Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study

alexandrossfakianakis shared this article with you from Inoreader Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study via International Journal of Epidemiology - Advance Access Abstract Background Low vitamin D status is often associated with systemic low-grade inflammation as reflected by elevated C-reactive protein (CRP) levels. We investigated the causality and direction of the association between vitamin D status and CRP using linear and non-linear Mendelian randomization (MR) analyses. Methods MR analyses were conducted using data from 294 970 unrelated participants of White-British ancestry from the UK Biobank. Serum 25-hydroxyvitamin D [25(OH)D] and CRP concentrations were instrumented using 35 and 46 genome-wide significant variants, respectively. Results In non-linear MR analysis, genetically predicted serum 25(OH)D had an L-shaped association with serum CRP, where CRP levels decreased sharply with increasing 25(OH)D concentration for participants within the deficiency range (<25 nmol/L) and levelled off at ∼50 nmol/L of 25(OH)D (Pnon-linear� ��= 1.49E-4). Analyses using several pleiotropy-robust methods provided consistent results in stratified MR analyses, confirming the inverse association between 25(OH)D and CRP in the deficiency range (P = 1.10E-05) but not with higher concentrations. Neither linear or non-linear MR analysis supported a causal effect of serum CRP level on 25(OH)D concentration (Plinear = 0.32 and Pnon-linear = 0.76). Conclusion The observed association between 25(OH)D and CRP is likely to be caused by vitamin D deficiency. Correction of low vitamin D status may reduce chronic inflammation. View on Web

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p53 missense mutant G242A subverts natural killer cells in sheltering mouse breast cancer cells against immune rejection

alexandrossfakianakis shared this article with you from Inoreader p53 missense mutant G242A subverts natural killer cells in sheltering mouse breast cancer cells against immune rejection via ScienceDirect Publication: Experimental Cell Research Publication date: Available online 18 May 2022 Source: Experimental Cell Research Author(s): Mohammad B. Uddin, Kartik R. Roy, Ronald A. Hill, Sagor C. Roy, Xin Gu, Li Li, Qian-Jin Zhang, Zongbing You, Yong-Yu Liu View on Web

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Endoscopic modified transseptal bi-nostril approach for pituitary tumors. Efficacy of complex preservation of every turbinate and olfaction: A STROBE analysis

alexandrossfakianakis shared this article with you from Inoreader Endoscopic modified transseptal bi-nostril approach for pituitary tumors. Efficacy of complex preservation of every turbinate and olfaction: A STROBE analysis via ScienceDirect Publication: European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online 18 May 2022 Source: European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): T. Takeda, K. Omura, E. Mori, R. Mori, Y. Ishii, N. Otori View on Web

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High dose chemoradiotherapy increases chance of organ preservation with satisfactory functional outcome for rectal cancer

alexandrossfakianakis shared this article with you from Inoreader High dose chemoradiotherapy increases chance of organ preservation with satisfactory functional outcome for rectal cancer via Radiation Oncology - Latest Articles High dose chemoradiotherapy offers a curative chance for patients with rectal cancer that are unfit or unwilling to undergo surgical resection, yet its long-term survival and functional outcomes have been rare... View on Web

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Transcranial electric and acoustic stimulation for tinnitus: study protocol for a randomized double-blind controlled trial assessing the influence of combined transcranial random noise and acoustic stimulation on tinnitus loudness and distress

alexandrossfakianakis shared this article with you from Inoreader Transcranial electric and acoustic stimulation for tinnitus: study protocol for a randomized double-blind controlled trial assessing the influence of combined transcranial random noise and acoustic stimulation on tinnitus loudness and distress via Trials - Latest Articles Tinnitus is the result of aberrant neuronal activity. As a novel treatment form, neuromodulation is used to modify neuronal activity of brain areas involved in tinnitus generation. Among the different forms of... View on Web

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PD-L1 expression in 117 sinonasal mucosal melanomas and its association with clinical outcome

alexandrossfakianakis shared this article with you from Inoreader PD-L1 expression in 117 sinonasal mucosal melanomas and its association with clinical outcome via Annals of Diagnostic Pathology Publication date: Available online 18 May 2022 Source: Annals of Diagnostic Pathology Author(s): Lining Wang, Honggang Liu View on Web

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‘T4b’ or not to ‘T4b’: addressing the resectability in T4b oral cavity squamous cell carcinoma

alexandrossfakianakis shared this article with you from Inoreader 'T4b' or not to 'T4b': addressing the resectability in T4b oral cavity squamous cell carcinoma via International Journal of Oral and Maxillofacial Surgery via MedWorm.com The treatment and management of patients with T4b oral cavity squamous cell carcinoma (OCSCC) has always been a strong topic of discussion and we commend the efforts made by Kumar et al.1 in their study assessing the role of the structures involved in T4b OCSCC. The authors performed a retrospective analysis of T4 OCSCC treated with surgery and the structures involved, and a comparative survival analysis was done. We are thankful to the authors for sharing their results, which may have therapeutic implications in addressing the surgical resection of T4b OCSCC. (Source: International Journal of Oral and Maxillofacial Surgery) View on Web

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Infrahyoid myocutaneous flap in head and neck reconstruction: a systematic review and meta-analysis

alexandrossfakianakis shared this article with you from Inoreader Infrahyoid myocutaneous flap in head and neck reconstruction: a systematic review and meta-analysis via International Journal of Oral and Maxillofacial Surgery via MedWorm.com The aim of this systematic review and meta-analysis was to analyse the literature on the infrahyoid myocutaneous flap (IHMCF) and evaluate its clinical outcomes. The MEDLINE, Embase, Web of Science, Cochrane Library, and Scopus databases were searched (inception to December 31, 2021). Meta-analyses were then conducted to estimate the overall rates of partial flap loss, total flap loss, salivary fistula, and surgical revision. The 21 studies that met the inclusion criteria included 768 patients undergoing head and neck reconstruction with 773 IHMCF. (Source: International Journal of Oral and Maxillofacial Surgery) View on Web

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Posterior tibial artery flap versus radial forearm flap in oral cavity reconstruction and donor site morbidity

alexandrossfakianakis shared this article with you from Inoreader Posterior tibial artery flap versus radial forearm flap in oral cavity reconstruction and donor site morbidity via International Journal of Oral and Maxillofacial Surgery via MedWorm.com The repair of soft tissue defects after oral cavity cancer resection is challenging. The aim of this study was to compare the outcomes and donor site morbidity of the radial forearm free flap (RFF) and posterior tibial artery perforator flap (PTAF) for oral cavity reconstruction after cancer ablation. All patients who underwent oral cavity reconstruction with a RFF or PTAF between January 2017 and December 2019 were included retrospectively in this study. All flaps were harvested with a long adipofascial extension. (Source: International Journal of Oral and Maxillofacial Surgery) View on Web

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Unignorable public health risk of avian influenza virus during COVID‐19 pandemic

alexandrossfakianakis shared this article with you from Inoreader Unignorable public health risk of avian influenza virus during COVID‐19 pandemic via Journal of Medical Virology Abstract Human infections with the newly emerging reassortant H5N6 avian influenza viruses (AIV) were reported1. AIV has been prevalent persistently worldwide, which results in a devastating impact on the poultry industry and even public health. Highly pathogenic AIV (HPAIV), including H5Ny lineages (H5N1, H5N2, H5N6, and H5N8) and H7N9 subtype, exhibit severe disease phenotype with high morbidity and mortality rates in birds, especially chickens. Although H9N2 AIV only could induce mild or no obvious clinical signs in poultry, the enlarged host species of H9N2 AIV could induce the potential threat to global health2 In late 2019, the novel coronavirus disease (COVID-19) broke out and swept the world population. Drastic mitigation measures were implemented among the international community to stop the COVID-19 crisis, including mass quarantine, physical distancing, and face mask usage. However, the elevated trend of human infections with the emer ging AIV during ongoing COVID-19 circulation still highlights the alert of the possible risk for the next human pandemic3. This article is protected by copyright. All rights reserved. View on Web

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Reducing gender differences in student motivational‐affective factors: A meta‐analysis of school‐based interventions

alexandrossfakianakis shared this article with you from Inoreader Reducing gender differences in student motivational‐affective factors: A meta‐analysis of school‐based interventions via British Journal of Educational Psychology Abstract Background Research shows that gender differences tend to exist in student motivational-affective factors in core subjects such as math, science or reading, where one gender is stereotypically disadvantaged. Aims This study aimed to investigate strategies that could reduce these gender differences by conducting a meta-analysis on school-based intervention studies that targeted student motivational-affective factors. We therefore evaluated whether interventions had differential effects for male and female students' motivational-affective factors in a given academic subject. We also evaluated potential moderator variables. Method After conducting a systematic database search and screening abstracts for inclusion, we synthesized 71 effect sizes from 20 primary studies. All included studies were conducted in science or mathematics-related subjects, which are stereotypically female-disadvantaged. Results While the interventions had significant positive effects for both genders, there was no statistically significant difference between the two genders with regard to the intervention effects on motivational-affective factors. However, the descriptive effect size for female students (g = .49) was far greater than for male students (g = .28). Moderator analyses showed no significant effects for grade level, intervention duration, or school subject, but there was a significant influence of intervention method used. Conclusions This study demonstrated that school-based interventions have positive effects on motivational-affective factors for both genders. It also provides evidence that interventions in subjects where female students are stereotypically disadvantaged may have greater effects for females than for males. Implications and suggestions for future research are discussed. View on Web

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