Daily Triglyceride Output Volume as an Early Predictor for Chyle Leak Following Pancreaticoduodenectomy

xlomafota13 shared this article with you from Inoreader Daily Triglyceride Output Volume as an Early Predictor for Chyle Leak Following Pancreaticoduodenectomy Via In vivo (Athens, Greece) In Vivo. 2021 Mar-Apr;35(2):1271-1276. doi: 10.21873/invivo.12378. ABSTRACT BACKGROUND/AIM: Useful prophylaxes of chyle leak (CL) after pancreatic surgery have not been established. The aim of the study was to identify an early clinical predictor for CL. PATIENTS AND METHODS: Fifty-five patients who underwent subtotal stomach preserved pancreaticoduodenectomy (SSPPD) were included. Clinical factors associated with postoperative CL were evaluated. RESULTS: Eleven patients (20%) developed a CL after SSPPD. Shorter operative time, absent pancreatic fistula, and triglyceride output volume at postoperative day (POD) two were independent risk factors for CL. The receiver operating characteristics curve of the daily triglyceride output volume at POD two indicated a cut-off point of 177 mg (AUC=0.782; p=0.004; 95% CI=0.639-0.925). CL was significantly associated with prolonged postoperative hospital stay in patients who did not dev elop a pancreatic fistula (p=0.003). CONCLUSION: Daily triglyceride output volume of >177 mg at POD two may be a predictor of CL following pancreaticoduodenectomy. PMID:33622930 | DOI:10.21873/invivo.12378 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Risk Factors for Lymph Node Metastasis in Pathological T1b Colorectal Cancer

xlomafota13 shared this article with you from Inoreader Risk Factors for Lymph Node Metastasis in Pathological T1b Colorectal Cancer Via In vivo (Athens, Greece) In Vivo. 2021 Mar-Apr;35(2):987-991. doi: 10.21873/invivo.12341. ABSTRACT BACKGROUND/AIM: The rate of lymph node metastasis (LNM) of colorectal carcinoma (CRC) with a submucosal (SM) invasion depth of 1000 µm or more can reach 12.5%, which is the most common reason for additional resection in daily practice. Other studies have reported that the rate of LNM is less than 2%, regardless of the depth of invasion, if the lesions show good histology, lymphovascular infiltration is negative, and tumor budding is limited. The purpose of this study was to investigate new risk factors for LNM in T1b colorectal cancer. PATIENTS AND METHODS: The 239 patients who were diagnosed with pathological T1b CRC after colorectal surgical resection at the Osaka Police Hospital in Japan between January 2008 and December 2018 were retrospectively reviewed in this study. RESULTS: The LNM rate was 11.3% (27/239). The variables identified as being si gnificant factors using multivariate analysis were: i) lymphatic invasion (Ly)-positive [odds ratio (OR)=5.97; 95% confidence interval (CI)=2.27-15.74], ii) female gender (OR=3.49; 95%CI=1.38-8.85), and iii) left-sided colorectal involvement (OR=4.98; 95%CI=1.22-20.39). If none of these risk factors were present with T1b, the LNM rate was 0% (0/28). CONCLUSIONS: Ly-positive, female gender, and left-sided colorectal involvement could be risk factors for LNM in T1b CRC. PMID:33622893 | DOI:10.21873/invivo.12341 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Response to Neoadjuvant Chemotherapy in Locally Advanced Cervical Cancer: The Role of Immune-related Factors

xlomafota13 shared this article with you from Inoreader Response to Neoadjuvant Chemotherapy in Locally Advanced Cervical Cancer: The Role of Immune-related Factors Via In vivo (Athens, Greece) In Vivo. 2021 Mar-Apr;35(2):1277-1283. doi: 10.21873/invivo.12379. ABSTRACT BACKGROUND/AIM: Treatment of locally advanced cervical cancer (LACC) consists of concomitant chemoradiation or neoadjuvant chemotherapy (NACT) plus radical surgery (RS). This study analyzed the prognostic role of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), tumor infiltrating lymphocytes (TILs), and PD-L1 expression in LACC patients, treated with NACT+RS. PATIENTS AND METHODS: We prospectively analyzed 37 LACC patients treated from December 2016 to September 2019. Patients were submitted to pelvic examination, biopsy and imaging. RESULTS: In 65% of cases, a nodal involvement was present at pre-treatment MRI. All cancers showed the presence of stromal TILs and PD-L1 staining of inflammatory cells. No significant correlations were found between clinicopathological parameters and the number of TILs and PDL-1 at baseline. Af ter NACT, 29 patients (78%) were submitted to RS; 28% of patients showed pathological complete response, 62% partial response and 10% stable disease. Seven (24%) patients reported a positive node. Patients with high levels of stromal TILs and low NLR and PLR showed a significantly better response to NACT. No significant correlation was observed between PD-L1 expression and response to NACT. CONCLUSION: The number of TILs, the expression of PDL1, and NLR and PLR ratios correlate significantly with the response of LACC patients to NACT. PMID:33622931 | DOI:10.21873/invivo.12379 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Perineural Invasion Correlates With Common Pathological Variables and Clinical Outcomes of Patients With Squamous Cell Carcinoma of the Vulva Treated With Primary Radical Surgery and Inguinal-femoral Lymphadenectomy

xlomafota13 shared this article with you from Inoreader Perineural Invasion Correlates With Common Pathological Variables and Clinical Outcomes of Patients With Squamous Cell Carcinoma of the Vulva Treated With Primary Radical Surgery and Inguinal-femoral Lymphadenectomy Via In vivo (Athens, Greece) In Vivo. 2021 Mar-Apr;35(2):1051-1056. doi: 10.21873/invivo.12349. ABSTRACT BACKGROUND/AIM: The aims of the study were: i) to assess the incidence of perineural invasion (PNI) in squamous cell carcinoma of the vulva and ii) to correlate PNI with common pathological prognostic variables and clinical outcome of patients. PATIENTS AND METHODS: The hospital records of 64 patients with vulvar squamous cell carcinoma who underwent primary radical surgery were reviewed. RESULTS: PNI was significantly related to stage (p=0.038), size (p=0.038), lymph-vascular space involvement (p=0.013) and nodal status (p=0.038), but not to patient age, tumor grade and stromal invasion. Five-year disease-free survival was 30.0% in patients with PNI and 53.1% in those without PNI (p=0.018), and the corresponding 5-year overall survival was 50.0% and 77.1% (p=0.031), respectively. CONCLUSION: PNI was associated with common pathological prognos tic variables and with a poorer clinical outcome in patients with vulvar squamous cell carcinoma. PMID:33622901 | DOI:10.21873/invivo.12349 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The Experience of Greece as a Model to Contain COVID-19 Infection Spread

xlomafota13 shared this article with you from Inoreader The Experience of Greece as a Model to Contain COVID-19 Infection Spread Via In vivo (Athens, Greece) In Vivo. 2021 Mar-Apr;35(2):1285-1294. doi: 10.21873/invivo.12380. ABSTRACT The severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) emerged in late 2019 and has caused a pandemic known as corona virus disease 2019 (COVID-19), responsible for the death of more than 2 million people worldwide. The outbreak of COVID-19 has posed an unprecedented threat on human lives and public safety. The aim of this review is to describe key aspects of the bio-pathology of the novel disease, and discuss aspects of its spread, as well as targeted protective strategies that can help shape the outcome of the present and future health crises. Greece is used as a model to inhibit SARS-COV-2 spread, since it is one of the countries with the lowest fatality rates among nations of the European Union (E.U.), following two consecutive waves of COVID-19 pandemic. Furthermore, niche research technological approaches and scientific recommendations that eme rged during the COVID-19 era are discussed. PMID:33622932 | DOI:10.21873/invivo.12380 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Outcome After Radiation Therapy in Canine Intracranial Meningiomas or Gliomas

xlomafota13 shared this article with you from Inoreader Outcome After Radiation Therapy in Canine Intracranial Meningiomas or Gliomas Via In vivo (Athens, Greece) In Vivo. 2021 Mar-Apr;35(2):1117-1123. doi: 10.21873/invivo.12357. ABSTRACT AIM: To characterize a group of dogs diagnosed with meningioma or glioma treated with radiation therapy and assess the clinical impact of diagnosis and radiation protocol on survival time. PATIENTS AND METHODS: Canine patient records from a single veterinary referral hospital, between 2011 and 2015, were searched for intracranial tumour cases treated with radiation therapy, as a sole modality. Thirty-two dogs were included. RESULTS: Median survival times were 524 days [95% confidence interval (CI)=287-677] in total, 512 days (95% CI=101-682) for the glioma group and 536 days (95% CI=249-677) for the meningioma group. No significant difference in survival was detected when using a definitive or a palliative protocol (p=0.130), nor other prognostic factors were found. CONCLUSION: Our results highlight the efficacy of radiation therapy in the tre atment of canine meningioma, as well as glioma, suggesting a change in the current perception of the response of glial tumours to radiation. PMID:33622909 | DOI:10.21873/invivo.12357 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Selection of the Appropriate Control Group Is Essential in Evaluating the Cytokine Storm in COVID-19

xlomafota13 shared this article with you from Inoreader Selection of the Appropriate Control Group Is Essential in Evaluating the Cytokine Storm in COVID-19 Via In vivo (Athens, Greece) In Vivo. 2021 Mar-Apr;35(2):1295-1298. doi: 10.21873/invivo.12381. ABSTRACT BACKGROUND/AIM: Lately, studies have reported contradicting results on the cytokine storm seen in critically-ill COVID-19 patients. Depending on the control group used, cytokines have been found to be higher, similar or even lower in COVID-19 compared to critical illnesses associated with elevated cytokine concentrations. However, most of these studies do not take into account critical illness severity. Hence, we decided to compare cytokine levels in critically-ill COVID-19 patients and critically-ill patients of a general intensive care unit (ICU), who did not have sepsis or septic shock, but had an equal disease severity. PATIENTS AND METHODS: Interleukin (IL)-6, IL-8, IL-10 and tumour necrosis factor-α (TNF-α) were measured on ICU admission in mechanically ventilated, COVID-19 (N=36) and non-COVID-19 (N=30) patients, who had not received dexamethason e, and had equal critical illness severity. Non-COVID-19 patients did not have sepsis or septic shock. RESULTS: In our case control study, circulating IL-6 and IL-10 were lower, while TNF-α and IL-8 levels were higher in critically-ill COVID-19 patients, compared to critically-ill non-COVID-19 patients. CONCLUSION: It is difficult to infer whether the cytokine storm seen in COVID-19 differs from other critical conditions. It is important to recognize that the conclusions of related studies may depend on control group selection. PMID:33622933 | DOI:10.21873/invivo.12381 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Impact of Smoking on the Survival of Patients With High-risk HPV-positive HNSCC: A Meta-analysis

xlomafota13 shared this article with you from Inoreader Impact of Smoking on the Survival of Patients With High-risk HPV-positive HNSCC: A Meta-analysis Via In vivo (Athens, Greece) In Vivo. 2021 Mar-Apr;35(2):1017-1026. doi: 10.21873/invivo.12345. ABSTRACT BACKGROUND/AIM: High risk Human papillomavirus (hr-HPV) and smoking are independant risk factors for head and neck squamous cell carcinomas (HNSCC). While hr-HPV+ HNSCC has a better prognosis than smoking-associated HNSCC no systematic data are yet available about the combined risk. PATIENTS AND METHODS: We performed a meta-analysis to assess the overall survival of HNSCC patients relative to the hr-HPV and smoking status. A literature review up to November 2019 was conducted in PubMed and Cochrane Library using the search terms 'HPV, Smoking and HNSCC'. RESULTS: Nine out of 748 articles were included, 1,436 out of 2,080 patients were hr-HPV+ The prevalence of hr-HPV+ smokers was 36%. The meta-analysis showed a significantly better 5-year overall survival for HPV+ non-smokers compared to smokers with risk ratio of 1.94 (95% confidence intervaI=1.46-2.58). CONCLUSION: Smoking is a negative prognostic factor for overall survival in patients with hr-HPV+ HNSCC and should thus be an important part of staging and treatment. PMID:33622897 | DOI:10.21873/invivo.12345 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Colorectal Cancer Surgery During the COVID-19 Pandemic: A Single Center Experience

xlomafota13 shared this article with you from Inoreader Colorectal Cancer Surgery During the COVID-19 Pandemic: A Single Center Experience Via In vivo (Athens, Greece) In Vivo. 2021 Mar-Apr;35(2):1299-1305. doi: 10.21873/invivo.12382. ABSTRACT BACKGROUND/AIM: A notable re-allocation of healthcare resources and specific clinical and organizational measures have been required to prevent COVID-19 infection among hospitalized patients and healthcare workers. PATIENTS AND METHODS: From March 9th to May 9th 2020 we performed colorectal cancer elective surgery on 25 patients: a pre-hospital screening was carried out in order to avoid hospitalization of patients suspected of COVID-19 infection. RESULTS: All patients (median age=76 years; range=37-88 years) were considered suitable for admission after telephone triage; the median interval between primary diagnosis and hospital admission was 23.1 days (range=1-55 days). The median hospitalization was 7.8 days (range=4-18 days). One COVID-19-associated death was reported. CONCLUSION: Our experience demonstrates that safe colorectal cancer elec tive surgery can be performed during the pandemic COVID-19. Further consensus and guidelines to prevent diffusion of pandemic diseases among hospitalized patients and healthcare workers still need to be implemented. PMID:33622934 | DOI:10.21873/invivo.12382 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Multiple Intraosseous Lipomatosis - A Case Report and a Review of the Literature

xlomafota13 shared this article with you from Inoreader Multiple Intraosseous Lipomatosis - A Case Report and a Review of the Literature Via In vivo (Athens, Greece) In Vivo. 2021 Mar-Apr;35(2):959-964. doi: 10.21873/invivo.12337. ABSTRACT BACKGROUND: Intraosseous lipomatosis is a rare and uncommon entity with only a few cases reported in the literature. CASE REPORT: We report a severe case where post-traumatic radiographs showed multiple cystic osseous lesions and a pathological fracture. The findings were expanded with whole-body magnetic resonance imaging (MRI), which showed multiple osseous lesions with typical MRI characteristics of intraosseous lipomas. CONCLUSION: Our case, together with very few other cases described in the literature, emphasizes that multiple intraosseous lipomatosis is an important differential diagnosis for multiple radiolucent lesions on plain radiographs. Multiple intraosseous lipomatosis can lead to pathological fractures and severe impairment of life quality. The presence of well-defined, osteolytic lesions in the bone calls for an MRI or computed tomogra phy scan. PMID:33622889 | DOI:10.21873/invivo.12337 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Prognostic Evaluation of the Site of Invasion in Pathological Stage T3a Renal Cell Carcinoma

xlomafota13 shared this article with you from Inoreader Prognostic Evaluation of the Site of Invasion in Pathological Stage T3a Renal Cell Carcinoma Via In vivo (Athens, Greece) In Vivo. 2021 Mar-Apr;35(2):1083-1089. doi: 10.21873/invivo.12353. ABSTRACT BACKGROUND/AIM: To investigate the prognostic values of fat invasion (FI) and renal vein invasion (RVI) in pT3a renal cell carcinoma (RCC), as single factors or concomitant presence. PATIENTS AND METHODS: We retrospectively reviewed the data of 173 patients who underwent radical or partial nephrectomy for RCC in our Institution. RESULTS: At a median follow-up time of 48 months, patients with RVI showed significantly increased risk of disease recurrence and worse cancer-specific survival (CSS) when compared to those with FI (p=0.007, p=0.022, respectively). Having combined RVI and FI did not show inferior prognosis compared to those with RVI only. In multivariable analysis, RVI was an independent factor for disease recurrence (HR=2.06, 95% CI=1.10-3.87, p=0.024) and CSS (HR=2.46, 95% CI=1.01-6.0, p=0.048). CONCLUSION: For patients with T3a rena l tumors, RVI was associated with inferior prognosis compared to those with FI. PMID:33622905 | DOI:10.21873/invivo.12353 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.