AbstractGlutamate Ionotropic Receptor Kainate Type Subunit 3 (GRIK3) is an important excitatory neurotransmitter receptor that plays a significant role in various neurodegenerative diseases. However, the biological functions of GRIK3 in malignancies are largely unknown because of limited related studies. Here, we primarily reported that the expression of GRIK3 was higher in breast cancer tissues than in adjacent noncancerous tissues. GRIK3 expression was also positively correlated with the...
Thu Apr 11, 2019 18:39
Saliva Tests Can Identify HPV16 PrecisionVaccinationsIn a cancer detection editorial published in JAMA, Ricardo J. Ramirez, MD and Jose P. Zevallos, MD, MPH, concluded that oral rinse samples are reliable when ...
Thu Apr 11, 2019 22:44
This paper describes a patient with hyperammonemia and delirium induced by capecitabine chemotherapy. Capecitabine and 5‐fluorouracil potentially induce hyperammonemia by inhibiting pyrimidine biosynthesis and thus decreasing ammonia utilization. The patient had risk factors for 5‐fluorouracil‐induced hyperammonemia, including genetic susceptibility and occult liver dysfunction, which are not rare.AbstractBackgroundCancer patients receiving chemotherapy often complain of "chemobrain" or...
Thu Apr 11, 2019 19:10
The use of antioxidants, such as acetylcysteine, in patients receiving chemotherapy is currently a hot topic in the literature. There are no studies in humans to verify the effect of acetylcysteine on toxicity, oxidative stress, and clinical response to cisplatin. This is the first randomized, double‐blind, placebo‐controlled trial to investigate this issue.AbstractThe protective antioxidant activity of acetylcysteine (NAC) against toxicity due to cisplatin has been reported in experimental...
Thu Apr 11, 2019 19:10
Purpose: We aimed to develop an ovarian cancer–specific predictive framework for clinical stage, histotype, residual tumor burden, and prognosis using machine learning methods based on multiple biomarkers.Experimental Design: Overall, 334 patients with epithelial ovarian cancer (EOC) and 101 patients with benign ovarian tumors were randomly assigned to "training" and "test" cohorts. Seven supervised machine learning classifiers, including Gradient Boosting Machine (GBM), Support Vector Machine, Random...
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AbstractBackgroundPediatric hepatocellular carcinoma (HCC) is a rare liver tumor in children with a poor prognosis. Comprehensive molecular profiling to understand the underlying genomic drivers of this tumor has not been completed, and it is unclear whether nonfibrolamellar pediatric HCC is more genomically similar to hepatoblastoma or adult HCC.ProcedureTo characterize the molecular landscape of these tumors, we analyzed a cohort of 15 pediatric non‐FL‐HCCs by sequencing a panel of cancer‐associated...
Thu Apr 11, 2019 19:14
AbstractOvarian angiosarcoma is a rare and aggressive vascular tumor, which has a 5‐year overall survival of less than 30% for patients with nonmetastatic disease and almost certain death within 1 year for those with metastasis. Here, we briefly review historical approaches to therapy and present a long‐term survivor in the case of an 11‐year‐old female with metastatic ovarian angiosarcoma. This is the second reported case to utilize heated intraperitoneal chemotherapy in the treatment of...
Thu Apr 11, 2019 19:13
Thu Apr 11, 2019 19:13
Abstract Background The use of intraoperative MRI (iMRI) during treatment of gliomas may increase extent of resection (EOR), decrease need for early reoperation, and increase progression-free and overall survival, but has not been fully validated, particularly in the pediatric population. Objective To assess the accuracy of iMRI to identify residual tumor...
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Oncology advanced practice registered nurses can play a critical role in providing primary palliative care to patients with cancer. (Source: CancerNetwork)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Thu Apr 11, 2019 06:00
Cancer Biotherapy and Radiopharmaceuticals, Volume 34, Issue 3, Page 135-140, April 2019.
Wed Apr 10, 2019 10:00
Outcomes of patients with ovarian high-grade serous carcinoma (HGSC) treated with neoadjuvant chemotherapy (NAC) have been widely studied, but there is limited information on the outcomes of patients with non-... (Source: BMC Cancer)
Thu Apr 11, 2019 02:00
Salivary gland carcinoma ranks the sixth in head and neck cancers while it is relatively rare in its incidence. Epidemiological studies have been based mostly on institutional data, leading to selection bias i... (Source: BMC Cancer)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Thu Apr 11, 2019 02:00
To perform quality assurance of non-coplanar, volumetric-modulated arc therapy featuring continuous couch rotation (CCR-VMAT) using a C-arm linear accelerator. (Source: Radiation Oncology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Thu Apr 11, 2019 02:00
Abstract The recent European Council Directive 2013/59/EURATOM requires the establishment of diagnostic reference levels (DRLs) to optimise radiation dose in diagnostic and interventional radiology procedures. At the time this directive was enacted, just a few European countries had already set paediatric DRLs and many of these were outdated. For this reason, the European Commission launched a project addressing European Guidelines on Diagnostic Reference Levels for Paediatric...
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Abstract Postmortem CT for investigating childhood deaths is increasingly utilised as a noninvasive adjunct or alternative to standard autopsy; however there are no standardised published imaging protocols. This article describes a standardised imaging protocol that has been developed based on current practices of international postmortem imaging practitioners and experts. This recommendation is expected to be useful for postmortem imaging centres wishing to update their existing...
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Abstract Background The significance of intrarenal reflux as a risk factor for renal scarring and hypertension has been discussed. Fluoroscopic detection of intrarenal reflux depends on the equipment, the training of the radiologists and the timing of spot film acquisition. Objective To evaluate the prevalence of intrarenal reflux and its association...
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Abstract This retrospective review of 33 children's dynamic 4-dimensional (4-D) computed tomography (CT) images of the airways, performed using volume scanning on a 320-detector array without anaesthesia (free-breathing) and 1.4-s continuous scanning, was undertaken to report technique, pitfalls, quality, radiation doses and findings. Tracheobronchomalacia (airway diameter collapse >28%) was recorded. Age-matched routine chest CT scans and bronchograms acted as benchmarks...
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Abstract The human immunodeficiency virus (HIV) epidemic seems largely controlled by anti-retroviral treatment with resultant large numbers of children growing up with the disease on long-term treatment, placing them at higher risk to develop HIV-related brain injury, ongoing cognitive impairment and treatment-related neurological complications. Cerebral white matter involvement is a common radiologic finding in HIV infection and the causes of this have overlapping appearances,...
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The clinic educates, evaluates, and guides patients with prostate cancer on available treatments and helps to control associated anxiety. (Source: CancerNetwork)
Thu Apr 11, 2019 06:00
The THRIVE Program includes an 8-hour retreat designed to teach staff skills for combating compassion fatigue and for promoting resilience. (Source: CancerNetwork)
Thu Apr 11, 2019 06:00
ConclusionsThe mapping algorithm successfully mapped the EORTC QLQ-C30 and QLQ-CR29 scales onto the EQ-5D-5L values; therefore, it enables policymakers to convert cancer-specific questionnaires scores to the preference-based scores. (Source: Journal of Gastrointestinal Cancer)
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Enzalutamide is an oral androgen receptor targeted agent that has been shown to improve survival in PREVAIL trials and has been approved for patients with chemo-na ïve metastatic castration-resistant prostate c... (Source: BMC Cancer)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Thu Apr 11, 2019 02:00
Hematopoietic stem cell transplantation (HSCT) remains an important therapeutic option for many hematologic malignancies. Bone marrow harvesting from an appropriate donor must be conducted for hematopoietic st... (Source: BMC Cancer)
Thu Apr 11, 2019 02:00
Cancer is currently the second leading cause of death globally and is expected to be responsible for approximately 9.6 million deaths in 2018. With an unprecedented understanding of the molecular pathways that...
Thu Apr 11, 2019 03:00
Prostate cancer (PCa) remains a challenge worldwide. Due to the development of castration-resistance, traditional first-line androgen deprivation therapy (ADT) became powerlessness. Epidermal growth factor rec...
Thu Apr 11, 2019 03:00
PD-L1 has proven to be a helpful but limited biomarker in helping clinicians choose cancer patients for immune checkpoint inhibition.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Jeffrey Weber comments on a promising approach for heavily pretreated melanoma patients that was recently presented at the 2019 AACR annual meeting.Medscape Oncology (Source: Medscape Allergy Headlines)
Thu Apr 11, 2019 23:52
His objectives including getting the Camden institute more active in cancer research. (Source: bizjournals.com Health Care:Physician Practices headlines)
Thu Apr 11, 2019 23:09
Mark Kris discusses the importance of dexamethasone in antiemetic regimens.Medscape Oncology (Source: Medscape Hematology-Oncology Headlines)
Thu Apr 11, 2019 20:29
(Source: The Doctors Lounge - Oncology)
Thu Apr 11, 2019 19:00
Hazard ratios for leukemia - specific death, all - cause death higher for patients with AML and LC (Source: The Doctors Lounge - Oncology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Thu Apr 11, 2019 19:00
(Source: The Doctors Lounge - Oncology)
Thu Apr 11, 2019 19:00
(Source: The Doctors Lounge - Oncology)
Thu Apr 11, 2019 16:00
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