Tuesday, January 29, 2019

Lewis Acid-Catalyzed Annulative Partial Dimerization of 3-Aryloxyacrylates to 4-Arylchroman-2-ones: Synthesis of Analogues of Tolterodine, RORγ Inhibitor and a GPR40 Agonist

Chem. Commun., 2019, Accepted Manuscript
DOI: 10.1039/C8CC09785B, Communication
Rodney Agustinho Fernandes, Rupesh A Kunkalkar
A beguiling annulative partial dimerization of 3-aryloxyacrylates to 4-arylchroman-2-ones catalyzed by Lewis acid (BF3·OEt2) has been developed. The reaction involves two molecules of 3-aryloxyacrylate, resulting in the loss of one...
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