Wednesday, November 11, 2020

Altered stress field of the human lens capsule after cataract surgery

Alexandros G.Sfakianakis shared this article with you from Inoreader
Μέσω Biomechanics

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Publication date: Available online 10 November 2020

Source: Journal of Biomechanics

Author(s): Caleb C. Berggren, Kurt A. Ameku, Ryan M. Pedrigi

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Hospital bed height influences biomechanics during bed egress: A comparative controlled study of patients with Parkinson’s Disease

Alexandros G.Sfakianakis shared this article with you from Inoreader
Μέσω Biomechanics

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Publication date: Available online 10 November 2020

Source: Journal of Biomechanics

Author(s): Hang Xu, Xiaotong Li, Yuanyuan Shi, Lun An, Dorothy Taylor, Marissa Christman, Janice Morse, Andrew Merryweather

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The effects of exterior boundary conditions on a internally heated tumor tissue with a thermoporoelastic model

Alexandros G.Sfakianakis shared this article with you from Inoreader
Μέσω Biomechanics

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Publication date: Available online 10 November 2020

Source: Journal of Biomechanics

Author(s): Assunta Andreozzi, Marcello Iasiello, Paolo Antonio Netti

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Modified SHI‐medium supports growth of a disease‐state subgingival polymicrobial community in vitro

Alexandros G.Sfakianakis shared this article with you from Inoreader

Summary

Developing a laboratory model of oral polymicrobial communities is essential for in vitro studies of the transition from healthy to diseased oral plaque. SHI‐medium is an enriched growth medium capable of supporting in vitro biofilms with similar diversity to healthy supragingival inocula; however, this medium does not maintain the diversity of gram‐negative bacteria more associated with subgingival plaque. Here, we systematically modified SHI‐medium components to investigate the impacts of varying nutrients and develop a medium capable of supporting a specific disease‐state subgingival community. A periodontal subgingival plaque sample was inoculated in SHI‐medium with increasing concentrations of sucrose (0, 0.1, 0.5%), fetal bovine serum (FBS) (0, 10, 20, 30, 50%), and mucin (0.1, 2.5, 8.0g/L) and grown for 48hrs, then the 16S rRNA profiles of the resulting biofilms were examined. In total, these conditions were able to capture 89 of the 119 species and 43 of the 51 genera found in the subgingival inoculum. Interestingly, biofilms grown in high sucrose media, although dominated by acidogenic Firmicutes with a low final pH, contained several uncultured taxa from the genus Treponema, information that may aid culturing these periodontitis‐associated fastidious organisms. Biofilms grown in a modified medium (here named subSHI‐v1 medium) with 0.1% sucrose and 10% FBS had a high diversity closest to the inoculum and maintained greater proportions of many gram‐negative species of interest from the subgingival periodontal pocket (including members of the genera Prevotella and Treponema, and the Candidate Phyla Radiation phylum Saccharibacteria), and therefore best represented the disease community.

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Use of Patient-Reported Symptoms from an Online Symptom Tracking Tool for Dementia Severity Staging: Development and Validation of a Machine Learning Approach

Alexandros G.Sfakianakis shared this article with you from Inoreader

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Functional and clinical significance of ROR1 in lung adenocarcinoma

Alexandros G.Sfakianakis shared this article with you from Inoreader

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Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is normally detectable in embryonic tissues and absent in adult tissues. ROR1 was shown to inhibit apoptosis, potentiate EGFR signaling and reported to be...
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Feasibility of improving patient’s safety with in vivo dose tracking in intracavitary and interstitial HDR brachytherapy

Alexandros G.Sfakianakis shared this article with you from Inoreader
Μέσω Brachytherapy

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Publication date: Available online 10 November 2020

Source: Brachytherapy

Author(s): Jessica Muenkel, Zhengzheng Xu, Bryan J. Traughber, Tanvir Baig, Keying Xu, Christian Langmack, Eleanor Harris, Tarun K. Podder

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EyeDose: An open-source tool for using published Monte Carlo results to estimate the radiation dose delivered to the tumor and critical ocular structures for 125I Collaborative Ocular Melanoma Study eye plaques

Alexandros G.Sfakianakis shared this article with you from Inoreader
Μέσω Brachytherapy

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Publication date: Available online 10 November 2020

Source: Brachytherapy

Author(s): Christopher L. Deufel, Sarah McCauley Cutsinger, Kimberly S. Corbin, Lauren A. Dalvin, Ivy A. Petersen

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Evidence for interleukin 17 involvement in severe immune-related neuroendocrine toxicity

Alexandros G.Sfakianakis shared this article with you from Inoreader

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Publication date: December 2020

Source: European Journal of Cancer, Volume 141

Author(s): Luca Mazzarella, Silvia Giugliano, Paolo D'Amico, Carmen Belli, Bruno Achutti Duso, Maria Rescigno, Giuseppe Curigliano

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Non-coding RNA derived from extracellular vesicles in cancer immune escape: Biological functions and potential clinical applications

Alexandros G.Sfakianakis shared this article with you from Inoreader
Μέσω Cancer Letters

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Publication date: Available online 10 November 2020

Source: Cancer Letters

Author(s): Mingyao Huang, Xueqiang Peng, Liang Yang, Shuo Yang, Xinyu Li, Shilei Tang, Bowen Li, Hongyuan Jin, Bo Wu, Jingang Liu, Hangyu Li

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Mitochondrial rewiring through mitophagy and mitochondrial biogenesis in cancer stem cells: A potential target for anti-CSC cancer therapy

Alexandros G.Sfakianakis shared this article with you from Inoreader
Μέσω Cancer Letters

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Publication date: Available online 10 November 2020

Source: Cancer Letters

Author(s): Prakash Priyadarshi Praharaj, Debasna Pritimanjari Panigrahi, Chandra Sekhar Bhol, Srimanta Patra, Soumya Ranjan Mishra, Kewal Kumar Mahapatra, Bishnu Prasad Behera, Amruta Singh, Shankargouda Patil, Sujit Kumar Bhutia

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PRMT6 deficiency induces autophagy in hostile microenvironment of hepatocellular carcinoma tumors by regulating BAG5-associated HSC70 stability

Alexandros G.Sfakianakis shared this article with you from Inoreader
Μέσω Cancer Letters

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Publication date: Available online 11 November 2020

Source: Cancer Letters

Author(s): Noélia Che, Kai-Yu Ng, Tin-Lok Wong, Man Tong, Phillis WF. Kau, Lok-Hei Chan, Terence K. Lee, Michael SY. Huen, Jing-Ping Yun, Stephanie Ma

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Modification of diet, exercise and lifestyle (MODEL) study: a randomised controlled trial protocol

Alexandros G.Sfakianakis shared this article with you from Inoreader

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Introduction

Most cardiovascular disease (CVD)-related events could be prevented or substantially delayed with improved diet and lifestyle. Providing information on structural vascular disease may improve CVD risk factor management, but its impact on lifestyle change remains unclear. This study aims to determine whether providing visualisation and pictorial representation of structural vascular disease (abdominal aortic calcification (AAC)) can result in healthful diet and lifestyle change.

Methods and analysis

This study, including men and women aged 60–80 years, is a 12-week, two-arm, multisite randomised controlled trial. At baseline, all participants will have AAC assessed from a lateral spine image captured using a bone densitometer. Participants will then be randomised to receive their AAC results at baseline (intervention group) or a usual care control group that will receive their results at 12 weeks. All participants will receive information about routinely assessed CVD risk factors and standardised (video) diet and lifestyle advice with three simple goals: (1) increase fruit and vegetable (FV) intake by at least one serve per day, (2) improve other aspects of the diet and (3) reduce sitting time and increase physical activity. Clinical assessments will be performed at baseline and 12 weeks.

Outcomes

The primary outcome is a change in serum carotenoid concentrations as an objective measure of FV intake. The study design, procedures and treatment of data will adhere to Standard Protocol Items for Randomized Trials guidelines.

Ethics and dissemination

Ethics approval for this study has been granted by the Edith Cowan University and the Deakin University Human Research Ethics Committees (Project Numbers: 20513 HODGSON and 2019-220, respectively). Results of this study will be published in peer-reviewed academic journals and presented in scientific meetings and conferences. Information regarding consent, confidentiality, access to data, ancillary and post-trial care and dissemination policy has been disclosed in the participant information form.

Trial registration number

Australian New Zealand Clinical Trial Registry (ACTRN12618001087246).

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