Treatment planning comparison in the PROTECT-trial randomising proton versus photon beam therapy in oesophageal cancer: results from eight european centres

alexandrossfakianakis shared this article with you from Inoreader Treatment planning comparison in the PROTECT-trial randomising proton versus photon beam therapy in oesophageal cancer: results from eight european centres Via radiotheraphy Publication date: Available online 2 May 2022 Source: Radiotherapy and Oncology Author(s): Lone Hoffmann, Hanna Mortensen, Muhammad Shamshad, Maaike Berbee, Nicola Bizzocchi, Rebecca Bütof, Richard Canters, Gilles Defraene, Mai Lykkegaard Ehmsen, Francesca Fiorini, Karin Haustermans, Ryan Hulley, Erik W. Korevaar, Matthew Clarke, Sebastian Makocki, Christina T. Muijs, Luke Murray, Owen Nicholas, Marianne Nordsmark, Ganesh Radhakrishna View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Angled ball and locator attachments for immediate loaded inclined implants used to retain maxillary overdentures: A cross over study of patient satisfaction and oral health related quality of life

alexandrossfakianakis shared this article with you from Inoreader Angled ball and locator attachments for immediate loaded inclined implants used to retain maxillary overdentures: A cross over study of patient satisfaction and oral health related quality of life Via Clinical Implant Dentistry and Related Research Abstract Objectives The aim of this was to compare the influence of two different angulated abutment designs on patient satisfaction, oral health-related quality of life, and prosthetic aspects of implant-supported maxillary overdentures. Materials and Methods For this cross-over study, 18 patients with completely edentulous maxillary ridges opposing implant-retained mandibular overdentures received 4 implants between the maxillary sinuses using computer-guided surgery. The anterior implants were installed at canine/lateral incisor areas and inclined 15° labially. The posterior implants were inserted just anterior to the maxillary sinuses and inclined 15o distally. Eight patients received maxillary overdentures retained by angled ball attachment (ball overdenture [BOD]) and angled locator attachment in random order. After 6 months, patients indicated satisfaction with their prosthesis using a visual analog scale (VAS), and oral health impact profile (OHIP-14). Moreover, postinsertion prosthodontic maintenance and complications were recorded for both attachments. Comparisons of patient satisfaction and prosthetic complications between groups were performed using the Wilcoxon matched-pairs test and the McNemar test, respectively. Results Locator overdenture (LOD) recorded significantly higher scores than the BOD group regarding all the VAS questions except for ease of cleaning (p < 0.007). LOD recorded significantly higher patient satisfaction regarding the pronunciation of sounds (p = 0.009), painful aching (p = 0.018), feeling tense (p = 0.011), unsatisfactory diet (p = 0.013), irritability with people (p = 0.005), and life in general (p = 0.004). The most common complications were matrix activation/renewal (n = 34). BOD showed a significantly higher incidence of attachment loosening (p = 0.002), and teeth fracture (p = 0.049) than LOD. LOD showed a significantly higher incidence of attachment wear and replacement than BOD (p <0.001). There was no difference between groups regarding soft tissue complications. Conclusion Within the limitations of this study, and in terms of improved patient-centered outcomes, angled locator attachments are recommended to retain maxillary implant overdentures opposed by implant retained mandibular overdentures at it was associated with increased patient satisfaction and oral health-related quality of life than angled ball attachments. However, locator attachment was associated with more postinsertion prosthodontic maintenance than ball attachment. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The effect of (-)-epigallocatechin gallate as an adjunct to non-surgical periodontal treatment: a randomized clinical trial

alexandrossfakianakis shared this article with you from Inoreader The effect of (-)-epigallocatechin gallate as an adjunct to non-surgical periodontal treatment: a randomized clinical trial Via Trials - Latest Articles EGCG is proven to be of good effect to relieve periodontal inflammation, but it has not been applied as a local delivery medicine in patients with periodontitis widely. The aim of this clinical trial was to ev... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Incidences and characteristics of primary lung malignancies in childhood i

alexandrossfakianakis shared this article with you from Inoreader Incidences and characteristics of primary lung malignancies in childhood in Germany: An analysis of population‐based data from German cancer registries Via Pediatric Blood & Cancer Abstract Background: Primary lung malignancies are a heterogeneous group of cancers that occur very rarely in childhood. Due to limited knowledge of their epidemiologic and clinical features, these tumors present a challenge to the treating physicians. This study aimed to increase the knowledge about the occurrence of primary lung malignancies in childhood in Germany. Materials and methods: Pseudonymized data of cases recorded at the German Center for Cancer Registry Data (ZfKD) between 1990 and 2017 were retrieved. Primary lung malignancies were identified using the ICD- and ICD-O classification. Numbers were compared to those reported to the German Childhood Cancer Registry (GCCR). Crude incidence rates were calculated using the ZfKD database. Results: A total of 168 patients diagnosed with primary lung malignancies in the age below 19 years were identified from the ZfKD. The median age at diagnosis was 13 years. The most common tumor entities were lung carcinoids (n = 49), lung carcinoma (n = 36), and pleuropulmonary blastoma (n = 14). An unexpected accumulation of lung cancer cases was noted in the first year of life without a clearly specified histopathological diagnosis. A substantial discrepancy in the numbers of primary lung malignancies between ZfKD and GCCR was found. Conclusions: We present population-based data on the occurrence of primary childhood lung malignancies in Germany, which were more frequent than previously anticipated but likely remained underreported. For better understanding and optimal treatment of these entities, cancer registration needs to be improved through mandatory reporting to the GCCR and regular data sharing between GCCR, population-based and clinical cancer registries. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Emergence of dalbavancin, vancomycin, and daptomycin non-susceptible Staphylococcus aureus in a patient treated with dalbavancin: Case report and isolate characterization

alexandrossfakianakis shared this article with you from Inoreader Emergence of dalbavancin, vancomycin, and daptomycin non-susceptible Staphylococcus aureus in a patient treated with dalbavancin: Case report and isolate characterization Via Clinical Infectious Diseases Advance Access Abstract A patient with end-stage renal disease received 2 doses of dalbavancin for methicillin-resistant Staphylococcus aureus arteriovenous fistula infection and presented 5-weeks later with infective endocarditis secondary to vancomycin, daptomycin, and dalbavancin non-susceptible MRSA. Resistance was associated with walK and scrA mutations, reduced long-chain lipid content, and reduced membrane fluidity. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Unsuspected clonal spread of Methicillin-resistant Staphylococcus aureus causing bloodstream infections in hospitalized adults detected using whole genome sequencing

alexandrossfakianakis shared this article with you from Inoreader Unsuspected clonal spread of Methicillin-resistant Staphylococcus aureus causing bloodstream infections in hospitalized adults detected using whole genome sequencing Via Clinical Infectious Diseases Advance Access Abstract Background Though detection of transmission clusters of methicillin-resistant Staphylococcus aureus (MRSA) infections is a priority for infection control personnel in hospitals, the transmission dynamics of MRSA among hospitalized patients with bloodstream infections (BSIs) has not been thoroughly studied. Whole genome sequencing (WGS) of MRSA isolates for surveillance is valuable for detecting outbreaks in hospitals, but the bioinformatic approaches used are diverse and difficult to compare. Methods We combined short-read WGS with genotypic, phenotypic, and epidemiological characteristics of 106 MRSA BSI isolates collected for routine microbiological diagnosis from inpatients in two hospitals over 12 months. Clinical data and hospitalization history were abstracted from electronic medical records. We compared three genome sequence alignment strategies to assess similarity in cluster asce rtainment. We conducted logistic regression to measure the probability of predicting prior hospital overlap between clustered patient isolates by the genetic distance of their isolates. Results While the three alignment approaches detected similar results, they showed some variation. A Gene-family-based alignment pipeline was most consistent across MRSA clonal complexes. We identified nine unique clusters of closely related BSI isolates. Most BSI were healthcare-associated and community-onset. Our logistic model showed that with 13 single nucleotide polymorphisms the likelihood that any two patients in a cluster had overlapped in a hospital was 50 percent. Conclusions Multiple clusters of closely related MRSA isolates can be identified using WGS among strains cultured from BSI in two hospitals. Genomic clustering of these infections suggest that transmission resulted from a mix of community spread and healthcare exposures long before BSI diagnosis. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Hypomethylating agent and venetoclax with FLT3 inhibitor “triplet” therapy in older/unfit patients with FLT3 mutated AML

alexandrossfakianakis shared this article with you from Inoreader Hypomethylating agent and venetoclax with FLT3 inhibitor “triplet” therapy in older/unfit patients with <i>FLT3</i> mutated AML Via Blood Cancer Journal - Issue - nature.com science feeds View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Investigating aluminum cookpots as a source of lead exposure

alexandrossfakianakis shared this article with you from Inoreader Investigating aluminum cookpots as a source of lead exposure in Afghan refugee children resettled in the United States Via Journal of Exposure Science and Environmental Epidemiology - Issue - nature.com science feeds Journal of Exposure Science & Environmental Epidemiology, Published online: 02 May 2022; doi:10.1038/s41370-022-00431-y Investigating aluminum cookpots as a source of lead exposure in Afghan refugee children resettled in the United States View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Predicted cardiovascular disease risk and prescribing of antihypertensive therapy among patients with hypertension in Australia using MedicineInsight

alexandrossfakianakis shared this article with you from Inoreader Predicted cardiovascular disease risk and prescribing of antihypertensive therapy among patients with hypertension in Australia using MedicineInsight Via Journal of Human Hypertension - Issue - nature.com science feeds Journal of Human Hypertension, Published online: 02 May 2022; doi:10.1038/s41371-022-00691-z Predicted cardiovascular disease risk and prescribing of antihypertensive therapy among patients with hypertension in Australia using MedicineInsight View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Screening auf Mangelernährung bei Kopf-Hals-Tumor-Patienten vor onkologischer Therapie

alexandrossfakianakis shared this article with you from Inoreader Screening auf Mangelernährung bei Kopf-Hals-Tumor-Patienten vor onkologischer Therapie Via Laryngo-Rhino-Otologie Laryngorhinootologie DOI: 10.1055/a-1823-1143 Hintergrund Patienten mit einem Kopf-Hals-Tumor besitzen ein hohes Risiko, peri- bzw. posttherapeutisch eine Mangelernährung zu entwickeln, die den onkologischen Therapieerfolg entscheidend beeinflussen kann. Prätherapeutisch ist hierüber wenig bekannt. Daher ist das Ziel der vorliegenden Studie die prätherapeutische systematische Erfassung des Ernährungszustandes und des Risikos für das Auftreten einer Mangelernährung. Material und Methoden Bei 102 Kopf-Hals-Tumor-Patienten erfolgte die prätherapeutische Untersuchung des Ernährungszustandes via Body-Mass-Index (BMI) sowie des Risikos für Mangelernährung via „Nutritional Risk Screening" (NRS). An möglichen Einflussfaktoren wurden Tumorstadium, -lokalisation, Patientenalter, -geschlecht und das Bestehen einer oropharyngealen Dysphagie, identifiziert über Flexible Endoskopische Evaluation des Schluckvorgangs (FEES), analysiert. Ergebnisse Eine Mangel- bzw. Unterernährung, bemessen am BMI, bestand prätherapeutisch bei bereits 6% der Patienten, ein Risiko für Mangelernährung laut NRS bei 27%, eine oropharyngeale Dysphagie bei 15%. Nur das Vorliegen einer oropharyngealen Dysphagie erwies sich in der linearen Regression als signifikanter Einflussfaktor auf das Risiko einer Mangelernährung (β = 0,380/3,776; p < 0,001). Schlussfolgerungen Bereits prätherapeutisch besteht ein Risiko einer Mangelernährung bei einem Viertel der Kopf-Hals-Tumor-Patienten. Um dieses frühzeitig zu erkennen und um bereits zu Beginn der onkologischen Therapie Maßnahmen zur ihrer Vermeidung einzuleiten, empfiehlt sich daher bereits prätherapeutisch die Untersuchung des Schluckvermögens sowie das systematische Screening auf Mangelernährung via NRS. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The tight rope act: A multicenter regional experience of tourniquets in acute trauma resuscitation

alexandrossfakianakis shared this article with you from Inoreader The tight rope act: A multicenter regional experience of tourniquets in acute trauma resuscitation Via Journal of Trauma and Acute Care Surgery - Current Issue BACKGROUND As tourniquets have become more prevalent, device use has been questioned. This study sought to characterize the incidence, indication, and efficacy of tourniquet placement in acute trauma resuscitation. METHODS Nine regional level 1 trauma centers prospectively enrolled for 12 months adult patients (18 years or older) who had a tourniquet placed. Age, sex, mechanism, tourniquet type, indication, applying personnel, location placed, level of occlusion, and degree of hemostasis were collected. Major vascular injury, imaging and operations performed, and outcomes were assessed. Analyses were performed with significance at p View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Extravasation and outcomes in computed tomography and angiography in patients with pelvic fractures requiring transcatheter arterial embolization: A single-center observational study

alexandrossfakianakis shared this article with you from Inoreader Extravasation and outcomes in computed tomography and angiography in patients with pelvic fractures requiring transcatheter arterial embolization: A single-center observational study Via Journal of Trauma and Acute Care Surgery - Current Issue BACKGROUND Extravasation on contrast-enhanced computed tomography (CECT) is a helpful indicator of the need for transcatheter arterial embolization (TAE) for pelvic fractures. However, previous reports were inconsistent on cases in which angiography is necessary, even though there is no extravasation on computed tomography. This study aimed to describe and analyze the contradictory findings in cases where extravasation is observed on angiography but not on CECT, to contribute to improved management of patients with pelvic fractures. METHODS This was a retrospective single-center study. Patients with pelvic fractures who underwent CECT and TAE between 2014 and 2020 were included. We classified the patients into three groups: CECT and angiography with extravasation (CT+Angio+), CECT with no extravasation and angiography with extravasation (CT−Angio+), and CECT with extravasation and angiography without extravasation (CT+Angio−). RESULTS A total of 113 patients were included in the study: the CT+Angio+ group had 54 patients, CT−Angio+ group, 47; and CT+Angio− group, 12. The CT−Angio+ group had a significantly longer time from arrival to CECT than the CT+Angio+ group (27 minutes vs. 23 minutes, p View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.