Tuesday, April 12, 2022

Status of IDH mutations in chondrosarcoma of the jaws

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The aim was to analyse the relationship between mutations of the isocitrate dehydrogenase gene (IDH) and clinical characteristics of chondrosarcoma of the jaw in order to provide new information on its molecular pathology. Tissue samples were collected from 25 patients diagnosed with chondrosarcoma of the jaw. IDH mutations were detected through polymerase chain reaction and direct sequencing. Clinicopathological data were analysed retrospectively. The study included 14 female and 11 male patients; the median patient age was 38 years. (Source: International Journal of Oral and Maxillofacial Surgery)
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Antibiotic-Induced Gut Microbiota Depletion Accelerates the Recovery of Radiation-Induced Oral Mucositis in Rats

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Publication date: Available online 8 April 2022

Source: International Journal of Radiation Oncology*Biology*Physics

Author(s): Ghanyah Al-Qadami, Gunjan Verma, Ysabella Van Sebille, Hien Le, Ian Hewson, Emma Bateman, Hannah Wardill, Joanne Bowen

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Acute Toxicity of Ultrahypofractionation Compared to Moderate Hypofractionation in Prostate Cancer Treatment – a Randomized Trial

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Publication date: Available online 10 April 2022

Source: International Journal of Radiation Oncology*Biology*Physics

Author(s): Winkle Kwan, Gaurav Bahl, David Kim, Allison Ye, Isabelle Gagne, Abraham Alexander, Samar Hejazi

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TCTAP C-175 Valve-In-Valve Transcatheter Aortic Valve Replacement in a Patient With Severe Left Ventricular Systolic Dysfunction in Previous Bentall Procedure

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Publication date: 19 April 2022

Source: Journal of the American College of Cardiology, Volume 79, Issue 15, Supplement

Author(s): Satej Janorkar, Sachin Shirke, Prashant Mishra, Nilesh Juvekar

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TCTAP C-176 Trans Catheter mitral Valve in Valve Replacement in a Severely Degenerated Bioprosthetic Valve

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Publication date: 19 April 2022

Source: Journal of the American College of Cardiology, Volume 79, Issue 15, Supplement

Author(s): Bhishma Chowdary Donepudi

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Long-Term Cardiovascular Outcomes After Bariatric Surgery in the Medicare Population

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Publication date: 19 April 2022

Source: Journal of the American College of Cardiology, Volume 79, Issue 15

Author(s): Amgad Mentias, Ali Aminian, Dalia Youssef, Ambarish Pandey, Venu Menon, Leslie Cho, Steven E. Nissen, Milind Y. Desai

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Principles of Surgery in Head and Neck Cutaneous Melanoma

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Surgical management of head and neck melanoma starts from the primary biopsy of the cutaneous site by a narrow excision with a 1 to 3  mm margins. The margin should include the whole breadth and sufficient depth of the lesion. The key is not to transect the lesion. With the advent of molecular testing, gene expression profiling, and immunotherapies, the surgical management of advanced melanoma has changed. Sentinel lymph node bio psy is an essential armamentarium for T2a and higher staging/greater than 1 mm thick and advance stage disease. Molecular pathogenesis and cancer immunology are recognized in the recent treatment protocols along with surgery in advanced stages of melanoma. (Source: Oral and Maxillofacial Surgery Clinics)
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Mohs Micrographic Surgery for the Treatment of Cutaneous Melanomas of the Head and Neck

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Surgical excision achieving clear histologic margins remains the mainstay treatment for primary cutaneous melanoma. Tumors of the head and neck, particularly those arising in chronically sun-damaged skin, often demonstrate extensive and asymmetric subclinical extension. Over the decades, this has proven to be a significant problem for tumors arising on the head and neck, as anatomic and functional complexities of these areas have led to suboptimal surgical treatment, yielding unacceptably high rates of local recurrence and persistently positive margins with traditional wide local excision. Patients who undergo Mohs micrographic surgery may have improved survival over those who undergo wide local excision. (Source: Oral and Maxillofacial Surgery Clinics)
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Poor Treatment Outcomes with Second-Line Chemotherapy in Advanced Synovial Sarcoma

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Via Oncology
CONCLUSION: Our exploratory study revealed that the response rate of second-line chemotherapy regimens for patients with synovial sarcoma was 9.4%. Therefore, there is an urgent need to develop more active therapeutic regimens for synovial sarcomas.PMID:35405680 | DOI:10.1159/000524500 (Source: Oncology)
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EMCrit 320 – MotR – Tension & Relaxation | Flow & Burnout

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Seek flow and avoid burnout...

EMCrit Project by Scott Weingart, MD FCCM.

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NeuroEMCrit – Time is Brain – Acute Ischemic Stroke Part 2: Mechanical Thrombectomy

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part II of the stroke update...

EMCrit Project by NeuroEMCrit Team (Casey & Neha).

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Introducing the Internet Book of NeuroCritical Care (IBNCC)

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Friends, Over the next several months we'll be adding ~26 additional chapters to the neurology section of the IBCC.  The ultimate goal is to create a complete neurocritical care textbook that is fully integrated into the IBCC.  (You can preview the final table of contents here.) Why more neurocrit?  The brain is one of the […]

EMCrit Project by Josh Farkas.

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Retrospective analysis of adjuvant radiotherapy in oral cavity or oropharyngeal cancer: Feasibility of omitting lower-neck irradiation

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by Sheng-Yow Ho, Wan-Chen Kao, Sheng-Yen Hsiao, Sheng-Fu Chiu, Sung-Wei Lee, Jia-Chun Chen, Li-Tsun Shieh

Objectives

Adjuvant radiotherapy is the standard of care in locally advanced head and neck cancers. The radiation field is correlated with the surgical field in the adjuvant radiotherapy setting; therefore, tailoring the irradiation field is reasonable.

Materials and methods

We retrospectively analyzed patients with oral cavity and oropharyngeal cancers included in the cancer registry between 2015 and 2019 in the study hospital. Patients who underwent whole-neck irradiation (WNI) were compared with those who underwent lower-neck–sparing (LNS) irradiation.

Results

A total of 167 patients with oral cavity and oropharyngeal cancers were included in the study. Cancer recurrence was recorded in 33% of the patients. The rate of recurrence of oral cavity and oropharyngeal cancer at neck level IV was 8%. The 2-year incidence of level IV recurrence was lower in the WNI group than in the LNS group (2% vs. 10%; p = 0.04). The 2-year disease-free survival rates were 75% and 63% in the WNI and LNS groups, respectively (p = 0.08).

Conclusion

The rate of level IV recurrence was higher in the LNS group than in the WNI group. Trends of improvement in disease-free survival with lower-neck irradiation suggested that it is premature to consider LNS irradiation as daily practice in patients with oral cavity and oropharyngeal cancer.

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