Thu Mar 21, 2019 17:00
Conditions: HIV Infections; Sexual Behavior; Risk Reduction Intervention: Other: Determine the Incidence and Retention Rate Sponsors: Hendrik Streeck; US Military HIV Research Program; United States Army Medical Materiel Development Activity; Federal Ministry of Health, Germany; German Center for Infection Research;...
Wed Mar 20, 2019 17:00
Condition: Rhinitis, Allergic, Seasonal Interventions: Drug: Mometasone furoate; Drug: Fluticasone propionate; Drug: Mometasone furoate placebo; Drug: Fluticasone propionate placebo Sponsor: Merck Sharp & Dohme Corp. Completed (Source: ClinicalTrials.gov)
Tue Mar 19, 2019 17:00
Conditions: Venezuelan Equine Encephalitis; Western Equine Encephalitis; Eastern Equine Encephalitis; Alphavirus Infections Interventions: Biological: VRC-WEVVLP073-00-VP; Other: VRC-GENMIX083-AL-VP Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); The EMMES Corporation;...
Tue Mar 19, 2019 17:00
Omalizumab as Monotherapy and as Adjunct Therapy to Multi-Allergen OIT in Food Allergic Participants
Conditions: Peanut Allergy; Multi-food Allergy Interventions: Drug: Omalizumab; Drug: Placebo for Omalizumab; Drug: Multi-Allergen Oral Immunotherapy; Drug: Placebo for Multi-Allergen Oral Immunotherapy; Other: Double-Blind Placebo-Controlled Food Challenge Based Treatment Sponsors: National...
Tue Mar 19, 2019 17:00
Condition: Lymphoma, B-Cell Intervention: Biological: TAC01-CD19 Sponsor: Triumvira Immunologics, Inc. Not yet recruiting (Source: ClinicalTrials.gov)
Tue Mar 19, 2019 17:00
Condition: Rhinitis, Allergic, Seasonal Interventions: Drug: Mometasone furoate nasal spray; Drug: Beclomethasone dipropionate nasal spray; Drug: Placebo nasal spray; Drug: Chlorpheniramine maleate syrup Sponsor: Merck Sharp & Dohme Corp. Completed (Source: ClinicalTrials.gov)
Tue Mar 19, 2019 17:00
Condition: Fungal Sinusitis Intervention: Procedure: sphenoidotomy versus sphenoid nasalisation Sponsor: Assiut University Not yet recruiting (Source: ClinicalTrials.gov)
Mon Mar 18, 2019 17:00
Condition: Healthy Volunteer Interventions: Biological: Ad4-Env145NFL; Biological: Ad4-Env150KN; Biological: VRC-HIVRGP096-00-VP (Trimer 4571) with alum Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
Mon Mar 18, 2019 17:00
Condition: Asthma Intervention: Other: Study questionnaires Sponsor: AstraZeneca Not yet recruiting (Source: ClinicalTrials.gov)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Tue Mar 26, 2019 05:00
(Louisiana State University) In healthy adults, RSV, or respiratory syncytial virus, feels like the common cold with a runny nose, chest congestion and cough. However, it is the second leading cause of death in infants. . A new publication in Frontiers in Immunology by Stephania Cormier, the LSU Department...
Tue Mar 26, 2019 14:20
Fitness instructor, 28, battling a mystery allergy that causes her face to swell like a 'pufferfish'
Carla Roberts, from Dublin, sees red rings appear all over her face and body for 'no reason'. The flare-ups can last as long as a month, leaving doctors baffled. (Source: the Mail online | Health)
Tue Mar 26, 2019 13:51
Primary endpoint of ocular itch score area under the curve achieved for both tested reproxalap concentrations Key secondary endpoint of clinically relevant two-point ocular itch score improvement achieved for both tested reproxalap concentrations Com... Biopharmaceuticals, Ophthalmology Aldeyra...
Tue Mar 26, 2019 12:57
Aldeyra Therapeutics Inc said on Tuesday its drug reproxalap to treat a form of allergic reaction to the eye met the main goal in a late-stage trial, sending shares up more than 60 percent. (Source: Reuters: Health)
Tue Mar 26, 2019 16:57
Quiet local biotech Aldeyra Therapeutics made some noise Tuesday, reporting that its first treatment for eye allergies succeeded in a late-stage trial. The 19-person company has largely flown under the radar in the Massachusetts biotech landscape, aside from raising one of the smallest amounts for...
Tue Mar 26, 2019 13:02
(Source: FDA Center for Drug Evaluation and Research - What's New)
Mon Mar 25, 2019 08:00
Title: mometasone furoate (Nasonex)Category: MedicationsCreated: 6/6/1999 12:00:00 AMLast Editorial Review: 3/25/2019 12:00:00 AM (Source: MedicineNet Allergies General)
Mon Mar 25, 2019 19:12
It's hardly news that the gastrointestinal tract is important to human health: It transports food from the mouth to the stomach, converts it into absorbable nutrients and stored energy, and shuttles waste back out of the body. If you don't properly nourish yourself, you don't live. It's that simple....
Mon Mar 25, 2019 17:03
MONDAY, March 25, 2019 -- When it's finally time to store away your winter coats and boots, it's also a good time to rid your home of the allergens that accumulated over the winter, an allergist suggests. " If you aren't someone who regularly... (Source: Drugs.com - Daily MedNews)MedWorm Message: Have...
Mon Mar 25, 2019 00:00
. (Source: Cochlear Implants International)
Mon Mar 25, 2019 00:00
This study examined whether ENI quality differed between early-implanted children and late-implanted adults. Auditory detection thresholds and most comfortable levels (MCLs) were obtained with monopolar and focused electrode configurations. Channel-to-channel variability and dynamic range were calculated...
Tue Mar 26, 2019 13:00
Who owns medical and genetic data? How to regulate gene editing? Where is the boundary of enhancing physical or cognitive human capabilities? What to do with biological differences widening the gap of the haves and have-nots? Could we define where is the boundary to augment life? Will we sue robots or...
Tue Mar 26, 2019 03:08
(Source: Notes from Dr. RW)
Mon Mar 25, 2019 20:51
New Jerseyans with terminal or life-shortening diseases and Compassion & Choices praised the state Assembly and Senate for passing the Aid in Dying for the Terminally Ill Act (S1072/A1504) after nearly seven years of debate on the issue and urged Governor Phil Murphy to promptly sign it into...
Mon Mar 25, 2019 17:00
Condition: Head and Neck Cancer Interventions: Drug: Paclitaxel; Drug: Cetuximab + Paclitaxel Sponsors: Grupo Español de Tratamiento de Tumores de Cabeza y Cuello; Merck Sharp & Dohme Corp.; Pivotal S.L. Terminated (Source: ClinicalTrials.gov)MedWorm Message: If you are looking to buy...
Mon Mar 25, 2019 17:00
Conditions: Colorectal Liver Metastases; Colorectal Cancer; Liver Metastases; Immunotherapy Intervention: Procedure: Hepatectomy Sponsor: Humanitas Clinical and Research Center Completed (Source: ClinicalTrials.gov)
Mon Mar 25, 2019 17:00
Condition: Colorectal Neoplasm Intervention: Other: Pretreatment group consultation Sponsor: Sahlgrenska University Hospital, Sweden Not yet recruiting (Source: ClinicalTrials.gov)
Mon Mar 25, 2019 17:00
Conditions: Hepatocellular Carcinoma; Liver Cancer; Liver Neoplasms; Metastatic Liver Cancer Interventions: Biological: ET1402L1-ARTEMIS™ T cells -IV; Biological: ET1402L1-ARTEMIS™ T cells -intra-hepatic artery; Biological: ET1402L1-ARTEMIS™ T cells -Intratumoral Injections Sponsors: ...
Mon Mar 25, 2019 17:00
Conditions: Hepatitis B Virus Positive; Malignant Solid Neoplasm Interventions: Other: Best Practice; Other: Laboratory Biomarker Analysis; Drug: Tenofovir Alafenamide Sponsors: Southwest Oncology Group; National Cancer Institute (NCI) Recruiting (Source: ClinicalTrials.gov)
Mon Mar 25, 2019 17:00
Condition: HPV-Related Cervical Carcinoma Intervention: Behavioral: knowledge questioannaire Sponsor: University Hospital, Geneva Not yet recruiting (Source: ClinicalTrials.gov)
Mon Mar 25, 2019 17:00
Condition: Breast Cancer Intervention: Drug: 5-FU, epirubicin and cyclophosphamide Sponsors: Henrik Lindman; Scandinavian Breast Cancer Group; Danish Breast Cancer Group; Swedish Cancer Society; Swedish Breast Cancer Association; Uppsala University Oncology Department Trust; Pharmacia Pharmaceutical Company;...
Mon Mar 25, 2019 17:00
Condition: Breast Cancer Intervention: Device: Ultrasound diagnosis Sponsors: Xin-Wu Cui; Xinhua Hospital, Shanghai Jiao Tong University School of Medicine; Taizhou Hospital; Wuhan Hospital of Traditional Chinese and Western Medicine; Macheng People's Hospital; Huangshi Central Hospital;...
Mon Mar 25, 2019 17:00
Condition: Esophageal Squamous Cell Carcinoma Intervention: Drug: Z650 Sponsor: Sunshine Lake Pharma Co., Ltd. Recruiting (Source: ClinicalTrials.gov)
Mon Mar 25, 2019 17:00
Condition: Cancer Intervention: Other: Occupational Therapy Health& Wellness Education Sponsors: University of Indianapolis; Indiana Clinical and Translational Sciences Institute Recruiting (Source: ClinicalTrials.gov)MedWorm Message: Have you tried our new medical search engine? More powerful...
Mon Mar 25, 2019 17:00
Condition: Prostate Cancer Metastatic Intervention: Drug: ARV-110 Sponsor: Arvinas Inc Recruiting (Source: ClinicalTrials.gov)
Mon Mar 25, 2019 17:00
Condition: Head and Neck Carcinoma Interventions: Other: Quality-of-Life Assessment; Other: Questionnaire Administration Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI) Recruiting (Source: ClinicalTrials.gov)
Mon Mar 25, 2019 17:00
Condition: Prostate Cancer Intervention: Sponsor: Chinese University of Hong Kong Recruiting (Source: ClinicalTrials.gov)
Mon Mar 25, 2019 17:00
Condition: Lung Cancer Intervention: Sponsor: University of Glasgow Recruiting (Source: ClinicalTrials.gov)
Mon Mar 25, 2019 17:00
Condition: Human Papillomavirus Infection Intervention: Other: VACs Sponsors: University of North Carolina, Chapel Hill; Centers for Disease Control and Prevention; American Cancer Society, Inc.; Wisconsin Department of Health and Family Services; New York State Department of Health; ...
Fri Mar 22, 2019 17:00
Condition: Chronic Pain Interventions: Procedure: radiofrequency splanchnic denervation; Procedure: retrocrural celiac denervation Sponsor: Assiut University Not yet recruiting (Source: ClinicalTrials.gov)
Fri Mar 22, 2019 17:00
Condition: Breast Cancer Interventions: Drug: oral vinorelbine; Drug: Capecitabine; Drug: Gemcitabine 1250 mg/m²; Drug: Gemcitabine 1000 mg/m²; Drug: Paclitaxel; Drug: Docetaxel Sponsor: Pierre Fabre Medicament Completed (Source: ClinicalTrials.gov)MedWorm Message: If you are looking...
Fri Mar 22, 2019 17:00
Condition: Neoplasms, Colorectal Interventions: Behavioral: Exercise training and nutritional guide; Other: Standard follow-up care Sponsors: St. Olavs Hospital; Alesund Hospital; Levanger Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Fri Mar 22, 2019 17:00
Condition: Pancreatic Cancer Intervention: Sponsors: Hoag Memorial Hospital Presbyterian; Baylor Research Institute Recruiting (Source: ClinicalTrials.gov)
Fri Mar 22, 2019 17:00
Conditions: Hematological Malignancy; Acute Leukemia in Remission; Acute Lymphoblastic Leukemia in Remission; Myelodysplastic Syndromes; Non-Hodgkin Lymphoma; Hodgkin Lymphoma Interventions: Biological: Cord blood stem cells; Drug: Valproic Acid; Drug: Fludarabine; Drug: cytoxan;...
Fri Mar 22, 2019 17:00
Conditions: Early-stage Breast Cancer; Carbohydrate Engorgement; Proliferation; Insulin Resistance; Estrogen Receptor-positive Breast Cancer Intervention: Dietary Supplement: PreOP Sponsor: Helse Stavanger HF Completed (Source: ClinicalTrials.gov)
Fri Mar 22, 2019 17:00
Conditions: Relapsed/Refractory Advanced Solid Tumors; Relapsed/Refractory Diffuse Large B-cell Lymphoma or Mantle Cell Lymphoma; Relapsed/Refractory Myelodysplasia; Relapsed/Refractory Myelofibrosis Intervention: Drug: PRT543 Sponsor: Prelude Therapeutics Recruiting (Source: ClinicalTrials.gov)
Fri Mar 22, 2019 17:00
Condition: Sarcoma Interventions: Drug: Talimogene Laherparepvec 100000000 PFU/1 ML Injection Suspension [IMLYGIC]; Drug: Nivolumab IV Soln 100 MG/10ML; Drug: Trabectedin 0.25 MG/1 VIAL Intravenous Powder for Solution Sponsor: Sarcoma Oncology Research Center, LLC Not yet recruiting (Source:...
Tue Mar 26, 2019 05:00
(The Translational Genomics Research Institute) Dr. Daniel D. Von Hoff, Distinguished Professor and Physician-In-Chief for the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, has been selected to receive the 2019 Distinguished Public Service Award from the American Association...
Tue Mar 26, 2019 00:00
Link also found with lower cancer survival rates Related items fromOnMedica Social prescribing workers to ease GP pressure Experts urge radical action on mental health crises Home births safe and cost-effective for low-risk women Eight in ten stillbirths might have been avoided BMA and College demand...
Tue Mar 26, 2019 22:05
SAN FRANCISCO - Phase 2 of the federal bellwether glyphosate cancer trial in California started March 20, after a jury the first phase found that the chemical, which is the active ingredient in Monsanto Co.'s herbicide Roundup, was "a substantial factor" in causing the plaintiff's non-Hodgkin lymphoma...
Tue Mar 26, 2019 22:05
SAN FRANCISCO - The attorneys representing the plaintiff and Monsanto Co. in the bellwether federal glyphosate cancer trial presented closing arguments on March 12 for Phase 1 of the trial, which deals with the sole issue of causation (In re: Roundup Products Liability Litigation, MDL No. 2741, N.D....
Tue Mar 26, 2019 22:05
LONDON - A study published in the International Journal of Epidemiology on March 18 found that there was an elevation of risk for non-Hodgkin lymphoma (NHL) in people who were exposed to glyphosate, the active ingredient in the herbicide Roundup. (Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal...
Tue Mar 26, 2019 22:05
HARRISBURG, Pa. - The Pennsylvania Supreme Court on March 5 agreed to hear an appeal in a wrongful death lawsuit to determine whether a divided lower court reached the correct conclusion regarding the application of the Frye evidence standard in a pesticide cancer lawsuit against numerous chemical companies...
Tue Mar 26, 2019 22:05
SAN FRANCISCO - The California federal judge presiding over the bellwether glyphosate cancer trial against Monsanto Co. on March 13 denied the company's motion for a directed verdict on causation (In re: Roundup Products Liability Litigation, MDL No. 2741, N.D. Calif.). (Source: LexisNexis® Mealey's™...
Tue Mar 26, 2019 22:05
SAN FRANCISCO - A jury in a federal bellwether glyphosate cancer trial in California on March 19 found that the chemical, which is the active ingredient in Monsanto Co.'s herbicide Roundup, was "a substantial factor" in causing the plaintiff's non-Hodgkin lymphoma. Phase 2 of the trial, to determine...
Tue Mar 26, 2019 22:05
SAN FRANCISCO - Monsanto Co. on March 4 filed a brief in California federal court contending that in the bellwether glyphosate cancer trial, the plaintiff's supplemental brief regarding alleged fraud at a laboratory that tested the chemical "misrepresents the historical record" and "has no relevance...
Tue Mar 26, 2019 21:28
A second medical device sterilization plant is slated to close this year, prompting the FDA and medtech manufacturers to scramble for replacements. The FDA warned on March 1 about a potential medical device shortage due to the recent shutdown of a Sterigenics plant in Willowbrook, Ill. linked to emissions...
Tue Mar 26, 2019 20:43
A lawyer for a man who said his cancer was caused by Bayer AG's glyphosate-based weed killer Roundup on Tuesday urged U.S. jurors to "send a message" to the company by holding it liable and awarding millions in damages. (Source: Reuters: Health)
Tue Mar 26, 2019 20:10
The 79-year-old newscaster, known for being straight-laced, revealed on Tuesday that he turned to the drug to ease his pain from multiple myeloma, a type of blood cancer. (Source: the Mail online | Health)
Tue Mar 26, 2019 18:04
The U.S. Department of Justice (DOJ) has shifted its position on the Patient...Read more on AuntMinnie.comRelated Reading: ACA has benefited low- and middle-income women How has the ACA affected breast cancer screening? DOJ action may hinder disabled access to imaging More women get breast screening...
Tue Mar 26, 2019 17:58
Dune Medical Devices said today that it launched a first-in-man trial of its Smart Biopsy device, touting that the first patients in the trial have already been treated. The first-in-man cases were performed by Dr. Noemi Weissenberg of Kfar Saba, Israel's Meir Medical Center, the Alpharetta, Ga.-based...
Tue Mar 26, 2019 16:48
A panel of experts convened by the FDA yesterday said that there's not enough data to pull textured breast implants from the market over concerns that they may be linked to a type of immune system cancer, according to an AP News report. The recommendation comes from the first day of a two-day panel...
Tue Mar 26, 2019 15:00
New research in mice suggests that eating all daily meals within a restricted window of time may be a good preventive strategy against cancer tumor growth. (Source: Health News from Medical News Today)
Tue Mar 26, 2019 14:59
A new study by the University of Bradford found these tiny pieces of a protein, known as EN2, are taken up by other cancerous cells, causing them to change shape or fuse together. (Source: the Mail online | Health)
Tue Mar 26, 2019 14:57
Demi-Lee Stewart, from Glasgow, is still three years away from the Government's smear testing threshold of 25. She has been suffering bleeding between periods - a sign of cervical cancer. (Source: the Mail online | Health)
Tue Mar 26, 2019 13:04
FDA is meeting to address the possible risks of breast implants after the agency reported that 457 cases of cancer have been detected in women with breast implants (Source: Health News: CBSNews.com)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your...
Tue Mar 26, 2019 11:51
EXCLUSIVE: Tina Potts, 40, from Wicklow Town, Ireland, has battled terminal cancer for 18 months. She married her partner of 13 years on Friday to 'make memories' for her two children. (Source: the Mail online | Health)
Tue Mar 26, 2019 10:46
CANCER WARNING: A common tropical disease found in certain holiday hotspots popular with British tourists could make victims more at risk of developing prostate cancer, new research has revealed. (Source: Daily Express - Health)
Tue Mar 26, 2019 10:43
(Natural News) Berries are known to be one of the greatest superfoods available. Many studies suggest that these are rich in antioxidants and possess cancer-fighting properties. For example, red raspberry — a type of berry scientifically known as Rubus idaeus — can protect against a type of head and...
Tue Mar 26, 2019 10:41
(Natural News) Scientists continue to search for natural cancer treatments. A team of researchers at Nagasaki International University in Japan found that a natural compound known as berberine can help protect against cancer, particularly leukemia, by inducing cancer cell death. For the study, the research...
Tue Mar 26, 2019 09:03
Here are some of the latest health and medical news developments, compiled by the editors of HealthDay: Too Early To Ban Breast Implant Linked With Cancer: FDA Panel It's too early to ban a type of breast implant recently linked to a rare form of... (Source: Drugs.com - Daily MedNews)MedWorm Message:...
Tue Mar 26, 2019 08:00
IRVING, TEXAS, March 26, 2019 —iKnowMed℠, McKesson's oncology practice electronic health record (EHR) system, has been named the top-ranked EHR platform for oncologists and hematologists for the eighth year in a row by Black Book™ Research, an unbiased industry-leading source for polling, surveys and......
Tue Mar 26, 2019 19:13
Patients undergoing hematopoietic stem cell transplant should be counseled that they have an ever-increasing risk for further malignancies, although their survival may not be affected, say experts.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)MedWorm Message: Have you tried our...
Tue Mar 26, 2019 17:40
Clinicians should continue to rely on matched donor stem cell transplants to treat childhood acute lymphoblastic leukemia, while more data on novel CAR T-cell therapies is gathered, says German expert.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Tue Mar 26, 2019 16:38
The most comprehensive study yet of this technique found no cases of breast cancer at 53 months, suggesting it is safe.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a...
Tue Mar 26, 2019 15:11
Women who require surgery for endometrial cancer enjoy a better quality of life if concomitant stress urinary incontinence is surgically repaired at the same time.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Tue Mar 26, 2019 05:00
(NYU Tandon School of Engineering) The American Institute for Medical and Biological Engineering has inducted Jin Kim Montclare, a professor of chemical and biomolecular engineering at the NYU Tandon School of Engineering, to its College of Fellows. AIMBE cited her 'outstanding contributions to biomaterials...
Tue Mar 26, 2019 05:00
(Michigan Medicine - University of Michigan) A frontline chemotherapy drug given to patients with pancreatic cancer is made less effective because similar compounds released by tumor-associated immune cells block the drug's action, research led by the University of Michigan Rogel Cancer Center found....
Tue Mar 26, 2019 05:00
(eLife) Researchers have identified a protein critical for the survival of a particular type of tumor cell, according to a study published today in eLife. (Source: EurekAlert! - Cancer)
Tue Mar 26, 2019 05:00
(University of Bradford) Prostate cancer cells change the behavior of other cells around them, including normal cells, by 'spitting out' a protein from their nucleus, new research has found. (Source: EurekAlert! - Biology)
Tue Mar 26, 2019 05:00
A series of communication-focused interventions were implemented to try to improve conversations about values, goals, and preferences with patients with life-limiting cancer. (Source: CancerNetwork)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com...
Mon Mar 25, 2019 08:00
Title: Could the U.S. Mail Deliver Better Colon Cancer Screening Rates?Category: Health NewsCreated: 3/22/2019 12:00:00 AMLast Editorial Review: 3/25/2019 12:00:00 AM (Source: MedicineNet Cancer General)
Tue Mar 26, 2019 05:00
(NYU Langone Health / NYU School of Medicine) A new study shows that compared to other patients, cancer patients use different forms of medical marijuana for unique reasons. (Source: EurekAlert! - Medicine and Health)MedWorm Message: Have you tried our new medical search engine? More powerful than before....
Tue Mar 26, 2019 08:00
Can an artificial intelligence (AI) algorithm interpret screening mammograms...Read more on AuntMinnie.comRelated Reading: Annual mammography shows higher recall rate AI may help women with ductal hyperplasia avoid surgery Mammo AI software yields workflow, economic benefits JNCI: Breast screening...
Tue Mar 26, 2019 08:00
Virtual reality may be a safer, more time-efficient alternative to conventional...Read more on AuntMinnie.comRelated Reading: VR, AR elevate radiologists' value in future of medicine Virtual reality may help plan, guide glioma resection 3D printing gives pediatric heart surgery a boost Virtual reality,...
Mon Mar 25, 2019 21:00
Radiation oncology vendor Elekta has received a Medical Device License from...Read more on AuntMinnie.comRelated Reading: Elekta initiates study on MR radiation therapy for cancer FDA clears Elekta's Unity MR radiation therapy system Elekta highlights Unity abstracts at ASTRO Elekta acquires software...
Sat Mar 23, 2019 00:00
March is Colorectal Cancer Awareness Month, a time to focus on one of the most common and preventable forms of cancer. Mayo Clinic is applying a new genomic lens to colorectal and other cancers to identify which are the types that run in families. The answer to that could open new treatment options and...
Tue Mar 26, 2019 08:36
What is the current state of knowledge concerning the use of active surveillance for low grade non-muscle invasive bladder cancer?Translational Andrology and Urology (Source: Medscape Today Headlines)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com...
Tue Mar 26, 2019 02:28
New research suggests hay-fever sufferers may be significantly less likely to develop certain cancers than those who breeze through the season unaffected by pollen-induced misery. (Source: the Mail online | Health)
Tue Mar 26, 2019 02:05
While industry representatives insisted the implants are safe, others at an F.D.A. panel meeting urged for warnings about links to illnesses and cancer. (Source: NYT Health)
Mon Mar 25, 2019 22:03
Marlee Pincus, 18, began coughing in September 2018, but thought she had come down with the flu. She was eventually taken to the hospital where she was diagnosed with leukemia, a blood cancer. (Source: the Mail online | Health)MedWorm Message: Have you tried our new medical search engine? More powerful...
Mon Mar 25, 2019 21:24
In a two-day meeting, officials are hearing from researchers, plastic surgeons, and women who say they've suffered a number of ailments as a result of their breast implants (Source: Health News: CBSNews.com)
Mon Mar 25, 2019 20:48
Patients, plastic surgeons, makers of breast implants, regulators and Health Canada officials participate in two-day meeting hosted by the U.S. Food and Drug Administration. (Source: CBC | Health)
Mon Mar 25, 2019 19:54
After he was diagnosed with Alzheimer's disease in 2016, Peter Wooding says he and his wife JoAnn decided they wanted to be "part of the solution" in finding the first effective treatment for the neurodegenerative disease. He volunteered to be part of a trial for a promising new drug called aducanumab....
Mon Mar 25, 2019 19:21
Elekta (STO:EKTA B) said today that it won Health Canada approval for its Elekta Unity magnetic resonance radiation therapy system. The Elekta Unity system consists of a high-field 1.5 Tesla MRI scanner and a linear accelerator alongside integrated real-time dose planning software for target monitoring,...
Mon Mar 25, 2019 19:07
(Natural News) Hemp and hemp seed oil are all the hype these days. Millions of people have jumped on the recent health craze by adding high-quality hemp protein powder or hemp hearts to their morning smoothies. But did you know that a pure extract of the cannabis bud could potentially cure cancer, with...
Mon Mar 25, 2019 15:03
MONDAY, March 25, 2019 -- State Medicaid programs must do more to make sure that people at high risk for lung cancer are screened for the deadly disease, a new American Lung Association report says. Medicaid is the public assistance program... (Source: Drugs.com - Daily MedNews)
Tue Mar 26, 2019 03:35
(MedPage Today) -- Lenalidomide-rituximab more than doubles PFS in relapsed/refractory disease (Source: MedPage Today Hematology/Oncology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income...
Mon Mar 25, 2019 20:54
Periodontitis affects nearly half of Americans ages 30 and older, and in its advanced stages, it could lead to early tooth loss or worse. Recent studies have shown that periodontitis could also increase risk of heart disease and Alzheimer 's disease. A team of UCLA researchers has developed methods that...
Tue Mar 26, 2019 17:46
Dr. Greg Riely from Memorial Sloan-Kettering Cancer Center reviews the limited data that help clarify the probability of benefit from new immunotherapy agents among patients with advanced NSCLC and an... Author: cancergrace Added: 03/26/2019 (Source: Oncology Tube)MedWorm Message: Have...
Tue Mar 26, 2019 15:18
Dr. West moderates a question & answer session with Drs. Leora Horn and Greg Riely on issues of acquired resistance to targeted therapies for patients with advanced NSCLC that harbors a driver mutatio... Author: cancergrace Added: 03/26/2019 (Source: Oncology Tube)
Sat Mar 23, 2019 16:04
Xalkori (crizotinib) has had great success treating ALK positive lung cancer patients. The next generation of ALK inhibitors are also showing great promise. In this video, Dr. Leena Gandhi of Dana-Far... Author: cancergrace Added: 03/23/2019 (Source: Oncology Tube)
Sat Mar 23, 2019 15:23
Xalkori (critzotinib) was the first approved treatment for ALK+ and ROS1 lung cancer. Since then, other drugs have been approved or are currently undergoing scientific review. In this video, Dr. Owoni... Author: cancergrace Added: 03/23/2019 (Source: Oncology Tube)
Sat Mar 23, 2019 14:31
The brain is a common site of disease in patients with ALK+ lung cancer. In this video, Dr. Horn illustrates the line-up of ALK+ treatments and how they work breaking through the blood/brain barrier. Author: cancergrace Added: 03/23/2019 (Source: Oncology Tube)
Sat Mar 23, 2019 14:20
Janet Daily-Freeman moderates a question & answer session with Drs. Leora Horn and Taofeek Owonikoko on issues of acquired resistance to targeted therapies for ALK+ and ROS1 patients. Author: cancergrace Added: 03/23/2019 (Source: Oncology Tube)MedWorm Message: If you are looking...
03:19
Authors: Short E, Sampson J Abstract Colorectal carcinoma (CRC) is the third most common cancer in men and the second most common cancer in women across the world. Most CRCs occur sporadically, but in 15-35% of cases, hereditary factors are important. Some patients with an inherited predisposition...
03:19
Authors: Dufner-Almeida LG, do Carmo RT, Masotti C, Haddad LA Abstract Pre-mRNA splicing, an essential step in eukaryotic gene expression, relies on recognition of short sequences on the primary transcript intron ends and takes place along transcription by RNA polymerase II. Exonic and intronic...
02:38
Publication date: 1 June 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 178Author(s): Xiuli Ren, Libang He, Xiaohan Tian, Peng Zhang, Zhenhua Chen, Xifan MeiAbstractIdeal nanoscale drug delivery system (DDS) should be biocompatible, having targeted recognition and controlled release properties....
02:38
In this report, the combined drug system loaded on the GO-PVP nanovehicle was found to be significantly more toxic than the individual drug loaded systems, as well as the free drugs, toward PA-1 cells compared to the toxicity toward IOSE-364 cells. The combined drug system loaded on the GO-PVP nanovehicle...
02:35
New J. Chem., 2019, Advance Article DOI: 10.1039/C8NJ06478D, PaperMarko Peri ć, Magdalena Radović, Marija Mirković, Aleksandar S. Nikolić, Predrag Iskrenović, Drina Janković, Sanja Vranješ-Đurić The advances in nanotechnology are directed towards the development of new theranostic agents based on magnetic...
01:55
CONCLUSION: This is a very unusual patient with a newly discovered variant of the CDC73 gene and a phenotype characterized by recurrent PC, brown tumors, and N1a metastasized thyroid carcinoma. The present case confirms that PC may not exhibit clear malignant properties at first assessment, contributing...
01:54
Conclusions: These results demonstrate leptin's role in mildly increasing the aggressive phenotype of PTC cells but without influencing the action of lenvatinib. Further studies will clarify whether it is possible to target OB-R, expressed in all aggressive PTCs, as an adjuvant treatment approach for...
01:15
Shiv Verma, Sanjeev Shukla, Mitali Pandey, Gregory T. MacLennan, Sanjay Gupta (Source: Frontiers in Genetics)
01:05
Authors: Jaros J, Lio P Abstract Low-dose naltrexone (LDN) has been successfully studied as an immunomodulatory and anti-inflammatory therapy in a wide range of conditions including Crohn's disease, fibromyalgia, major depressive disorder, cancer, chronic regional pain syndrome, Charcot-Marie-Tooth,...
01:05
Authors: Donaldson MR, Weber A Abstract Perineural invasion (PNI) is associated with high risk keratinocyte carcinomas. Identification of PNI during Mohs surgery is important for staging and post-adjuvant treatment decisions but can be challenging. To confirm or exclude PNI suspected on hematoxylin...
01:05
Conclusion: Findings indicate that topical 5FU/AS is an effective treatment for multiple distal AKs, with a proper safety profile. J Drugs Dermatol. 2019;18(3):285-288. PMID: 30909350 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
00:11
CONCLUSION: Postoperative AF is frequently observed in patients undergoing oesophagectomy for cancer. It is associated with an increased risk of death and postoperative complications. PMID: 30908612 [PubMed - in process] (Source: The British Journal of Surgery)
00:11
CONCLUSION: The outcome of rSLNB is not an important prognostic factor for distant recurrence, and its value as a staging tool in patients with IBTR seems disputable. PMID: 30908615 [PubMed - in process] (Source: The British Journal of Surgery)
00:07
Conclusion: Employment consistently predicted systemic and radiation treatment, and age and income were predictors of breast reconstruction in a universal health care system. Further research is required to determine precisely how socioeconomic factors affect care and to minimize possible disparities...
00:07
Conclusion: Increased age, longer Barrett's segment and presence of mucosal irregularities were associated with increased risk of dysplastic and neoplastic progression. In addition to dysplasia, these factors may help stratify patients according to risk of neoplastic progression and be used to individualize...
Tue Mar 26, 2019 23:59
This study was to collect the evidence of disease-modulatory activities of Huci by analyzing the published literature on the chemicals and drugs. A list of its compounds and direct protein targets is predicted by using Bioinformatics Analysis Tool for Molecular Mechanism of TCM. A protein-protein interaction...
Tue Mar 26, 2019 23:41
ConclusionLocal thermal ablation for the oligoprogressive lesions with continuous EGFR-TKI treatment is associated with additional 10 months of disease control and should be recommended in TKI acquired resistant-NSCLC patients. (Source: CardioVascular and Interventional Radiology)MedWorm Message: If...
Tue Mar 26, 2019 23:41
ConclusionsPost-radioembolization AFP and ALBI scores were significant OS prognosticators. A decrease in post-therapeutic Laboratory Score, which combines AFP and ALBI, correlates with an improved OS. (Source: CardioVascular and Interventional Radiology)
Tue Mar 26, 2019 23:41
AbstractAs medical imaging advancements have improved the detectability of hepatocellular carcinoma (HCC) in early stages, the approach to percutaneous thermal ablation for curative treatment has concomitantly advanced. Although many centers are adopting cross-sectional imaging to guide percutaneous...
Tue Mar 26, 2019 22:39
No abstract available (Source: Postgraduate Obstetrics and Gynecology)
Tue Mar 26, 2019 22:24
Conclusion: Abdominal pain was absent in 16% of LIP patients with autoimmune rheumatic diseases, and this absence was a poor prognostic factor in this cohort. Moreover, higher age, chronic kidney disease, systemic vasculitis, and LIP due to malignancy were associated with significantly increased mortality....
Tue Mar 26, 2019 22:24
Authors: Al-Khodir FAI, Abumelha HMA, Al-Warhi T, Al-Issa SA Abstract New Pd(II) and Pt(IV) triazine complexes [Pt3(L 1 )2(Cl)9(H2O)3].3Cl.3H2O (1), [Pt3(L 2 )2(Cl)9(H2O)3].3Cl (2), [Pt3(L 3 )2(Cl)9(H2O)3].3Cl (3), [Pt2(L 4 )2(Cl)6(H2O)2] .2Cl.4H2O (4), [Pd3(L 1 )2(H2O)6] .3Cl2 (5), [Pd3(L...
Tue Mar 26, 2019 22:24
Blockage of TGF-α Induced by Spherical Silica Nanoparticles Inhibits Epithelial-Mesenchymal Transition and Proliferation of Human Lung Epithelial Cells. Biomed Res Int. 2019;2019:8231267 Authors: Li Y, Li H, Duan Y, Cai X, You D, Zhou F, Yang C, Tuo X, Liu Z Abstract Background....
Tue Mar 26, 2019 22:16
ConclusionSpNQ-Ch-27 is applicable for Chinese cancer patients with better validity and higher internal consistency, and it can be used as a tool to assess the spiritual needs of cancer patients. (Source: International Journal of Nursing Sciences)
Tue Mar 26, 2019 21:42
Publication date: Available online 5 March 2019Source: Current Medicine Research and PracticeAuthor(s): Amitabh Gautam (Source: Current Medicine Research and Practice)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the...
Tue Mar 26, 2019 21:08
Pediatric gastrointestinal endoscopy has been established as safe and effective for diagnosis and management of many pediatric gastrointestinal diseases. Nevertheless, certain patient and procedure factors should be recognized that increase the risk of intra- and/or postprocedural adverse events (AEs)....
Tue Mar 26, 2019 21:08
We describe the hepatic outcome of 3 children with MAS referred to a single national liver unit. All presented with high gamma-glutamyl transpeptidase cholestasis and hepatitis. Cholestasis resolved by 1 year; but hepatic inflammation persisted, and 2 children developed progressive atypical focal nodular...
Tue Mar 26, 2019 01:00
This JAMA Patient Page explains the use of thyroglobulin measurement to monitor for recurrence in patients who have had thyroid cancer. (Source: JAMA)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the...
Tue Mar 26, 2019 01:00
To the Editor Dr Johnson and colleagues summarized the adverse events associated with immune checkpoint inhibitor therapy used to manage advanced cancers, which predominantly respond to treatment with glucocorticoids. However, we want to emphasize an irreversible adverse effect, autoimmune diabetes,...
Tue Mar 26, 2019 00:00
Conclusions: Surgical treatment induced a dramatic reduction of the plasmatic levels of exosomes expressing CD63 as early as 1 week after resection. This first result suggests that the tumour mass is responsible of the high levels of circulating exosomes detected in cancer patients. At the same time...
Tue Mar 26, 2019 20:39
In this study, we reported that KDM5C was highly expressed in PCa and CRPC specimens, and the high expression promoted CRPC cell proliferation through repressing phosphatase and tensin homolog (PTEN) gene epigenetically. Moreover, KDM5C was transcriptionally upregulated by bromodomain-containing protein...
Tue Mar 26, 2019 20:39
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Xiwei Ji, Yuan Lu, Huifang Tian, Xiangrui Meng, Minji Wei, William C. ChoAbstractChemoresistance is one of the major challenges for the breast cancer treatment. Owing to its heterogeneous nature, the chemoresistance...
Tue Mar 26, 2019 20:23
Authors: Guan X, Zhao Y, Liu X, Shang B, Xing F, Zhou L, Wang Y, Zhang C, Bhatnagar D, Liu Y Abstract Aflatoxin is a carcinogenic secondary metabolite produced mainly by Aspergillus flavus and Aspergillus parasiticus, which can seriously endanger the health of humans and animals. Oxidative...
Tue Mar 26, 2019 00:00
AbstractA 45-year-old male visited our clinic due to right palmar anhidrosis and contralateral hyperhidrosis. Chest computed tomography (CT) showed a solitary pulmonary nodule with mediastinal lymph node enlargement, but a cause for atypical palmar anhidrosis was not identified. Subsequent fluorine-18-fluorodeoxyglucose...
Tue Mar 26, 2019 00:00
Navigating metabolic pathways to enhance antitumour immunity and immunotherapy, Published online: 26 March 2019; doi:10.1038/s41571-019-0203-7The metabolic conditions in tumours can result in phenotypic reprogramming of non-tumour cells, including immune cells, in the tumour microenvironment. This Review...
Tue Mar 26, 2019 00:00
In this study, we showed that siRNA-mediated depletion of stromal interaction molecule 1 (STIM1) and transient receptor potential channel 1 (TRPC1), two players of the store-operated calcium entry, dramatically reduced CDDP cytotoxicity in NSCLC cells. This was associated with an inhibition of the DNA...
Tue Mar 26, 2019 19:45
Tanja Eisemann, Barbara Costa, Heike Peterziel, Peter Angel (Source: Frontiers in Oncology)
Tue Mar 26, 2019 19:45
Nicholas G. Minutolo, Erin E. Hollander, Daniel J. Powell (Source: Frontiers in Oncology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Tue Mar 26, 2019 19:45
Susanne Wiegand, Gunnar Wichmann, Andreas Dietz (Source: Frontiers in Oncology)
Tue Mar 26, 2019 19:45
Alessia Cimadamore, Matteo Santoni, Francesco Massari, Silvia Gasparrini, Liang Cheng, Antonio Lopez-Beltran, Rodolfo Montironi, Marina Scarpelli (Source: Frontiers in Oncology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of...
Tue Mar 26, 2019 19:44
Publication date: Available online 25 March 2019Source: Seminars in Cancer BiologyAuthor(s): Takeshi IjuinAbstractPhosphoinositides are a group of lipids that regulate intracellular signaling and subcellular biological events. The signaling by phosphatidylinositol-3,4,5-trisphosphate and Akt mediates...
Tue Mar 26, 2019 19:44
Publication date: Available online 25 March 2019Source: Seminars in Cancer BiologyAuthor(s): Akira Motegi, Mitsuko Masutani, Ken-ichi Yoshioka, Tadayoshi BesshoAbstractCancer cells show various types of mutations and aberrant expression in genes involved in DNA repair responses. These alterations induce...
Tue Mar 26, 2019 19:44
Publication date: Available online 18 February 2019Source: Practical Radiation OncologyAuthor(s): H. Michael Gach, Olga L. Green, Phillip S. Cuculich, Erin J. Wittland, Areti Marko, Molly E. Luchtefeld, Jill M. Entwistle, Deshan Yang, David J. Wilber, Sasa Mutic, Clifford G. RobinsonAbstractMagnetic...
Tue Mar 26, 2019 19:44
ConclusionsOf the patients with LGG who had documented failures after PRT, most recurred within the radiation field with few marginal failures, indicating that even with PRT, which often can have steeper dose gradients, coverage is adequate. Survival was poor for patients whose tumors recurred. (Source:...
Tue Mar 26, 2019 19:44
ConclusionsNeoadjuvant chemoradiation therapy effectively downstages the majority of locally advanced type II endometrial cancers, thereby increasing the likelihood of achieving complete resection with negative margins. (Source: Practical Radiation Oncology)MedWorm Message: If you are looking to buy...
Tue Mar 26, 2019 19:44
ConclusionsThis study demonstrated that with 4-dimensional simulated APBI that uses stringent dosimetric constraints and image guidance radiation therapy, it is possible to obtain acceptable cosmetic outcomes. We report no locoregional recurrences in 3 years and no toxicity grade>3. The observed decline...
Tue Mar 26, 2019 19:44
ConclusionOur findings suggested that polymorphisms of MIR17HG rs7336610 and rs1428 were correlated with MM risk and prognosis. (Source: Clinical Lymphoma Myeloma and Leukemia)
Tue Mar 26, 2019 19:44
Publication date: Available online 25 March 2019Source: Cancer GeneticsAuthor(s): Henry T. Lynch, Rosemary Nustas, Thamer Kassim, Carrie Snyder, Trudy Shaw, Osama DiabAbstractA high percentage of individuals at risk for hereditary cancer syndromes are unaware of their risk. This is especially detrimental...
Tue Mar 26, 2019 19:44
Publication date: Available online 25 March 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Jun Liu, Xu Tan, Ying-Ying Ma, Yao Liu, Li Gao, Lei Gao, PeiYang Kong, Xian-Gui Peng, Xi Zhang, Cheng ZhangAbstractApproximately 30-60% of acute B-lymphocytic leukemia(B-ALL) patients show refractory...
Tue Mar 26, 2019 19:44
ConclusionsOur findings suggest that p15(INK4B) methylation may play an important in the development, progression, and poor prognosis of MDS. More prospective studies with larger study populations are needed. (Source: Clinical Lymphoma Myeloma and Leukemia)
Tue Mar 26, 2019 19:44
Publication date: Available online 25 March 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Faiz Anwer, Kevin Mathew Gee, Ahmad Iftikhar, Mirza Baig, Atlantis Dawn Russ, Sabina Saeed, Muhammad Abu Zar, Faryal Razzaq, Jennifer Carew, Steffan Nawrocki, Hussam Al-Katab, Nadia Nunes Cavalcante,...
Tue Mar 26, 2019 19:44
ConclusionThe patterns of variation in myeloma incidence, mortality and survival, as well as their trends over time may be used to assist research into the causes and management of myeloma in New Zealand. (Source: Cancer Epidemiology)MedWorm Message: Have you tried our new medical search engine? More...
Tue Mar 26, 2019 19:41
ConclusionsVEGFR2 overexpression significantly correlated with long-term PFS in HGSOC patients, independent of age, FIGO stage, tumor residual and VEGFA expression. (Source: Journal of Cancer Research and Clinical Oncology)MedWorm Message: Have you tried our new medical search engine? More powerful than...
Tue Mar 26, 2019 19:41
ConclusionAdherence to the EAU guidelines for PC was quite high across the eight European centres involved in the study. This notwithstanding, strategies for further improvement should be developed and evenly adopted. (Source: Journal of Cancer Research and Clinical Oncology)MedWorm Message: If you are...
Tue Mar 26, 2019 19:41
ConclusionsOur findings present new evidence that flotillins play a key role in the aggressive behaviors of residual cancer cells after insufficient RFA and provide new insights into the regulatory mechanism of Wnt/ β-catenin signaling. (Source: Journal of Cancer Research and Clinical Oncology)
Tue Mar 26, 2019 19:41
ConclusionsA high rate of distant site failure is associated with SMG carcinoma, resulting in a poor survival rate. Lymph node ratio might help predict recurrence, distant metastasis, and death due to SMG carcinoma. (Source: Journal of Cancer Research and Clinical Oncology)
Tue Mar 26, 2019 19:41
ConclusionsThis retrospective study indicates a very poor performance of regorafenib in recurrent high-grade astrocytoma with a fairly high number of CTC °3 adverse events. In addition, regorafenib does not seem to bear a potential for infiltrative tumor growth promotion. (Source: Journal of Cancer Research...
Tue Mar 26, 2019 19:41
ConclusionsMissense mutation ofTTN may act as a beneficial role in lung squamous cell carcinoma, but not in lung adenocarcinoma. (Source: Journal of Cancer Research and Clinical Oncology)
Tue Mar 26, 2019 19:38
CONCLUSIONS Taken together, our results showed that miR-222-3p induced DOX resistance via suppressing FOXP2, upregulating P-gp, and inhibiting the caspase pathway. PMID: 30904920 [PubMed - in process] (Source: Medical Science Monitor)
Tue Mar 26, 2019 19:38
CONCLUSIONS LINC01138 activated the MAPK signaling pathway by inhibiting miR-1273e to promote GC cell proliferation, invasion, and migration, and inhibit GC cell apoptosis, suggesting that the LINC01138/miR-1273e/MAPK axis is a promising therapeutic target for GC. PMID: 30902962 [PubMed - in process]...
Tue Mar 26, 2019 00:00
Authors: Oneeb Rehman Hanqi Zhuang Ali Muhamed Ali Ali Ibrahim Zhongwei Li Certain small noncoding microRNAs (miRNAs) are differentially expressed in normal tissues and cancers, which makes them great candidates for biomarkers for cancer. Previously, a selected subset of miRNAs has...
Tue Mar 26, 2019 00:00
Authors: Isaku Kohama Nobuyoshi Kosaka Hirotaka Chikuda Takahiro Ochiya Sarcomas are rare solid tumors, but at least one-third of patients with sarcoma die from tumor-related disease. MicroRNA (miRNA) is a noncoding RNA that regulates gene expression in all cells and plays a key role...
Tue Mar 26, 2019 00:00
In this study, we investigated the ability of one metabolite, 2,4,6-trihydroxybenzoic acid (2,4,6-THBA) to inhibit Cyclin Dependent Kinase (CDK) activity and cancer cell proliferation. Using in vitro kinase assays, we demonstrated that 2,4,6-THBA dose-dependently inhibited CDKs 1, 2 and 4 and in silico...
Tue Mar 26, 2019 18:31
CONCLUSIONS: There is a positive correlation between CXCR4 overexpression and BM involvement. CXCR4 and CCR7 overexpression is associated with poorer overall survival, especially in CXCR4 and CCR7 copositive patients. CXCR4, CCR7, Ki-67 index, and MYC were independent prognostic factors for DLBCL. Blocking...
Tue Mar 26, 2019 18:29
CONCLUSIONS: Checkpoint inhibitors neurological side effects are frequent. A wide variety of central or peripheral nervous system symptoms may develop. In the setting of brain tumors, inflammation due to immune system activation might lead to pseudoprogression. Further studies are needed to better describe...
Tue Mar 26, 2019 00:00
Systematic screening and assessment of psychosocial well-being and care needs of people with cancer.
CONCLUSIONS: We found low-certainty evidence that does not support the effectiveness of screening of psychosocial well-being and care needs in people with cancer. Studies were heterogeneous in population, intervention, and outcome assessment.The results of this review suggest a need for more uniformity...
Tue Mar 26, 2019 17:41
Publication date: Available online 25 March 2019Source: Biocybernetics and Biomedical EngineeringAuthor(s): Bikesh Kumar SinghAbstractEarly detection of breast cancer plays crucial role in planning and result of associated treatment. The purpose of this article is threefold: (i) to investigate whether...
Tue Mar 26, 2019 17:38
Publication date: Available online 25 March 2019Source: Journal of Clinical NeuroscienceAuthor(s): Erick M. Westbroek, Matthew L. Goodwin, Ferdinand Hui, Majid A. Khan, Daniel M. SciubbaAbstractMetastatic disease to the spine are becoming increasingly common with an aging population and improvements...
Tue Mar 26, 2019 16:46
Correlations of neck ultrasound and pathology in cervical lymph node of papillary thyroid carcinoma.
CONCLUSIONS: Preoperative neck US is a valuable tool in the detection of cervical lymph node metastases from papillary thyroid cancer and can provide reliable information to assist in surgical management. PMID: 30905261 [PubMed - as supplied by publisher] (Source: Acta Chirurgica Belgica)
Tue Mar 26, 2019 16:28
CONCLUSION: We suggest that the limitation of effort was due to a limitation of muscular oxygen extraction, which could be explained by possible muscular toxicity due to chemotherapy. PMID: 30902442 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Tue Mar 26, 2019 16:28
Authors: Pairon JC, Azoury H, Catto M, Dalphin JC, Gehanno JF, Housset B, L'huillier JP, Serveau S, Straus C Abstract Compensation for occupational pulmonary diseases requires the establishment of guidelines based on standardized and objective criteria, in order to provide compensation that...
Tue Mar 26, 2019 16:28
Authors: Leduc C, Quoix E Abstract Antigen-specific immunotherapy also known as cancer vaccination offers a novel approach for the treatment of non-small cell lung cancer patients. It relies on specific priming of the immune system in order to provoke or increase adaptive antitumor immune response...
Tue Mar 26, 2019 16:06
CONCLUSIONS: Based on the availability of different formulations of CTA-based vaccines, future researches should compare efficiency of these modalities. PMID: 30909205 [PubMed - as supplied by publisher] (Source: Human Antibodies)
Tue Mar 26, 2019 16:06
CONCLUSIONS: Taken together, lncRNAs constitute a novel vast area of research to find answer to fundamental biologic questions. PMID: 30909207 [PubMed - as supplied by publisher] (Source: Human Antibodies)
Tue Mar 26, 2019 15:11
In conclusion, DHA inhibits canine mammary tumours cells migration and invasiveness by regulating the expression of EMT-related genes. (Source: Research in Veterinary Science)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account....
Tue Mar 26, 2019 15:08
CONCLUSIONS: The analyses of the clinical and pathological data collected within the framework of this study justify enucleation as the treatment of choice for the patients of this study. Magnetic resonance imaging was not found to be an optimum screening method to detect scleral infiltration in this...
Tue Mar 26, 2019 15:02
Publication date: Available online 25 March 2019Source: Research in MicrobiologyAuthor(s): Fernanda Cornejo-Granados, Ana María Calderón de la Barca, Nimbe Torres, Esperanza Martínez-Romero, Javier Torres, Yolanda López-Vidal, Xavier Soberón, Laila P. Partida-Martínez, Sandra Pinto-Cardoso, Luis David...
Tue Mar 26, 2019 14:35
This study aimed to determine the effect of religious psychotherapy emphasizing the importance of prayers on mental health and pain in cancer patients. This study is a clinical trial that was conducted in 2017 in Yasuj, Iran. According to the purpose of the study, the patients were randomly assigned...
Tue Mar 26, 2019 14:34
CONCLUSION: In our study population, the most common type of carcinoma arising in fibroadenomas was DCIS, followed by lobular carcinoma in-situ. Lobular carcinoma in-situ was more likely to be confined to the fibroadenoma while most DCIS involved surrounding breast tissue. PMID: 30909180 [PubMed...
Tue Mar 26, 2019 14:34
CONCLUSIONS: ANC should be a standard protocol in AUS positive patients as they invariably have high axillary disease burden while ANC can be omitted in case of select AUS negative and SLNB patients. However, further studies with more subjects may be require to substantiate the findings. PMID: 30909179...
Tue Mar 26, 2019 14:28
CONCLUSION:: In patients with nonsuperior sulcus lung cancer with chest wall invasion, induction chemoradiation therapy followed by resection is associated with improved OS. PMID: 30905273 [PubMed - as supplied by publisher] (Source: Tumori)
Tue Mar 26, 2019 14:28
Authors: Livi L, Detti B, Francolini G, Terziani F, Triggiani L, D'Angelillo RM, Ingrosso G Abstract Prostate cancer is the second most frequent cancer worldwide, with a very high rate of progression despite treatment. The most aggressive form of the disease is known as castration-resistant...
Tue Mar 26, 2019 14:28
CONCLUSIONS:: Our analysis demonstrates that EGFR-TKIs confer significant PFS and OS benefits in the real-world practice for Korean female with advanced lung cancer. PMID: 30905312 [PubMed - as supplied by publisher] (Source: Tumori)MedWorm Message: If you are looking to buy something in the January...
Tue Mar 26, 2019 14:28
CONCLUSION:: Mortality of survivors not directly due to the diagnosed cancer was significantly higher than in the general population. It affected the estimates of cure proportions for all age classes and RS in the elderly. PMID: 30905274 [PubMed - as supplied by publisher] (Source: Tumori)
Tue Mar 26, 2019 14:09
This study was designed to evaluate the effect of DmdNKΔC20 for sensitizing human cancer cell lines towards gemcitabine and to further investigate its role in reversal of acquired drug resistance in gemcitabine-resistant cancer cell line. The DmdNKΔC20 gene was delivered to three different cancer cell...
Tue Mar 26, 2019 12:42
In conclusion, we suggest that both VDR and CaSR might be useful as molecular markers for predicting treatment outcomes and identifying the CRC patient subgroups who might benefit from 5-FU-based chemotherapy combined with vitamin D analog. (Source: The Journal of Steroid Biochemistry and Molecular Biology)MedWorm...
Tue Mar 26, 2019 12:09
CONCLUSIONS: 25(OH)D deficiency was directly related to BC while total vitamin D and supplemental vitamin D intakes had an inverse relationship with this outcome. Randomized clinical trials are warranted pending further evidence from primary meta-analyses of observational studies. PMID: 30904218...
Tue Mar 26, 2019 12:02
CONCLUSIONS: As expected, the frequency of imaging was highest during early follow-up. Cross-sectional imaging use for detection of recurrences following surgery for localized R.C.C. did not improve O.S. post-recurrence. Prospective studies are needed to determine the value of imaging in follow-up. ...
Tue Mar 26, 2019 11:36
Xin Feng, Jialiang Li, Han Li, Hang Chen, Fei Li, Quewang Liu, Zhu-Hong You, Fengfeng Zhou (Source: Frontiers in Genetics)
Tue Mar 26, 2019 00:00
Molecules, Vol. 24, Pages 1180: Oligonucleotide –Palladacycle Conjugates as Splice-Correcting Agents
Molecules, Vol. 24, Pages 1180: Oligonucleotide–Palladacycle Conjugates as Splice-Correcting Agents Molecules doi: 10.3390/molecules24061180 Authors: Madhuri Hande Osama Saher Karin E. Lundin C. I. Edvard Smith Rula Zain Tuomas Lönnberg 2'-O-Methylribo phosphorothioate oligonucleotides...
Tue Mar 26, 2019 00:00
Conclusions: Methodologically, it is valid to treat rural-urban codes directly as continuous variables in cancer studies, in addition to converting them into categories. This proposed continuous-variable method offers researchers more flexibility in their choice of analytic methods and preserves the...
Tue Mar 26, 2019 00:00
Authors: Zeyi Ai Shuyuan Liu Fengfeng Qu Haojie Zhang Yuqiong Chen Dejiang Ni The transcellular transport and metabolism of eight green tea catechins (GTCs) were studied in Caco-2 monolayers, with the aim of investigating the effect of cis–trans isomerism on the membrane permeability...
Tue Mar 26, 2019 10:49
Conclusions: The findings suggest that the prevalence of pain acceptance is relatively low for Chinese cancer patients. The cancer pain acceptance is affected by age, gender, pain duration, number of pain sites, and duration of taking analgesics. The acceptance of cancer pain is negatively correlated...
Tue Mar 26, 2019 10:11
No abstract available (Source: Journal of Bronchology and Interventional Pulmonology)
Tue Mar 26, 2019 10:11
Since the development of third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors for lung cancer treatment, the need for a rebiopsy has increased. To select an appropriate therapeutic regimen, the genetic alterations in cancerous tissue should be determined. A rebiopsy plays...
Tue Mar 26, 2019 10:11
Conclusion: Genetic mutation analysis can be performed on malignant pleural effusions secondary to lung adenocarcinoma, independent of fluid volume. (Source: Journal of Bronchology and Interventional Pulmonology)
Tue Mar 26, 2019 10:11
Optimizing the Approach to Patients With Pleural Effusion and Radiologic Findings Suspect for Cancer
The objective of this study was to evaluate whether concurrent thoracentesis and tissue biopsy is superior to sequential sampling. Methods: Retrospective chart review was performed for patients who had a pleural cytology from May 2014 until January 2017. Patients without parenchymal, pleural, or mediastinal...
Tue Mar 26, 2019 10:11
Conclusion: We conclude that BTVA may have a future role in the treatment of lung cancer and should be investigated further in clinical trials. (Source: Journal of Bronchology and Interventional Pulmonology)
Tue Mar 26, 2019 10:11
No abstract available (Source: Journal of Bronchology and Interventional Pulmonology)
Tue Mar 26, 2019 09:27
Authors: Chen K, Kang G, Zhao H, Zhang K, Zhang J, Yang F, Wang J Abstract INTRODUCTION: Liquid biopsy is a promising method for the management of lung cancer, but previous studies focused mainly on patients with advanced-stage disease. As the methodology has progressed for the detection of...
Tue Mar 26, 2019 09:08
CONCLUSION While further investigation of conservative treatment is ongoing, patients considering this approach should be advised and managed according to study methods and related guidelines to promote informed shared decision-making and optimize their chance of similar outcomes as described in published...
Tue Mar 26, 2019 09:05
Conclusion: Optical density ratio can serve as an additional test to differentiate between choroidal melanoma and choroidal metastases. (Source: RETINA)
Tue Mar 26, 2019 09:05
No abstract available (Source: International Ophthalmology Clinics)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Mar 26, 2019 09:05
No abstract available (Source: International Ophthalmology Clinics)
Tue Mar 26, 2019 09:05
No abstract available (Source: International Ophthalmology Clinics)
Mon Mar 25, 2019 01:00
The purpose/aim of this study was to 1) use magnetic resonance diffusion tensor imaging (DTI), fibre bundle/tract-based spatial statistics (TBSS) and machine learning methods to study changes in the white matt... (Source: Cancer Imaging)
Mon Mar 25, 2019 01:00
Following publication of the original (Source: BMC Pulmonary Medicine)
Mon Mar 25, 2019 01:00
European guidelines for cervical cancer screening now recommend the use of clinically validated assays for high-risk HPV-DNA sequences as primary test in women older than 30 years, performed in centralized lab... (Source: BMC Women's Health)MedWorm Message: Have you tried our new medical search engine?...
Tue Mar 26, 2019 00:00
ConclusionsOur patient developed thyroiditis during cancer treatment with nivolumab and subsequently exhibited isolated adrenocorticotropic hormone deficiency 4 months after discontinuing the drug. Administration of nivolumab in combination with a genetic predisposition to polyglandular autoimmunity...
Mon Mar 25, 2019 00:00
(Source: Digestive and Liver Disease)
Mon Mar 25, 2019 00:00
This retrospective study was performed to review 1038 patients who underwent mandibular reconstruction with free vascularized bone flaps at a single institution between 2006 and 2017. Of these patients, 827 (79.67%) had fibula flaps, 197 (18.98%) had deep circumflex iliac artery perforator (DCIA) flaps,...
Mon Mar 25, 2019 00:00
(Source: Digestive and Liver Disease)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Mon Mar 25, 2019 00:00
Semin Liver Dis DOI: 10.1055/s-0039-1678727Immune dysregulation and accumulation of leukocytes is a hallmark of adult chronic liver diseases. Progressive hepatic inflammation can lead to fibrosis and cirrhosis with a high risk of liver failure or hepatocellular cancer (HCC). Recent advances have been...
Tue Mar 26, 2019 07:34
In this study, we examined the importance of neutrophils and the neutrophil-derived DAMP protein, MRP14, in antibody production. Splenic neutrophils and MRP14 that are present in the splenic peri-MZ region have a close contact with MZ B cells and promote their differentiation into plasma cells. Using...
Tue Mar 26, 2019 00:00
AbstractMailed outreach promoting colorectal cancer (CRC) screening with a stool blood test kit may increase participation, but magnitude and consistency of benefit of this intervention strategy is uncertain. Our aim was to conduct a systematic review and meta-analysis of randomized controlled trials...
Mon Mar 25, 2019 00:00
Conclusions The worldwide adherence to surveillance colonoscopy guidelines was low, with more than 50 % of patients undergoing repeat colonoscopies either too early or too late. Early repeat colonoscopies occurred with the highest frequency for patients in whom only hyperplastic polyps or low risk adenomas...
Mon Mar 25, 2019 00:00
(Source: Digestive and Liver Disease)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Mon Mar 25, 2019 00:00
Endoscopic submucosal dissection (ESD) is becoming the preferred method for certain early GI malignances; however, very few U.S. physicians have adopted this technique. This is in part due to the technically challenging nature of the procedure and the long learning curve. Several endoscopic robots are...
Mon Mar 25, 2019 00:00
Authors: Rominiyi Al-Tamimi Collis In this perspective, we congratulate the international efforts to highlight critical challenges in brain tumor research through a recent Consensus Statement. We also illustrate the importance of developing more accurate and clinically relevant early...
Mon Mar 25, 2019 00:00
Drug Res (Stuttg) DOI: 10.1055/a-0855-8464Chitosan-coated magnetic nanoparticles are an appropriate drug delivery method which can improve the therapeutic properties of chemotherapy agents and also can be useful as MRI contrast agent for early cancer diagnosis. This research discovers the optimization...
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