Radioactive iodine therapy may not improve disease-specific survival in follicular variant papillary thyroid cancer without distant metastasis: A propensity score-matched analysis.

xlomafota13 shared this article with you from Inoreader Radioactive iodine therapy may not improve disease-specific survival in follicular variant papillary thyroid cancer without distant metastasis: A propensity score-matched analysis. Via radioactive iodine Related Articles Radioactive iodine therapy may not improve disease-specific survival in follicular variant papillary thyroid cancer without distant metastasis: A propensity score-matched analysis. Head Neck. 2021 Feb 09;: Authors: Wang X, Zheng X, Zhu J, Li Z, Wei T Abstract BACKGROUND: Whether radioactive iodine (RAI) therapy is effective in improving disease-specific survival (DSS) in patients with follicular variant papillary thyroid cancer (FVPTC) without distant metastasis remains unclear. METHODS: Patients with FVPTC were identified from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2015. The Kaplan-Meier method and the Cox proportional hazards regression model were used to evaluate DSS. Propensity score-matched analysis was performed to reduce the influence of confounding bias. RESULTS: RAI did not improve DSS, even in patients with aggressive features such as T4 classification (p = 0.658), extrathyroidal extension (p = 0.083), lateral lymph node metastasis (p = 0.544), and ≥5 metastatic lymph nodes (p = 0.599). CONCLUSION: RAI did not affect DSS in patients with FVPTC without distant metastases in this SEER database study. Multicenter, prospective studies including recurrence and molecular information should be conducted to comprehensively evaluate the effects of RAI on FVPTC. PMID: 33559196 [PubMed - as supplied by publisher] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Results of a survey on elderly head and neck cancer patients on behalf of the Italian Association of Radiotherapy and Clinical Oncology (AIRO).

xlomafota13 shared this article with you from Inoreader Results of a survey on elderly head and neck cancer patients on behalf of the Italian Association of Radiotherapy and Clinical Oncology (AIRO). Via Acta Otorhinolaryngol Ital Related Articles Results of a survey on elderly head and neck cancer patients on behalf of the Italian Association of Radiotherapy and Clinical Oncology (AIRO). Acta Otorhinolaryngol Ital. 2020 Dec;40(6):405-409 Authors: Belgioia L, De Felice F, Bacigalupo A, Alterio D, Argenone A, D'Angelo E, Desideri I, Franco PF, Merlotti A, Musio D, Orlandi E, Ursino S, Paiar F Abstract Objective: Over the years, evidence-based data and technical improvements have consolidated the central role of radiation therapy (RT) in head and neck cancer (HNC) treatment, even in the elderly. This survey aimed to describe the management of the elderly HNC patients among Italian Radiation Oncology Departments (RODs) and provide possible suggestions for improvement. Methods: An online survey based on 43 questions was sent to RODs via email. For each RODs, a radiation oncologist with expertise in HNC was invited to answer questions addressing his/her demographic data, ROD multidisciplinary unit (MU) organisation and ROD management policy in elderly HNC patients. Results: In total, 68 RODs answered, representing centres located in 16 Italian regions. MU was considered the core of HNC patient management in almost all the entire country. However, in many RODs, there was minimal access to a routinely comprehensive geriatric assessment at diagnosis. Most treatments were reported by respondents as curative (89% on average) and the preferred treatment technique was intensity modulated radiation therapy (IMRT). A considerable variation between RODs was found for RT target volumes. There was a relation between the specialist's years of experience and type of concomitant systemic therapy prescribed. Conclusions: Substantial differences in elderly HNC management have been found, especially concerning patient clinical evaluation and target volume delineation. This survey shows the necessity to design a prospective national trial to provide a uniform treatment strategy and define an effective patient-centred approach. PMID: 33558767 [PubMed - in process] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Micronucleus, nucleoplasmic bridge and nuclear bud frequencies in patients with laryngeal carcinoma.

xlomafota13 shared this article with you from Inoreader Micronucleus, nucleoplasmic bridge and nuclear bud frequencies in patients with laryngeal carcinoma. Via Acta Otorhinolaryngol Ital Related Articles Micronucleus, nucleoplasmic bridge and nuclear bud frequencies in patients with laryngeal carcinoma. Acta Otorhinolaryngol Ital. 2020 Dec;40(6):410-414 Authors: Yazici I, Caglar O, Guclu O, Cobanoglu H, Coskun M, Coskun M, Kilic A, Dereköy FS PMID: 33558768 [PubMed - in process] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Are sinonasal dissection courses a valid instrument for endoscopic sinus surgeons? A report on 7-years of experience.

xlomafota13 shared this article with you from Inoreader Are sinonasal dissection courses a valid instrument for endoscopic sinus surgeons? A report on 7-years of experience. Via Acta Otorhinolaryngol Ital Related Articles Are sinonasal dissection courses a valid instrument for endoscopic sinus surgeons? A report on 7-years of experience. Acta Otorhinolaryngol Ital. 2020 Dec;40(6):415-420 Authors: Pagella F, Emanuelli E, Benazzo M, Pusateri A, Ugolini S, Melegatti M, Ciorba A, Pelucchi S PMID: 33558769 [PubMed - in process] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Effectiveness of superior eyelid endoscopic-assisted approach in the management of selected orbital abscess: considerations on 4 cases.

xlomafota13 shared this article with you from Inoreader Effectiveness of superior eyelid endoscopic-assisted approach in the management of selected orbital abscess: considerations on 4 cases. Via Acta Otorhinolaryngol Ital Related Articles Effectiveness of superior eyelid endoscopic-assisted approach in the management of selected orbital abscess: considerations on 4 cases. Acta Otorhinolaryngol Ital. 2020 Dec;40(6):421-425 Authors: Dallan I, Cristofani-Mencacci L, Cambi C, Scarano M, Casani AP, Seccia V PMID: 33558770 [PubMed - in process] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Structural changes in the extracellular matrix after cross-linking of nasal polyp tissue.

xlomafota13 shared this article with you from Inoreader Structural changes in the extracellular matrix after cross-linking of nasal polyp tissue. Via Acta Otorhinolaryngol Ital Related Articles Structural changes in the extracellular matrix after cross-linking of nasal polyp tissue. Acta Otorhinolaryngol Ital. 2020 Dec;40(6):426-434 Authors: Coronel N, Pezato R, do Amaral JB, Ticlia L, Pinto Bezerra TF, Gomes LF, Dreyfuss J, Chamon W, Gregório LC PMID: 33558771 [PubMed - in process] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Effects of biological therapies on chronic rhinosinusitis in severe asthmatic patients.

xlomafota13 shared this article with you from Inoreader Effects of biological therapies on chronic rhinosinusitis in severe asthmatic patients. Via Acta Otorhinolaryngol Ital Related Articles Effects of biological therapies on chronic rhinosinusitis in severe asthmatic patients. Acta Otorhinolaryngol Ital. 2020 Dec;40(6):435-443 Authors: Bandi F, Gallo S, Preti A, Mozzanica F, Visca D, Marelli M, Maddalone E, Gambarini C, Vaghi A, Spanevello A, Castelnuovo P Abstract Objective: The introduction of monoclonal antibody (mAb) therapies represents a promising treatment for refractory chronic rhinosinusitis (CRS). We assessed the effects of selected mAbs (omalizumab, mepolizumab, benralizumab) on CRS in severe asthmatic patients in a real-life setting. Methods: A prospective observational study on severe asthmatic patients, treated with 3 different mAb (omalizumab, mepolizumab, benralizumab), and comorbid CRS was conducted. All patients were followed for 52 weeks. The degree of nasal control, SinoNasal Outcome Test (SNOT) 22, Nasal Polyp Score (NPS), Lund Kennedy Score (LKS) were collected at baseline and at 52-week. Results: 40 patients (33 with nasal polyps) were studied. 33 patients (82.5%) had uncontrolled nasal disease at baseline, and 15 (37.5%) were uncontrolled after 52 weeks. Significant improvement was observed for SNOT 22 (P < 0.001), SNOT 1-12 (P < 0.001) and degree of nasal control (P < 0.001). Differences in NPS (P = 0.130) and LKS (P = 0.124) were not significant. Net change in the above-mentioned parameters among the three treatment groups was not significantly different. Conclusions: The study shows an improvement of nasal symptoms after 52 weeks of mAb treatment, which was not associated with significant improvement of endoscopic findings. Larger studies are needed to assess the real-life efficacy of mAbs in CRS. PMID: 33558772 [PubMed - in process] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Evaluation of a large cohort of adult patients with Meniere's disease: bedside and clinical history.

xlomafota13 shared this article with you from Inoreader Evaluation of a large cohort of adult patients with Ménière's disease: bedside and clinical history. Via Acta Otorhinolaryngol Ital Related Articles Evaluation of a large cohort of adult patients with Ménière's disease: bedside and clinical history. Acta Otorhinolaryngol Ital. 2020 Dec;40(6):444-449 Authors: Teggi R, Battista RA, Di Berardino F, Familiari M, Cangiano I, Gatti O, Bussi M Abstract Objective: The purpose of this study was to assess vestibular findings and clinical history in a large cohort of patients affected by Ménière's disease. Methods: We retrospectively analysed 511 adult patients fulfilling criteria for definite unilateral Ménière's disease according to Barany Society. Thorough clinical history, audiometric exam, central nervous system MRI, quantification of serum autoantibodies and complete vestibular function test were performed. Results: Mean age at clinical record was 55.4 years, while age at onset of the first vertigo attack was 47.4 ± 14.3 years. Ménière's disease overlapped with migraine in 43.4% of patients. In 31.7% of cases, positivity was found for at least one autoantibody. Forty-nine patients (9.6%) had family history for Ménière's disease. Bedside examination resulted in 14.7% positivity for video head impulse test, 58.9% for skull vibration-induced nystagmus, 38.7% for the positional test and 23.1% for the post head shaking test. Complete negative examination was reported in 115 cases. Conclusions: Ménière's disease was seen to present a characteristic phenotypic pattern in our cohort, confirming the crucial role of thorough anamnesis and bedside examination in diagnosis. PMID: 33558773 [PubMed - in process] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Subtotal petrosectomy and cochlear implantation.

xlomafota13 shared this article with you from Inoreader Subtotal petrosectomy and cochlear implantation. Via Acta Otorhinolaryngol Ital Related Articles Subtotal petrosectomy and cochlear implantation. Acta Otorhinolaryngol Ital. 2020 Dec;40(6):450-456 Authors: D'Angelo G, Donati G, Bacciu A, Guida M, Falcioni M Abstract Objective: The objective of this study is to analyse surgical outcomes in a series of patients who underwent subtotal petrosectomy in combination with cochlear implantation. Methods: Retrospective chart review. Thirty patients (32 ears) underwent subtotal petrosectomy and cochlear implantation in one stage. Indications for subtotal petrosectomy included the following: cholesteatoma, chronic otitis media, previous canal wall-down, osteoradionecrosis, revision surgery for clinical reasons, inner ear malformations, middle ear anatomical variations and severe cochlear ossification. Results: Follow-up ranged from 2 to 54 months. Only 2 complications related to the subtotal petrosectomy (1 subcutaneous abdominal haematoma and 1 subcutaneous abdominal seroma) occurred in this series. Complete electrode insertion was achieved in all but 4 cases. Conclusions: Subtotal petrosectomy is a safe procedure and can offer technical advantages in some cases of complex cochlear implantation. PMID: 33558774 [PubMed - in process] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The effect of N-acetyl cysteine on biofilm layers in an experimental model of chronic otitis media.

xlomafota13 shared this article with you from Inoreader The effect of N-acetyl cysteine on biofilm layers in an experimental model of chronic otitis media. Via Acta Otorhinolaryngol Ital Related Articles The effect of N-acetyl cysteine on biofilm layers in an experimental model of chronic otitis media. Acta Otorhinolaryngol Ital. 2020 Dec;40(6):457-462 Authors: Ersoy ÃallıoÄlu E, Berçin S, BaÅdemir G, KiriÅ M, Tatar Ä°, Tuzuner A, OÄuzhan T, Müderris T, Sargon MF, Korkmaz MH Abstract Objectıve: The aim of this study was to investigate the efficacy of N-acetylcysteine (NAC) on biofilm layers and on the course of disease in chronic otitis media. Methods: Twenty-five rats that were induced with chronic otitis media (COM) were separated into three groups. In Group 1 (N = 18), 0.2% ciprofloxacin + 0.1% dexamethasone sodium phosphate + 0.5 mg/ml NAC solution was locally injected to the right ear of the rats; in Group 2, (N=18) 0.2% ciprofloxacin + 0.1% dexamethasone sodium phosphate was locally injected to the left ear of the rats. No treatment was applied to either ear of rats in Group 3 (N = 5). Histopathological and scanning electron microscope (SEM) evaluations were performed in all groups. Results: SEM revealed biofilm formation in all COM induced groups. No significant difference was seen between groups 1 and 2 in terms of suppuration levels, fibrosis, inner ear involvement, infection staging and biofilm formation (p > 0.05). Conclusıons: In this study, while histopathological and SEM evaluation revealed no effect of 0.5 mg/ml NAC on the biofilm layer in COM-induced rats, further studies with NAC at different concentrations are still needed on different types of experimental animals. PMID: 33558775 [PubMed - in process] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The Effects of Using Bioglue in Nasal Septal Surgery.

xlomafota13 shared this article with you from Inoreader The Effects of Using Bioglue in Nasal Septal Surgery. Via ear nose throat Related Articles The Effects of Using Bioglue in Nasal Septal Surgery. Ear Nose Throat J. 2021 Feb 09;:145561321991349 Authors: Subasi B, Guclu E Abstract OBJECTIVES: Nasal septal surgery is one of the most common surgical procedure performed by otolaryngologists. Nasal packs are used for bleeding control, prevention of septal hematoma, replacement of mucoperichondrial flaps, and stabilization of the septum after nasal septal surgery. The aim of this study was to investigate the effects of albumin-glutaraldehyde-based tissue adhesive (Bioglue), which can be used as an alternative to nasal pack on the nasal septum after experimental nasal septum surgery. METHODS: A total of 16 female Wistar albino rats were randomly separated into the study group (n = 10) and the control group (n = 6). After raising the mucoperichondrial flap on one side of the septum, Bioglue was used to fix the mucoperichondrial flap over the septal cartilage ın the study group and nasal packs (Merocel) were used for fixation in the control group. The rats were sacrificed at 2 and 4 weeks after septoplasty. All the tissue samples were evaluated under light microscope by the same pathologist in respect of foreign-body reaction, degree of inflammation, granulation tissue, fibrosis, cartilage damage, and cilia and goblet cell damage. In the control group, the Merocel packs were removed after 2 days and the groups were compared in terms of hematoma. RESULTS: No hematoma was observed in any group. Septal perforation was determined in all the study group participants and loss of cilia and goblet cells and foreign-body reaction were found in 8 samples of the study group participants and in none of the control group. CONCLUSIONS: The results of this study show that Bioglue caused segmental cartilage injury; therefore, it may not suitable for use following septal surgery. PMID: 33559491 [PubMed - as supplied by publisher] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.