Sunday, March 13, 2022

Graves' disease diagnosed in remnant thyroid after lobectomy for thyroid cancer

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PLoS One. 2022 Mar 11;17(3):e0265332. doi: 10.1371/journal.pone.0265332. eCollection 2022.

ABSTRACT

BACKGROUND: The coexistence of Graves' disease with thyroid cancer is well-known and total thyroidectomy is recommended in such cases. However, Graves' disease might be dormant at the time of surgery and diagnosed after lobectomy for thyroid cancer.

METHODS: We assessed the incidence and clinicopathological characteristic of newly developed Graves' disease after lobectomy for t hyroid cancer between 2010 and 2019.

RESULTS: In all, 11043 patients underwent lobectomy for thyroid cancer during the study period, and 26 (0.2%) were diagnosed with Graves' disease during follow-up. The median age was 43.8 years, 88.5% were female, and all were euthyroid before surgery. The median time from lobectomy to the diagnosis of Graves' disease was 3.3 years. Half of the patients were diagnosed based on thyroid function tests during routine follow-up, and others were diagnosed due to symptoms of thyrotoxicosis. Among patients who had checked preoperative thyroid autoantibodies, 61.1% showed positivity. Twenty-one (80.8%), and 2 (7.7%) patients received antithyroid drugs and radioactive iodine therapy, respectively, and 3 (11.5%) underwent completion thyroidectomy.

CONCLUSION: Although rare, Graves' disease can occur in the remnant thyroid after lobectomy. Such patients are more likely to have autoantibodies. An appropriate workup is required when hyperthyroidis m is found during the follow-up of patients after lobectomy.

PMID:35275968 | PMC:PMC8916678 | DOI:10.1371/journal.pone.0265332

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Does the Perception of Own Voice Affect Our Behavior?

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This study aimed to investigate what are the factors that influence the perception of one's own voice, and if there are any differences using voice between speaking and singing. Further the study purported to examine how these attitudes affect individuals' vocal behavior in personal and social contexts. A total of 100 participants completed the survey which comprised 23 questions about demographics, music experience, speaking voice, and singing voice. The quantitative data were analyzed by correlations and paired t test.
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Thursday, March 10, 2022

Hearing preservation in cochlear implant recipients: A cross‐sectional cohort study

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Abstract

Objectives

A surge of new developments and research regarding cochlear implants and hearing preservation resulted in several treatment options in the last 5 years. By reviewing our CI population of this period, we aimed to investigate hearing preservation rates and the effect of different treatment options on hearing preservation.

Design

Retrospectively, all adult cochlear implant recipients with preoperative residual hearing at lower frequencies (threshold <80 dB hearing level) in a single tertiary referral centre between 2015 and 2020 were analysed. Patients were classified into four groups based on their hearing preservation outcome. Subsequently, differences between the four groups regarding several patient dependent and independent factors were investigated.

Results

In this study, 140 patients were included, which is 46% of all adult CI recipients. Complete hearing preservation was achieved in 14 patients (10%), and complete loss of residual hearing in 48 patients (34%). The lateral wall array and local application of corticosteroids were associated with better hearing preservation. Intravenous corticosteroids, local hyaluronic acid and surgical experience had no effect on hearing preservation rates. Speech perception was not better in patients with residual hearing.

Conclusion

Approximately half of all adult cochlear implant recipients had residual hearing at lower frequencies before surgery. In current medical practice, only electrode choice seems to have a clear effect on hearing preservation rates. The majority of CI recipients lose their residual hearing after cochlear implantation. Much improvement in treating CI recipients is needed to preserve their residual hearing in the future.

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Porokeratosis: a differential diagnosis to consider in benign lichenoid keratosis

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Int J Clin Exp Pathol. 2022 Feb 15;15(2):56-62. eCollection 2022.

ABSTRACT

Porokeratosis is a disorder of keratinization with many clinical variants. The histological hallmark feature of porokeratosis is a cornoid lamella. Other accompanying features include lichenoid inflammation, atrophy towards the centre of the lesion, dermal cytoid bodies, and adjacent lichenoid changes. Lichenoid keratosis is a benign cutaneous condition, thought to largely represent a degenerating seborrheic keratosis or solar lentigo. The classical histologic appearances are characterized by parakeratosis, epidermal acanthosis, and a dense band of lichenoid lymphocytic infiltrate. Since a lichenoid inflammatory reaction pattern can be seen in porokeratosis it has the potential to be misdiagnosed as a lichenoid keratosis if the cornoid lamella is not identified or missed due to sampling selection. We critically review 104 cases of benign lichenoid keratosis to e stablish whether any of these cases had features to support a diagnosis of porokeratosis. With 9.6% of cases considered for re-classification, we review clues to reaching this histologic diagnosis.

PMID:35265253 | PMC:PMC8902476

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Bilateral vertebral arteries arising distal to the left subclavian artery: embryological and anatomical description

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Surg Radiol Anat. 2022 Mar 9. doi: 10.1007/s00276-022-02903-0. Online ahead of print.

ABSTRACT

Abnormalities in the origin of vertebral arteries are relatively uncommon, but extremely rare when this abnormality happens on both sides. We present an anatomic variation in which both vertebral arteries came from the proximal descending thoracic aorta beyond the left subclavian artery with no other supra-aortic vessels accompanying the abnormality. The right vertebral artery took a retro-oesophageal course (lusoria artery), while the right and the left vertebral arteries enter the transverse foramina at the 7th cervical vertebra. From an embryological point of view, and overall controversial, this anomaly can be explained by the bilateral persistence of the 8th intersegmental artery as the origin of vertebral artery, instead of the dorsal segment of the 7th intersegmental artery being the origin, which is normally the case. The adequate identification of vertebral artery anomalies in complementary explorations is very important to avoid misdiagnosed vertebral occlusions or unexpected vertebral artery injuries during supra-aortic trunks, thyroid, and oesophagus open surgeries, among others, or even over the course of endovascular procedures.

PMID:35266028 | DOI:10.1007/s00276-022-02903-0

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Epidemiology and Management of Zenker Diverticulum in a Low-Threshold Single-payer Health Care System

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This cohort study examines population-wide incidence of Z enker diverticulum in Finland over a 20-year period and management strategies across specialties and treatment settings.
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Defining the limits and indications of the Draf III endoscopic approach to the lateral frontal sinus and maximizing visualization and maneuverability: a cadaveric and radiological study

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Eur Arch Otorhinolaryngol. 2022 Mar 9. doi: 10.1007/s00405-022-07323-9. Online ahead of print.

ABSTRACT

PURPOSE: The DRAF III procedure has been used for access to the lateralmost part of the frontal sinus. We sought to identify anatomical and radiological measurements as well as modifications that predict the lateral limits of visualization and surgical access after this procedure.

METHODS: Seven cadaver heads were imaged with computed tomography scan. The distance from midline to the medial orbital wall (MOWD), midline to the lateral end of the frontal sinus (MLD), the sum of MLDs (SMLD), interorbital distance (IOD) and the shortest anteroposterior distance of the frontal recess (APD) were utilized. The ratios MLD/MOWD, and SMLD/IOD were calculated. The same distances were measured on 41 CT scans. Orbital transposition (OT) and partial resection of the piriform aperture (PAR) were performed; the visualization and reach were ass essed. The angle of insertion was measured before and after the modifications.

RESULTS: Only the ratio MLD/MOWD was consistently predictive of access to the lateral, superior and posterior wall of the frontal sinus. Following the modifications, a visualization of 100% laterally was achieved with the 30- and 45 degree endoscopes and every lateral recess could be reached with the 70 degree suction. A mean increase of the angle of insertion of 25.3 and 59.6% was recorded after OT and PAR, respectively.

CONCLUSIONS: IOD rather than APD defines the limits of the Draf III approach to the lateral frontal sinus and MLD/MOWD ratio can serve as a useful preoperative tool. Along to the already described OT, PAR increases visualization and reach of the lateral frontal sinus.

PMID:35266026 | DOI:10.1007/s00405-022-07323-9

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Kaposiform Hemangioendothelioma of Internal Auditory Canal Presenting in 4-Week-Old Newborn

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This case report describes a rare case of a kaposiform heman gioendothelioma in the internal auditory canal of a 4-week-old newborn.
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Quality Indicators for the Diagnosis and Management of Primary Hyperparathyroidism

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This quality improvement study develops quality indicator s to evaluate the diagnosis and treatment of primary hyperparathyroidism that could measure, improve, and optimize quality of care and outcomes for patients with this disease.
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Chemosensory Psychophysical Evaluation of Gustatory Dysfunction in Patients With Long-Term COVID-19

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This cross-sectional study evaluates self-reported gustat ory dysfunction in patients with long-term COVID-19.
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Use of FDG-PET/CT to Predict Immunotherapy Treatment Response in Patients With OCSCC

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This study assesses whether there are changes on fluoro-[ 18F]-deoxy-2-D-glucose positron emission tomography/computed tomography scans in patients with oral cavity squamous cell cancer receiving neoadjuvant immunotherapy.
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Is a 4-Day Low-Iodine Diet Sufficient for Radioactive Iodine Ablation in Differentiated Thyroid Cancer Treatment?

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Clinical Thyroidology, Volume 34, Issue 3, Page 123-126, March 2022.
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