Wednesday, January 16, 2019

PROTAC-mediated crosstalk between E3 ligases

Chem. Commun., 2019, Accepted Manuscript
DOI: 10.1039/C8CC09541H, Communication
Christian Steinebach, Hannes Kehm, Stefanie Lindner, Lan Phuong Vu, Simon Köpff, Álvaro López Mármol, Corinna Weiler, Karl G Wahner, Michaela Reichenzeller, Jan Krönke, Michael Gütschow
Small-molecule heterobifunctional degraders can effectively control protein levels and are useful research tools. We assembled proteolysis targeting chimeras (PROTACs) from a cereblon (CRBN) and a von-Hippel-Lindau (VHL) ligase ligand and...
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