Relevance of Intraparotid Metastases in Head and Neck Skin Squamous Cell Carcinoma

xlomafota13 shared this article with you from Inoreader Relevance of Intraparotid Metastases in Head and Neck Skin Squamous Cell Carcinoma Via The Laryngoscope Objectives Parotid lymph node metastases are common in head and neck cutaneous squamous cell carcinoma (cSCCHN). Here we evaluate the diagnostic, prognostic, and therapeutic implications of intraglandular lymph node (IGLN) metastases in cSCCHN. Study Design Retrospective study in a tertiary referral university cancer institute. Methods We included patients with cSCCHN who underwent parotidectomy and neck dissection (ND), with or without synchronous resection of the skin primary, between January 1999 and January 2018. The characteristics of cSCCHN with or without IGLN involvement were compared. Results Altogether, 68 patients were included. Of the 29 (42.6%) patients classified as cN0, eight were upstaged pN+ and had concomitant IGLN involvement. Of 21 patients with pN0 disease, IGLN metastases were absent in only three cases, resulting in a specificity and sensitivity of parotid metastases to diagnose occult nodal neck metastases of 14.29% and 100%, respectively. The positive and negative predictive values were 14.29% and 100%, respectively. Univariate analyses only displayed a significantly higher rate of moderately and poorly differentiated primaries in patients with IGLN metastases (P = .015). Only advanced T‐stages were significantly associated with neck recurrences. Conclusion IGLN status in advanced cSCCHN is potentially predictive for occul nodal neck metastases. Our results suggest that ND in patients with histopathologically negative IGLNs and clinically negative neck lymph nodes may not be necessary given the high negative predictive value of IGLN status in this group of patients. Therefore, accurate diagnostic evaluation of IGLN involvement is mandatory. Level of Evidence 4 Laryngoscope, 131:788–793, 2021 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Primary Hyperparathyroidism During Pregnancy Treated With Parathyroidectomy: A Systematic Review

xlomafota13 shared this article with you from Inoreader Primary Hyperparathyroidism During Pregnancy Treated With Parathyroidectomy: A Systematic Review Via The Laryngoscope Objectives/Hypothesis The primary objective of this study was to assess the safety of parathyroidectomy during pregnancy as treatment for hyperparathyroidism (HPTH) in comparison to nonsurgical management plans. Secondary outcomes involved analyzing the safety of surgery in the third trimester and the benefit of operating on asymptomatic pregnant patients. Study Design Systematic review. Methods PRISMA‐guided systematic review of all cases of primary hyperparathyroidism during pregnancy published in peer‐reviewed English journals on PubMed/MEDLINE, EMBASE, and SCOPUS from 1980 to 2020. Results A total of 75 manuscripts were included in this review describing 382 cases of gestational hyperparathyroidism. The median maternal age was 31 years. Overall, 108 cases (28.3%) underwent parathyroidectomy during pregnancy while 274 cases (71.7%) were treated nonsurgically. The majority of surgeries took place during the second trimester (67.6%). Complications and/or deaths were less likely to occur after surgery in the second trimester (4.48%) as compared to surgery in the third trimester (21.1%). Nine surgically treated cases resulted in infant complications and/or death; however, none of these nine cases had any surgical complications. Despite these complications, the overall infant complication rate for patients who underwent surgical treatment remained lower than that of patients treated with conservative therapy (9.1% vs. 38.9%). Conclusions This review suggests that for all pregnant patients with diagnosed HPTH, parathyroidectomy should be considered regardless of symptomatology. Our data suggest that parathyroidectomy is associated with fewer risks than more conservative treatments and results in better fetal outcomes. Surgery during the third trimester is feasible and surgery should be considered in both symptomatic and asymptomatic patients. Laryngoscope, 2021 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Blue, Green, or Radioisotope: Which Modality Is Best for Head and Neck Melanoma SLN Identification?

xlomafota13 shared this article with you from Inoreader Blue, Green, or Radioisotope: Which Modality Is Best for Head and Neck Melanoma SLN Identification? Via The Laryngoscope View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Hoffman Syndrome as a Rare Presentation of a Common Thyroid Condition

xlomafota13 shared this article with you from Inoreader Hoffman Syndrome as a Rare Presentation of a Common Thyroid Condition Via Clinical Thyroidology Clinical Thyroidology, Volume 33, Issue 3, Page 140-146, March 2021. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Radiofrequency Ablation for Papillary Thyroid Microcarcinoma Is Safe and Effective in Long-Term Follow-up

xlomafota13 shared this article with you from Inoreader Radiofrequency Ablation for Papillary Thyroid Microcarcinoma Is Safe and Effective in Long-Term Follow-up Via Clinical Thyroidology Clinical Thyroidology, Volume 33, Issue 3, Page 121-123, March 2021. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Withholding Radioactive Iodine for Lower-Risk Papillary Thyroid Cancers Is Safe, but Delays the Certainty of Treatment Response

xlomafota13 shared this article with you from Inoreader Withholding Radioactive Iodine for Lower-Risk Papillary Thyroid Cancers Is Safe, but Delays the Certainty of Treatment Response Via Clinical Thyroidology Clinical Thyroidology, Volume 33, Issue 3, Page 117-120, March 2021. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Lingering Questions about Active Surveillance for Papillary Thyroid Microcarcinomas

xlomafota13 shared this article with you from Inoreader Lingering Questions about Active Surveillance for Papillary Thyroid Microcarcinomas Via Clinical Thyroidology Clinical Thyroidology, Volume 33, Issue 3, Page 128-130, March 2021. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The Usefulness of Contrast-Enhanced Ultrasound to Evaluate Small Solid Thyroid Nodules Compared to TI-RADS

xlomafota13 shared this article with you from Inoreader The Usefulness of Contrast-Enhanced Ultrasound to Evaluate Small Solid Thyroid Nodules Compared to TI-RADS Via Clinical Thyroidology Clinical Thyroidology, Volume 33, Issue 3, Page 114-116, March 2021. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Molecular Genetic Testing Can Be Performed on Thyroid Cytology Slides Using the ThyroSeq v3 Genomic Classifier

xlomafota13 shared this article with you from Inoreader Molecular Genetic Testing Can Be Performed on Thyroid Cytology Slides Using the ThyroSeq v3 Genomic Classifier Via Clinical Thyroidology Clinical Thyroidology, Volume 33, Issue 3, Page 110-113, March 2021. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Combination Pembrolizumab Plus Lenvatinib May Be Option in Anaplastic and Poorly Differentiated Thyroid Cancers

xlomafota13 shared this article with you from Inoreader Combination Pembrolizumab Plus Lenvatinib May Be Option in Anaplastic and Poorly Differentiated Thyroid Cancers Via Clinical Thyroidology Clinical Thyroidology, Volume 33, Issue 3, Page 131-133, March 2021. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Solute Carrier Proteins and Their Role in Thyroid Hormone Synthesis

xlomafota13 shared this article with you from Inoreader Solute Carrier Proteins and Their Role in Thyroid Hormone Synthesis Via Clinical Thyroidology Clinical Thyroidology, Volume 33, Issue 3, Page 107-109, March 2021. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Preoperative Vitamin D Deficiency Is a Risk Factor for Postsurgical Hypoparathyroidism

xlomafota13 shared this article with you from Inoreader Preoperative Vitamin D Deficiency Is a Risk Factor for Postsurgical Hypoparathyroidism Via Clinical Thyroidology Clinical Thyroidology, Volume 33, Issue 3, Page 137-139, March 2021. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Who Is Eligible for Thyroid Cancer Active Surveillance in a Population with a Restrictive Diagnostic Protocol?

xlomafota13 shared this article with you from Inoreader Who Is Eligible for Thyroid Cancer Active Surveillance in a Population with a Restrictive Diagnostic Protocol? Via Clinical Thyroidology Clinical Thyroidology, Volume 33, Issue 3, Page 124-127, March 2021. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.