‘Is It Brain Talking to the Ear’: Neuro-otological Evaluation of Tinnitus Using Auditory Brainstem Response Audiometry

xlomafota13 shared this article with you from Inoreader 'Is It Brain Talking to the Ear': Neuro-otological Evaluation of Tinnitus Using Auditory Brainstem Response Audiometry Via Otolaryngology Indian Abstract Tinnitus is hypothesized to be an auditory phantom phenomenon resulting from spontaneous neuronal activity somewhere along the auditory pathway. The neural abnormalities underlying tinnitus are largely unknown. We evaluated the functional characteristics and the auditory system synchronization using Auditory Brainstem Response (ABR) in normal hearing tinnitus patients. In this observational comparative cross-sectional study, patients with chief complaints of Tinnitus and equal number of age and sex matched controls without hearing loss and tinnitus were enrolled. All patients underwent a full ENT assessment, pure tone audiometry and Brainstem evoked response audiometry (BERA) tests. The study population consisted of 100 patients with tinnitus, 55 controls without tinnitus and 45 controls with tinnitus. Statistical analysis showed significant relation (p < 0.05) between hearing loss and tinnitus between cases and controls with tinnitus, between abs olute latency of wave III amongst cases and controls without tinnitus, Interpeak Latency between wave III and V amongst cases and controls with tinnitus and interpeak latency of wave I and wave III amongst controls without and with tinnitus. Brainstem evoked response audiometry results that we obtained from the patients of tinnitus and controls with and without tinnitus are different from one person to another. This suggests impaired neural firing synchronization and transmission in the central auditory pathway in tinnitus patients. These findings also indicate that the pathology underlying tinnitus is not the same in every individual, with possible brainstem involvement in some cases. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Neck Dissection in Salvage Surgery for Larynx Cancer: National Cancer Database Review

xlomafota13 shared this article with you from Inoreader Neck Dissection in Salvage Surgery for Larynx Cancer: National Cancer Database Review Via otol rhinol Ann Otol Rhinol Laryngol. 2021 Jun 10:34894211024062. doi: 10.1177/00034894211024062. Online ahead of print. ABSTRACT OBJECTIVE: Salvage laryngeal surgery is the preferred treatment after failure of non-surgical treatment of larynx cancer. This study aims to identify the impact of ND in salvage surgery on survival and factors predictive of nodal metastasis. METHODS: The National Cancer Database was used to identify patients who received salvage laryngeal surgery. Demog raphics, disease characteristics, and survival were compared between the subgroups of patients stratified according to performance of ND and presence of nodal metastasis. RESULTS: Sixty-two percent of patients underwent ND. A total of 26% of patients undergoing ND had nodal metastasis. Younger age and lesser time since radiation were associated with nodal metastasis. While undergoing ND did not significantly affect survival, those with nodal metastasis had poorer survival (P = .001). CONCLUSIONS: Although ND did not show a survival benefit, younger patients and those who have had a shorter time elapsed between the start of radiation and salvage surgery may benefit from the prognostic data provided by ND. Nonetheless, the risks and benefits of elective ND in salvage larynx cancer treatment should be evaluated on an individual case basis as the data do not support a broadly applicable recommendation. PMID:34111981 | DOI:10.1177/00034894211024062 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Gorham Stout disease of the temporal bone with cerebrospinal fluid leak

xlomafota13 shared this article with you from Inoreader Gorham Stout disease of the temporal bone with cerebrospinal fluid leak Via leak of cerebrospinal fluid Childs Nerv Syst. 2021 Jun 11. doi: 10.1007/s00381-021-05245-1. Online ahead of print. ABSTRACT Gorham Stout disease (GSD) is a rare disease characterized by the proliferation of endothelial lined vessels and replacement of bone by fibrous tissue. The main imaging features are progressive osteolysis and cortical resorption. Temporal bone involvement is rare but presents as a destructive bone lesion that may be misinterpreted as more common lytic processes in the pediatric population, such as infection or Langerhans cell histiocytosis. GSD of the temporal bone is associated with cerebrospinal fluid (CSF) leaks, may present with otorrhea, and can mimic other causes of ear drainage. Here, we report the clinical course, imaging features, and outcomes of a 3-year-old girl with GSD of the temporal bone presenting with CSF leak initially attributed to infection. PMID:34115176 | DOI:10.1007/s00381-021-05245-1 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Actinomycosis of the nasal cavity

xlomafota13 shared this article with you from Inoreader Actinomycosis of the nasal cavity Via Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial Braz J Otorhinolaryngol. 2021 May 25:S1808-8694(21)00088-4. doi: 10.1016/j.bjorl.2021.05.003. Online ahead of print. ABSTRACT INTRODUCTION: Actinomycosis of the nasal cavity is very rare. OBJECTIVE: The purpose of this study was to investigate the clinical features, treatment methods, and treatment results of actinomycosis of the nasal cavity in our hospital. METHODS: We retrospectively enrolled 11 patients with histopathologically identified actinomycosis of the nasal cavity from January 2010 to May 2020. RESULTS: This study included five males and six females. The most common symptom was purulent nasal discharge (36.4%). Nasal actinomycosis occurred in the maxillary sinus in 5 (45.5%) patients, the ethmoid sinus in two, the hard palate in two, the frontal sinus in one, and the nasal septum in one. After surgery, intravenous administration of antibiotics was performed on average for 7.4 days and oral antibiotics were prescribed for about 120.5 days. The clinical characteristics of the patients with nasal actinomycosis and the duration of antibiotic usage were not significantly different. Trauma was significantly associated with repeated nasal actinomycosis infections (p < 0.05). CONCLUSION: Actinomycosis of the nasal cavity should be suspected when a patient with chronic sinusitis does not respond to medical therapy and has a history of dental treatment, local surgery or radiation therapy. Nasal can be sufficiently treated with antibiotics and endoscopic surgery. PMID:34112606 | DOI:10.1016/ j.bjorl.2021.05.003 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Effectiveness of a Blended-Learning Intervention in Teachers’ Vocal Health

xlomafota13 shared this article with you from Inoreader Effectiveness of a Blended-Learning Intervention in Teachers' Vocal Health Via Journal of Voice To verify the effectiveness of a blended-learning voice assistance program for elementary school teachers. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Francis Kiernan (1800-1874) and his unique contribution to liver anatomy

xlomafota13 shared this article with you from Inoreader Francis Kiernan (1800-1874) and his unique contribution to liver anatomy Via radiol anat Surg Radiol Anat. 2021 Jun 11. doi: 10.1007/s00276-021-02779-6. Online ahead of print. NO ABSTRACT PMID:34115178 | DOI:10.1007/s00276-021-02779-6 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Epidermal growth factor as a potential prognostic and predictive biomarker of response to platinum-based chemotherapy

xlomafota13 shared this article with you from Inoreader Epidermal growth factor as a potential prognostic and predictive biomarker of response to platinum-based chemotherapy Via Head and neck cancers by Margot Geens, Sofie Stappers, Heleen Konings, Benedicte Y. De Winter, Pol Specenier, Jan P. Van Meerbeeck, Gert A. Verpooten, Steven Abrams, Annelies Janssens, Marc Peeters, Paul Van de Heyning, Olivier M. Vanderveken, Kristien J. Ledeganck In this study, we investigated serum epidermal growth factor (EGF) in an oncological population of head- and neck and pulmonary neoplasms and whether serum EGF could serve as a prognostic marker of survival and as a predictive marker for treatment response to platinum-based chemotherapy. A total of 59 oncological patients and a control group of age- and sex-matched healthy volunteers were included in this study. Pre-treatment serum EGF from both groups was determined. Patient's and tumour characteristics and mortality were recorded during a 5-year follow up period. Baseline serum EGF significantly differed between the oncological patients and the healthy volunteers (p View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

REM-related obstructive sleep apnea and vertigo: A retrospective case-control study

xlomafota13 shared this article with you from Inoreader REM-related obstructive sleep apnea and vertigo: A retrospective case-control study Via Tinnitus by Po-Yueh Chen, Tzu-Ying Chen, Pin-Zhir Chao, Wen-Te Liu, Chyi-Huey Bai, Sheng-Teng Tsao, Yi-Chih Lin Background In recent population-based case-control studies, sleep apnea was significantly associated with a higher incidence (hazard ratio, 1.71) of vertigo and the risk of tinnitus was found to increase 1.36 times in patients with sleep apnea. The possibility that obstructive sleep apnea (OSA) might affect neurotological consequences was not noticed, until studies using polysomnography (PSG) for these patients. Objectives The purpose of this study was to investigate the relationship between vertigo and OSA. Methods The collected data among patients from May 1st, 2018 to October 31th, 2018 at Shuang Ho Hospital. Eligibility criteria included an age older than 20 years, a diagnosis of obstructive sleep apnea. The diagnosis of OSA was defined as an oxygen desaturation index of at least 5, was established with the use of polysomnographic examination at hospital. Patients were excluded from the study if they had head injury, brain tumour, headache history and hearing los s. Patients who had vertigo were labeled as Vertigo group. In the other hand, patients who had no dizziness were labeled as control group. 58 patients were in the Vertigo group, and 113 were in the control group. Results After PSG examination, 58 patients who had vertigo, were diagnosed OSA (29 males, average age = 57.07 years old, BMI = 26.64, RDI = 24.69, ESS = 8.65), and 24 patients of them (41.3%) were REM-related OSA. Meanwhile, in the control group, 113 patients had OSA (92male, average age = 49.66 years old, BMI = 26.06, RDI = 35.19, ESS = 11.43), and 18 patients of them (15.9%) were REM-related OSA (Table 1). Therefore, patient who had vertigo, would have higher proportion of REM OSA (P Conclusions The vertigo patients have a higher rate of REM-related OSA, and the acceptance rate to CPAP use is low. Further research is needed to explore novel therapeutic approaches, or combination of currently available non-CPAP therapies, in patients with REM OSA. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Clinical Validation of the Champagne Algorithm for Evoked Response Source Localization in Magnetoencephalography

xlomafota13 shared this article with you from Inoreader Clinical Validation of the Champagne Algorithm for Evoked Response Source Localization in Magnetoencephalography Via cortical auditory Brain Topogr. 2021 Jun 11. doi: 10.1007/s10548-021-00850-4. Online ahead of print. ABSTRACT Magnetoencephalography (MEG) is a robust method for non-invasive functional brain mapping of sensory cortices due to its exceptional spatial and temporal resolution. The clinical standard for MEG source localization of functional landmarks from sensory evoked responses is the equivalent current dipole (ECD) localization algorithm, known to be sensitive to initialization, noise, and manual choice of the number of dipoles. Recently many automated and robust algorithms have been developed, including the Champagne algorithm, an empirical Bayesian algorithm, with powerful abilities for MEG source reconstruction and time course estimation (Wipf et al. 2010; Owen et al. 2012). Here, we evaluate automated Champagne performance in a clinical population of tumor patients where there was minimal failure in localizing sensory evoked responses using the clinical st andard, ECD localization algorithm. MEG data of auditory evoked potentials and somatosensory evoked potentials from 21 brain tumor patients were analyzed using Champagne, and these results were compared with equivalent current dipole (ECD) fit. Across both somatosensory and auditory evoked field localization, we found there was a strong agreement between Champagne and ECD localizations in all cases. Given resolution of 8mm voxel size, peak source localizations from Champagne were below 10mm of ECD peak source localization. The Champagne algorithm provides a robust and automated alternative to manual ECD fits for clinical localization of sensory evoked potentials and can contribute to improved clinical MEG data processing workflows. PMID:34114168 | DOI:10.1007/s10548-021-00850-4 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Conventional approaches versus laser CO2 surgery in stapes surgery: a multicentre retrospective study

xlomafota13 shared this article with you from Inoreader Conventional approaches versus laser CO2 surgery in stapes surgery: a multicentre retrospective study Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Jun 11. doi: 10.1007/s00405-021-06926-y. Online ahead of print. ABSTRACT PURPOSE: To analyze and compare surgical and audiological outcomes of conventional approaches versus laser CO2 surgery in stapes surgery. METHODS: 333 patients who underwent stapes surgery were enrolled in the study; the patient population was divided into three groups: group 1: 170 patients treated with conventional stapedotomy with manual microdrill (average age 49.13 years); group 2: 119 patients treated with conventional stapedotomy with electrical microdrill (average age 51.06 years); group 3: 44 patients (average age 50.4 years) who underwent CO2 laser stapedotomy. Intra-operative, postoperative outcomes and audiological results were investigated. RESULTS: The average surgical time of laser CO2 surgery was longer than for other surgical procedures. No statistical differences emerged in post-operative abnormal taste sensation. There was also no difference in postoperative dizziness. Air-bone gap (ABG) went down from 29.7 ± 10 dB (group 1) and 27.32 ± 9.20 (group 2) to 10 ± 6.9 dB (group 1) and 10.7 ± 6.03 dB (group 2). In group 3 the preoperative ABG was lowered from 28.3 ± 10.1 to 11.8 ± 10.9, with a statistical difference in auditory recovery (p = 0.0001); The group of patients treated with laser CO2 showed a percentage of patients with an ABG closure of between 0 and 10 dB higher than in the group treated with manual microdrills (77.2% vs. 60%, respectively; p = 0.03). CONCLUSION: Overall surgical results of CO2 laser and conventional stapedotomy are comparable without any significant difference; however, the group treated with CO2 laser appears to have a percentage of patients with an ABG closure 0-10 dB higher than the group treated using the conventional technique. PMID:34115200 | DOI:10.1007/s00405-021-06926-y View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The pathologic diagnosis of mantle cell lymphoma

xlomafota13 shared this article with you from Inoreader The pathologic diagnosis of mantle cell lymphoma Via Cellular and Molecular Biology Histol Histopathol. 2021 Jun 11:18351. doi: 10.14670/HH-18-351. Online ahead of print. ABSTRACT Mantle cell lymphoma (MCL) is a mature B-cell non-Hodgkin lymphoma usually characterized by t(11;14) (q13;q32), or CCND1 translocation and Cyclin D1 over expression. A very small subset of MCL may lack the t(11;14) (q13;q32) translocation and Cyclin D1 over expression, but show alternative translocations involving CCND2 and CCND3, and over expression of SOX11. In general, MCL has been considered a very aggressive and incurable lymphoma and patients with MCL usually have a poor prognosis. However, indolent variants, including in situ mantle cell neoplasm and the recently recognized leukemic non-nodal MCL do exist. In recent years, genome-wide molecular genetic studies have revealed a characteristic MCL genetic profile. This review will focus on the pathologic diagnosis of MCL using the traditional morphological and immunophenotypic strategies combined with cytogenetic characteristics and recently identified molecular profile. Morphological subtypes, immunophenotypic variants, recently recognized indolent variants, as well as MCL risk stratification will also be discussed. PMID:34114641 | DOI:10.14670/HH-18-351 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.