT detects neuroendocrine tumor recurrenceGa-68 DOTATOC PET/MRI tops PET/CT for staging neuroendocrine tumorsOriginal enclosures: 2019_12_13_19_51_1879_carcinoid_neuroendocrine_tumor_400.jpg...
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Magnetic detection of sentinel nodes in oral squamous cell carcinoma by means of superparamagnetic iron oxide contrast: AbstractThe aim was to evaluate sentinel node detection capacity by means of a magnetic probe in 11 patients with oral squamous cell carcinoma at stages T1‐T2 received submucosal injections of a superparamagnetic iron oxide contrast agent (SPIO). A magnetic probe was used for sentinel node biopsy. The use of SPIO and magnetic probes in the early stages of oral cancer may offer an...
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Oncoplastic breast‐conserving surgery using chest wall perforator flaps: Three‐dimensional quantitative analysis of the percentage of breast volume excised and changes over time in flap volume: AbstractBackground and ObjectivesWe investigated the effects of oncoplastic breast‐conserving surgery (BCS) using chest wall perforator flaps (CWPFs) on the subsequent expected deformity and evaluated the longevity of flap volume.MethodsWe retrospectively reviewed oncological and cosmetic outcomes of 33 women...
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Intraperitoneal dye injection method for visualizing the functioning lymphatic vascular system in zebrafish and medaka.: Related ArticlesIntraperitoneal dye injection method for visualizing the functioning lymphatic vascular system in zebrafish and medaka.Dev Dyn. 2019 Dec 13;:Authors: Saito E, Isogai S, Deguchi T, Ishida K, Nozaki T, Ishiyama E, Wayama M, Shimoda HAbstract A hierarchically organized lymphatic vascular system extends throughout the vertebrate body for tissue fluid homeostasis,...
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Molecular and Cellular Mechanisms of the Organogenesis and Development of the Mammalian Carotid Body.: Related ArticlesMolecular and Cellular Mechanisms of the Organogenesis and Development of the Mammalian Carotid Body.Dev Dyn. 2019 Dec 14;:Authors: Kameda YAbstract Despite significant advancements in understanding physiological properties of the carotid body, little attention has been paid to its organogenesis. This review addresses the molecular and cellular mechanisms underlying organogenesis...
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Beyond Physicalism: Philosopher Hedda Hassel Mørch defends the idea that consciousness pervades the cosmos-- Read more on ScientificAmerican.com Original enclosures: Credit: Ben Harrison Getty ImagesPhilosophy has taken a beating lately, even, or especially, from philosophers, who are compulsive critics, even, especially, of their own calling. But bright young women and men still aspire to be full-time truth-seekers in our corrupt, capitalist world. Over the past five years, I have...
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Risk Factors for Hen's Egg Allergy in Europe: EuroPrevall birth cohort: Publication date: Available online 14 December 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Kate E.C. Grimshaw, Graham Roberts, Anna Selby, Andreas Reich, Indra Butiene, Michael Clausen, Ruta Dubakiene, Ana Fiandor, Alessandro Fiocchi, Linus.B. Grabenhenrich, Jose Ignacio Larco, Marek L. Kowalski, Odilija Rudzeviciene, Nikolaos.G. Papadopoulos, Leonard Rosenfeld, Sigurveig Th. Sigurdardottir,...
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Endovascular management of iatrogenic dissection into the petrous segment of the internal carotid artery during mechanical thrombectomy for acute stroke.: Related ArticlesEndovascular management of iatrogenic dissection into the petrous segment of the internal carotid artery during mechanical thrombectomy for acute stroke.J Clin Neurosci. 2019 Dec 10;:Authors: Bass DI, Walker M, Kim LJ, Levitt MRAbstract Iatrogenic dissection of the internal carotid artery is a well-known complication that...
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The association between pineal gland calcification and white matter hyperintensities of presumed vascular origin in older adults. A population-based study.: Related ArticlesThe association between pineal gland calcification and white matter hyperintensities of presumed vascular origin in older adults. A population-based study.J Clin Neurosci. 2019 Dec 10;:Authors: Del Brutto OH, Mera RM, Castle P, Kiernan J, Del Brutto VJ, Recalde BY, Sedler MJAbstract Pineal gland calcification (PGC) has...
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Negative-FLAIR vascular hyperintensities serve as a marker of no recanalization during hospitalization in acute stroke.: Related ArticlesNegative-FLAIR vascular hyperintensities serve as a marker of no recanalization during hospitalization in acute stroke.J Clin Neurosci. 2019 Dec 10;:Authors: Aoki J, Suzuki K, Suda S, Okubo S, Mishina M, Kimura KAbstract BACKGROUND: Since acute fluid-attenuated inversion recovery vascular hyperintensity (FVH) is indicative of disordered blood flow, FVH is...
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Craniofacial surgery and specific airway problems: AbstractInfants and children undergoing craniofacial surgery may present with a wide range of diseases and conditions posing an array of challenges to the anesthesiologist. Optimal perioperative care requires an understanding of these diseases and their impact on airway and anesthetic management. For those children with anomalies affecting airway anatomy, soft tissues of the head and neck, or skeletal mobility, advanced airway management techniques...
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Generalized chronic itch induced by small‐fiber neuropathy: clinical profile and proposed diagnostic criteria: AbstractBackgroundSmall‐fiber neuropathy (SFN) is a known cause for pain, however it may be also associated with chronic itch. The clinical profile of chronic itch due to SFN is poorly defined and accordingly under diagnosed in clinical care.ObjectivesTo establish the clinical profile of patients with SFN and to propose diagnostic criteria for this patient population.MethodsClinical data...
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Alterations in innate immunity and epithelial cell differentiation are the molecular pillars of hidradenitis suppurativa: AbstractBackgroundThe large unmet need of hidradenitis suppurativa/acne inversa (HS) therapy requires the elucidation of disease‐driving mechanisms and tissue targeting.ObjectiveRobust characterization of the underlying HS mechanisms and detection of the involved skin compartments.MethodsHS molecular taxonomy and key signaling pathways were studied by whole transcriptome profiling....
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Digital follow up by means of dermatoscopy and reflectance confocal microscopy of actinic keratosis treated with Imiquimod 3.75% cream: AbstractBackgroundImiquimod 3.75% cream (Zyclara® Meda, Stockholm, Sweden) is a new field‐directed therapy for actinic keratosis (AK).ObjectivesThe aim is to evaluate efficacy and the morphologic dynamic changes induced by this treatment by means of dermatoscopy and reflectance confocal microscopy (RCM) of imiquimod 3.75% cream for the treatment of AKs of the face...
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The Warburg effect and tumor immune microenvironment in extramammary Paget's disease: Overexpression of LDHA correlates with immune resistance.: AbstractBackgroundExtramammary Paget's disease (EMPD) is a rare malignant skin cancer. One of the hallmarks of cancers, including EMPD, is an enhancement of aerobic glycolysis, which is also known as the Warburg effect. In the last step of glycolysis, the enzyme lactate dehydrogenase A (LDHA) catalyzes the conversion of pyruvate to lactic acid, the accumulation...
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Effectiveness of a music intervention on pruritus: an open randomized prospective study: AbstractBackgroundPruritus is a common symptom in many skin diseases. Music interventions have demonstrated their efficacy in different symptoms or diseases such as pain, depression, anxiety.ObjectiveTo evaluate the effects of a music intervention on pruritus.Patients and methodsA randomized controlled trial was conducted from November 2018 to April 2019. Fifty inpatients with pruritus intensity ≥3/10 in various...
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Intraoperative imaging in the neurosurgery operating theatre: A review of the most commonly used techniques for brain tumour surgery.: Related ArticlesIntraoperative imaging in the neurosurgery operating theatre: A review of the most commonly used techniques for brain tumour surgery.Neurocirugia (Astur). 2019 Dec 10;:Authors: Tejada Solís S, de Quintana Schmidt C, Gonzalez Sánchez J, Fernández Portales I, Del Álamo de Pedro M, Rodríguez Berrocal V, Díez Valle R, Grupo de trabajo de la SENECAbstract...
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Loss of Parkin contributes to mitochondrial turnover and dopaminergic neuronal loss in aged mice: Publication date: Available online 15 December 2019Source: Neurobiology of DiseaseAuthor(s): Sachiko Noda, Shigeto Sato, Takahiro Fukuda, Norihiro Tada, Yasuo Uchiyama, Keiji Tanaka, Nobutaka HattoriAbstractParkinson's disease (PD), the second most common neurodegenerative disorder, is characterized by the loss of nigrostriatal dopamine neurons. PARK2 mutations cause early-onset Parkinson's disease (EO-PD)....
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Effects of 12-week avocado consumption on cognitive function among adults with overweight and obesity: Publication date: Available online 14 December 2019Source: International Journal of PsychophysiologyAuthor(s): Caitlyn G. Edwards, Anne M. Walk, Sharon V. Thompson, Ginger E. Reeser, John W. Erdman, Nicholas A. Burd, Hannah D. Holscher, Naiman A. KhanAbstractObjectivesExcess adiposity increases risk for cognitive impairment. Consumption of avocado, a highly bioavailable source of the xanthophyll...
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Wrinkled metal based quantum sensor for In vitro cancer diagnosis: Publication date: Available online 14 December 2019Source: Biosensors and BioelectronicsAuthor(s): Srisankari Ganesan, Krishnan Venkatakrishnan, Bo TanAbstractThis article presents a unique 3D biocompatible Aluminum-based quantum structure (QS) for in vitro cancer detection using Surface Enhanced Raman Scattering (SERS). The Al-based QSs fabricated using ultrashort pulsed laser are of two distinct surface characters, wrinkled and...
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Cardiac involvement in toluene intoxication: Publication date: Available online 14 December 2019Source: The American Journal of Emergency MedicineAuthor(s): Edgar Francisco Carrizales-Sepúlveda, Raymundo Vera-Pineda, Raúl Alberto Jiménez-Castillo, Alejandro Ordaz-FaríasThe most common route of exposure is via inhalation. Symptoms of toluene poisoning include CNS effects (headache, dizziness, ataxia, drowsiness, euphoria, hallucinations, tremors, seizures, and coma), ventricular arrythmias, chemical...
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Palaeochannels of Australia's Riverine Plain - Reconstructing past vegetation environments across the Late Pleistocene and Holocene: Publication date: Available online 15 December 2019Source: Palaeogeography, Palaeoclimatology, PalaeoecologyAuthor(s): Matt Forbes, Nathan Jankowski, Tim Cohen, Felicitas Hopf, Daniela Mueller, Michael Bird, Simon Haberle, Zenobia JacobsAbstractRiverine Plain palaeochannels record periods of fluvial activity for Late Pleistocene southeastern Australia. In an attempt...
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Edible insects: an alternative of nutritional, functional and bioactive compounds: Publication date: Available online 13 December 2019Source: Food ChemistryAuthor(s): Andressa JANTZEN DA SILVA LUCAS, Lauren MENEGON DE OLIVEIRA, Meritaine DA ROCHA, Carlos PRENTICEAbstractThe ingestion of insects has become a new trend in food science approximately since 2013, when the Food and Agriculture Organization of the United Nations (FAO) published a document entitled "Edible Insects: Future Perspectives of...
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Prolonged febrile seizure history exacerbates seizure severity in a pentylenetetrazole rat model of epilepsy: Publication date: February 2020Source: Brain Research Bulletin, Volume 155Author(s): Oluwole Ojo Alese, Cleopatra Rakgantsho, Nombuso V. Mkhize, Simo Zulu, Musa V. MabandlaAbstractEpilepsy is a debilitating neurological illness that affects all aspect of an individual life. Despite advancement in research there is little reduction in the incidence of this disease. Prolonged febrile seizure...
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Giant Cerebral Aneurysm: Radiology: Giant cerebral aneurysms are ones that measure >25 mm in greatest dimension. Appearances will depend on whether the aneurysm is non-thrombosed, or partially or completely thrombosed. Giant intracranial aneurysms have always been, and remain, among the most difficult cerebrovascular lesions to treat. This patient presented with seizures and showed giant MCA aneurysm on imaging. Case submitted by Dr MGK Murthy.Famous Radiology Blog http://www.sumerdoc.blogspot.com...
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Molecular Determinants of Statin-sensitivity in Cancer:
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Influence of weather and seasonal variations in temperature and humidity on supersaturation and enhanced deposition of submicron aerosols in the human respiratory tract: Publication date: Available online 14 December 2019Source: Atmospheric EnvironmentAuthor(s): Alexander IshmatovAbstractIn this review, all available data on the effects of supersaturation in human airways were summarized and analysed, and the most critical parameters identified. The analysis shows the boundary conditions for increased...
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Reproductive Senescence and Ischemic Stroke Remodel the Gut Microbiome and Modulate the Effects of Estrogen Treatment in Female Rats: AbstractOur previous work has shown that reproductively senescent (or middle-aged; 10–12-month-old) Sprague–Dawley female rats, that are naturally estrogen-deficient, have worse stroke outcomes as compared to normally estrous-cycling adult (5–6-month-old) females. Paradoxically, estrogen replacement to this middle-aged group exacerbates stroke outcomes, while it is...
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Paper based point of care immunosensor for the impedimetric detection of cardiac troponin I biomarker: AbstractAdvancements in health care monitoring demand a rapid, accurate and reliable early diagnosis of "Heart Attack" (acute myocardial infarction) with an objective to develop a cost-effective, rapid and label-free point of care diagnostic test kit for the detection of cardiac troponin I (cTnI) on paper-based multi-frequency impedimetric transducers. Paper based sensing platforms were developed...
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The role of melatonin in Multiple Sclerosis: AbstractMelatonin is a neurohormone mainly produced by the pineal gland following a circadian rhythm. It is characterized as a pleiotropic factor because it not only regulates the wake–sleep rhythm but also exerts antinociceptive, antidepressant, anxiolytic, and immunomodulating properties. Recent studies suggest that dysregulation of melatonin secretion is associated with the pathogenesis of various autoimmune diseases, such as, rheumatoid arthritis (RA),...
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Analysis of the effects of subthalamic nucleus deep brain stimulation on somatosensation in Parkinson's disease patients: AbstractObjectiveDespite the subthalamic nucleus (STN) deep brain stimulation (DBS) is a treatment commonly used to ameliorate the motor symptoms of Parkinson's disease (PD), its effects on somatosensation is unclear. The purpose of this study was to investigate the potential effects of DBS on temperature, proprioceptive, tactile, exteroceptive, pain and cortical sensations, and...
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Autophagy and Age-Related Eye Diseases: Background. Autophagy is a catabolic process that depends on the lysosome. It is usually used to maintain cellular homeostasis, survival and development by degrading abnormal substances and dysfunctional organelles, especially when the cell is exposed to starvation or other stresses. Increasing studies have reported that autophagy is associated with various eye diseases, of which aging is one of the important factors. Objective. To summarize the functional...
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Antitumoral and Immunomodulatory Effect of Mahonia aquifolium Extracts: The prodrug potential of Mahonia aquifolium, a plant used for centuries in traditional medicine, recently gained visibility in the literature, and the activity of several active compounds isolated from its extracts was studied on biologic systems in vitro and in vivo. Whereas the antioxidative and antitumor activities of M. aquifolium-derived compounds were studied at some extent, there are very few data about their outcome on...
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Toxic Optic Neuropathy From Quinine Overdose: Abstract: A 45-year-old man presented with longstanding poor vision in both eyes. His medical history was significant for a remote overdose of quinine. After the ingestion, he fell into a coma and on awakening was not able to see light out of both eyes. Several days later, his central vision began to gradually recover and continued to improve over the span of several months. Presently, he had 20/20 visual acuity in both eyes with severely constricted...
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Visual Outcome Improvement in Tacrolimus-Related Bilateral Optic Neuropathy:
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Jugular Paraganglioma and Bilateral Vestibular Schwannoma Presenting to an Acute Ophthalmology Service:
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Idiopathic Intracranial Hypertension and Anemia: A Matched Case–Control Study: Background: An association between idiopathic intracranial hypertension (IIH) and anemia has been speculated from previous case reports and case series. Retrospective studies to date have not used matched case controls to compare standardized complete blood count (CBC) values for the presence of anemia.Methods: At our tertiary care facility, 50 patients with IIH were matched with 50 case–control patients to compare CBC...
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Novel Mitochondrial Translation Optimizer-1 Mutations as a Cause of Hereditary Optic Neuropathy:
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Recurrent Bilateral Myelin Oligodendrocyte Glycoprotein Antibody Optic Neuritis in a Leber Hereditary Optic Neuropathy Carrier:
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IJERPH, Vol. 16, Pages 5129: A Review on Recent Treatment Technology for Herbicide Atrazine in Contaminated Environment: IJERPH, Vol. 16, Pages 5129: A Review on Recent Treatment Technology for Herbicide Atrazine in Contaminated EnvironmentInternational Journal of Environmental Research and Public Health doi: 10.3390/ijerph16245129Authors: Huijun He Yongpan Liu Shaohong You Jie Liu He Xiao Zhihong Tu Atrazine is a kind of triazine herbicide that is widely used for weed control due to...
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Atmospheric particulate matters in an Indian urban area: Health implications from potentially hazardous elements, cytotoxicity, and genotoxicity studies: Publication date: 15 February 2020Source: Journal of Hazardous Materials, Volume 384Author(s): Nazrul Islam, Anjum Dihingia, Puja Khare, Binoy K. SaikiaAbstractThe nature of the atmospheric particulate matters (PMs) varies depending on their sizes and their origin from different activities in the background environment. These PMs are associated...
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Hazards of bisphenol A (BPA) exposure: A systematic review of plant toxicology studies: Publication date: 15 February 2020Source: Journal of Hazardous Materials, Volume 384Author(s): Changyun Xiao, Lihong Wang, Qing Zhou, Xiaohua HuangAbstractThe widespread use of bisphenol A (BPA) has led to its ubiquity in the natural environment. Thus, BPA is considered as a contaminant of emerging concern. Due to its widespread use, BPA has been detected in a range of soils and surface waters. This is of concern...
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Luminescent lanthanide metal-organic framework test strip for immediate detection of tetracycline antibiotics in water: Publication date: 15 February 2020Source: Journal of Hazardous Materials, Volume 384Author(s): Chongliang Li, Chenghui Zeng, Zhao Chen, Yefei Jiang, Hua Yao, Yangyi Yang, Wing-Tak WongAbstractTetracycline antibiotics (TCs) are a kind of commonly used antibiotics for treating infections, however, the overuse of TCs has adversely affected human health and the ecosystem. Thus, detection...
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Cross-Sectional Analysis of Cognitive Dysfunction in Patients With Vestibular Disorders: Objective: The relationship of cognitive dysfunction and vestibular dysfunction has been established by various studies. However, the available Patient-Reported Outcome Measures questionnaires that address the main vestibular complaint fail to highlight this domain of dysfunction in this patient population. The objective of this study was to quantify and compare cognitive impairment using a validated cognitive...
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Hormesis in plants under Cd exposure: From toxic to beneficial element?: Publication date: 15 February 2020Source: Journal of Hazardous Materials, Volume 384Author(s): Marcia E.A. Carvalho, Paulo R.C. Castro, Ricardo A. AzevedoAbstractTolerance level to cadmium (Cd) toxicity is generally associated with reductions of the internal Cd accumulation in living organisms. In plants, Cd exposure frequently triggers negative effects on their growth and productivity. However, an increased number of studies...
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Impaired Autophagy in the Fibroblasts by Titanium Particles Increased the Release of CX3CL1 and Promoted the Chemotactic Migration of Monocytes: Abstract Aseptic loosening (AL) is the most frequent cause of failure of total hip arthroplasties (THA). Prosthetic wear particle-induced monocyte recruitment to the periprosthetic tissue and subsequent inflammatory response are thought to be the major contribution to AL. Fibroblast is a dominant cell type in interfacial membrane (IFM) which is the main...
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Overlapping genetic architecture between Parkinson disease and melanoma: AbstractEpidemiologic studies have reported inconsistent results regarding an association between Parkinson disease (PD) and cutaneous melanoma (melanoma). Identifying shared genetic architecture between these diseases can support epidemiologic findings and identify common risk genes and biological pathways. Here, we apply polygenic, linkage disequilibrium-informed methods to the largest available case–control, genome-wide association...
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Colon cancer of Peutz-Jeghers syndrome with gallolyticus endocarditis: AbstractWe report a case of Peutz-Jeghers syndrome with gallolyticus endocarditis which has not yet been reported. Colon cancer was observed and implicated in Peutz-Jeghers syndrome. A 44-year-old female with fever and heart murmur was diagnosed as infective endocarditis caused by streptococcus gallolyticus. After treatment with antibiotics and mitral valbuloplasty, we performed gastrointestinal endoscopic studies and found polyps...
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Surgical Strategies for Multicystic Ameloblastoma: Ameloblastoma is the second most common odontogenic tumor arising in the maxillary bones. The WHO classified ameloblastoma in: solid/multicystic (SMA); unicystic; peripheral and desmoplastic. A conservative or radical approach may be performed for SMA treatment to achieve total excision of the lesion.In this case report, a 47-year-old woman, presented a deformation of the left mandibular region and paresthesia of the left hemi-labium, at the ortopanoramic...
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The Effect of Hyaluronidase on the Fat Graft: Background: Fat grafting has been widely used for facial rejuvenation and soft tissue reconstruction. However, it is associated with a lower retention rate than expected and complications such as fat necrosis or calcification. Several techniques that may increase the survival rate of fat grafts have been proposed. The techniques that promote the recipient sites vascularity to increase the survival rate of fat grafts include administration of growth factors,...
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Hypertension and Diabetes are Associated With Clinical Characteristics in Patients Undergoing Microvascular Decompression for Hemifacial Spasm: Objectives: The aim of the present study is to investigate effect of hypertension and diabetes on neuroelectrophysiology, outcomes and complications in patients with hemifacial spasm (HFS) treated by microvascular decompression (MVD).Methods: From June 2014 to December 2016, 476 consecutive HFS patients who had undergone MVD were divided into 2 groups according...
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Bite Force Simulator: A Novel Technique to Simulate Craniofacial Strain In Vitro: Existing in vitro simulators rely on external manipulation of the skull to replicate masticatory forces; however, external manipulations do not accurately represent internal loads as in physiological muscle forces.The purpose of the project is to develop an in vitro simulator that internally replicates the forces of mastication. The simulator has 3-dimensional-printed piston mounts that are reverse-engineered using...
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GSE121055 Chromatin maturation of the HIV provirus in primary resting CD4+ T cells: Contributors : Birgitta Lindqvist ; Sara S Akusjärvi ; Marios Dimitirou ; Anders Sönnerborg ; J P SvenssonSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensHuman immunodeficiency virus (HIV) infection is a chronic condition, where viral DNA integrates into the genome. The fate of the provirus determines the infection course. Latently infected cells form a persistent,...
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Sarcopenic obesity: research advances in pathogenesis and diagnostic criteria: AbstractSarcopenic obesity (SO) refers to an obesity disease accompanied by low skeletal muscle quality, strength and/or function, which is more common in the elderly and seriously affects their quality of life and can lead to falls, unstable walking, balance disorders and fractures in the elderly. The increase in aging populations and the various health problems and medical costs associated with SO have aroused widespread...
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Choice of Single-Staged Reconstruction of Nasal Defect: Introduction: The nasal defect is still a challenge for plastic surgeon now. Many surgical options are reported in previous literatures. There are few studies reported about the 1-staged repair of large nasal defect. In this article, the authors describe the experience about the nasal reconstruction in the last 8 years.Patients and Methods: Fifty-two patients diagnosed with nasal defect were retrospectively examined between 2011 and 2018. All...
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Electromagnetic Navigation in Craniofacial Surgery Based on Automatic Registration of Dental Splints
Electromagnetic Navigation in Craniofacial Surgery Based on Automatic Registration of Dental Splints: Optical navigation method cannot be used in partial craniofacial surgery due to light blocking. At present, electromagnetic navigation method can be used instead. The occlusal splint obtained from the patient's dental mold is used in the traditional electromagnetic navigation registration. Then, marker points are selected manually for registration through imaging data during the operation, which...
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The Role of Overriding Preseptal Orbicularis Oculi Muscle in Development of Involutional Lower Eyelid Entropion: Microscopic Viewpoints: The aim of this study was to demonstrate the extent of preseptal orbicularis oculi muscle (OOM) override onto the pretarsal OOM in the lower eyelids. In this experimental microscopic study, 22 exenterated specimens from 22 Japanese cadavers were prepared as full-thickness sagittal sections. All exenterated specimens were devoid of lower eyelid entropion. The tarsal...
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Unilateral Condylar Hyperplasia: A Comparison With Two Open-Source Softwares: Unilateral condylar hyperplasia (UCH) is a condyle disorder that arises due to osteoblastic hyperactivity, resulting in facial asymmetry, malocclusion and dysfunction. Authors, in this retrospective study, compared "gold standard" manual-segmentation with a "semi-manual one" using 2 kinds of open-source software (Horos and ITK-SNAP; Penn Image Computing and Science Laboratory) to calculate volume of 80 UCH condyles (40...
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The Effect of Concentrated Growth Factor on Calvarial Bone in Diabetic Healing: The aim of this study was to evaluate the effect of Concentrated Growth Factor (CGF) on bone healing in diabetic rat model. Experimental diabetes was induced in 24 male Sprague–Dawley rats by streptozotocin. Twenty-four animals served as healthy controls. The animals were divided into 4 subgroups; empty bone defect, grafting with xenogenous graft (Geno-os, OsteoBiol, Turin-Italy), CGF administration, and combined application...
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Epidemiological Analysis of Venous Malformation of the Orbit: Orbital venous malformation (OVM) is one of the most common orbital mass of adults, accounting for approximately 5% to 15% of all vascular abnormalities in the central nervous system and representing 9% of orbital lesions. Clinical presentation is variable from asymptomatic cases to symptomatic ones. The purpose of the authors' work is to analyze OVM incidence and prevalence in a cohort of patients referred over the last 40 years to the...
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Changes of Occlusal Plane in Growing Patients With Increased Vertical Dimension During Class II Correction by Using Cervical Headgear: This retrospective research aimed to highlight the changes of occlusal plane in Class II hyperdivergent subjects that received cervical headgear treatment and compared them to untreated controls in order to evaluate the occlusal changes that might be connected to a potential mandibular rotation.The sample of this investigation was represented by 20 hyperdivergent...
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Reconstruction of Craniomaxillofacial Bone Defects With Customized Prosthesis of Hydroxyapatite/Epoxide Acrylate Maleic Compound Designed by Computer-Aided Technique: The purpose of this study is to evaluate the clinical technique of reconstruction of craniomaxillofacial bone defects by using hand-made customized prosthesis of hydroxyapatite (HA)/epoxide acrylate maleic (EAM) compound with computer-aided technique. Between 2008 and 2015, eleven patients underwent computed tomography, three-dimensional...
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Course of the Maxillary Vein and its Positional Relationship With the Mandibular Ramus Require Attention During Mandibuloplasty: Purpose: The maxillary vein is associated with major hemorrhage, an intraoperative risk factor during mandibuloplasty. Our objectives in this study were to identify the anatomical course of the maxillary vein relative to the mandible, and to ascertain the relationship of its course with that of the maxillary artery.Methods: Thirteen sides of 13 cadavers in the possession...
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Deep Convolutional Neural Networks for Automatic Detection of Orbital Blowout Fractures: Orbital blow out fracture is a common disease in emergency department and a delay or failure in diagnosis can lead to permanent visual changes. This study aims to evaluate the ability of an automatic orbital blowout fractures detection system based on computed tomography (CT) data.Orbital CT scans of adult orbital blowout fractures patients and normal cases were obtained from Shanghai Ninth People's Hospital...
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Oblique Plane Cutting of Cone Beam Computed Tomography Analysis on the Safe Zone for Micro-Implants of Maxillary Molar Region: Objective: To explore the safe zone for micro-implants of the maxillary molar region by oblique plane cutting mode of cone beam computed tomography (CBCT).Methods: Thirty-nine patients with orthodontic alignment were enrolled with CBCT. In this study, the areas between the maxillary second premolar and the first molar were analyzed by the image reconstruction with CS 3D Imaging...
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Calvarial Reconstruction With Autologous Sagittal Split Rib Bone Graft and Latissimus Dorsi Rib Myoosseocutaneous Free Flap: Objective: Cranioplasty is essential because cranial defects cause cosmetic and functional problems, and neurologic sequalae in patients. However, reconstruction options are limited in patients with unfavorable conditions. This study aimed to review our experience with skull defect reconstruction using autogenous bone with sagittal split rib bone grafts or latissimus dorsi...
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Mixed lichenoid and psoriasiform drug eruption induced by rifampicin: AbstractRifampicin is an essential first line anti‐tuberculosis drug. However, several cases of adverse reactions associated with this drug have been reported, the most common of which are cutaneous drug reactions. We report a case of mixed lichenoid and psoriasiform drug eruption induced by rifampicin.
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Chemotherapy in Esthesioneuroblastoma/Olfactory Neuroblastoma: An Analysis of the Surveillance Epidemiology and End Results (SEER) 1973-2015 Database: Objective: Chemotherapy has been proposed as an adjunct to primary local therapy in esthesioneuroblastoma (ENB)/olfactory neuroblastoma (ON), but its role has not been precisely defined. Here, we evaluated its role in ENB treatment.Materials and Methods: The Surveillance Epidemiology and End Results (SEER) database was queried for ENB/ON (International...
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Comparison of the 8th UICC staging system for esophageal and gastric cancers in Siewert type II junctional adenocarcinomas: Publication date: Available online 14 December 2019Source: European Journal of Surgical OncologyAuthor(s): Karl-Frederick Karstens, Tarik Ghadban, Sahar Sawez, Leonie Konczalla, Anna Woestemeier, Kai Bachmann, Faik G. Uzunoglu, Michael Tachezy, Eik Vettorazzi, Jakob R. Izbicki, Matthias ReehAbstractBackgroundThe aim of this study is to evaluate whether adenocarcinomas of the...
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Charge-reversal nanocarriers: An emerging paradigm for smart cancer nanomedicine: Publication date: Available online 14 December 2019Source: Journal of Controlled ReleaseAuthor(s): Mingzhen Zhang, Xiaoxiao Chen, Chao Li, Xian ShenAbstractThe surface charge of nanoparticles (NPs) plays an essential role in determining their biological properties both in vitro and in vivo. In view of the complex features associated with the biological or physiological microenvironment of solid tumors, such as electrostatic...
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Parasympathetic arousal-related cortical activity is associated with attention during cognitive task performance: Publication date: Available online 14 December 2019Source: NeuroImageAuthor(s): Anita D. Barber, Majnu John, Pamela DeRosse, Michael L. Birnbaum, Todd Lencz, Anil K. MalhotraAbstractParasympathetic arousal is associated with states of heightened attention and well-being. Arousal may affect widespread cortical and subcortical systems across the brain, however, little is known about its...
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Acoustic biomolecules enhance hemodynamic functional ultrasound imaging of neural activity: Publication date: Available online 15 December 2019Source: NeuroImageAuthor(s): David Maresca, Thomas Payen, Audrey Lee-Gosselin, Bill Ling, Dina Malounda, Charlie Demené, Mickaël Tanter, Mikhail G. ShapiroAbstractHemodynamic functional ultrasound imaging (fUS) of neural activity provides a unique combination of spatial coverage, spatiotemporal resolution and compatibility with freely moving animals. However,...
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Clinical evaluation of botulinum toxin A in the management of temporomandibular myofascial pain: We did a clinical service evaluation of patient-reported outcomes for pain and change in interincisal distance in patients treated with botulinum toxin A (BTX-A) for temporomandibular myofascial pain at nurse-led clinics. We retrospectively reviewed the clinical records of 100 patients and the prescribing patterns of two OMFS consultants. The mean starting pain score of 7.54 out of 10 was reduced by a...
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Assessment of the contralateral facial artery pedicle nasolabial island flap for buccal defect repair: The facial artery pedicle nasolabial island flap (FAPNIF) is widely used for oral and maxillofacial reconstruction. However, its use in reconstruction after malignant tumour resection is limited by the possibility of ipsilateral cervical lymph node metastasis along the facial artery. Through fine dissection, it was found that the contralateral FAPNIF can be used to repair the defect after buccal...
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miR-451: A Novel Biomarker and Potential Therapeutic Target for Cancer: Authors Bai H, Wu SReceived 13 September 2019Accepted for publication 28 November 2019Published 16 December 2019 Volume 2019:12 Pages 11069—11082DOI https://doi.org/10.2147/OTT.S230963Checked for plagiarism YesReview by Single-blindPeer reviewers approved by Ms Aruna NarulaPeer reviewer comments 3Editor who approved publication: Dr XuYu YangHua Bai, Suhui WuDepartment of Gynecology and Obstetrics, Shanxi Dayi Hospital Affiliated...
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CDK4/6 Inhibitor Palbociclib Amplifies the Radiosensitivity to Nasopharyngeal Carcinoma Cells via Mediating Apoptosis and Suppressing DNA Damage Repair: Authors Xie X, Zheng W, Chen T, Lin W, Liao Z, Liu J, Ding YReceived 10 October 2019Accepted for publication 26 November 2019Published 16 December 2019 Volume 2019:12 Pages 11107—11117DOI https://doi.org/10.2147/OTT.S234221Checked for plagiarism YesReview by Single-blindPeer reviewers approved by Ms Swati SharmaPeer reviewer comments 2Editor who...
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Blood screening for heavy metals and organic pollutants in cancer patients exposed to toxic waste in southern Italy: A pilot study: In Italy, in the eastern area of the Campania region, hazardous waste exposure has been suggested to associate with increased cancer development. We evaluated blood levels of heavy metals in 95 cancer patients residing in this area and in 27 healthy individuals. Our results showed high blood concentrations of heavy metals in some municipalities, including Giugliano,...
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Thyroid® Open Access Articles: Latest Impact Factor: 7.786The Official Journal of: American Thyroid Association®Read these new open access articles today:Changes in the Stoichiometry of Uniplex Decrease Mitochondrial Calcium Overload and Contribute to Tolerance of Cardiac Ischemia/Reperfusion Injury in HypothyroidismHéctor Chapoy-Villanueva, Christian Silva-Platas, Ana K. Gutiérrez-Rodríguez, Noemí García, Edgar Acuña-Morin, Leticia Elizondo-Montemayor, Yuriana Oropeza-Almazán, Alejandro Aguilar-Saenz,...
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Treatment with brentuximab vedotin plus bendamustine in unselected patients with CD30‐positive aggressive lymphomas: AbstractObjectivesA treatment regimen consisting of bendamustine and brentuximab vedotin (BV) has been described as a highly potent salvage therapy and as an effective induction therapy leading to high response rates before autologous stem cell transplantation (ASCT) in patients with classical Hodgkin lymphoma (cHL). In this retrospective analysis, we aimed to assess this therapy's...
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Protective effect of Oxymatrine against acute spinal cord injury in rats via modulating oxidative stress, inflammation and apoptosis: AbstractThe present study was performed to examine the effect of oxymatrine (OMT) on motor functions and histopathologic changes after spinal cord injury and the mechanism underlying its neuroprotective effects. Results suggested that, OMT causes regain of lost motor function near to normal via attenuating oxidative stress, inflammatory response and cellular apoptosis....
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Efficacy of folic acid as an adjunct to lithium therapy on manic-like behaviors, oxidative stress and inflammatory parameters in an animal model of mania: AbstractEvaluate the efficacy of folic acid (FA) as a therapeutic adjunct to lithium (Li) on the manic-like behaviors as well as parameters of oxidative stress and inflammation in an animal model of mania induced by m-amphetamine (m-AMPH). Wistar rats first received m-AMPH or saline (NaCl 0.9%, Sal) for 14 days. Between the 8th and 14th day, rats...
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"Video Assisted Thoracoscopic Surgery (VATS) for all Stages of Empyema Thoracis: a Single Centre Experience": AbstractVideo assisted thoracoscopic surgery (VATS) is a surgical treatment option for empyema thoracis (ET). However, very few studies have been reported from India. The present study aims to evaluate the role, implementation and outcomes of VATS for all stages of ET. A prospective evaluation of 33 patients with ET managed by VATS decortication from January 2016 to December 2017 was performed....
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Common Internal Iliac Vein Joining Inferior Vena Cava—a Rare Anatomical Variation: Anatomic and Surgical Relevance: AbstractAn unusual anatomical variation of the internal iliac veins (IIV) was found in a 26-year-old lady who was undergoing retroperitoneal lymphadenectomy for a recurrent ovarian cancer. Intraoperatively the right and left internal iliac veins were converging to form a common trunk which was draining into the inferior vena cava along with the right and left external iliac veins. These...
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Novel mutation in optineurin causing aggressive ALS+/−frontotemporal dementia: AbstractObjectiveMutations in optineurin (OPTN) have been identified in familial and sporadic amyotrophic lateral sclerosis (ALS). We screened a cohort of Chinese patients for mutations in optineurin. We also performed an extensive literatures review of all mutations in optineurin identified previously to detect genotype–phenotype associations.MethodsAll 16 exons of the OPTN gene in a cohort of 15 familial ALS indexes...
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The cost‐utility of pitolisant as narcolepsy treatment: AbstractObjectivesThe cost‐effectiveness of available pharmacological treatments for narcolepsy is largely unknown. Available pharmacological treatments are associated with tolerability, abuse and adherence issues. Pitolisant is the first inverse agonist of the histamine H3 receptor to be prescribed for the treatment of narcolepsy with and without cataplexy. Studies suggest that pitolisant is both as effective as previously introduced drugs...
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Spontaneous progression of experimental peri‐implantitis in augmented and pristine bone. A pre‐clinical in vivo study: AbstractObjectiveTo examine progression of experimental peri‐implantitis around different implants placed in augmented and pristine sites.M&M6 Labrador dogs were used. 3 months after tooth extraction, 4 implants with different surface modifications were installed on each side of the mandible. A standard osteotomy was applied on one side, while on the contralateral side the osteotomy...
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Neonatal cardiac hypertrophy: the role of hyperinsulinism—a review of literature: AbstractHypertrophic cardiomyopathy (HCM) in neonates is a rare and heterogeneous disorder which is characterized by hypertrophy of heart with histological and functional disruption of the myocardial structure/composition. The prognosis of HCM depends on the underlying diagnosis. In this review, we emphasize the importance to consider hyperinsulinism in the differential diagnosis of HCM, as hyperinsulinism is widely...
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Ziziphus spina-christi leaf extract attenuates mercury chloride-induced testicular dysfunction in rats: AbstractMercury (Hg) is a heavy metal toxicant, causing several adverse reactions to animals and humans including reproductive dysfunction. The potential protective role of Ziziphus spina-christi leaf extract (ZSCLE) against testicular impairments associated with mercury chloride (HgCl2) exposure in rats was investigated in the current study. Four experimental groups were employed as follows (n = 7):...
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Maternal elevated salt consumption and the development of autism spectrum disorder in the offspring: Autism spectrum disorder (ASD) is a prevalent neurodevelopmental condition with no known etiology or cure. Several possible contributing factors, both genetic and environmental, are being actively investigated...
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CUREXO's CUVIS robot approved: "Curexo, a local medical device company, said that the Ministry of Food and Drug Safety has approved CUVIS-spine, a robot-assisted spine surgery device.The device helps conduct spinal screw insertion, and its benefits include conducting accurate surgery within 1 millimeter of error range and can perform both open surgery and minimally invasive surgery as it is compatible with two-dimensional (C-Arm) and three-dimensional images (O-Arm).Based on the approval, the company...
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Biomolecules, Vol. 9, Pages 878: Hypertrophic Cardiomyopathy: An Overview of Genetics and Management: Biomolecules, Vol. 9, Pages 878: Hypertrophic Cardiomyopathy: An Overview of Genetics and ManagementBiomolecules doi: 10.3390/biom9120878Authors: Polakit Teekakirikul Wenjuan Zhu Helen C. Huang Erik Fung Hypertrophic cardiomyopathy (HCM) is a genetically heterogeneous cardiac muscle disorder with a diverse natural history, characterized by unexplained left ventricular hypertrophy (LVH), with...
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Successful Instrument Guidance Through Deep and Convulted Blood Vessel NetworksDecember 3, 2019Latest breakthrough by Professor Sylvain Martel's team at Polytechnique Montréal opens up new horizons for endovascular surgery.Montréal – A team led by Professor Sylvain Martel at the Polytechnique Montréal Nanorobotics Laboratory has developed a novel approach to tackling one of the biggest challenges of endovascular surgery: how to reach the most difficult-to-access physiological locations. Their solution...
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Current management of juvenile idiopathic arthritis affecting the craniovertebral junction: AbstractPurposeCraniovertebral instability is a rare and serious problem. While previously treated surgically, better understanding of disease processes has permitted the field to move towards conservative management. Juvenile idiopathic arthritis (JIA) is one cause of pediatric craniovertebral instability. Early recognition and institution of appropriate medical therapy and bracing in a multidisciplinary...
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In Vitro Cytotoxicity of Parasporins from Native Algerian Bacillus thuringiensis Strains Against Laryngeal and Alveolar Cancers: AbstractParasporins (PS), a class of non-insecticidal and non-hemolytic crystal proteins of Bacillus thuringiensis (Bt), are being explored as promising anti-cancer agents due to their specific toxicity to cancer cells. This work is considered as a first initiative aiming at investigating Algerian soil Bt isolates' activity and cytotoxic potential against cancer cells....
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AI-assisted FDG-PET/CT advances lung nodule detection: Swiss researchers have developed an artificial intelligence (AI) algorithm...Read more on AuntMinnieEurope.comRelated Reading:European societies join in ethical AI statementIt's official: AI will cause major changeTraining in FDG-PET/CT advances lung cancer outcomeEuSoMII supports worldwide survey on radiology AIPET/CT rivals CT for NSCLC recurrenceOriginal enclosures: 2019_12_13_22_48_9657_AI_FDG_PET_lung_20191213225727.jpg
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Development of a clinical prediction tool for cancer-associated venous thromboembolism (CAT): the MD Anderson Cancer Center CAT model.: Related ArticlesDevelopment of a clinical prediction tool for cancer-associated venous thromboembolism (CAT): the MD Anderson Cancer Center CAT model.Support Care Cancer. 2019 Dec 11;:Authors: Rojas-Hernandez CM, Tang VK, Sanchez-Petitto G, Qiao W, Richardson M, Escalante CAbstract INTRODUCTION: Cancer-associated venous thromboembolism (CAT) is a major complication...
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Effects of Chemotherapy-Induced Peripheral Neuropathy in Women With Breast Cancer: A Structural Equation Approach With the Theory of Unpleasant Symptoms: Background Chemotherapy-induced peripheral neuropathy (CIPN) is a common neurotoxic effect. Chemotherapy-induced peripheral neuropathy symptoms have multidimensional characteristics that are associated with various physiologic, psychological, and situational factors and affect individual's abilities to effectively function in performing daily tasks....
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A Metal-Polyphenol-Coordinated Nanomedicine for Synergistic Cascade Cancer Chemotherapy and Chemodynamic Therapy.: Related ArticlesA Metal-Polyphenol-Coordinated Nanomedicine for Synergistic Cascade Cancer Chemotherapy and Chemodynamic Therapy.Adv Mater. 2019 Dec 13;:e1906024Authors: Ren Z, Sun S, Sun R, Cui G, Hong L, Rao B, Li A, Yu Z, Kan Q, Mao ZAbstract The clinical application of chemotherapy is impeded by the unsatisfactory efficacy and severe side effects. Chemodynamic therapy (CDT)...
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Thymic epithelial tumor treatment in Japan: analysis of hospital cancer registry and insurance claims data, 2012-2014.: Related ArticlesThymic epithelial tumor treatment in Japan: analysis of hospital cancer registry and insurance claims data, 2012-2014.Jpn J Clin Oncol. 2019 Dec 12;:Authors: Kanemura H, Tamura T, Nishimura N, Kobayashi D, Higashi TAbstract INTRODUCTION: Thymic epithelial tumors are a rare type of neoplasm. Accordingly, it is difficult to perform phase III trials in patients...
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Prognostic value of early radiological response to first-line platinum-containing chemotherapy in patients with metastatic nasopharyngeal carcinoma.: Related ArticlesPrognostic value of early radiological response to first-line platinum-containing chemotherapy in patients with metastatic nasopharyngeal carcinoma.Cancer Med. 2019 Dec 13;:Authors: Liu GY, Li WZ, Peng KQ, Lv X, Ke LR, Wu YS, Wang DL, Liang H, Liu KY, Lv SH, Guo X, Xiang YQ, Xia WXAbstract BACKGROUND: To explore the prognostic...
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Progress toward liquid biopsies in pediatric solid tumors: AbstractPediatric solid tumors have long been known to shed tumor cells, DNA, RNA, and proteins into the blood. Recent technological advances have allowed for improved capture and analysis of these typically scant circulating materials. Efforts are ongoing to develop "liquid biopsy" assays as minimally invasive tools to address diagnostic, prognostic, and disease monitoring needs in childhood cancer care. Applying these highly sensitive technologies...
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Whole-genome resequencing analysis of 20 Micro-pigs: AbstractBackgroundMiniature pigs have been increasingly used as mammalian model animals for biomedical research because of their similarity to human beings in terms of their metabolic features and proportional organ sizes. However, despite their importance, there is a severe lack of genome-wide studies on miniature pigs.ObjectiveIn this study, we performed whole-genome sequencing analysis of 20 Micro-pigs obtained from Medi Kinetics to elucidate...
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Cancers, Vol. 11, Pages 2024: Chimeric Antigen Receptor T-Cell Therapy for Multiple Myeloma: Cancers, Vol. 11, Pages 2024: Chimeric Antigen Receptor T-Cell Therapy for Multiple MyelomaCancers doi: 10.3390/cancers11122024Authors: Naoki Hosen CD19 Chimeric antigen receptor (CAR) T cell therapy has been shown to be effective for B cell leukemia and lymphoma. Many researchers are now trying to develop CAR T cells for various types of cancer. For multiple myeloma (MM), B-cell maturation antigen (BCMA)...
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Oral vinorelbine versus intravenous vinorelbine, in combination with epirubicin as first-line chemotherapy in Chinese patients with metastatic breast cancer: AbstractOral VRL offers easier administration, better quality of life, and cost saving. This study aimed to evaluate the treatment efficacy in terms of tumor response of the two formulations of vinorelbine (VRL, oral and IV) in combination with epirubicin (EPI); and the effect of EPI co-administration on VRL pharmacokinetics (PK) in Chinese...
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Age at last birth and risk of developing breast cancer: a meta-analysis: Objectives Results from epidemiologic studies on age at last birth (ALB) and the risk of developing breast cancer were inconsistent. Therefore, we conducted this meta-analysis to evaluate the association between ALB and the risk of developing breast cancer quantitatively.Methods Relevant articles published up to May 2019 were identified by searching systematically in PubMed, Web of Science, China National Knowledge Infrastructure,...
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Vitamin B12 Deficiency Is Prevalent Among Czech Vegans Who Do Not Use Vitamin B12 Supplements.: Related ArticlesVitamin B12 Deficiency Is Prevalent Among Czech Vegans Who Do Not Use Vitamin B12 Supplements.Nutrients. 2019 Dec 10;11(12):Authors: Selinger E, Kühn T, Procházková M, Anděl M, Gojda JAbstract As not much is known about the prevalence and predictors of nutritional deficiencies among vegans in the Czech Republic, we evaluated whether supplement use and duration of adherence to the...
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Management of recurrent and metastatic oral cavity cancer: Raising the bar a step higher.: Related ArticlesManagement of recurrent and metastatic oral cavity cancer: Raising the bar a step higher.Oral Oncol. 2019 Dec 11;101:104492Authors: Szturz P, Vermorken JBAbstract In recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M-SCCHN), the armamentarium of systemic anti-cancer modalities continues to grow in parallel with innovations in and better integration of local...
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Management of recurrent and metastatic oral cavity cancer: Raising the bar a step higher.: Related ArticlesManagement of recurrent and metastatic oral cavity cancer: Raising the bar a step higher.Oral Oncol. 2019 Dec 11;101:104492Authors: Szturz P, Vermorken JBAbstract In recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M-SCCHN), the armamentarium of systemic anti-cancer modalities continues to grow in parallel with innovations in and better integration of local...
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Prosthetic joint infection: an extremely rare complication of intravesicular BCG therapy: A 66-year-old man was seen in clinic due to concerns of tuberculosis of the right hip. He had a history of urothelial bladder carcinoma, which was treated via transurethral resection followed by intravesicular instillations of Mycobacterium bovis BCG (BCG). A few months later, he developed slowly worsening pain over his prosthetic right hip, and it was recommended he undergo surgical revision. During surgery,...
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Herpes Simplex Virus Pneumonia: Importance of Aspiration Etiology: Herpes simplex virus (HSV) pneumonia caused by aspiration from the oropharyngeal exudates is described. An 89-year-old Japanese male in a poor performance state complained of appetite loss followed by difficulty in swallowing, and bilateral pulmonary infiltrates with interstitial reactions were radiologically pointed out. Antibiotics administration was ineffective, and he died on the 6th day of hospitalization. At autopsy, HSV-induced...
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Tubercular involvement of the lateral malleolus and adjacent calcaneus: presentation of a rare case and review of the literature: Osteoarticular tuberculosis (TB), despite being on the wane in the developed world, stays a problem of significance in the developing world. The issue is compounded by unusual presentations, inadequate diagnostic skills and limited understanding of its management. For foot infections, despite an increased awareness, many patients may be misdiagnosed, with associated treatment...
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Complication of massive trauma by fungal infection and bone tuberculosis: Publication date: March 2020Source: Medical Mycology Case Reports, Volume 27Author(s): Fatehi Elzein, Nazik Mohammed, Maria Arafah, Ahmed Albarrag, Rabea Habib, Aqeel FaqehiAbstractWe report a middle aged man who was admitted with severe necrotising fasciitis following a motor vehicle accident (MVA). Histopathology of the excised tissue suggested mucormycosis while a bone tissue culture revealed fully sensitive Mycobacterium...
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Involuntary movements in an adolescent: what are the causes?: Involuntary movements can be a troublesome condition and represent a real challenge for emergency doctors, particularly for patients of paediatric age. We report a case of a 17-year-old boy with painful involuntary movements mostly affecting his mouth and lower limbs, but also the trunk. After reviewing the patient's history, it was revealed that the adolescent had had acute alcohol intoxication with severe acute agitation and therefore...
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Intrascrotal lipoblastoma in adulthood: This case report describes the case of a 37-year-old man that noticed an intrascrotal right mass with 1 month of evolution. During physical exam presented with a large mass at the inferior portion of the right testicle, clearly separated from the testicle, with a tender consistency and mobile. An ultrasound was performed that showed a solid and subcutaneous nodular lesion, extra testicular, heterogeneous, measuring 7.2 cm. Pelvic magnetic resonance imageMRI...
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Congenital chloride diarrhoea: Congenital chloride diarrhoea is one of the rare causes of diarrhoea during infancy and it is infrequently reported throughout the world. It is an autosomal recessive condition which is more prevalent in Poland, Finland, Saudi Arabia and Kuwait while rarely reported in Pakistan. Our patient was 7.5-month-old baby boy who presented with diarrhoea since neonatal period. He had consanguineous parents. On examination, baby had distended abdomen, hypotonia and hyporeflexia....
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Trimethoprim-Sulfamethoxazole-Induced Aseptic Meningitis: A Rare Presentation of Commonly Used Antibiotic: Drug-induced aseptic meningitis is a rare medical condition with trimethoprim-sulfamethoxazole being one of the most common antimicrobial agents associated with it. Here, I report a case of a 56-year-old male who presented to a health care facility with shock and meningitis-like syndrome in two occasions, one year apart following an exposure to trimethoprim-sulfamethoxazole for treatment of...
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Management of Multiple Arteriovenous Malformations of the Small Bowel: A 62-year-old Japanese female was referred to our hospital with gastrointestinal bleeding. Although small-bowel bleeding was suspected, no bleeding source was identified by enhanced computed tomography (CT), video capsule endoscopy (VCE), and double-balloon enteroscopy (DBE). Five years later, the patient had recurrent intermittent bloody stools with a significant decrease in hemoglobin levels. Although no active bleeding was...
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Metastatic melanoma of the gallbladder presenting as polyp in acute cholecystitis: AbstractMalignant melanoma is an aggressive neural crest cell-derived neoplasm with a propensity for metastasis to almost any organ. Gastrointestinal metastasis may manifest as gallbladder polyps. We report a case of metastatic malignant melanoma diagnosed in an 81-year-old male after cholecystectomy performed for acute cholecystitis. Cholecystectomy remains the standard of care for treatment of isolated gallbladder...
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Lymphangiography and focal pleurodesis treatment of chylothorax with an aberrant thoracic duct following oesophagectomy: a case report: AbstractBackgroundManagement of postoperative chylothorax usually consists of nutritional regimens, pharmacological therapies such as octreotide, and surgical therapies such as ligation of thoracic duct, but a clear consensus is yet to be reached. Further, the variation of the thoracic duct makes chylothorax difficult to treat. This report describes a rare case of...
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Risk of vasopressin use: a case of acute pulmonary oedema, post intramyometrial infiltration of vasopressin in laparoscopic myomectomy: A 34-year-old patient underwent a laparoscopic myomectomy, complicated by a profound episode of bradycardia and hypotension following intramyometrial infiltration of vasopressin (20 IU), promptly corrected with intravenous ephedrine (6 mg) and glycopyrrolate (200 µg). At extubation, pink frothy fluid was noted in the endotracheal tube; she was visibly distressed,...
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Natural recovery from long-lasting generalised dissociative amnesia and of cerebral blood flow: A 40-year-old man presented with generalised dissociative amnesia. At 2 weeks after onset, N-isopropyl-[123I] p-iodoamphetamine-single-photon emission CT imaging of the brain revealed hypoperfusion in the right medial temporal area. Organic brain damage was ruled out. His inability to recall information was attributed to psychological stress related to his employment. Consistent with this diagnosis, his...
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Opioid-induced hypoadrenalism resulting in fasting hypoglycaemia: An 18-year-old woman with a history of hollow visceral myopathy presented with a small-bowel obstruction. High-dose opioid analgesia was required subsequently during hospital admission. She suffered two episodes of documented fasting hypoglycaemia, despite adjustment of parenteral carbohydrate administration. Investigations for non-insulin-mediated hypoglycaemia revealed a low morning cortisol of 109 nmol/L and an inappropriately low...
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Treatment-resistant eosinophilic oesophagitis successfully managed with tofacitinib: We present a case of a 34-year-old man with long-term diagnosis of eosinophilic oesophagitis (EoE) who did not achieve control of disease after multiple therapies including topical and systemic steroids, immune modulators and biologics. Initial endoscopic findings showed signs of active eosinophilic oesophagitis and biopsies were significant for up to 100 eosinophils per high power field during his various treatments....
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Jerky Movement with Ceftazidime: A Case of Ceftazidime-Induced Neurotoxicity with a Review of the Literature: Neurotoxicity manifested as confusion and seizures has been recognized as a side effect of multiple cephalosporins including ceftazidime. Renal impairment and inappropriate dosing are the most common contributors to the development of neurological abnormalities in patients receiving these antibiotics. The presence of baseline neurological abnormalities likely contributes to the frequency...
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An Atypical Cause of an Epiglottic Abscess: An epiglottic abscess is a rare complication of acute epiglottitis and is life threatening. We describe a case report of a diabetic adult male, who presented with an epiglottic abscess. Culture results showed Aeromonas hydrophila, an organism rarely reported as a cause of acute epiglottitis. Early recognition can be lifesaving.microbewiki.kenyon.eduAeromonas hydrophila is a heterotrophic, Gram-negative, rod-shaped bacterium mainly found in areas with a warm...
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Complete resection of local advanced thymic carcinoma with total aortic arch replacement after chemotherapy: a case report: AbstractBackgroundAlthough complete surgical resection of thymic carcinoma is a prognostic factor, it is not always an option for advanced tumors because of locoregional invasion. Extended surgery combined with a major blood vessel procedure remains controversial because of the increased risk of mortality.Case presentationChest computed tomography (CT) uncovered an abnormal...
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Contralateral migration of Kirschner wire from right acromioclavicular joint to left side of neck: a case report: AbstractBackgroundKirschner wire migration is one of the most common complications after internal fixation of fracture or dislocation in the shoulder region. However, cases of contralateral wire migration are rare. We present a case of contralateral loosened Kirschner wire migration from the right acromioclavicular joint to the left side of the neck without damage to any important structures...
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Osteogenesis imperfecta and pregnancy: a case report: AbstractBackgroundOsteogenesis imperfecta is a rare connective tissue disorder of varying phenotypic presentations. In pregnancies complicated by osteogenesis imperfecta, there is an increased risk to both the mother and fetus.Case presentationWe present a case of a 34-year-old, wheelchair-bound, primigravid African (Zimbabwean) patient with short stature and skeletal deformities. Her care, requiring a multidisciplinary team approach, resulted...
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Iris metastasis as the initial presentation of upper gastrointestinal tract carcinoma: a case report
Iris metastasis as the initial presentation of upper gastrointestinal tract carcinoma: a case report: AbstractBackgroundWe report a case of a patient with iris metastasis as the initial manifestation of a systemic cancer: upper gastrointestinal tract carcinoma.Case presentationA 24-year-old Asian man presented to our hospital with complaints of red left eye, decreased visual acuity, pain, and photophobia for about 3 weeks with no prior history of cancer or any other medical abnormality. Ocular examination...
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Graves disease-induced thrombotic thrombocytopenic purpura: a case report: AbstractBackgroundThrombotic thrombocytopenic purpura is an autoimmune disease that carries a high mortality. Very few case reports in the literature have described a relationship between Graves disease and thrombotic thrombocytopenic purpura. We present a case of a patient with Graves disease who was found to be biochemically and clinically hyperthyroid with concurrent thrombotic thrombocytopenic purpura.Case presentationOur...
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Whole exome sequencing in a child with acute disseminated encephalomyelitis, optic neuritis, and periodic fever syndrome: a case report: AbstractBackgroundAcute disseminated encephalomyelitis is generally preceded by an infection, and it is usually self-limiting and non-recurrent. However, when there are multiple attacks of acute disseminated encephalomyelitis followed by optic neuritis, it is defined as acute disseminated encephalomyelitis-optic neuritis. To the best of our knowledge, there are...
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Development of an abdominal wall abscess caused by fish bone ingestion: a case report: AbstractBackgroundA small percentage of patients with foreign body ingestion develop complications, which have a variety of clinical presentations. Less than 1% of cases require surgical intervention. We present a patient with an abdominal wall abscess resulting from a fish bone that pierced the cecum. The patient was treated laparoscopically.Case presentationA 55-year-old Japanese man presented to our hospital...
09:10
Lime-induced phytophotodermatitis: AbstractPhytophotodermatitis, also commonly known as phototoxic dermatitis, is a common skin condition that occurs after contact with certain plants and subsequent exposure to sunlight. It is often confused with skin burns due to the blistering nature of its lesions. We herein report a case of phytophotodermatitis that developed in a 26-year-old male following contact with lime and subsequent exposure to sunlight.
09:09
Leukemic infiltration in the settings of acute respiratory failure: AbstractHematological malignancies need special attention in the intensive care unit (ICU). Leukemia has numerous presentations in the ICU. Most commonly, these patients present with complications of therapy. Infection and neutropenia are major reasons for ICU admission. Pulmonary complications in patients with leukemia are often due to pneumonia, hemorrhage, edema or drug toxicity; however, pulmonary leukemic infiltration is a well-known...
09:09
Cervicogenic dizziness: AbstractCervical muscles have numerous connections with vestibular, visual and higher centres, and their interactions can produce effective proprioceptive input. Dysfunction of the cervical proprioception because of various neck problems can alter orientation in space and cause a sensation of disequilibrium. Cervicogenic dizziness (CGD) is a clinical syndrome characterized by the presence of dizziness and associated neck pain in patients with cervical pathology. Here, we report...
09:09
Septo-optic dysplasia with amniotic band syndrome sequence: a case report: AbstractIntroductionDe Morsier syndrome, or septo-optic dysplasia, is a rare, heterogeneous, complex condition with a highly variable phenotype. It is characterized by optic nerve hypoplasia, pituitary gland hypoplasia, and midline brain abnormalities, including absence of septum pellucidum and corpus callosum dysgenesis. Diagnosis is made clinically by the presence of any two or more features from the clinical triad.Case...
09:08
New morphological evidence of the 'fate' of growth plate hypertrophic chondrocytes in the general context of endochondral ossification: Necrotic cytoplasmic material from hypertrophic chondrocytes (in the figure still surrounded by the cellular membrane) below the vascular invasion line was documented. These 'hypertrophic chondrocyte ghosts' and the same material not bound to a membrane started the macrophagic reaction. AbstractThe 'fate' of growth plate hypertrophic chondrocytes has been long debated...
09:08
What about limb long bone nutrient canal(s)? – a 3D investigation in mammals: This study proposes qualitative and quantitative parameters to describe the shape of the nutrient canal in three dimensions in stylopod bones of various mammals. It discusses the diversity in e.g., morphology, orientation, and diameter encountered, within a single bone, species and between taxa.AbstractThe nutrient arteries, located in the long bone diaphysis, are the major blood supply to long bones, especially during...
09:07
Anatomy and academies of art II − a tale of two cities: Anatomy played a role in elevating the artisan to artist and his guild to an art academy. Many academies of art, with Professors of Anatomy, were established in Europe and the Americas from the 16th to the 19th centuries. Unlike the Royal Academy in London, the Royal Hibernian Academy in Dublin has had a turbulent history, burned to the ground in 1916, before being rebuilt in Ely Place and re-opening its school in 2008, where anatomy is taught...
09:07
Anatomy of the coronary arteries in fetal pigs: comparison with human anatomy: AbstractIn this study, 94 fetal pigs were used to comprehensively investigate the origins, number, location, and distribution of the coronary arteries to enrich knowledge on the coronary circulation in fetal pigs, and allow comparison with adult pigs and humans. In fetal pigs, the posterior interventricular sulcus branch always arose from the right coronary artery and the circumflex artery was rarely extended to the posterior...
09:07
Intercostal nerve block of the anterior cutaneous branches and the sensibility of the female breast: AbstractIntroductionBetter sensation in the reconstructed breast improves quality of life. Sensory nerve coaptation is a valuable addition to autologous breast reconstruction. There are few publications concerning the sensory nerves of the breast and the nipple‐areola complex and reports are contradictory, so it is unknown which nerve is best suited as recipient for coaptation. The current study serves...
09:07
Magnetic Resonance Imaging Anatomy and Morphometry of Lumbar Intervertebral Foramina to Guide Safe Transforaminal Subarachnoid Punctures: ABSTRACTPercutaneous transforaminal lumbar punctures (TFLPs) offer alternative access routes to the lumbar subarachnoid cistern. Safe fluoroscopic insertion of a needle through a lumbar intervertebral foramen (IVF) should ideally avoid the exiting spinal nerve and surrounding vascular pedicles. A crescentic region in the posterior aspect of IVF is the conventional...
09:07
Mapping the Genicular Arteries to Provide a Caution Zone During Knee Surgery: AbstractIntroductionReports from the current literature show a lack of detail with depictions of the genicular arteries (GA). The intricate anatomy and infrequency of operating in the posterior knee may lead to surgeons being unfamiliar with the anatomy. The goal of this cadaveric study was to quantitatively map the arteries and create a caution zone that can be utilized when preparing and performing surgical procedures...
09:06
Clinical Implications of Nervus Intermedius Variants in Patients with Geniculate Neuralgia: Let Anatomy Be the Guide: AbstractGeniculate neuralgia (GN) is an uncommon, but severe, condition that is characterized by excruciating paroxysmal pain in the seventh cranial nerve's cutaneous distribution of general somatic afferent fibers carried through the nervus intermedius (NI). GN becomes a surgical disease in refractory cases of pain after exhaustive medical management. Surgical intervention in the...
09:06
Tranexamic Acid for Acute Hemorrhage: A Narrative Review of Landmark Studies and a Critical Reappraisal of Its Use Over the Last Decade: The publication of the Clinical Randomization of an Antifibrinolytic in Significant Hemorrhage-2 (CRASH-2) study and its intense dissemination prompted a renaissance for the use of the antifibrinolytic agent tranexamic acid (TXA) in acute trauma hemorrhage. Subsequent studies led to its widespread use as a therapeutic as well as prophylactic agent across different...
09:05
Use of Cardiopulmonary Bypass for Treatment of Malignant Hyperthermia: MALIGNANT HYPERTHERMIA (MH) is a well-described and known complication of modern anesthesia, with volatile anesthetics and succinylcholine recognized as triggering agents. Incidence rates vary, but it is estimated to occur in 1 in 50,000 to 100,000 individuals undergoing general anesthesia.1 The authors present a case of a patient undergoing a surgical mitral valve replacement who developed MH during separation from cardiopulmonary...
09:05
Postoperative Nausea and Vomiting After Craniotomy: An Evidence-based Review of General Considerations, Risk Factors, and Management: One of the most common and distressing symptoms after craniotomy is postoperative nausea and vomiting (PONV). PONV could generate delayed postanesthesia care and hospitalization discharge, lower patient satisfaction, and an increase in overall hospitalization costs. The incidence of reported PONV after craniotomy is 22% to 70% without prophylaxis, and a multimodal...
09:05
Morphological changes of the dorsal contour of the corpus callosum during the first two years of life: AbstractBackgroundIn the medicolegal literature, focal concavities or notching of the corpus callosum has been thought to be associated with fetal alcohol spectrum disorders. Recent work suggests corpus callosum notching is a dynamic and normal anatomical feature, although it has not yet been defined in early life or infancy.ObjectiveOur purpose was to characterize the dorsal contour of the corpus...
09:03
The effects of doxapram on time to tracheal extubation and early recovery in young morbidly obese patients scheduled for bariatric surgery: A randomised controlled trial: BACKGROUND Bariatric surgery is a well established treatment of the obese. Postoperative respiratory failure and airway obstruction after bariatric surgery can often be attributed to the residual depressant effects of anaesthetics, sedatives and opioids. Peri-operative management of morbidly obese patients is still a concern for...
09:03
Association of Mondor's disease with oral contraceptive pills: Mondor's disease (MD) is a rare disease characterised by thrombophlebitis of superficial veins in the body. We describe a case of a 28-year-old woman with a painful cord-like lesion of the right breast (3 cm) overlying the right upper quadrant. The patient was recently prescribed metformin and oral contraceptive pills for symptomatic polycystic ovarian syndrome. Right breast ultrasound showed a tubular anechoic structure with several...
09:03
Ventricular arrhythmia and tachycardia-induced cardiomyopathy in Gitelman syndrome, hypokalaemia is not the only culpable: Gitelman syndrome (GS) is an autosomal recessive tubulopathy recently implicated in cases with ventricular arrhythmias (VAs), the latter being considered linked to electrolytes' imbalance. However, a direct causal relationship is considered to be an oversimplification for a complex molecular dysfunction. Recent work has suggested a degree of microvascular dysfunction in patients...
09:03
Subcutaneous fat necrosis of the newborn: A term infant developed subcutaneous fat necrosis of the newborn (SFNN) 17 days following completion of therapeutic hypothermia for hypoxic ischaemic encephalopathy. Initial calcium was normal, however hypercalcaemia requiring hyperhydration and furosemide developed at 4 weeks. Parathyroid hormone and vitamin D were suppressed. At 13 months, she remains on low calcium formula, and has gross motor delay, central hypotonia and early hand preference. Review...
09:02
Acute macular neuroretinopathy (AMN) related to energy drink consumption: This case identifies a newly found association between energy drinks and acute macular neuroretinopathy (AMN). Our patient, a 34-year-old woman with no significant ocular or previous medical history, presented with a 3-day history of decreased vision after consumption of multiple energy drinks. After near infrared and optical coherence tomography imaging, we were able to diagnose her with AMN. Our patient's vision improved...
09:02
A novel model for designing and performing parietal whorl hair transplantation: AbstractBackgroundHair transplantation is the gold standard method for the treatment of alopecia. Recently, demand for the surgery has increased rapidly. However, high demands also require more professional training for the surgeons. With the maturing of hairline design skills, parietal whorl design has become the next challenge and no appropriate training models have yet been reported.AimsTo present an innovative, simple,...
09:00
Surgically-induced brain injury: where are we now?: AbstractNeurosurgical procedures cause inevitable brain damage from the multitude of surgical manipulations utilized. Incisions, retraction, thermal damage from electrocautery, and intraoperative hemorrhage cause immediate and long-term brain injuries that are directly linked to neurosurgical operations, and these types of injuries, collectively, have been termed surgical brain injury (SBI). For the past decade, a model developed to study the underlying...
09:00
Diagnostic accuracy of presepsin in predicting bacteraemia in elderly patients admitted to the emergency department: prospective study in Japan: ObjectiveEarly prediction of bacteraemia in the elederly is needed in the emergency department (ED).Design, setting and participantsA prospective study in Japan; single-centre trial in patients who satisfied the sepsis criteria was conducted between September 2014 and March 2016. Forty-six elderly patients aged ≥70 years were included. The study protocol...
08:59
DIVERT-Collaboration Action Research and Evaluation (CARE) Trial Protocol: a multiprovincial pragmatic cluster randomised trial of cardiorespiratory management in home care: IntroductionHome care clients are increasingly medically complex, have limited access to effective chronic disease management and have very high emergency department (ED) visitation rates. There is a need for more appropriate and targeted supportive chronic disease management for home care clients. We aim to evaluate the effectiveness...
08:58
Barriers and facilitators to buprenorphine use for opioid agonist treatment: protocol for a scoping review: IntroductionIn the context of the opioid crisis in North America, the benefits of evidence-based opioid agonist treatments such as buprenorphine/naloxone have not been optimised due to low uptake. Numerous factors contribute to the underuse of buprenorphine, and theory-informed approaches to identify and address implementation barriers and facilitators are needed. This scoping review aims to...
08:58
Association between hyperlipidemia and mortality after incident acute myocardial infarction or acute decompensated heart failure: a propensity score matched cohort study and a meta-analysis: ObjectiveTo examine the effect of HLP, defined as having a pre-existing or a new in-hospital diagnosis based on low density lipoprotein cholesterol (LDL-C) level ≥100 mg/dL during index hospitalisation or within the preceding 6 months, on all-cause mortality after hospitalisation for acute myocardial infarction...
08:57
Health-related preferences of older patients with multimorbidity: an evidence map: ObjectivesTo systematically identify knowledge clusters and research gaps in the health-related preferences of older patients with multimorbidity by mapping current evidence.DesignEvidence map (systematic review variant).Data sourcesMEDLINE, EMBASE, PsycINFO, PSYNDEX, CINAHL and Science Citation Index/Social Science Citation Index/-Expanded from inception to April 2018.Study selectionStudies reporting primary research...
08:56
Use of oral anticoagulants in older people with atrial fibrillation in UK general practice: protocol for a cohort study using the Clinical Practice Research Datalink (CPRD) database: IntroductionWarfarin has frequently been underused in older people for stroke prevention in atrial fibrillation (AF). Direct oral anticoagulants (DOACs) entered the UK market from 2008 and have been recommended as an alternative to warfarin. This study aimed to describe any changes in the prescribing of oral anticoagulants...
08:56
Door-to-needle time for thrombolysis: a secondary analysis of the TIPS cluster randomised controlled trial: ObjectiveThe current study aimed to evaluate the effects of a multi-component in-hospital intervention on the door-to-needle time for intravenous thrombolysis in acute ischaemic stroke.DesignThis study was a post hoc analysis of door-to-needle time data from a cluster-randomised controlled trial testing an intervention to boost intravenous thrombolysis implementation.SettingThe study was conducted...
08:55
Effect of polycystic ovary syndrome on cardiac autonomic function at a late fertile age: a prospective Northern Finland Birth Cohort 1966 study: ObjectivesPrevious studies of women in their 20s and 30s have reported impaired autonomic function in women with polycystic ovary syndrome (PCOS). We aimed to study, for the first time, whether PCOS is associated with impaired cardiac autonomic function independent of metabolic and hormonal status in their late reproductive years.DesignA prospective Northern...
08:55
Extinction is a fact of life. Could we stop it – or even reverse it?: The fossil record tells us extinctions happen all the time. The question is what part we play – and whether we could ever bring back creatures like the dinosaurs
08:54
Hypophysitis: An update on the novel forms, diagnosis and management of disorders of pituitary inflammation: Publication date: Available online 12 December 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Sriram Gubbi, Fady Hannah-Shmouni, Joseph G. Verbalis, Christian A. KochAbstractHypophysitis is a heterogeneous condition that leads to inflammation of the sella and/or suprasellar region, potentially resulting in hormonal deficiencies and/or mass effects....
08:54
Systemic safety analysis of mycophenolate in Graves' orbitopathy: AbstractPurposeThe dual antiproliferative mechanism of mycophenolate appears to be beneficial in Graves' orbitopathy (GO).MethodsSafety data from the two published mycophenolate trials and the original database of the European Group on Graves' Orbitopathy (EUGOGO) trial were systematically analyzed. Treatment efficacy stratified by individual visual parameters of activity and severity were compared.ResultsA total of 129 adverse events...
08:54
Gut microbiome and cardiometabolic risk: AbstractThe last decade has been characterized by an intense research on the composition of the gut microbiome and the links with human health. While previous work was focused on the effects of prebiotics and probiotics, nowadays several laboratories are describing the gut microbiome and its metabolic functions. Gut microbiome interaction with nutrients allows the gut microbiome to survive and at the same time determines the production of metabolites that...
08:53
Kisspeptin and neurokinin B analogs use in gynecological endocrinology: where do we stand?: AbstractBackgroundRecent studies have found that kisspeptin/neurokinin B/dynorphin neurons (KNDy neurons) in the infundibular nucleus play a crucial role in the reproductive axis. Analogs, both agonists and antagonists, of kisspeptin and neurokinin B (NKB) are particularly important in explaining the physiological role of KNDy in the reproductive axis in animals. The use of kisspeptin and NKB analogs has helped...
08:53
Improvement in Polysomnographic Objective Sleep Quality in Adults with Pectus Excavatum After the Nuss Procedure.: Related ArticlesImprovement in Polysomnographic Objective Sleep Quality in Adults with Pectus Excavatum After the Nuss Procedure.World J Surg. 2019 Dec 13;:Authors: Yang MC, Lan CC, Wu YK, Hsieh MS, Wei BC, Cheng YLAbstract BACKGROUND: Patients with pectus excavatum have a poorer subjective sleep quality and quality of life than the general population. The Nuss procedure has...
08:53
Invasiveness and Metastatic Aggressiveness in Small Differentiated Thyroid Cancers: Demography of Small Papillary Thyroid Carcinomas in the Swedish Population.: Related ArticlesInvasiveness and Metastatic Aggressiveness in Small Differentiated Thyroid Cancers: Demography of Small Papillary Thyroid Carcinomas in the Swedish Population.World J Surg. 2019 Dec 13;:Authors: Bayadsi H, Bergman M, Sund M, Hennings JAbstract BACKGROUND: The western world is seeing a rising incidence of thyroid cancer....
08:53
Maternal adipose tissue expansion, a missing link in the prediction of birth weight centile.: Related ArticlesMaternal adipose tissue expansion, a missing link in the prediction of birth weight centile.J Clin Endocrinol Metab. 2019 Dec 13;:Authors: Jarvie EM, Stewart FM, Ramsay JE, Brown EA, Meyer BJ, Olivecrona G, Griffin BA, Freeman DJAbstract CONTEXT: Maternal body mass index (BMI) is associated with increased birth weight but does not explain all the variance in fetal adiposity. ...
08:53
A 15 year institutional experience of well-differentiated follicular cell-derived thyroid carcinomas; impact of the new 2017 TNM and WHO Classifications of Tumors of Endocrine Organs on the epidemiological trends and pathological characteristics: AbstractPurposeOur study aimed to describe the evolution of the rate of pathological subtypes of well-differentiated follicular-cell derived thyroid carcinomas (DTCs) in the Department of Pathology, Emergency County Hospital Targu-Mures, Romania over a 15...
08:52
Impact of adjuvant chemotherapy regimen on survival outcomes in immunohistochemical subtypes of ampullary carcinoma: AbstractBackground and ObjectivesAmpullary adenocarcinoma (AA) is classified by immunohistochemical (IHC) subtypes into intestinal (IN), pancreatobiliary (PB), and ambiguous (AM). The impact of adjuvant therapy on IHC subtype and disease stage is unclear. We examined the effect of adjuvant chemotherapy regimen on survival of ampullary cancers by IHC subtype and disease stage.MethodsReview...
08:51
miR-509-5p Inhibits the Proliferation and Invasion of Osteosarcoma by Targeting TRIB2: Osteosarcoma (OS) is one of the most common malignant bone tumors in adolescents with a poor prognosis. Though miR-509-5p has been reported as a tumor suppressor in several human cancers, the role of miR-509-5p in OS remains unclear. In this study, our result of real-time PCR (RT-PCR) showed that the expression of miR-509-5p was significantly decreased in OS tissues and cell lines. Overexpression of miR-509-5p...
08:51
P2Y2 Nucleotide Receptor Is a Regulator of the Formation of Cardiac Adipose Tissue and Its Fat-Associated Lymphoid ClustersP2Y2 Nucleotide Receptor Is a Regulator of the Formation of Cardiac Adipose Tissue and Its Fat-Associated Lymphoid Clusters: Stem Cells and Development, Ahead of Print. AbstractThe formation of pericardial adipose tissue (PAT) and its regulatory function in cardiac inflammation are not well understood. We investigated the potential role of the ubiquitous ATP/UTP nucleotide receptor...
Fri Dec 13, 2019 10:18
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