Tuesday, March 26, 2019

MedWorm

Thu Mar 21, 2019 17:00
Prospective Observational Cohort HIV and STIs Study in Germany
 
Conditions:   HIV Infections;   Sexual Behavior;   Risk Reduction Intervention:   Other: Determine the Incidence and Retention Rate Sponsors:   Hendrik Streeck;   US Military HIV Research Program;   United States Army Medical Materiel Development Activity;   Federal Ministry of Health, Germany;   German Center for Infection Research;...
Wed Mar 20, 2019 17:00
Mometasone Furoate Aqueous Nasal Spray vs Placebo and Flonase ® in Seasonal Allergic Rhinitis Patients (I94-001)
 
Condition:   Rhinitis, Allergic, Seasonal Interventions:   Drug: Mometasone furoate;   Drug: Fluticasone propionate;   Drug: Mometasone furoate placebo;   Drug: Fluticasone propionate placebo Sponsor:   Merck Sharp & Dohme Corp. Completed (Source: ClinicalTrials.gov)
Tue Mar 19, 2019 17:00
VRC 313: A Trivalent Virus-like Particle (VLP) Encephalitis Vaccine (WEVEE) in Healthy Adults
 
Conditions:   Venezuelan Equine Encephalitis;   Western Equine Encephalitis;   Eastern Equine Encephalitis;   Alphavirus Infections Interventions:   Biological: VRC-WEVVLP073-00-VP;   Other: VRC-GENMIX083-AL-VP Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   The EMMES Corporation;...
Tue Mar 19, 2019 17:00
Omalizumab as Monotherapy and as Adjunct Therapy to Multi-Allergen OIT in Food Allergic Participants
 
Conditions:   Peanut Allergy;   Multi-food Allergy Interventions:   Drug: Omalizumab;   Drug: Placebo for Omalizumab;   Drug: Multi-Allergen Oral Immunotherapy;   Drug: Placebo for Multi-Allergen Oral Immunotherapy;   Other: Double-Blind Placebo-Controlled Food Challenge Based Treatment Sponsors:   National...
Tue Mar 19, 2019 17:00
Autologous TAC T Cells Targeting CD19 in R/R Large B-Cell Lymphoma
 
Condition:   Lymphoma, B-Cell Intervention:   Biological: TAC01-CD19 Sponsor:   Triumvira Immunologics, Inc. Not yet recruiting (Source: ClinicalTrials.gov)
Tue Mar 19, 2019 17:00
Dose-Ranging Study of Mometasone Furoate (MK-0887/SCH 032088) Nasal Spray in the Treatment of Children (Ages 6-11) With Seasonal Allergic Rhinitis (C95-161)
 
Condition:   Rhinitis, Allergic, Seasonal Interventions:   Drug: Mometasone furoate nasal spray;   Drug: Beclomethasone dipropionate nasal spray;   Drug: Placebo nasal spray;   Drug: Chlorpheniramine maleate syrup Sponsor:   Merck Sharp & Dohme Corp. Completed (Source: ClinicalTrials.gov)
Tue Mar 19, 2019 17:00
Sphenoid Nasalization in Allergic Fungal Sphenoidal Sinusitis
 
Condition:   Fungal Sinusitis Intervention:   Procedure: sphenoidotomy versus sphenoid nasalisation Sponsor:   Assiut University Not yet recruiting (Source: ClinicalTrials.gov)
Mon Mar 18, 2019 17:00
Safety and Immunogenicity of Ad4-HIV Envelope Vaccine Vectors in Healthy Volunteers
 
Condition:   Healthy Volunteer Interventions:   Biological: Ad4-Env145NFL;   Biological: Ad4-Env150KN;   Biological: VRC-HIVRGP096-00-VP (Trimer 4571) with alum Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
Mon Mar 18, 2019 17:00
Prevalence of Asthma and Allergies Among Children in UAE
 
Condition:   Asthma Intervention:   Other: Study questionnaires Sponsor:   AstraZeneca Not yet recruiting (Source: ClinicalTrials.gov)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Tue Mar 26, 2019 05:00
Pediatric health researchers offer insights for RSV vaccine
 
(Louisiana State University) In healthy adults, RSV, or respiratory syncytial virus, feels like the common cold with a runny nose, chest congestion and cough. However, it is the second leading cause of death in infants. . A new publication in Frontiers in Immunology by Stephania Cormier, the LSU Department...
Tue Mar 26, 2019 14:20
Fitness instructor, 28, battling a mystery allergy that causes her face to swell like a 'pufferfish'
 
Carla Roberts, from Dublin, sees red rings appear all over her face and body for 'no reason'. The flare-ups can last as long as a month, leaving doctors baffled. (Source: the Mail online | Health)
Tue Mar 26, 2019 13:51
Aldeyra Therapeutics Announces Positive Top-Line Results from the Phase 3 ALLEVIATE Trial in Patients with Allergic Conjunctivitis
 
Primary endpoint of ocular itch score area under the curve achieved for both tested reproxalap concentrations Key secondary endpoint of clinically relevant two-point ocular itch score improvement achieved for both tested reproxalap concentrations Com... Biopharmaceuticals, Ophthalmology Aldeyra...
Tue Mar 26, 2019 12:57
Aldeyra's eye drug meets main goal in late-stage study, shares surge
 
Aldeyra Therapeutics Inc said on Tuesday its drug reproxalap to treat a form of allergic reaction to the eye met the main goal in a late-stage trial, sending shares up more than 60 percent. (Source: Reuters: Health)
Tue Mar 26, 2019 16:57
Aldeyra stock jumps 50 percent after eye allergy trial success
 
Quiet local biotech Aldeyra Therapeutics made some noise Tuesday, reporting that its first treatment for eye allergies succeeded in a late-stage trial. The 19-person company has largely flown under the radar in the Massachusetts biotech landscape, aside from raising one of the smallest amounts for...
Tue Mar 26, 2019 13:02
May 8, 2019: Meeting of the Pulmonary-Allergy Drugs Advisory Committee Meeting Announcement
 
(Source: FDA Center for Drug Evaluation and Research - What's New)
Mon Mar 25, 2019 08:00
mometasone furoate (Nasonex)
 
Title: mometasone furoate (Nasonex)Category: MedicationsCreated: 6/6/1999 12:00:00 AMLast Editorial Review: 3/25/2019 12:00:00 AM (Source: MedicineNet Allergies General)
Mon Mar 25, 2019 19:12
Here 's Everything You Need to Know About Gut Health
 
It's hardly news that the gastrointestinal tract is important to human health: It transports food from the mouth to the stomach, converts it into absorbable nutrients and stored energy, and shuttles waste back out of the body. If you don't properly nourish yourself, you don't live. It's that simple....
Mon Mar 25, 2019 17:03
A Good Spring Clean Can Help Tame Seasonal Allergies
 
MONDAY, March 25, 2019 -- When it's finally time to store away your winter coats and boots, it's also a good time to rid your home of the allergens that accumulated over the winter, an allergist suggests. " If you aren't someone who regularly... (Source: Drugs.com - Daily MedNews)MedWorm Message: Have...
Mon Mar 25, 2019 00:00
Cochlear implant in a subject affected by the Chudley-McCullough Syndrome
 
. (Source: Cochlear Implants International)
Mon Mar 25, 2019 00:00
The Estimated Electrode-Neuron Interface in Cochlear Implant Listeners Is Different for Early-Implanted Children and Late-Implanted Adults
 
This study examined whether ENI quality differed between early-implanted children and late-implanted adults. Auditory detection thresholds and most comfortable levels (MCLs) were obtained with monopolar and focused electrode configurations. Channel-to-channel variability and dynamic range were calculated...
Tue Mar 26, 2019 13:00
The Most Pressing Issues In Bioethics
 
Who owns medical and genetic data? How to regulate gene editing? Where is the boundary of enhancing physical or cognitive human capabilities? What to do with biological differences widening the gap of the haves and have-nots? Could we define where is the boundary to augment life? Will we sue robots or...
Tue Mar 26, 2019 03:08
Growing evidence challenges conservative transfusion dogma
 
(Source: Notes from Dr. RW)
Mon Mar 25, 2019 20:51
New Jersey Assembly, Senate Pass Aid in Dying Bill After Nearly 7 Years of Debate
 
New Jerseyans with terminal or life-shortening diseases and Compassion & Choices praised the state Assembly and Senate for passing the Aid in Dying for the Terminally Ill Act (S1072/A1504) after nearly seven years of debate on the issue and urged Governor Phil Murphy to promptly sign it into...
Mon Mar 25, 2019 17:00
Paclitaxel vs Paclitaxel + Cetuximab in Recurrent - Metastatic Head & Neck Carcinoma After Failure of a 1 º Chemotherapy
 
Condition:   Head and Neck Cancer Interventions:   Drug: Paclitaxel;   Drug: Cetuximab + Paclitaxel Sponsors:   Grupo Español de Tratamiento de Tumores de Cabeza y Cuello;   Merck Sharp & Dohme Corp.;   Pivotal S.L. Terminated (Source: ClinicalTrials.gov)MedWorm Message: If you are looking to buy...
Mon Mar 25, 2019 17:00
The Role of Tumor-associated Macrophages in Colorectal Liver Metastases
 
Conditions:   Colorectal Liver Metastases;   Colorectal Cancer;   Liver Metastases;   Immunotherapy Intervention:   Procedure: Hepatectomy Sponsor:   Humanitas Clinical and Research Center Completed (Source: ClinicalTrials.gov)
Mon Mar 25, 2019 17:00
Pretreatment Group Consultation for Patients With Colorectal Cancer
 
Condition:   Colorectal Neoplasm Intervention:   Other: Pretreatment group consultation Sponsor:   Sahlgrenska University Hospital, Sweden Not yet recruiting (Source: ClinicalTrials.gov)
Mon Mar 25, 2019 17:00
ET1402L1-ARTEMIS ™2 T Cells in AFP Expressing Hepatocellular Carcinoma
 
Conditions:   Hepatocellular Carcinoma;   Liver Cancer;   Liver Neoplasms;   Metastatic Liver Cancer Interventions:   Biological: ET1402L1-ARTEMIS™ T cells -IV;   Biological: ET1402L1-ARTEMIS™ T cells -intra-hepatic artery;   Biological: ET1402L1-ARTEMIS™ T cells -Intratumoral Injections Sponsors:  ...
Mon Mar 25, 2019 17:00
Tenofovir Alafenamide in Preventing Liver Complications in Participants With Current or Past Hepatitis B Virus Who Are Receiving Anti-Cancer Therapy for Solid Tumors
 
Conditions:   Hepatitis B Virus Positive;   Malignant Solid Neoplasm Interventions:   Other: Best Practice;   Other: Laboratory Biomarker Analysis;   Drug: Tenofovir Alafenamide Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI) Recruiting (Source: ClinicalTrials.gov)
Mon Mar 25, 2019 17:00
Knowledge and Attitudes Towards Human Papillomavirus Infections and HPV Vaccination
 
Condition:   HPV-Related Cervical Carcinoma Intervention:   Behavioral: knowledge questioannaire Sponsor:   University Hospital, Geneva Not yet recruiting (Source: ClinicalTrials.gov)
Mon Mar 25, 2019 17:00
Individually Dose-adjusted FEC Compared to Standard FEC as Adjuvant Chemotherapy for Node Positive or High-risk Node Negative Breast Cancer
 
Condition:   Breast Cancer Intervention:   Drug: 5-FU, epirubicin and cyclophosphamide Sponsors:   Henrik Lindman;   Scandinavian Breast Cancer Group;   Danish Breast Cancer Group;   Swedish Cancer Society;   Swedish Breast Cancer Association;   Uppsala University Oncology Department Trust;   Pharmacia Pharmaceutical Company;...
Mon Mar 25, 2019 17:00
Application of Ultrasound Artificial Intelligence and Elastography in Differential Diagnosis of Breast Nodules
 
Condition:   Breast Cancer Intervention:   Device: Ultrasound diagnosis Sponsors:   Xin-Wu Cui;   Xinhua Hospital, Shanghai Jiao Tong University School of Medicine;   Taizhou Hospital;   Wuhan Hospital of Traditional Chinese and Western Medicine;   Macheng People's Hospital;   Huangshi Central Hospital;...
Mon Mar 25, 2019 17:00
Z650 in Advanced Esophageal Squamous Cell Carcinoma With EGFR Over Expression or Gene Amplification
 
Condition:   Esophageal Squamous Cell Carcinoma Intervention:   Drug: Z650 Sponsor:   Sunshine Lake Pharma Co., Ltd. Recruiting (Source: ClinicalTrials.gov)
Mon Mar 25, 2019 17:00
Integrating an Occupational Therapy Health and Wellness Program Into an Existing Cancer Support Community
 
Condition:   Cancer Intervention:   Other: Occupational Therapy Health& Wellness Education Sponsors:   University of Indianapolis;   Indiana Clinical and Translational Sciences Institute Recruiting (Source: ClinicalTrials.gov)MedWorm Message: Have you tried our new medical search engine? More powerful...
Mon Mar 25, 2019 17:00
A Phase 1 Clinical Trial of ARV-110 in Patients With Metastatic Castration-resistant Prostate Cancer.
 
Condition:   Prostate Cancer Metastatic Intervention:   Drug: ARV-110 Sponsor:   Arvinas Inc Recruiting (Source: ClinicalTrials.gov)
Mon Mar 25, 2019 17:00
Clinical Data Collection in Studying Clinical Factors Associated With Post-Surgery Chronic Opioid Use in Patients With Head and Neck Cancers
 
Condition:   Head and Neck Carcinoma Interventions:   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI) Recruiting (Source: ClinicalTrials.gov)
Mon Mar 25, 2019 17:00
A Cross Sectional Study to Assess the Effect of Androgen Deprivation Therapy on Gut and Urinary Microbiota in Patients With Prostate Cancer
 
Condition:   Prostate Cancer Intervention:   Sponsor:   Chinese University of Hong Kong Recruiting (Source: ClinicalTrials.gov)
Mon Mar 25, 2019 17:00
bnP for pRediction of Outcome FollowIng Lung rEsection Surgery
 
Condition:   Lung Cancer Intervention:   Sponsor:   University of Glasgow Recruiting (Source: ClinicalTrials.gov)
Mon Mar 25, 2019 17:00
Quality Improvement Strategies to Increase Human Papillomavirus (HPV) Vaccination in Integrated Healthcare Delivery Systems
 
Condition:   Human Papillomavirus Infection Intervention:   Other: VACs Sponsors:   University of North Carolina, Chapel Hill;   Centers for Disease Control and Prevention;   American Cancer Society, Inc.;   Wisconsin Department of Health and Family Services;   New York State Department of Health;  ...
Fri Mar 22, 2019 17:00
Radiofrequency Splanchnic Denervation Versus Retrocrural Neurolytic Celiac Block for Pancreatic Cancer Pain
 
Condition:   Chronic Pain Interventions:   Procedure: radiofrequency splanchnic denervation;   Procedure: retrocrural celiac denervation Sponsor:   Assiut University Not yet recruiting (Source: ClinicalTrials.gov)
Fri Mar 22, 2019 17:00
Study of Oral Vinorelbine Plus Capecitabine Versus Taxane-gemcitabine Combinations as 1st Line Chemotherapy in Metastatic Breast Cancer
 
Condition:   Breast Cancer Interventions:   Drug: oral vinorelbine;   Drug: Capecitabine;   Drug: Gemcitabine 1250 mg/m²;   Drug: Gemcitabine 1000 mg/m²;   Drug: Paclitaxel;   Drug: Docetaxel Sponsor:   Pierre Fabre Medicament Completed (Source: ClinicalTrials.gov)MedWorm Message: If you are looking...
Fri Mar 22, 2019 17:00
Physically Active During Cancer Treatment (FAKT)
 
Condition:   Neoplasms, Colorectal Interventions:   Behavioral: Exercise training and nutritional guide;   Other: Standard follow-up care Sponsors:   St. Olavs Hospital;   Alesund Hospital;   Levanger Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Fri Mar 22, 2019 17:00
U01-Biomarkers for Noninvasive and Early Detection of Pancreatic Cancer
 
Condition:   Pancreatic Cancer Intervention:   Sponsors:   Hoag Memorial Hospital Presbyterian;   Baylor Research Institute Recruiting (Source: ClinicalTrials.gov)
Fri Mar 22, 2019 17:00
VPA Expanded UCB Transplantation for Treatment of Patients With Hematological Malignancies
 
Conditions:   Hematological Malignancy;   Acute Leukemia in Remission;   Acute Lymphoblastic Leukemia in Remission;   Myelodysplastic Syndromes;   Non-Hodgkin Lymphoma;   Hodgkin Lymphoma Interventions:   Biological: Cord blood stem cells;   Drug: Valproic Acid;   Drug: Fludarabine;   Drug: cytoxan;...
Fri Mar 22, 2019 17:00
Breast Cancer Diet Intervention Study
 
Conditions:   Early-stage Breast Cancer;   Carbohydrate Engorgement;   Proliferation;   Insulin Resistance;   Estrogen Receptor-positive Breast Cancer Intervention:   Dietary Supplement: PreOP Sponsor:   Helse Stavanger HF Completed (Source: ClinicalTrials.gov)
Fri Mar 22, 2019 17:00
A Study of PRT543 in Participants With Advanced Solid Tumors and Hematologic Malignancies
 
Conditions:   Relapsed/Refractory Advanced Solid Tumors;   Relapsed/Refractory Diffuse Large B-cell Lymphoma or Mantle Cell Lymphoma;   Relapsed/Refractory Myelodysplasia;   Relapsed/Refractory Myelofibrosis Intervention:   Drug: PRT543 Sponsor:   Prelude Therapeutics Recruiting (Source: ClinicalTrials.gov)
Fri Mar 22, 2019 17:00
Talimogene Laherparepvec, Nivolumab and Trabectedin for Sarcoma
 
Condition:   Sarcoma Interventions:   Drug: Talimogene Laherparepvec 100000000 PFU/1 ML Injection Suspension [IMLYGIC];   Drug: Nivolumab IV Soln 100 MG/10ML;   Drug: Trabectedin 0.25 MG/1 VIAL Intravenous Powder for Solution Sponsor:   Sarcoma Oncology Research Center, LLC Not yet recruiting (Source:...
Tue Mar 26, 2019 05:00
TGen physician-in-chief receives Distinguished Public Service Award from AACR
 
(The Translational Genomics Research Institute) Dr. Daniel D. Von Hoff, Distinguished Professor and Physician-In-Chief for the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, has been selected to receive the 2019 Distinguished Public Service Award from the American Association...
Tue Mar 26, 2019 00:00
GP gatekeepers linked to reduced patient satisfaction
 
Link also found with lower cancer survival rates Related items fromOnMedica Social prescribing workers to ease GP pressure Experts urge radical action on mental health crises Home births safe and cost-effective for low-risk women Eight in ten stillbirths might have been avoided BMA and College demand...
Tue Mar 26, 2019 22:05
Bellwether Glyphosate Cancer Trial Heads To Phase 2 To Determine Liability
 
SAN FRANCISCO - Phase 2 of the federal bellwether glyphosate cancer trial in California started March 20, after a jury the first phase found that the chemical, which is the active ingredient in Monsanto Co.'s herbicide Roundup, was "a substantial factor" in causing the plaintiff's non-Hodgkin lymphoma...
Tue Mar 26, 2019 22:05
Attorneys Present Closing Arguments In Phase 1 Of Glyphosate Cancer Trial
 
SAN FRANCISCO - The attorneys representing the plaintiff and Monsanto Co. in the bellwether federal glyphosate cancer trial presented closing arguments on March 12 for Phase 1 of the trial, which deals with the sole issue of causation (In re: Roundup Products Liability Litigation, MDL No. 2741, N.D....
Tue Mar 26, 2019 22:05
Study: People Exposed To Glyphosate Have Increased Risk Of Cancer
 
LONDON - A study published in the International Journal of Epidemiology on March 18 found that there was an elevation of risk for non-Hodgkin lymphoma (NHL) in people who were exposed to glyphosate, the active ingredient in the herbicide Roundup. (Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal...
Tue Mar 26, 2019 22:05
Pennsylvania High Court To Hear Pesticide Cancer Case, Rule On Evidence Standard
 
HARRISBURG, Pa. - The Pennsylvania Supreme Court on March 5 agreed to hear an appeal in a wrongful death lawsuit to determine whether a divided lower court reached the correct conclusion regarding the application of the Frye evidence standard in a pesticide cancer lawsuit against numerous chemical companies...
Tue Mar 26, 2019 22:05
Judge Denies Monsanto A Directed Verdict In Phase 1 Of Glyphosate Cancer Trial
 
SAN FRANCISCO - The California federal judge presiding over the bellwether glyphosate cancer trial against Monsanto Co. on March 13 denied the company's motion for a directed verdict on causation (In re: Roundup Products Liability Litigation, MDL No. 2741, N.D. Calif.). (Source: LexisNexis® Mealey's™...
Tue Mar 26, 2019 22:05
Glyphosate A 'Substantial Factor' In Causing Cancer, Jury Says; Trial Continues
 
SAN FRANCISCO - A jury in a federal bellwether glyphosate cancer trial in California on March 19 found that the chemical, which is the active ingredient in Monsanto Co.'s herbicide Roundup, was "a substantial factor" in causing the plaintiff's non-Hodgkin lymphoma. Phase 2 of the trial, to determine...
Tue Mar 26, 2019 22:05
Monsanto: Laboratory Fraud Not Relevant In Bellwether Glyphosate Cancer Trial
 
SAN FRANCISCO - Monsanto Co. on March 4 filed a brief in California federal court contending that in the bellwether glyphosate cancer trial, the plaintiff's supplemental brief regarding alleged fraud at a laboratory that tested the chemical "misrepresents the historical record" and "has no relevance...
Tue Mar 26, 2019 21:28
Another medtech sterilization plant will close in 2019
 
A second medical device sterilization plant is slated to close this year, prompting the FDA and medtech manufacturers to scramble for replacements. The FDA warned on March 1 about a potential medical device shortage due to the recent shutdown of a Sterigenics plant in Willowbrook, Ill. linked to emissions...
Tue Mar 26, 2019 20:43
U.S. jury to determine liability, damages in Roundup cancer trial
 
A lawyer for a man who said his cancer was caused by Bayer AG's glyphosate-based weed killer Roundup on Tuesday urged U.S. jurors to "send a message" to the company by holding it liable and awarding millions in damages. (Source: Reuters: Health)
Tue Mar 26, 2019 20:10
Tom Brokaw, 79, reveals he takes medical marijuana to relieve his pain after beating blood cancer
 
The 79-year-old newscaster, known for being straight-laced, revealed on Tuesday that he turned to the drug to ease his pain from multiple myeloma, a type of blood cancer. (Source: the Mail online | Health)
Tue Mar 26, 2019 18:04
DOJ says ACA should be struck down
 
The U.S. Department of Justice (DOJ) has shifted its position on the Patient...Read more on AuntMinnie.comRelated Reading: ACA has benefited low- and middle-income women How has the ACA affected breast cancer screening? DOJ action may hinder disabled access to imaging More women get breast screening...
Tue Mar 26, 2019 17:58
Dune Medical launches first-in-man Smart Biopsy trial
 
Dune Medical Devices said today that it launched a first-in-man trial of its Smart Biopsy device, touting that the first patients in the trial have already been treated. The first-in-man cases were performed by Dr. Noemi Weissenberg of Kfar Saba, Israel's Meir Medical Center, the Alpharetta, Ga.-based...
Tue Mar 26, 2019 16:48
FDA Panel: Too early to pull textured breast implants over cancer risk, need more data
 
A panel of experts convened by the FDA yesterday said that there's not enough data to pull textured breast implants from the market over concerns that they may be linked to a type of immune system cancer, according to an AP News report. The recommendation comes from the first day of a two-day panel...
Tue Mar 26, 2019 15:00
Medical News Today: Time-restricted eating may prevent tumor growth
 
New research in mice suggests that eating all daily meals within a restricted window of time may be a good preventive strategy against cancer tumor growth. (Source: Health News from Medical News Today)
Tue Mar 26, 2019 14:59
Prostate tumours 'spread by spiting out a protein that activates dormant cancer cells'
 
A new study by the University of Bradford found these tiny pieces of a protein, known as EN2, are taken up by other cancerous cells, causing them to change shape or fuse together. (Source: the Mail online | Health)
Tue Mar 26, 2019 14:57
Woman, 22, slams the NHS after she was denied a smear test
 
Demi-Lee Stewart, from Glasgow, is still three years away from the Government's smear testing threshold of 25. She has been suffering bleeding between periods - a sign of cervical cancer. (Source: the Mail online | Health)
Tue Mar 26, 2019 13:04
Breast surgeon "astonished" by cancer case amid FDA implant review
 
FDA is meeting to address the possible risks of breast implants after the agency reported that 457 cases of cancer have been detected in women with breast implants (Source: Health News: CBSNews.com)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your...
Tue Mar 26, 2019 11:51
Mother of two reveals she planned her wedding and funeral after being diagnosed with ovarian cancer 
 
EXCLUSIVE: Tina Potts, 40, from Wicklow Town, Ireland, has battled terminal cancer for 18 months. She married her partner of 13 years on Friday to 'make memories' for her two children. (Source: the Mail online | Health)
Tue Mar 26, 2019 10:46
Cancer warning: Prostate cancer could be caused by disease found in popular holiday spots
 
CANCER WARNING: A common tropical disease found in certain holiday hotspots popular with British tourists could make victims more at risk of developing prostate cancer, new research has revealed. (Source: Daily Express - Health)
Tue Mar 26, 2019 10:43
Red raspberry found to prevent head and neck cancers from developing and spreading
 
(Natural News) Berries are known to be one of the greatest superfoods available. Many studies suggest that these are rich in antioxidants and possess cancer-fighting properties. For example, red raspberry — a type of berry scientifically known as Rubus idaeus — can protect against a type of head and...
Tue Mar 26, 2019 10:41
A compound found in goldenseal proven to possess cancer-fighting properties
 
(Natural News) Scientists continue to search for natural cancer treatments. A team of researchers at Nagasaki International University in Japan found that a natural compound known as berberine can help protect against cancer, particularly leukemia, by inducing cancer cell death. For the study, the research...
Tue Mar 26, 2019 09:03
Health Highlights: March 26, 2019
 
Here are some of the latest health and medical news developments, compiled by the editors of HealthDay: Too Early To Ban Breast Implant Linked With Cancer: FDA Panel It's too early to ban a type of breast implant recently linked to a rare form of... (Source: Drugs.com - Daily MedNews)MedWorm Message:...
Tue Mar 26, 2019 08:00
iKnowMed Named Top-Performing Electronic Health Record by Black Book Research for Eighth Consecutive Year
 
IRVING, TEXAS, March 26, 2019 —iKnowMed℠, McKesson's oncology practice electronic health record (EHR) system, has been named the top-ranked EHR platform for oncologists and hematologists for the eighth year in a row by Black Book™ Research, an unbiased industry-leading source for polling, surveys and......
Tue Mar 26, 2019 19:13
Stem Cell Transplant Patients Face Lifelong Cancer Risk Stem Cell Transplant Patients Face Lifelong Cancer Risk
 
Patients undergoing hematopoietic stem cell transplant should be counseled that they have an ever-increasing risk for further malignancies, although their survival may not be affected, say experts.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)MedWorm Message: Have you tried our...
Tue Mar 26, 2019 17:40
HSCT Remains Standard in Childhood ALL, Despite CAR T-Cells HSCT Remains Standard in Childhood ALL, Despite CAR T-Cells
 
Clinicians should continue to rely on matched donor stem cell transplants to treat childhood acute lymphoblastic leukemia, while more data on novel CAR T-cell therapies is gathered, says German expert.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Tue Mar 26, 2019 16:38
Prophylactic Nipple-Sparing Mastectomy: Longer-Term Data Prophylactic Nipple-Sparing Mastectomy: Longer-Term Data
 
The most comprehensive study yet of this technique found no cases of breast cancer at 53 months, suggesting it is safe.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a...
Tue Mar 26, 2019 15:11
Two Surgeries at Once: Endometrial Cancer & Stress Incontinence Two Surgeries at Once: Endometrial Cancer & Stress Incontinence
 
Women who require surgery for endometrial cancer enjoy a better quality of life if concomitant stress urinary incontinence is surgically repaired at the same time.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Tue Mar 26, 2019 05:00
NYU Tandon professor inducted into biomedical engineering elite
 
(NYU Tandon School of Engineering) The American Institute for Medical and Biological Engineering has inducted Jin Kim Montclare, a professor of chemical and biomolecular engineering at the NYU Tandon School of Engineering, to its College of Fellows. AIMBE cited her 'outstanding contributions to biomaterials...
Tue Mar 26, 2019 05:00
Tumor-associated immune cells hinder frontline chemotherapy drug in pancreatic cancer
 
(Michigan Medicine - University of Michigan) A frontline chemotherapy drug given to patients with pancreatic cancer is made less effective because similar compounds released by tumor-associated immune cells block the drug's action, research led by the University of Michigan Rogel Cancer Center found....
Tue Mar 26, 2019 05:00
Scientists uncover novel strategy to target common type of cancer
 
(eLife) Researchers have identified a protein critical for the survival of a particular type of tumor cell, according to a study published today in eLife. (Source: EurekAlert! - Cancer)
Tue Mar 26, 2019 05:00
Protein 'spat out' by cancer cells promotes tumor growth
 
(University of Bradford) Prostate cancer cells change the behavior of other cells around them, including normal cells, by 'spitting out' a protein from their nucleus, new research has found. (Source: EurekAlert! - Biology)
Tue Mar 26, 2019 05:00
Adopting Clinician Training to Prompt Comprehensive End-of-Life Conversations
 
A series of communication-focused interventions were implemented to try to improve conversations about values, goals, and preferences with patients with life-limiting cancer. (Source: CancerNetwork)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com...
Tue Mar 26, 2019 01:00
Move More, Live Longer
 
(Source: Cancercompass News: Other Cancer)
Mon Mar 25, 2019 08:00
Could the U.S. Mail Deliver Better Colon Cancer Screening Rates?
 
Title: Could the U.S. Mail Deliver Better Colon Cancer Screening Rates?Category: Health NewsCreated: 3/22/2019 12:00:00 AMLast Editorial Review: 3/25/2019 12:00:00 AM (Source: MedicineNet Cancer General)
Tue Mar 26, 2019 05:00
Study shows that patients with or without cancer use different forms of marijuana
 
(NYU Langone Health / NYU School of Medicine) A new study shows that compared to other patients, cancer patients use different forms of medical marijuana for unique reasons. (Source: EurekAlert! - Medicine and Health)MedWorm Message: Have you tried our new medical search engine? More powerful than before....
Tue Mar 26, 2019 08:00
AI and radiologists: Better together in screening mammo
 
Can an artificial intelligence (AI) algorithm interpret screening mammograms...Read more on AuntMinnie.comRelated Reading: Annual mammography shows higher recall rate AI may help women with ductal hyperplasia avoid surgery Mammo AI software yields workflow, economic benefits JNCI: Breast screening...
Tue Mar 26, 2019 08:00
SIR: Virtual reality beats fluoroscopy for catheter placement
 
Virtual reality may be a safer, more time-efficient alternative to conventional...Read more on AuntMinnie.comRelated Reading: VR, AR elevate radiologists' value in future of medicine Virtual reality may help plan, guide glioma resection 3D printing gives pediatric heart surgery a boost Virtual reality,...
Mon Mar 25, 2019 21:00
Elekta gets Canadian clearance for Unity MR
 
Radiation oncology vendor Elekta has received a Medical Device License from...Read more on AuntMinnie.comRelated Reading: Elekta initiates study on MR radiation therapy for cancer FDA clears Elekta's Unity MR radiation therapy system Elekta highlights Unity abstracts at ASTRO Elekta acquires software...
Sat Mar 23, 2019 00:00
Science Saturday: A new era in colon cancer detection and treatment
 
March is Colorectal Cancer Awareness Month, a time to focus on one of the most common and preventable forms of cancer. Mayo Clinic is applying a new genomic lens to colorectal and other cancers to identify which are the types that run in families. The answer to that could open new treatment options and...
Tue Mar 26, 2019 08:36
Active Surveillance for Non-Muscle Invasive Bladder Cancer Active Surveillance for Non-Muscle Invasive Bladder Cancer
 
What is the current state of knowledge concerning the use of active surveillance for low grade non-muscle invasive bladder cancer?Translational Andrology and Urology (Source: Medscape Today Headlines)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com...
Tue Mar 26, 2019 02:28
Hay fever sufferers are much less likely to develop certain cancers, study claims 
 
New research suggests hay-fever sufferers may be significantly less likely to develop certain cancers than those who breeze through the season unaffected by pollen-induced misery. (Source: the Mail online | Health)
Tue Mar 26, 2019 02:05
Women at Breast Implant Hearing Call for Disclosure of Safety Risks
 
While industry representatives insisted the implants are safe, others at an F.D.A. panel meeting urged for warnings about links to illnesses and cancer. (Source: NYT Health)
Mon Mar 25, 2019 22:03
Thriving college student, 18, who passed off cough as freshman flu is diagnosed with leukemia
 
Marlee Pincus, 18, began coughing in September 2018, but thought she had come down with the flu. She was eventually taken to the hospital where she was diagnosed with leukemia, a blood cancer. (Source: the Mail online | Health)MedWorm Message: Have you tried our new medical search engine? More powerful...
Mon Mar 25, 2019 21:24
FDA reviews breast implant safety amid cancer concerns
 
In a two-day meeting, officials are hearing from researchers, plastic surgeons, and women who say they've suffered a number of ailments as a result of their breast implants (Source: Health News: CBSNews.com)
Mon Mar 25, 2019 20:48
Too soon to pull breast implants tied to cancer, U.S. panel
 
Patients, plastic surgeons, makers of breast implants, regulators and Health Canada officials participate in two-day meeting hosted by the U.S. Food and Drug Administration. (Source: CBC | Health)
Mon Mar 25, 2019 19:54
What the End of a Promising Alzheimer 's Drug Trial Means for One Patient in the Study
 
After he was diagnosed with Alzheimer's disease in 2016, Peter Wooding says he and his wife JoAnn decided they wanted to be "part of the solution" in finding the first effective treatment for the neurodegenerative disease. He volunteered to be part of a trial for a promising new drug called aducanumab....
Mon Mar 25, 2019 19:21
Elekta wins Health Canada approval for Elekta Unity MR radiation therapy system
 
Elekta (STO:EKTA B) said today that it won Health Canada approval for its Elekta Unity magnetic resonance radiation therapy system. The Elekta Unity system consists of a high-field 1.5 Tesla MRI scanner and a linear accelerator alongside integrated real-time dose planning software for target monitoring,...
Mon Mar 25, 2019 19:07
Have you tried this powerful, popular cannabis oil recipe?
 
(Natural News) Hemp and hemp seed oil are all the hype these days. Millions of people have jumped on the recent health craze by adding high-quality hemp protein powder or hemp hearts to their morning smoothies. But did you know that a pure extract of the cannabis bud could potentially cure cancer, with...
Mon Mar 25, 2019 15:03
Medicaid Coverage for Lung Cancer Screening All Over the Map
 
MONDAY, March 25, 2019 -- State Medicaid programs must do more to make sure that people at high risk for lung cancer are screened for the deadly disease, a new American Lung Association report says. Medicaid is the public assistance program... (Source: Drugs.com - Daily MedNews)
Tue Mar 26, 2019 03:35
Big Jump in PFS With Combo for Indolent NHL
 
(MedPage Today) -- Lenalidomide-rituximab more than doubles PFS in relapsed/refractory disease (Source: MedPage Today Hematology/Oncology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income...
Mon Mar 25, 2019 20:54
New class of membranes shown to regenerate tissue and bone, viable solution for periodontitis
 
Periodontitis affects nearly half of Americans ages 30 and older, and in its advanced stages, it could lead to early tooth loss or worse. Recent studies have shown that periodontitis could also increase risk of heart disease and Alzheimer 's disease. A team of UCLA researchers has developed methods that...
Tue Mar 26, 2019 17:46
What is the Role of Immunotherapy for Patients with Advanced NSCLC and a Driver Mutation_ [360p]
 
Dr. Greg Riely from Memorial Sloan-Kettering Cancer Center reviews the limited data that help clarify the probability of benefit from new immunotherapy agents among patients with advanced NSCLC and an... Author: cancergrace Added: 03/26/2019 (Source: Oncology Tube)MedWorm Message: Have...
Tue Mar 26, 2019 15:18
Panel Q & A Session on Acquired Resistance with Drs. Riely & Horn [360p]
 
Dr. West moderates a question & answer session with Drs. Leora Horn and Greg Riely on issues of acquired resistance to targeted therapies for patients with advanced NSCLC that harbors a driver mutatio... Author: cancergrace Added: 03/26/2019 (Source: Oncology Tube)
Sat Mar 23, 2019 16:04
How Do the New ALK Inhibitor Drugs Compare to Xalkori (Crizotinib) for ALK+ Lung Cancer Patients_ [360p]
 
Xalkori (crizotinib) has had great success treating ALK positive lung cancer patients. The next generation of ALK inhibitors are also showing great promise. In this video, Dr. Leena Gandhi of Dana-Far... Author: cancergrace Added: 03/23/2019 (Source: Oncology Tube)
Sat Mar 23, 2019 15:23
New Ideas and New Treatment Options for Acquired Resistance for ALK_ROS1 [360p]
 
Xalkori (critzotinib) was the first approved treatment for ALK+ and ROS1 lung cancer. Since then, other drugs have been approved or are currently undergoing scientific review. In this video, Dr. Owoni... Author: cancergrace Added: 03/23/2019 (Source: Oncology Tube)
Sat Mar 23, 2019 14:31
The Blood_Brain Barrier for ALK Patients [360p]
 
The brain is a common site of disease in patients with ALK+ lung cancer. In this video, Dr. Horn illustrates the line-up of ALK+ treatments and how they work breaking through the blood/brain barrier. Author: cancergrace Added: 03/23/2019 (Source: Oncology Tube)
Sat Mar 23, 2019 14:20
Panel Q & A Session on ALK+ and ROS1 Acquired Resistance with Drs. Horn and Owonikoko [360p]
 
Janet Daily-Freeman moderates a question & answer session with Drs. Leora Horn and Taofeek Owonikoko on issues of acquired resistance to targeted therapies for ALK+ and ROS1 patients. Author: cancergrace Added: 03/23/2019 (Source: Oncology Tube)MedWorm Message: If you are looking...
03:19
The role of inherited genetic variants in colorectal polyposis syndromes.
 
Authors: Short E, Sampson J Abstract Colorectal carcinoma (CRC) is the third most common cancer in men and the second most common cancer in women across the world. Most CRCs occur sporadically, but in 15-35% of cases, hereditary factors are important. Some patients with an inherited predisposition...
03:19
Understanding human DNA variants affecting pre-mRNA splicing in the NGS era.
 
Authors: Dufner-Almeida LG, do Carmo RT, Masotti C, Haddad LA Abstract Pre-mRNA splicing, an essential step in eukaryotic gene expression, relies on recognition of short sequences on the primary transcript intron ends and takes place along transcription by RNA polymerase II. Exonic and intronic...
02:38
pH and folic acid dual responsive polysaccharide nanospheres used for nuclear targeted cancer chemotherapy
 
Publication date: 1 June 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 178Author(s): Xiuli Ren, Libang He, Xiaohan Tian, Peng Zhang, Zhenhua Chen, Xifan MeiAbstractIdeal nanoscale drug delivery system (DDS) should be biocompatible, having targeted recognition and controlled release properties....
02:38
Functionalized graphene oxide as a nanocarrier for dual drug delivery applications: The synergistic effect of quercetin and gefitinib against ovarian cancer cells
 
In this report, the combined drug system loaded on the GO-PVP nanovehicle was found to be significantly more toxic than the individual drug loaded systems, as well as the free drugs, toward PA-1 cells compared to the toxicity toward IOSE-364 cells. The combined drug system loaded on the GO-PVP nanovehicle...
02:35
The analysis of 2,3-dicarboxypropane-1,1-diphosphonic acid-coated magnetite nanoparticles under an external magnetic field and their radiolabeling for possible theranostic applications
 
New J. Chem., 2019, Advance Article DOI: 10.1039/C8NJ06478D, PaperMarko Peri ć, Magdalena Radović, Marija Mirković, Aleksandar S. Nikolić, Predrag Iskrenović, Drina Janković, Sanja Vranješ-Đurić The advances in nanotechnology are directed towards the development of new theranostic agents based on magnetic...
01:55
Challenges in the treatment of parathyroid carcinoma: a case report.
 
CONCLUSION: This is a very unusual patient with a newly discovered variant of the CDC73 gene and a phenotype characterized by recurrent PC, brown tumors, and N1a metastasized thyroid carcinoma. The present case confirms that PC may not exhibit clear malignant properties at first assessment, contributing...
01:54
Expression of Leptin Receptor and Effects of Leptin on Papillary Thyroid Carcinoma Cells.
 
Conclusions: These results demonstrate leptin's role in mildly increasing the aggressive phenotype of PTC cells but without influencing the action of lenvatinib. Further studies will clarify whether it is possible to target OB-R, expressed in all aggressive PTCs, as an adjuvant treatment approach for...
01:15
Differentially Expressed Genes and Molecular Pathways in an Autochthonous Mouse Prostate Cancer Model
 
Shiv Verma, Sanjeev Shukla, Mitali Pandey, Gregory T. MacLennan, Sanjay Gupta (Source: Frontiers in Genetics)
01:05
Low Dose Naltrexone in Dermatology
 
Authors: Jaros J, Lio P Abstract Low-dose naltrexone (LDN) has been successfully studied as an immunomodulatory and anti-inflammatory therapy in a wide range of conditions including Crohn's disease, fibromyalgia, major depressive disorder, cancer, chronic regional pain syndrome, Charcot-Marie-Tooth,...
01:05
Dual Immunostaining With SOX10 and AE1/AE3 to Confirm Perineural Invasion on Mohs Sections
 
Authors: Donaldson MR, Weber A Abstract Perineural invasion (PNI) is associated with high risk keratinocyte carcinomas. Identification of PNI during Mohs surgery is important for staging and post-adjuvant treatment decisions but can be challenging. To confirm or exclude PNI suspected on hematoxylin...
01:05
0.5% 5-Fluorouracil/10% Salicylic Acid for the Treatment of Distal Actinic Keratoses Under Daily Practice Conditions
 
Conclusion: Findings indicate that topical 5FU/AS is an effective treatment for multiple distal AKs, with a proper safety profile. J Drugs Dermatol. 2019;18(3):285-288. PMID: 30909350 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
00:11
Meta-analysis of risk factors and complications associated with atrial fibrillation after oesophagectomy.
 
CONCLUSION: Postoperative AF is frequently observed in patients undergoing oesophagectomy for cancer. It is associated with an increased risk of death and postoperative complications. PMID: 30908612 [PubMed - in process] (Source: The British Journal of Surgery)
00:11
Prognostic impact of repeat sentinel lymph node biopsy in patients with ipsilateral breast tumour recurrence.
 
CONCLUSION: The outcome of rSLNB is not an important prognostic factor for distant recurrence, and its value as a staging tool in patients with IBTR seems disputable. PMID: 30908615 [PubMed - in process] (Source: The British Journal of Surgery)
00:07
Relation between socioeconomic variables and surgical, systemic and radiation treatment in a cohort of patients with breast cancer in an urban Canadian centre
 
Conclusion: Employment consistently predicted systemic and radiation treatment, and age and income were predictors of breast reconstruction in a universal health care system. Further research is required to determine precisely how socioeconomic factors affect care and to minimize possible disparities...
00:07
Predictors of dysplastic and neoplastic progression of Barrett 's esophagus
 
Conclusion: Increased age, longer Barrett's segment and presence of mucosal irregularities were associated with increased risk of dysplastic and neoplastic progression. In addition to dysplasia, these factors may help stratify patients according to risk of neoplastic progression and be used to individualize...
Tue Mar 26, 2019 23:59
Network Pharmacology Analysis of Damnacanthus indicus C.F.Gaertn in Gene-Phenotype.
 
This study was to collect the evidence of disease-modulatory activities of Huci by analyzing the published literature on the chemicals and drugs. A list of its compounds and direct protein targets is predicted by using Bioinformatics Analysis Tool for Molecular Mechanism of TCM. A protein-protein interaction...
Tue Mar 26, 2019 23:41
Local Thermal Ablation with Continuous EGFR Tyrosine Kinase Inhibitors for EGFR-Mutant Non-small Cell Lung Cancers that Developed Extra-Central Nervous System (CNS) Oligoprogressive Disease
 
ConclusionLocal thermal ablation for the oligoprogressive lesions with continuous EGFR-TKI treatment is associated with additional 10  months of disease control and should be recommended in TKI acquired resistant-NSCLC patients. (Source: CardioVascular and Interventional Radiology)MedWorm Message: If...
Tue Mar 26, 2019 23:41
Prognosticating Survival in Hepatocellular Carcinoma with Elevated Baseline Alpha-fetoprotein Treated with Radioembolization Using a Novel Laboratory Scoring System: Initial Development and Validation
 
ConclusionsPost-radioembolization AFP and ALBI scores were significant OS prognosticators. A decrease in post-therapeutic Laboratory Score, which combines AFP and ALBI, correlates with an improved OS. (Source: CardioVascular and Interventional Radiology)
Tue Mar 26, 2019 23:41
Fusion Imaging and Virtual Navigation to Guide Percutaneous Thermal Ablation of Hepatocellular Carcinoma: A Review of the Literature
 
AbstractAs medical imaging advancements have improved the detectability of hepatocellular carcinoma (HCC) in early stages, the approach to percutaneous thermal ablation for curative treatment has concomitantly advanced. Although many centers are adopting cross-sectional imaging to guide percutaneous...
Tue Mar 26, 2019 22:39
Sentinel Lymph Node Dissection in Endometrial Cancer
 
No abstract available (Source: Postgraduate Obstetrics and Gynecology)
Tue Mar 26, 2019 22:24
The Association between Absence of Abdominal Pain and Mortality in Lower Intestinal Perforation in Patients with Autoimmune Rheumatic Diseases.
 
Conclusion: Abdominal pain was absent in 16% of LIP patients with autoimmune rheumatic diseases, and this absence was a poor prognostic factor in this cohort. Moreover, higher age, chronic kidney disease, systemic vasculitis, and LIP due to malignancy were associated with significantly increased mortality....
Tue Mar 26, 2019 22:24
New Platinum(IV) and Palladium(II) Transition Metal Complexes of s-Triazine Derivative: Synthesis, Spectral, and Anticancer Agents Studies.
 
Authors: Al-Khodir FAI, Abumelha HMA, Al-Warhi T, Al-Issa SA Abstract New Pd(II) and Pt(IV) triazine complexes [Pt3(L 1 )2(Cl)9(H2O)3].3Cl.3H2O (1), [Pt3(L 2 )2(Cl)9(H2O)3].3Cl (2), [Pt3(L 3 )2(Cl)9(H2O)3].3Cl (3), [Pt2(L 4 )2(Cl)6(H2O)2] .2Cl.4H2O (4), [Pd3(L 1 )2(H2O)6] .3Cl2 (5), [Pd3(L...
Tue Mar 26, 2019 22:24
Blockage of TGF- α Induced by Spherical Silica Nanoparticles Inhibits Epithelial-Mesenchymal Transition and Proliferation of Human Lung Epithelial Cells.
 
Blockage of TGF-α Induced by Spherical Silica Nanoparticles Inhibits Epithelial-Mesenchymal Transition and Proliferation of Human Lung Epithelial Cells. Biomed Res Int. 2019;2019:8231267 Authors: Li Y, Li H, Duan Y, Cai X, You D, Zhou F, Yang C, Tuo X, Liu Z Abstract Background....
Tue Mar 26, 2019 22:16
Reliability and validity of the Chinese version of spiritual needs questionnaire with 27 items (SpNQ-Ch-27) in cancer patients
 
ConclusionSpNQ-Ch-27 is applicable for Chinese cancer patients with better validity and higher internal consistency, and it can be used as a tool to assess the spiritual needs of cancer patients. (Source: International Journal of Nursing Sciences)
Tue Mar 26, 2019 21:42
Cancer and immunity – The contributions of Thomas Starzl
 
Publication date: Available online 5 March 2019Source: Current Medicine Research and PracticeAuthor(s): Amitabh Gautam (Source: Current Medicine Research and Practice)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the...
Tue Mar 26, 2019 21:08
Pediatric Endoscopy and High-risk Patients: A Clinical Report From the NASPGHAN Endoscopy Committee
 
Pediatric gastrointestinal endoscopy has been established as safe and effective for diagnosis and management of many pediatric gastrointestinal diseases. Nevertheless, certain patient and procedure factors should be recognized that increase the risk of intra- and/or postprocedural adverse events (AEs)....
Tue Mar 26, 2019 21:08
Hepatic Lesions Associated With McCune Albright Syndrome
 
We describe the hepatic outcome of 3 children with MAS referred to a single national liver unit. All presented with high gamma-glutamyl transpeptidase cholestasis and hepatitis. Cholestasis resolved by 1 year; but hepatic inflammation persisted, and 2 children developed progressive atypical focal nodular...
Tue Mar 26, 2019 01:00
Thyroglobulin for Monitoring for Thyroid Cancer Recurrence
 
This JAMA Patient Page explains the use of thyroglobulin measurement to monitor for recurrence in patients who have had thyroid cancer. (Source: JAMA)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the...
Tue Mar 26, 2019 01:00
Adverse Events Associated With Immune Checkpoint Inhibitors
 
To the Editor Dr Johnson and colleagues summarized the adverse events associated with immune checkpoint inhibitor therapy used to manage advanced cancers, which predominantly respond to treatment with glucocorticoids. However, we want to emphasize an irreversible adverse effect, autoimmune diabetes,...
Tue Mar 26, 2019 00:00
Cancers, Vol. 11, Pages 429: A Pilot Clinical Study on the Prognostic Relevance of Plasmatic Exosomes Levels in Oral Squamous Cell Carcinoma Patients
 
Conclusions: Surgical treatment induced a dramatic reduction of the plasmatic levels of exosomes expressing CD63 as early as 1 week after resection. This first result suggests that the tumour mass is responsible of the high levels of circulating exosomes detected in cancer patients. At the same time...
Tue Mar 26, 2019 20:39
KDM5C is transcriptionally regulated by BRD4 and promotes castration-resistance prostate cancer cell proliferation by repressing PTEN
 
In this study, we reported that KDM5C was highly expressed in PCa and CRPC specimens, and the high expression promoted CRPC cell proliferation through repressing phosphatase and tensin homolog (PTEN) gene epigenetically. Moreover, KDM5C was transcriptionally upregulated by bromodomain-containing protein...
Tue Mar 26, 2019 20:39
Chemoresistance mechanisms of breast cancer and their countermeasures
 
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Xiwei Ji, Yuan Lu, Huifang Tian, Xiangrui Meng, Minji Wei, William C. ChoAbstractChemoresistance is one of the major challenges for the breast cancer treatment. Owing to its heterogeneous nature, the chemoresistance...
Tue Mar 26, 2019 20:23
The bZIP transcription factor Afap1 mediates the oxidative stress response and aflatoxin biosynthesis in Aspergillus flavus.
 
Authors: Guan X, Zhao Y, Liu X, Shang B, Xing F, Zhou L, Wang Y, Zhang C, Bhatnagar D, Liu Y Abstract Aflatoxin is a carcinogenic secondary metabolite produced mainly by Aspergillus flavus and Aspergillus parasiticus, which can seriously endanger the health of humans and animals. Oxidative...
Tue Mar 26, 2019 00:00
Ipsilateral Hyperhidrosis: Atypical Symptom of Small Lung Adenocarcinoma Evaluated by 18 F-FDG PET-CT
 
AbstractA 45-year-old male visited our clinic due to right palmar anhidrosis and contralateral hyperhidrosis. Chest computed tomography (CT) showed a solitary pulmonary nodule with mediastinal lymph node enlargement, but a cause for atypical palmar anhidrosis was not identified. Subsequent fluorine-18-fluorodeoxyglucose...
Tue Mar 26, 2019 00:00
Navigating metabolic pathways to enhance antitumour immunity and immunotherapy
 
Navigating metabolic pathways to enhance antitumour immunity and immunotherapy, Published online: 26 March 2019; doi:10.1038/s41571-019-0203-7The metabolic conditions in tumours can result in phenotypic reprogramming of non-tumour cells, including immune cells, in the tumour microenvironment. This Review...
Tue Mar 26, 2019 00:00
Cancers, Vol. 11, Pages 430: Store-Operated Calcium Entry Contributes to Cisplatin-Induced Cell Death in Non-Small Cell Lung Carcinoma
 
In this study, we showed that siRNA-mediated depletion of stromal interaction molecule 1 (STIM1) and transient receptor potential channel 1 (TRPC1), two players of the store-operated calcium entry, dramatically reduced CDDP cytotoxicity in NSCLC cells. This was associated with an inhibition of the DNA...
Tue Mar 26, 2019 19:45
Podoplanin Positive Myeloid Cells Promote Glioma Development by Immune Suppression
 
Tanja Eisemann, Barbara Costa, Heike Peterziel, Peter Angel (Source: Frontiers in Oncology)
Tue Mar 26, 2019 19:45
The Emergence of Universal Immune Receptor T Cell Therapy for Cancer
 
Nicholas G. Minutolo, Erin E. Hollander, Daniel J. Powell (Source: Frontiers in Oncology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Tue Mar 26, 2019 19:45
Perspectives of Induction With Chemo and/or Immune Check Point Inhibition in Head and Neck Organ Preservation Treatment
 
Susanne Wiegand, Gunnar Wichmann, Andreas Dietz (Source: Frontiers in Oncology)
Tue Mar 26, 2019 19:45
Microbiome and Cancers, With Focus on Genitourinary Tumors
 
Alessia Cimadamore, Matteo Santoni, Francesco Massari, Silvia Gasparrini, Liang Cheng, Antonio Lopez-Beltran, Rodolfo Montironi, Marina Scarpelli (Source: Frontiers in Oncology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of...
Tue Mar 26, 2019 19:44
Phosphoinositide Phosphatases in Cancer Cell Dynamics—Beyond PI3K and PTEN
 
Publication date: Available online 25 March 2019Source: Seminars in Cancer BiologyAuthor(s): Takeshi IjuinAbstractPhosphoinositides are a group of lipids that regulate intracellular signaling and subcellular biological events. The signaling by phosphatidylinositol-3,4,5-trisphosphate and Akt mediates...
Tue Mar 26, 2019 19:44
Aberrations in DNA repair pathways in cancer and therapeutic significances
 
Publication date: Available online 25 March 2019Source: Seminars in Cancer BiologyAuthor(s): Akira Motegi, Mitsuko Masutani, Ken-ichi Yoshioka, Tadayoshi BesshoAbstractCancer cells show various types of mutations and aberrant expression in genes involved in DNA repair responses. These alterations induce...
Tue Mar 26, 2019 19:44
Lessons Learned From the First Human Low-Field MRI Guided Radiation Therapy of the Heart in the Presence of an Implantable Cardiac Defibrillator
 
Publication date: Available online 18 February 2019Source: Practical Radiation OncologyAuthor(s): H. Michael Gach, Olga L. Green, Phillip S. Cuculich, Erin J. Wittland, Areti Marko, Molly E. Luchtefeld, Jill M. Entwistle, Deshan Yang, David J. Wilber, Sasa Mutic, Clifford G. RobinsonAbstractMagnetic...
Tue Mar 26, 2019 19:44
Patterns of Failure Among Patients With Low-grade Glioma Treated With Proton Radiation Therapy
 
ConclusionsOf the patients with LGG who had documented failures after PRT, most recurred within the radiation field with few marginal failures, indicating that even with PRT, which often can have steeper dose gradients, coverage is adequate. Survival was poor for patients whose tumors recurred. (Source:...
Tue Mar 26, 2019 19:44
Neoadjuvant Chemoradiation Therapy Followed by Extrafascial Hysterectomy in Locally Advanced Type II Endometrial Cancer Clinically Extending to Cervix
 
ConclusionsNeoadjuvant chemoradiation therapy effectively downstages the majority of locally advanced type II endometrial cancers, thereby increasing the likelihood of achieving complete resection with negative margins. (Source: Practical Radiation Oncology)MedWorm Message: If you are looking to buy...
Tue Mar 26, 2019 19:44
Patient-Reported Outcomes and Cosmesis in a Feasibility Study of 4-Dimensional Simulated Image Guided Accelerated Partial Breast Irradiation
 
ConclusionsThis study demonstrated that with 4-dimensional simulated APBI that uses stringent dosimetric constraints and image guidance radiation therapy, it is possible to obtain acceptable cosmetic outcomes. We report no locoregional recurrences in 3 years and no toxicity grade>3. The observed decline...
Tue Mar 26, 2019 19:44
Correlation of microRNA 17-92 cluster host gene (MIR17HG) polymorphisms with susceptibility and prognosis for multiple myemola
 
ConclusionOur findings suggested that polymorphisms of MIR17HG rs7336610 and rs1428 were correlated with MM risk and prognosis. (Source: Clinical Lymphoma Myeloma and Leukemia)
Tue Mar 26, 2019 19:44
The Benefits of A Model of Interval Comprehensive Assessments (MICA) in Hereditary Cancer Syndromes: Hereditary Diffuse Gastric Cancer (HDGC) as an Example
 
Publication date: Available online 25 March 2019Source: Cancer GeneticsAuthor(s): Henry T. Lynch, Rosemary Nustas, Thamer Kassim, Carrie Snyder, Trudy Shaw, Osama DiabAbstractA high percentage of individuals at risk for hereditary cancer syndromes are unaware of their risk. This is especially detrimental...
Tue Mar 26, 2019 19:44
Study on the prognostic value of aberrant antigen in patients with acute B lymphocytic leukemia
 
Publication date: Available online 25 March 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Jun Liu, Xu Tan, Ying-Ying Ma, Yao Liu, Li Gao, Lei Gao, PeiYang Kong, Xian-Gui Peng, Xi Zhang, Cheng ZhangAbstractApproximately 30-60% of acute B-lymphocytic leukemia(B-ALL) patients show refractory...
Tue Mar 26, 2019 19:44
Role of p15(INK4B) methylation in patients with myelodysplastic syndromes: a systematic meta-analysis
 
ConclusionsOur findings suggest that p15(INK4B) methylation may play an important in the development, progression, and poor prognosis of MDS. More prospective studies with larger study populations are needed. (Source: Clinical Lymphoma Myeloma and Leukemia)
Tue Mar 26, 2019 19:44
Future of personalized therapy targeting aberrant signaling pathways in multiple myeloma
 
Publication date: Available online 25 March 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Faiz Anwer, Kevin Mathew Gee, Ahmad Iftikhar, Mirza Baig, Atlantis Dawn Russ, Sabina Saeed, Muhammad Abu Zar, Faryal Razzaq, Jennifer Carew, Steffan Nawrocki, Hussam Al-Katab, Nadia Nunes Cavalcante,...
Tue Mar 26, 2019 19:44
Trends in myeloma incidence, mortality and survival in New Zealand (1985–2016)
 
ConclusionThe patterns of variation in myeloma incidence, mortality and survival, as well as their trends over time may be used to assist research into the causes and management of myeloma in New Zealand. (Source: Cancer Epidemiology)MedWorm Message: Have you tried our new medical search engine? More...
Tue Mar 26, 2019 19:41
Vascular endothelial growth factor receptor 2 (VEGFR2) correlates with long-term survival in patients with advanced high-grade serous ovarian cancer (HGSOC): a study from the Tumor Bank Ovarian Cancer (TOC) Consortium
 
ConclusionsVEGFR2 overexpression significantly correlated with long-term PFS in HGSOC patients, independent of age, FIGO stage, tumor residual and VEGFA expression. (Source: Journal of Cancer Research and Clinical Oncology)MedWorm Message: Have you tried our new medical search engine? More powerful than...
Tue Mar 26, 2019 19:41
Adherence to the EAU guidelines on Penile Cancer Treatment: European, multicentre, retrospective study
 
ConclusionAdherence to the EAU guidelines for PC was quite high across the eight European centres involved in the study. This notwithstanding, strategies for further improvement should be developed and evenly adopted. (Source: Journal of Cancer Research and Clinical Oncology)MedWorm Message: If you are...
Tue Mar 26, 2019 19:41
Insufficient radiofrequency ablation promotes the metastasis of residual hepatocellular carcinoma cells via upregulating flotillin proteins
 
ConclusionsOur findings present new evidence that flotillins play a key role in the aggressive behaviors of residual cancer cells after insufficient RFA and provide new insights into the regulatory mechanism of Wnt/ β-catenin signaling. (Source: Journal of Cancer Research and Clinical Oncology)
Tue Mar 26, 2019 19:41
Lymph node ratio predictive of recurrence, distant metastasis, and survival in submandibular gland carcinoma patients
 
ConclusionsA high rate of distant site failure is associated with SMG carcinoma, resulting in a poor survival rate. Lymph node ratio might help predict recurrence, distant metastasis, and death due to SMG carcinoma. (Source: Journal of Cancer Research and Clinical Oncology)
Tue Mar 26, 2019 19:41
Regorafenib in patients with recurrent high-grade astrocytoma
 
ConclusionsThis retrospective study indicates a very poor performance of regorafenib in recurrent high-grade astrocytoma with a fairly high number of CTC °3 adverse events. In addition, regorafenib does not seem to bear a potential for infiltrative tumor growth promotion. (Source: Journal of Cancer Research...
Tue Mar 26, 2019 19:41
Aggregate analysis based on TCGA: TTN missense mutation correlates with favorable prognosis in lung squamous cell carcinoma
 
ConclusionsMissense mutation ofTTN may act as a beneficial role in lung squamous cell carcinoma, but not in lung adenocarcinoma. (Source: Journal of Cancer Research and Clinical Oncology)
Tue Mar 26, 2019 19:38
Downregulation of miR-222-3p Reverses Doxorubicin-Resistance in LoVo Cells Through Upregulating Forkhead Box Protein P2 (FOXP2) Protein.
 
CONCLUSIONS Taken together, our results showed that miR-222-3p induced DOX resistance via suppressing FOXP2, upregulating P-gp, and inhibiting the caspase pathway. PMID: 30904920 [PubMed - in process] (Source: Medical Science Monitor)
Tue Mar 26, 2019 19:38
Long Intergenic Non-Protein-Coding RNA 01138 Accelerates Tumor Growth and Invasion in Gastric Cancer by Regulating miR-1273e.
 
CONCLUSIONS LINC01138 activated the MAPK signaling pathway by inhibiting miR-1273e to promote GC cell proliferation, invasion, and migration, and inhibit GC cell apoptosis, suggesting that the LINC01138/miR-1273e/MAPK axis is a promising therapeutic target for GC. PMID: 30902962 [PubMed - in process]...
Tue Mar 26, 2019 00:00
Cancers, Vol. 11, Pages 431: Validation of miRNAs as Breast Cancer Biomarkers with a Machine Learning Approach
 
Authors: Oneeb Rehman Hanqi Zhuang Ali Muhamed Ali Ali Ibrahim Zhongwei Li Certain small noncoding microRNAs (miRNAs) are differentially expressed in normal tissues and cancers, which makes them great candidates for biomarkers for cancer. Previously, a selected subset of miRNAs has...
Tue Mar 26, 2019 00:00
Cancers, Vol. 11, Pages 428: An Insight into the Roles of MicroRNAs and Exosomes in Sarcoma
 
Authors: Isaku Kohama Nobuyoshi Kosaka Hirotaka Chikuda Takahiro Ochiya Sarcomas are rare solid tumors, but at least one-third of patients with sarcoma die from tumor-related disease. MicroRNA (miRNA) is a noncoding RNA that regulates gene expression in all cells and plays a key role...
Tue Mar 26, 2019 00:00
Cancers, Vol. 11, Pages 427: The Flavonoid Metabolite 2,4,6-Trihydroxybenzoic Acid Is a CDK Inhibitor and an Anti-Proliferative Agent: A Potential Role in Cancer Prevention
 
In this study, we investigated the ability of one metabolite, 2,4,6-trihydroxybenzoic acid (2,4,6-THBA) to inhibit Cyclin Dependent Kinase (CDK) activity and cancer cell proliferation. Using in vitro kinase assays, we demonstrated that 2,4,6-THBA dose-dependently inhibited CDKs 1, 2 and 4 and in silico...
Tue Mar 26, 2019 18:31
CXCR4 and CCR7 Expression in Primary Nodal Diffuse Large B-Cell Lymphoma-A Clinical and Immunohistochemical Study.
 
CONCLUSIONS: There is a positive correlation between CXCR4 overexpression and BM involvement. CXCR4 and CCR7 overexpression is associated with poorer overall survival, especially in CXCR4 and CCR7 copositive patients. CXCR4, CCR7, Ki-67 index, and MYC were independent prognostic factors for DLBCL. Blocking...
Tue Mar 26, 2019 18:29
[Checkpoint inhibitors neurological side effects].
 
CONCLUSIONS: Checkpoint inhibitors neurological side effects are frequent. A wide variety of central or peripheral nervous system symptoms may develop. In the setting of brain tumors, inflammation due to immune system activation might lead to pseudoprogression. Further studies are needed to better describe...
Tue Mar 26, 2019 00:00
Systematic screening and assessment of psychosocial well-being and care needs of people with cancer.
 
CONCLUSIONS: We found low-certainty evidence that does not support the effectiveness of screening of psychosocial well-being and care needs in people with cancer. Studies were heterogeneous in population, intervention, and outcome assessment.The results of this review suggest a need for more uniformity...
Tue Mar 26, 2019 17:41
Determining relevant biomarkers for prediction of breast cancer using anthropometric and clinical features: A comparative investigation in machine learning paradigm
 
Publication date: Available online 25 March 2019Source: Biocybernetics and Biomedical EngineeringAuthor(s): Bikesh Kumar SinghAbstractEarly detection of breast cancer plays crucial role in planning and result of associated treatment. The purpose of this article is threefold: (i) to investigate whether...
Tue Mar 26, 2019 17:38
Thermal injury to spinal cord, a rare complication of percutaneous microwave spine tumor ablation: Case report
 
Publication date: Available online 25 March 2019Source: Journal of Clinical NeuroscienceAuthor(s): Erick M. Westbroek, Matthew L. Goodwin, Ferdinand Hui, Majid A. Khan, Daniel M. SciubbaAbstractMetastatic disease to the spine are becoming increasingly common with an aging population and improvements...
Tue Mar 26, 2019 16:46
Correlations of neck ultrasound and pathology in cervical lymph node of papillary thyroid carcinoma.
 
CONCLUSIONS: Preoperative neck US is a valuable tool in the detection of cervical lymph node metastases from papillary thyroid cancer and can provide reliable information to assist in surgical management. PMID: 30905261 [PubMed - as supplied by publisher] (Source: Acta Chirurgica Belgica)
Tue Mar 26, 2019 16:28
[Assessment of muscular toxicity due to chemotherapy by cardio-pulmonary exercise testing].
 
CONCLUSION: We suggest that the limitation of effort was due to a limitation of muscular oxygen extraction, which could be explained by possible muscular toxicity due to chemotherapy. PMID: 30902442 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Tue Mar 26, 2019 16:28
[Evaluation of permanent disability levels in occupational pulmonary diseases].
 
Authors: Pairon JC, Azoury H, Catto M, Dalphin JC, Gehanno JF, Housset B, L'huillier JP, Serveau S, Straus C Abstract Compensation for occupational pulmonary diseases requires the establishment of guidelines based on standardized and objective criteria, in order to provide compensation that...
Tue Mar 26, 2019 16:28
[Vaccines for the treatment of non-small cell lung cancer].
 
Authors: Leduc C, Quoix E Abstract Antigen-specific immunotherapy also known as cancer vaccination offers a novel approach for the treatment of non-small cell lung cancer patients. It relies on specific priming of the immune system in order to provoke or increase adaptive antitumor immune response...
Tue Mar 26, 2019 16:06
Cancer-testis antigens: An update on their roles in cancer immunotherapy.
 
CONCLUSIONS: Based on the availability of different formulations of CTA-based vaccines, future researches should compare efficiency of these modalities. PMID: 30909205 [PubMed - as supplied by publisher] (Source: Human Antibodies)
Tue Mar 26, 2019 16:06
Long non-coding RNAs: Diverse roles in various disorders.
 
CONCLUSIONS: Taken together, lncRNAs constitute a novel vast area of research to find answer to fundamental biologic questions. PMID: 30909207 [PubMed - as supplied by publisher] (Source: Human Antibodies)
Tue Mar 26, 2019 15:11
Effect of dihydroartemisinin on epithelial-to-mesenchymal transition in canine mammary tumour cells
 
In conclusion, DHA inhibits canine mammary tumours cells migration and invasiveness by regulating the expression of EMT-related genes. (Source: Research in Veterinary Science)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account....
Tue Mar 26, 2019 15:08
Clinical and histopathological features of choroidal melanoma-related enucleated eyes in a Spanish tertiary hospital.
 
CONCLUSIONS: The analyses of the clinical and pathological data collected within the framework of this study justify enucleation as the treatment of choice for the patients of this study. Magnetic resonance imaging was not found to be an optimum screening method to detect scleral infiltration in this...
Tue Mar 26, 2019 15:02
Microbiome-MX 2018: Microbiota and Microbiome opportunities in Mexico, a megadiverse country
 
Publication date: Available online 25 March 2019Source: Research in MicrobiologyAuthor(s): Fernanda Cornejo-Granados, Ana María Calderón de la Barca, Nimbe Torres, Esperanza Martínez-Romero, Javier Torres, Yolanda López-Vidal, Xavier Soberón, Laila P. Partida-Martínez, Sandra Pinto-Cardoso, Luis David...
Tue Mar 26, 2019 14:35
The Effect of Religious Psychotherapy Emphasizing the Importance of Prayers on Mental Health and Pain in Cancer Patients
 
This study aimed to determine the effect of religious psychotherapy emphasizing the importance of prayers on mental health and pain in cancer patients. This study is a clinical trial that was conducted in 2017 in Yasuj, Iran. According to the purpose of the study, the patients were randomly assigned...
Tue Mar 26, 2019 14:34
A clinicopathological study of fibroadenomas with epithelial proliferation including lobular carcinoma in-situ, atypical ductal hyperplasia, DCIS and invasive carcinoma.
 
CONCLUSION: In our study population, the most common type of carcinoma arising in fibroadenomas was DCIS, followed by lobular carcinoma in-situ. Lobular carcinoma in-situ was more likely to be confined to the fibroadenoma while most DCIS involved surrounding breast tissue. PMID: 30909180 [PubMed...
Tue Mar 26, 2019 14:34
A comparative analysis of axillary nodal burden in ultrasound/biopsy positive axilla vs ultrasound negative sentinel lymph node biopsy positive axilla.
 
CONCLUSIONS: ANC should be a standard protocol in AUS positive patients as they invariably have high axillary disease burden while ANC can be omitted in case of select AUS negative and SLNB patients. However, further studies with more subjects may be require to substantiate the findings. PMID: 30909179...
Tue Mar 26, 2019 14:28
Induction chemoradiation is associated with improved survival in chest wall invasion lung cancer.
 
CONCLUSION:: In patients with nonsuperior sulcus lung cancer with chest wall invasion, induction chemoradiation therapy followed by resection is associated with improved OS. PMID: 30905273 [PubMed - as supplied by publisher] (Source: Tumori)
Tue Mar 26, 2019 14:28
Combining abiraterone and radiotherapy in metastatic castration-resistant prostate cancer: a review of current evidence.
 
Authors: Livi L, Detti B, Francolini G, Terziani F, Triggiani L, D'Angelillo RM, Ingrosso G Abstract Prostate cancer is the second most frequent cancer worldwide, with a very high rate of progression despite treatment. The most aggressive form of the disease is known as castration-resistant...
Tue Mar 26, 2019 14:28
Survival benefit of first-generation epidermal growth factor receptor-tyrosine kinase inhibitors in female with advanced lung cancer.
 
CONCLUSIONS:: Our analysis demonstrates that EGFR-TKIs confer significant PFS and OS benefits in the real-world practice for Korean female with advanced lung cancer. PMID: 30905312 [PubMed - as supplied by publisher] (Source: Tumori)MedWorm Message: If you are looking to buy something in the January...
Tue Mar 26, 2019 14:28
Excess risk of dying of other causes of cured cancer patients.
 
CONCLUSION:: Mortality of survivors not directly due to the diagnosed cancer was significantly higher than in the general population. It affected the estimates of cure proportions for all age classes and RS in the elderly. PMID: 30905274 [PubMed - as supplied by publisher] (Source: Tumori)
Tue Mar 26, 2019 14:09
Recombinant deoxyribonucleoside kinase from Drosophila melanogaster can improve gemcitabine based combined gene/chemotherapy for targeting cancer cells.
 
This study was designed to evaluate the effect of DmdNKΔC20 for sensitizing human cancer cell lines towards gemcitabine and to further investigate its role in reversal of acquired drug resistance in gemcitabine-resistant cancer cell line. The DmdNKΔC20 gene was delivered to three different cancer cell...
Tue Mar 26, 2019 12:42
Tacalcitol increases the sensitivity of colorectal cancer cells to 5-fluorouracil by downregulating the thymidylate synthase
 
In conclusion, we suggest that both VDR and CaSR might be useful as molecular markers for predicting treatment outcomes and identifying the CRC patient subgroups who might benefit from 5-FU-based chemotherapy combined with vitamin D analog. (Source: The Journal of Steroid Biochemistry and Molecular Biology)MedWorm...
Tue Mar 26, 2019 12:09
Vitamin D and breast cancer: A systematic review and meta-analysis of observational studies.
 
CONCLUSIONS: 25(OH)D deficiency was directly related to BC while total vitamin D and supplemental vitamin D intakes had an inverse relationship with this outcome. Randomized clinical trials are warranted pending further evidence from primary meta-analyses of observational studies. PMID: 30904218...
Tue Mar 26, 2019 12:02
Increased use of cross-sectional imaging for follow-up does not improve post-recurrence survival of surgically treated initially localized R.C.C.: results from a European multicenter database (R.E.C.U.R.).
 
CONCLUSIONS: As expected, the frequency of imaging was highest during early follow-up. Cross-sectional imaging use for detection of recurrences following surgery for localized R.C.C. did not improve O.S. post-recurrence. Prospective studies are needed to determine the value of imaging in follow-up. ...
Tue Mar 26, 2019 11:36
Age Is Important for the Early-Stage Detection of Breast Cancer on Both Transcriptomic and Methylomic Biomarkers
 
Xin Feng, Jialiang Li, Han Li, Hang Chen, Fei Li, Quewang Liu, Zhu-Hong You, Fengfeng Zhou (Source: Frontiers in Genetics)
Tue Mar 26, 2019 00:00
Molecules, Vol. 24, Pages 1180: Oligonucleotide –Palladacycle Conjugates as Splice-Correcting Agents
 
Molecules, Vol. 24, Pages 1180: Oligonucleotide–Palladacycle Conjugates as Splice-Correcting Agents Molecules doi: 10.3390/molecules24061180 Authors: Madhuri Hande Osama Saher Karin E. Lundin C. I. Edvard Smith Rula Zain Tuomas Lönnberg 2'-O-Methylribo phosphorothioate oligonucleotides...
Tue Mar 26, 2019 00:00
IJERPH, Vol. 16, Pages 1076: Continuous Rural-Urban Coding for Cancer Disparity Studies: Is It Appropriate for Statistical Analysis?
 
Conclusions: Methodologically, it is valid to treat rural-urban codes directly as continuous variables in cancer studies, in addition to converting them into categories. This proposed continuous-variable method offers researchers more flexibility in their choice of analytic methods and preserves the...
Tue Mar 26, 2019 00:00
Molecules, Vol. 24, Pages 1185: Effect of Stereochemical Configuration on the Transport and Metabolism of Catechins from Green Tea across Caco-2 Monolayers
 
Authors: Zeyi Ai Shuyuan Liu Fengfeng Qu Haojie Zhang Yuqiong Chen Dejiang Ni The transcellular transport and metabolism of eight green tea catechins (GTCs) were studied in Caco-2 monolayers, with the aim of investigating the effect of cis–trans isomerism on the membrane permeability...
Tue Mar 26, 2019 10:49
Pain Acceptance and Its Associated Factors among Cancer Patients in Mainland China: A Cross-Sectional Study.
 
Conclusions: The findings suggest that the prevalence of pain acceptance is relatively low for Chinese cancer patients. The cancer pain acceptance is affected by age, gender, pain duration, number of pain sites, and duration of taking analgesics. The acceptance of cancer pain is negatively correlated...
Tue Mar 26, 2019 10:11
Intrapleural Urokinase Directly Under Medical Thoracoscopy for the Diagnosis of Malignant Pleural Mesothelioma With Severe Multiloculated Pleural Effusions
 
No abstract available (Source: Journal of Bronchology and Interventional Pulmonology)
Tue Mar 26, 2019 10:11
A Repeated Biopsy by EBUS-TBNA Contributed to the Selection of an Appropriate Therapeutic Regimen for a Lung Cancer Patient
 
Since the development of third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors for lung cancer treatment, the need for a rebiopsy has increased. To select an appropriate therapeutic regimen, the genetic alterations in cancerous tissue should be determined. A rebiopsy plays...
Tue Mar 26, 2019 10:11
Yield of Malignant Pleural Effusion for Detection of Oncogenic Driver Mutations in Lung Adenocarcinoma
 
Conclusion: Genetic mutation analysis can be performed on malignant pleural effusions secondary to lung adenocarcinoma, independent of fluid volume. (Source: Journal of Bronchology and Interventional Pulmonology)
Tue Mar 26, 2019 10:11
Optimizing the Approach to Patients With Pleural Effusion and Radiologic Findings Suspect for Cancer
 
The objective of this study was to evaluate whether concurrent thoracentesis and tissue biopsy is superior to sequential sampling. Methods: Retrospective chart review was performed for patients who had a pleural cytology from May 2014 until January 2017. Patients without parenchymal, pleural, or mediastinal...
Tue Mar 26, 2019 10:11
Bronchoscopically Delivered Thermal Vapor Ablation of Human Lung Lesions
 
Conclusion: We conclude that BTVA may have a future role in the treatment of lung cancer and should be investigated further in clinical trials. (Source: Journal of Bronchology and Interventional Pulmonology)
Tue Mar 26, 2019 10:11
Diagnosis of Combined Adenocarcinoma Small Cell Lung Cancer By Endobronchial Ultrasound Transbronchial Needle Aspiration
 
No abstract available (Source: Journal of Bronchology and Interventional Pulmonology)
Tue Mar 26, 2019 09:27
Liquid biopsy in newly diagnosed patients with locoregional (I-IIIA) non-small cell lung cancer.
 
Authors: Chen K, Kang G, Zhao H, Zhang K, Zhang J, Yang F, Wang J Abstract INTRODUCTION: Liquid biopsy is a promising method for the management of lung cancer, but previous studies focused mainly on patients with advanced-stage disease. As the methodology has progressed for the detection of...
Tue Mar 26, 2019 09:08
Methods of conservative antibiotic treatment of acute uncomplicated appendicitis: A systematic review
 
CONCLUSION While further investigation of conservative treatment is ongoing, patients considering this approach should be advised and managed according to study methods and related guidelines to promote informed shared decision-making and optimize their chance of similar outcomes as described in published...
Tue Mar 26, 2019 09:05
Optical density ratio of the subretinal fluid in choroidal melanoma and metastasis
 
Conclusion: Optical density ratio can serve as an additional test to differentiate between choroidal melanoma and choroidal metastases. (Source: RETINA)
Tue Mar 26, 2019 09:05
Ophthalmic Oncology Outreach: Harnessing the Power of Social Media
 
No abstract available (Source: International Ophthalmology Clinics)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Mar 26, 2019 09:05
An Update on Eyelid Sebaceous Cell Carcinoma
 
No abstract available (Source: International Ophthalmology Clinics)
Tue Mar 26, 2019 09:05
Targeted Biological Drugs and Immune Check Point Inhibitors for Locally Advanced or Metastatic Cancers of the Conjunctiva, Eyelid, and Orbit
 
No abstract available (Source: International Ophthalmology Clinics)
Mon Mar 25, 2019 01:00
Application of a machine learning method to whole brain white matter injury after radiotherapy for nasopharyngeal carcinoma
 
The purpose/aim of this study was to 1) use magnetic resonance diffusion tensor imaging (DTI), fibre bundle/tract-based spatial statistics (TBSS) and machine learning methods to study changes in the white matt... (Source: Cancer Imaging)
Mon Mar 25, 2019 01:00
Correction to: Are there differences among operators in false-negative rates of endosonography with needle aspiration for mediastinal nodal staging of non-small cell lung cancer?
 
Following publication of the original (Source: BMC Pulmonary Medicine)
Mon Mar 25, 2019 01:00
HPV testing for cervical cancer screening: technical improvement of laboratory logistics and good clinical performance of the cobas 6800 in comparison to the 4800 system
 
European guidelines for cervical cancer screening now recommend the use of clinically validated assays for high-risk HPV-DNA sequences as primary test in women older than 30  years, performed in centralized lab... (Source: BMC Women's Health)MedWorm Message: Have you tried our new medical search engine?...
Tue Mar 26, 2019 00:00
Isolated adrenocorticotropic hormone deficiency and thyroiditis associated with nivolumab therapy in a patient with advanced lung adenocarcinoma: a case report and review of the  literature
 
ConclusionsOur patient developed thyroiditis during cancer treatment with nivolumab and subsequently exhibited isolated adrenocorticotropic hormone deficiency 4  months after discontinuing the drug. Administration of nivolumab in combination with a genetic predisposition to polyglandular autoimmunity...
Mon Mar 25, 2019 00:00
Pc.01.5 recurrence and cancer-specific mortality during followup of low-and high-risk endoscopically resected pt1 colorectal cancers: a meta-analysis
 
(Source: Digestive and Liver Disease)
Mon Mar 25, 2019 00:00
Oromandibular reconstruction using microvascularized bone flap: report of 1038 cases from a single institution
 
This retrospective study was performed to review 1038 patients who underwent mandibular reconstruction with free vascularized bone flaps at a single institution between 2006 and 2017. Of these patients, 827 (79.67%) had fibula flaps, 197 (18.98%) had deep circumflex iliac artery perforator (DCIA) flaps,...
Mon Mar 25, 2019 00:00
Oc.02.6 eus-guided placement of new golden fiducial markers in stereotactic body radiation therapy in locally advanced pancreatic cancer: preliminary results of feasibility and safety
 
(Source: Digestive and Liver Disease)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Mon Mar 25, 2019 00:00
Novel Targets in the Immune Microenvironment of the Hepatic Sinusoids for Treating Liver Diseases
 
Semin Liver Dis DOI: 10.1055/s-0039-1678727Immune dysregulation and accumulation of leukocytes is a hallmark of adult chronic liver diseases. Progressive hepatic inflammation can lead to fibrosis and cirrhosis with a high risk of liver failure or hepatocellular cancer (HCC). Recent advances have been...
Tue Mar 26, 2019 07:34
Neutrophil-Derived MRP14 Supports Plasma Cell Commitment and Protects Myeloma Cells from Apoptosis.
 
In this study, we examined the importance of neutrophils and the neutrophil-derived DAMP protein, MRP14, in antibody production. Splenic neutrophils and MRP14 that are present in the splenic peri-MZ region have a close contact with MZ B cells and promote their differentiation into plasma cells. Using...
Tue Mar 26, 2019 00:00
Mailed Outreach Is Superior to Usual Care Alone for Colorectal Cancer Screening in the USA: A Systematic Review and Meta-analysis
 
AbstractMailed outreach promoting colorectal cancer (CRC) screening with a stool blood test kit may increase participation, but magnitude and consistency of benefit of this intervention strategy is uncertain. Our aim was to  conduct a systematic review and meta-analysis of randomized controlled trials...
Mon Mar 25, 2019 00:00
Adherence to post-polypectomy surveillance guidelines: a systematic review and meta-analysis
 
Conclusions The worldwide adherence to surveillance colonoscopy guidelines was low, with more than 50 % of patients undergoing repeat colonoscopies either too early or too late. Early repeat colonoscopies occurred with the highest frequency for patients in whom only hyperplastic polyps or low risk adenomas...
Mon Mar 25, 2019 00:00
Oc.03.2 pathological "second-look" significantly alters clinical management in endoscopically resected pt1 colorectal cancer
 
(Source: Digestive and Liver Disease)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Mon Mar 25, 2019 00:00
Robot-assisted endoscopic submucosal dissection versus conventional ESD for colorectal lesions: outcomes of a randomized pilot study in endoscopists without prior ESD experience (with video)
 
Endoscopic submucosal dissection (ESD) is becoming the preferred method for certain early GI malignances; however, very few U.S. physicians have adopted this technique. This is in part due to the technically challenging nature of the procedure and the long learning curve. Several endoscopic robots are...
Mon Mar 25, 2019 00:00
Cancers, Vol. 11, Pages 426: The 'Ins and Outs' of Early Preclinical Models for Brain Tumor Research: Are They Valuable and Have We Been Doing It Wrong?
 
Authors: Rominiyi Al-Tamimi Collis In this perspective, we congratulate the international efforts to highlight critical challenges in brain tumor research through a recent Consensus Statement. We also illustrate the importance of developing more accurate and clinically relevant early...
Mon Mar 25, 2019 00:00
Preparation and Evaluation of pH Sensitive Novel Anticancer Drug Carrier Based on Magnetic Chitosan Quartets
 
Drug Res (Stuttg) DOI: 10.1055/a-0855-8464Chitosan-coated magnetic nanoparticles are an appropriate drug delivery method which can improve the therapeutic properties of chemotherapy agents and also can be useful as MRI contrast agent for early cancer diagnosis. This research discovers the optimization...

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