Elusive Primary in Low Grade Mucoepidermoid Carcinoma: Dilemma of Chronology and Terminology

xlomafota13 shared this article with you from Inoreader Elusive Primary in Low Grade Mucoepidermoid Carcinoma: Dilemma of Chronology and Terminology Via Otolaryngology Indian Abstract Salivary gland tumours constitute an uncommon and diverse group of neoplasms that vary considerably in their histology and biologic behaviour. As per Globocon 2018, salivary gland malignancy account for 0.3% of all cancer cases and 0.2% of all cancer deaths worldwide, reflecting the rarity of these neoplasms. Mucoepidermoid carcinoma (MEC) is a common malignant tumour of major and minor salivary gland, which comprises about 10% of all salivary gland neoplasms and approximately 35% of malignant salivary gland neoplasms. While three fourth of cases of MEC arise in the parotid, they account for a large proportion of salivary gland neoplasms occurring in minor salivary glands. Appending to the uncommonness, unusual presentations like MEC arising in heterotopic rests of salivary gland tissue in intraparotid or extraparotid lymph nodes, and MEC arising in lingual tonsils have been reported. Such diversity of clinical presentation may present a diagnostic challenge . In this continuum, we report a rare and unique case of low grade mucoepidermoid carcinoma of minor salivary gland, which primarily presented as cervical lymph node metastasis, three years before the primary intraoral lesion occurred. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Dupilumab has an additional benefit in treatment of chronic rhinosinusitis with nasal polyps

xlomafota13 shared this article with you from Inoreader Dupilumab has an additional benefit in treatment of chronic rhinosinusitis with nasal polyps Via hno HNO. 2021 Mar 18. doi: 10.1007/s00106-021-01018-z. Online ahead of print. ABSTRACT BACKGROUND: For patients with severe chronic rhinosinusitis with nasal polyps (CRSwNP) which cannot be controlled by continuous therapy with intranasal corticosteroids (INCS) and systemic corticosteroids and/or surgical treatment, there were no approved curative options for a long time. For CRSwNP treatment with T2-addressing biologics is possible. On October 24, 2019, the European Commission granted extended approval for dupilumab as the first biological agent for treatment of insufficiently controlled severe CRSwNP. The Federal Joint Committee (G‑BA) evaluates the benefits of reimbursable drugs with new active ingredients. This includes assessment of the additional benefit and its therapeutic relevance. METHODS: A meta-analysis was performed using individual patient data based on two phase III studies. Both studies examined the safety and efficacy of dupilumab as an add-on therapy to INCS for treatment of CRSwNP in adults inadequately controlled with systemic corticosteroids and/or surgery compared to INCS alone. RESULTS: Based on the present data, the G‑BA decided that there is an indication of a considerable additional benefit of dupilumab compared to mometasone furoate. CONCLUSION: For patients with severe CRSwNP inadequately controlled with INCS and systemic corticosteroids and/or surgery, there is an indication of a considerable additional be nefit for the administration of dupilumab as an add-on therapy to INCS compared to mometasone furoate alone. PMID:33738558 | DOI:10.1007/s00106-021-01018-z View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Impact of the Paraglottic Space on Voice Production in an MRI-Based Vocal Fold Model

xlomafota13 shared this article with you from Inoreader Impact of the Paraglottic Space on Voice Production in an MRI-Based Vocal Fold Model Via Journal of Voice While the vocal fold is in direct contact anteriorly with the thyroid cartilage, posteriorly the vocal fold connects to the thyroid cartilage through a soft tissue layer in the paraglottic space. Currently the paraglottic space is often neglected in computational models of phonation, in which a fixed boundary condition is often imposed on the lateral surface of the vocal fold. The goal of this study was to investigate the effect of the paraglottic space on voice production in an MRI-based vocal fold model, and how this effect may be counteracted by vocal fold stiffening due to laryngeal muscle activation. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The Effects of Caffeine on Voice: A Systematic Review

xlomafota13 shared this article with you from Inoreader The Effects of Caffeine on Voice: A Systematic Review Via Journal of Voice Caffeine is considered a dehydrating agent due to its diuretic effects and influences the body's fluid balance. The relationship between voice and hydration has been widely investigated and it is accepted that inadequate hydration has detrimental effects on phonation. Since dehydration negatively affects the vocal folds and caffeine is considered a dehydrating agent, it can be hypothesized that voice might be negatively affected by caffeine intake. This systematic review aims to summarize and appraise the available evidence regarding the effects of caffeine on voice. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Evaluation of vestibular function following endolymphatic sac surgery

xlomafota13 shared this article with you from Inoreader Evaluation of vestibular function following endolymphatic sac surgery Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Mar 19. doi: 10.1007/s00405-021-06743-3. Online ahead of print. ABSTRACT PURPOSE: To evaluate objective vestibular function after endolymphatic sac surgery (ELSS) for Menière's disease (MD), using comparative vestibular function tests: videonystagmography (VNG), vestibular evoked myogenic potentials (VEMP) and video head-impulse test (VHIT) METHODS: Patients with definite MD using the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) of 1995 criteria modified in 2015 and treated with ELSS (sac decompression or sac opening) were included. The primary outcome was the preservation of vestibular function, comparing pre- and postoperative vestibular function tests: VNG, VEMP, VHIT. Secondary outcomes were control of episodes of vertigo, hearing outcome using AAO-HNS criteria, and QoL using the Menière's disease outcome questionnaire. RESULTS: 73 patients were included in the study. We found a significant preservation of vestibular function as measured by VNG and VHIT. There was no statistical difference in the presence or absence of cervical and ocular (P13/N23 and N1/P1) waves on VEMP pre- and postoperatively. 67% of patients had good control of episodes of vertigo post-operatively, with significantly better results in the sac opening group (75%). There was no significant change in hearing postoperatively, and QoL scores were significantly improved after surgery (p < 0.0001). CONCLUSION: Endolymphatic sac surgery (ELSS) is a conservative surgical treatment, which does not negatively impact vestibular function. It was associated with improved control of episodes of vertigo, preservation of hearing, and a clear improvement in QoL scores. Despite its pathophysiology not being fully understood, it remains a first-line procedure preserving vestibular function, for MD refractory to medical management. PMID:33740085 | DOI:10.1007/s00405-021-06743-3 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A comparison of the Thunderbeat and standard electrocautery devices in head and neck surgery: a prospective randomized controlled trial

xlomafota13 shared this article with you from Inoreader A comparison of the Thunderbeat and standard electrocautery devices in head and neck surgery: a prospective randomized controlled trial Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Mar 19. doi: 10.1007/s00405-021-06739-z. Online ahead of print. ABSTRACT PURPOSE: New energy-based sutureless vessel ligation devices, such as the Thunderbeat (Olympus Medical Systems Corp., Tokyo, Japan), could reduce operative time and limit blood loss in head and neck surgery; however, efficacy and safety in major head and neck surgery have not been investigated in a prospective, randomized study. METHODS: This prospective, double-arm, randomized controlled trial consisted of two parts: total laryngectomy (TL) and neck dissection (ND). Thirty patients planned for TL were randomized in two groups. For the ND part, forty-two operative sides were likewise randomized. In both parts, Thunderbeat was used in addition to the standard instrumentation in the intervention groups, while only standard instrumentation was used in the control groups. Primary outcome values were blood loss, operative time and complication rate. RESULTS: For the TL part there was no difference in mean blood loss (p = 0.062), operative time (p = 0.512) and complications (p = 0.662) between both hemostatic techniques. For the neck dissection part, there was a reduction in blood loss (mean 210 mL versus 431 mL, p = 0.046) and in operative time (median 101 (IQR 85-130) minutes versus 150 (IQR 130-199) minutes, p = 0.014) when Thunderbeat was used. There was no difference in complication rate between both hemostatic systems (p = 0.261). CONCLUSION: The Thunderbeat hemostatic device significantly reduces operative blood loss and operative time for neck dissections, without increase in complications. In TL, blood loss using Thunderbeat was comparable with the standard technique, but the operative time tended to be shorter. TRIAL REGISTRATION: UMCG Research Register, Reg. no. 201700041, date of registration: 18/1/2017. PMID:33740084 | DOI:10.1007/s00405-021-06739-z View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Primary neoplasms of the parapharyngeal space: diagnostic and therapeutic pearls and pitfalls

xlomafota13 shared this article with you from Inoreader Primary neoplasms of the parapharyngeal space: diagnostic and therapeutic pearls and pitfalls Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Mar 19. doi: 10.1007/s00405-021-06718-4. Online ahead of print. ABSTRACT PURPOSE: Parapharyngeal space neoplasms (PSNs) are rare tumors of the head and neck region. In this study, we report our institutional experience with PSNs over a 27-years period. METHODS: Patients treated between 1992 and 2018 were identified through our tumor board database. Data concerning demographics, clinical presentation, disease features, treatment, complications and follow-up were obtained retrospectively. RESULTS: In total, 48 patients were identified. Most patients had benign tumors (67.5%), with pleomorphic adenoma and schwannoma being the most frequent entities. Malignant tumors represented the remaining 32.5% of neoplasms. Concerning tissue of origin, 67.5% of neoplasms originated from salivary glands and 17.5% were neurogenic. The vast majority of PSNs required open surgical approaches (77%). The most freq uent reversible and irreversible complications included paralysis of facial, vagal, and hypoglossal nerves (transient 62.5%, permanent 31.3%). Tumor recurrences occurred in 16.7% of our patients. CONCLUSION: Neoplasms of the parapharyngeal space (PPS) are rare. In our series, consistent with the literature, most patients had benign tumors. Fine-needle aspiration cytology (FNAC) and/or transoral biopsy in selected cases combined with radiographic imaging are helpful to plan the optimal approach (open/transoral) and extent of primary surgery. Close follow-up in malignant neoplasms is crucial to assess recurrence early. We present one of the largest recent studies on PPS tumors treated in a center. Given the low incidence of these tumors, our results contribute to the existing sparse evidence regarding the management and outcome of such tumors. PMID:33740083 | DOI:10.1007/s00405-021-06718-4 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

miR-454-3p prevents ox-LDL-induced apoptosis in HAECs by targeting TRPC3

xlomafota13 shared this article with you from Inoreader miR-454-3p prevents ox-LDL-induced apoptosis in HAECs by targeting TRPC3 Via Experimental and therapeutic medicine Exp Ther Med. 2021 Apr;21(4):323. doi: 10.3892/etm.2021.9754. Epub 2021 Feb 5. ABSTRACT Endothelial-cell (EC) apoptosis serves a vital role in the pathogenesis of atherosclerosis. Accumulating evidence has implicated microRNA (miRNA/miR) dysregulation in EC apoptosis. Although the role of miR-454-3p in carcinogenesis has been well documented, its role and underlying mechanism in EC apoptosis remain unclear. In the present study, the results revealed that miR-454-3p expression was substantially downregulated in human aortic endothelial cells (HAECs) following oxidized low-density lipoprotein (ox-LDL) treatment. miR-454-3p suppression significantly attenuated the viability of HAECs, while miR-454-3p overexpression repressed ox-LDL-induced HAEC apoptosis. Bioinformatics analysis and luciferase reporter assays revealed that transient receptor potential canonical 3 (TRPC3), a key regulator of atherosclerosis development, was the direct targ et of miR-454-3p. Furthermore, TRPC3 overexpression abolished the anti-apoptotic effect of miR-454-3p on HAECs. These results revealed a novel role of miR-454-3p in ox-LDL-induced apoptosis in HAECs. PMID:33732296 | PMC:PMC7905327 | DOI:10.3892/etm.2021.9754 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Long non-coding RNA small nucleolar RNA host gene 1 knockdown suppresses the proliferation, migration and invasion of osteosarcoma cells by regulating microRNA-424-5p/FGF2 in vitro

xlomafota13 shared this article with you from Inoreader Long non-coding RNA small nucleolar RNA host gene 1 knockdown suppresses the proliferation, migration and invasion of osteosarcoma cells by regulating microRNA-424-5p/FGF2 <em>in vitro</em> Via Experimental and therapeutic medicine Exp Ther Med. 2021 Apr;21(4):325. doi: 10.3892/etm.2021.9756. Epub 2021 Feb 5. ABSTRACT The aim of the present study was to clarify the effect of long non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) on the proliferation, migration and invasion of osteosarcoma (OS) cells and to explore the potential underlying mechanisms. The expression levels of SNHG1, microRNA (miR)-424-5p and fibroblast growth factor 2 (FGF2) in OS tissues and cells were detected using reverse transcription-quantitative polymerase chain reaction. OS cell proliferation, migration and invasion were analysed by MTT, wound healing and Transwell invasion assays, respectively. The targeting relationships between SNHG1 and miR-424-5p, as well as between miR-424-5p and FGF2, were confirmed using RNA-binding protein immunoprecipitation and/or dual-luciferase reporter gene assays. The results demonstrated that the expression levels of SNHG1 and FGF2 were upregu lated, whereas the expression of miR-424-5p was downregulated in OS tissues and cells. The silencing of SNHG1 significantly inhibited the proliferation, migration and invasion of OS cells. Additionally, FGF2 was shown to be a target of miR-424-5p, which in turn, was a target of SNHG1. miR-424-5p silencing and FGF2 overexpression both reversed the suppressive effects of SNHG1 knockdown on the proliferation, migration and invasion of OS cells. Thus, the silencing of SNHG1 may inhibit the proliferation, migration and invasion of OS cells by regulating the miR-424-5p/FGF2 axis. PMID:33732298 | PMC:PMC7903380 | DOI:10.3892/etm.2021.9756 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Early diagnosis of serum sICAM-1 and sRAGE in severe acute pancreatitis, and efficacy and prognosis prediction of glutamine combined with ulinastatin

xlomafota13 shared this article with you from Inoreader Early diagnosis of serum sICAM-1 and sRAGE in severe acute pancreatitis, and efficacy and prognosis prediction of glutamine combined with ulinastatin Via Experimental and therapeutic medicine Exp Ther Med. 2021 Apr;21(4):324. doi: 10.3892/etm.2021.9755. Epub 2021 Feb 5. ABSTRACT Acute pancreatitis (AP) is a common gastrointestinal disease that can become severe, so that intensive care may be required. This study was to examine serum soluble intercellular adhesion molecule-1 (sICAM-1), and soluble receptor for advanced glycation end products (sRAGE) for efficacy and prognosis prediction of glutamine (Glu) combined with ulinastatin (UTI) on severe acute pancreatitis (SAP). Fifty-four mild acute pancreatitis (MAP) patients admitted to Yidu Central Hospital of Weifang were selected as the MAP group (MAPG), 80 with SAP were divided as the SAP group (SAPG), and 60 healthy individuals who came to Yidu Central Hospital of Weifang for physical examination during the same period were included to the normal group (NG). Serum sICAM-1 and sRAGE were measured and their predictive value of efficacy and prognosis were analyzed. In view of the treatment effectiveness and prognosis, the patients were divided into effective group (EG) and ineffective group (IG), good prognosis group (GPG) and poor prognosis group (PPG). The levels of D-lactate, diamine oxidase (DAO), endotoxin and T-lymphocyte subsets (CD3+, CD4+, CD8+ and CD4+/CD8+) were measured and the changes before and after treatment were analyzed. The AUC values of NG and MAPG, NG and SAPG, MAPG and SAPG were 0.857, 0.939 and 0.856, respectively, those of predicting efficacy were 0.920 and 0.874, respectively, and those of poor prognosis in the SAPG were 0.914 and 0.879, respectively. In the SAPG, D-lactate, DAO, endotoxin and CD8+ decreased markedly after treatment, but CD3+, CD4+, and CD4+/CD8+ were opposite. SICAM-1 and sRAGE were also independent risk factors for poor prognosis in the SAPG. Serum sICAM-1 and sRAGE have high predictive value for early diagnosis, efficacy and prognosis of Glu combined with UTI. PMID:33732297 | PMC:PMC7903449 | DOI:10.3892/etm.2021.9755 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Evaluation and comparison of a novel Scheimpflug-based optical biometer with standard partial coherence interferometry for biometry and intraocular lens power calculation

xlomafota13 shared this article with you from Inoreader Evaluation and comparison of a novel Scheimpflug-based optical biometer with standard partial coherence interferometry for biometry and intraocular lens power calculation Via Experimental and therapeutic medicine Exp Ther Med. 2021 Apr;21(4):326. doi: 10.3892/etm.2021.9757. Epub 2021 Feb 5. ABSTRACT In the present study, the axial length (AL), corneal curvature, anterior chamber depth (ACD) and white-to-white (WTW) distance were assessed using the Pentacam AXL (Oculus Optikgeraete GmbH), a novel Scheimpflug-based optical biometer with standard partial coherence interferometry (PCI). The Pentacam AXL and PCI biometer (IOLMaster 500; Carl Zeiss AG) were compared in terms of their intraocular lens (IOL) power calculations. The medical records of patients (eyes, n=190) who underwent cataract surgery were retrospectively reviewed. Biometry measurements involved the eyes of patients with cataract and were performed by the same examiner with the Pentacam AXL biometer and the IOLMaster 500 device. Following determination of the AL, mean keratometry (Km), ACD and WTW distance, the IOL power calculation was compared between the two devices using the Sand ers, Retzlaff and Kraff theoretical (SRK/T) and Haigis formulas. The AL, Km and WTW values for the Pentacam AXL group were significantly lower compared with those of the IOLMaster 500 group. The difference was -0.02±0.04 mm, -0.20±0.28 D and -0.10±0.20 mm, respectively (P<0.001). The ACD for the Pentacam AXL group was higher compared with that of the IOLMaster 500 group with a difference of 0.02±0.13 mm (P=0.13). The IOL power calculated using the SRK/T and Haigis formulas exhibited significant differences between the two devices (t=11.48 and 10.97, respectively; P<0.001). In conclusion, the AL, ACD, WTW measurement and IOL power indicated optimal agreement and strong correlations between the two devices. However, constant optimization may be necessary for the novel biometer Pentacam AXL. PMID:33732299 | PMC:PMC7903467 | DOI:10.3892/etm.2021.9757 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.