Donor site complications and satisfaction in autologous fat grafting for breast reconstruction: A systematic review

xlomafota13 shared this article with you from Inoreader Donor site complications and satisfaction in autologous fat grafting for breast reconstruction: A systematic review Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2022 Jan 25:S1748-6815(22)00043-2. doi: 10.1016/j.bjps.2022.01.029. Online ahead of print. ABSTRACT BACKGROUND: Breast cancer is the most common cancer in females worldwide. One option for total breast reconstruction following total breast amputation is autologous fat transfer (AFT). However, this is still an upcoming reconstruction technique, and little is known about the donor site complications and their influence on the patient's overall satisfaction. OBJECTIVES: This systematic review aims to review the current literature regarding donor site complications and donor site satisfaction following AFT for total breast reconstruction. SEARCH METHODS: A literature search was performed in PubMed, Web of Science, Embase, Cochrane, TRIP pro, and Prospero. All published original literature reporting on complications or satisfaction at the donor site in patients who underwent liposuction, followed b y high-volume lipofilling was considered. MAIN RESULTS: This systematic review resulted in the inclusion of 21 cohort studies, consisting of 2241 participants. None of the studies reported donor site satisfaction scores of any kind. The most frequently reported donor site complication was ecchymosis (268 cases), followed by pain (122 cases), haematoma (58 cases), irregularities (12 cases), burns (four cases), and infection (three cases). Reports on follow-up and management of donor site complications were generally lacking. AUTHOR'S CONCLUSIONS: Results regarding the donor site are inconclusive. Pre-specified complications, a standardized manner of reporting, long-term follow-up, and patient-reported outcome measures are lacking in most of the studies. The impact of the donor site on quality of life after autologous fat grafting in breast reconstruction remains a blind spot. PROSPERO registration number: CRD42020222870. PMID:35165073 | DOI:10.1016/j.bjps.2022.01.029 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

New AMM: Nivolumab as an adjuvant for oesophageal and gastroesophageal junction cancer

xlomafota13 shared this article with you from Inoreader New AMM: Nivolumab as an adjuvant for oesophageal and gastroesophageal junction cancer Via Association française pour l'étude du cancer Bull Cancer. 2022 Feb 11:S0007-4551(22)00009-1. doi: 10.1016/j.bulcan.2021.11.018. Online ahead of print. NO ABSTRACT PMID:35164916 | DOI:10.1016/j.bulcan.2021.11.018 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Behavioural Interventions in People with Oropharyngeal Dysphagia: A Systematic Review and Meta-Analysis of Randomised Clinical Trials

xlomafota13 shared this article with you from Inoreader Behavioural Interventions in People with Oropharyngeal Dysphagia: A Systematic Review and Meta-Analysis of Randomised Clinical Trials Via swallowing exercises J Clin Med. 2022 Jan 28;11(3):685. doi: 10.3390/jcm11030685. ABSTRACT OBJECTIVE: To determine the effects of behavioural interventions in people with oropharyngeal dysphagia. METHODS: Systematic literature searches were conducted to retrieve randomized controlled trials in four different databases (CINAHL, Embase, PsycINFO, and PubMed). The methodological quality of eligible articles was assessed using the Revised Cochrane risk-of-bias tool for randomised trials (RoB 2), afte r which meta-analyses were performed using a random-effects model. RESULTS: A total of 37 studies were included. Overall, a significant, large pre-post interventions effect size was found. To compare different types of interventions, all behavioural interventions and conventional dysphagia treatment comparison groups were categorised into compensatory, rehabilitative, and combined compensatory and rehabilitative interventions. Overall, significant treatment effects were identified favouring behavioural interventions. In particular, large effect sizes were found when comparing rehabilitative interventions with no dysphagia treatment, and combined interventions with compensatory conventional dysphagia treatment. When comparing selected interventions versus conventional dysphagia treatment, significant, large effect sizes were found in favour of Shaker exercise, chin tuck against resistance exercise, and expiratory muscle strength training. CONCLUSIONS: Behavioural interven tions show promising effects in people with oropharyngeal dysphagia. However, due to high heterogeneity between studies, generalisations of meta-analyses need to be interpreted with care. PMID:35160137 | DOI:10.3390/jcm11030685 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Secondary primary malignancy in patients with head and neck squamous cell carcinoma

xlomafota13 shared this article with you from Inoreader Secondary primary malignancy in patients with head and neck squamous cell carcinoma: 27-year experience from the perspective of diagnostic tools Via Head and neck squamous cell carcinoma by Shih-Wei Wang, Leong-Perng Chan, Ling-Feng Wang, Che-Wei Wu, Sheng-Hsuan Lin, Tzu-Yen Huang, Ka-Wo Lee Background The survival rate of head and neck squamous cell carcinoma (HNSCC) patients with secondary primary malignancy (SPM) showed no significant improvement for decades, however, the impact of advances in diagnostic tools is rarely mentioned. This study investigated the clinical characteristic of HNSCC with SPM over a 27-year period especially from the perspective of diagnostic tools. Methods This study evaluated 157 HNSCC patients with SPM. The patients were divided into two groups according to the time of SPM diagnosis (Group A:1992–2003; Group B: 2004–2014). Age, gender, stage of first primary malignancy (FPM), SPM interval, overall survival, and disease-free survival were compared between groups. Results Group B had significantly more SPM developed rate (p = 0.002), more SPM patients with advanced stage of FPM (p = 0.001), synchronous SPM (p = 0.006), and shorter SPM interval (p Conclusion Among patients diagnosed with HNSCC recently, more SPMs are diagnosed in a shorter time interval and in a more advanced stage. The overall advances in diagnostic tools cannot significantly improve SPM survival, however, it enables more patients to receive corresponding treatment. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The Extent of Thyroid Surgery in Differentiated Thyroid Cancer Patients with Low and Intermediate Risks of Recurrence

xlomafota13 shared this article with you from Inoreader The Extent of Thyroid Surgery in Differentiated Thyroid Cancer Patients with Low and Intermediate Risks of Recurrence Via Clinical Thyroidology Clinical Thyroidology, Volume 34, Issue 2, Page 63-66, February 2022. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Predisposition to and Prognosis of Thyroid Cancer May Not Be Affected by Graves’ Disease, But Some Questions Still Remain

xlomafota13 shared this article with you from Inoreader Predisposition to and Prognosis of Thyroid Cancer May Not Be Affected by Graves' Disease, But Some Questions Still Remain Via Clinical Thyroidology Clinical Thyroidology, Volume 34, Issue 2, Page 59-62, February 2022. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Diagnostic Value of Preoperative Serum Calcitonin Levels in Medullary Thyroid Carcinoma

xlomafota13 shared this article with you from Inoreader Diagnostic Value of Preoperative Serum Calcitonin Levels in Medullary Thyroid Carcinoma Via Clinical Thyroidology Clinical Thyroidology, Volume 34, Issue 2, Page 85-88, February 2022. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Herpes Zoster of The Larynx: A Narrow Diagnostic and Therapeutic Window

xlomafota13 shared this article with you from Inoreader Herpes Zoster of The Larynx: A Narrow Diagnostic and Therapeutic Window Via ear nose throat Ear Nose Throat J. 2022 Feb 15:1455613221077594. doi: 10.1177/01455613221077594. Online ahead of print. ABSTRACT We hereby present a rare case of laryngeal zoster presenting with unilateral odynophagia and hemifacial pain in an immunocompetent host. Visualization of the characteristic vesicles is challenging given their short-lived and at times delayed appearance; thus, laryngeal zoster may be a largely unrecognized cause of laryngitis and cranial neuropathies. Heightened aw areness may improve prompt diagnosis, referral and initiation of antiviral therapy, while guiding patient counselling on the associated long-term sequelae such as voice and swallowing impairments, and post-herpetic neuralgia. PMID:35166603 | DOI:10.1177/01455613221077594 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The clinicopathological and prognostic characteristics of mucinous micropapillary carcinoma of the breast

xlomafota13 shared this article with you from Inoreader The clinicopathological and prognostic characteristics of mucinous micropapillary carcinoma of the breast Via Cellular and Molecular Biology Histol Histopathol. 2022 Feb 15:18436. doi: 10.14670/HH-18-436. Online ahead of print. ABSTRACT BACKGROUND: Mucinous micropapillary carcinoma (MMPC) is a unique subtype of breast cancer, and there is as yet no detailed report on the clinical characteristics of MMPC. METHODS: MMPC, pure mucinous breast carcinoma (PMBC), and invasive micropapillary carcinoma (IMPC) samples were enrolled simultaneously, and immunohistochemistry analysis was performed to explore the clinicopathological attributes of MMPC. Moreover, survival analyses of MMPC were performed among the MMPC, PMBC, and IMPC groups and within the MMPC group. RESULTS: The results showed that MMPC demonstrated distinct pathological features and that vascular invasion and lymph node metastasis were two significant clinical attributes of MMPC. MMPC leads to a shorter survival time than PMBC but an increased survival time compared to IMPC, while the tumor-node-metastasis stage and lymph node metastasis were identified as two independent prognostic elements for disease-free survival in discerning the MMPC prognosis. CONCLUSIONS: The gathered data implied that further understanding and classification of MMPC may provide better individualized therapeutic strategies for MMPC treatment. PMID:35166367 | DOI:10.14670/HH-18-436 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Quantitative lateral flow immunoassay for rapid detection and monitoring of cerebrospinal fluid leakage following incidental durotomy

xlomafota13 shared this article with you from Inoreader Quantitative lateral flow immunoassay for rapid detection and monitoring of cerebrospinal fluid leakage following incidental durotomy Via leak of cerebrospinal fluid Anal Chim Acta. 2022 Mar 1;1196:339544. doi: 10.1016/j.aca.2022.339544. Epub 2022 Jan 25. ABSTRACT Cerebrospinal fluid (CSF) leakage due to incidental durotomy is an inherent complication of spine surgery. With appropriate treatment, complications of CSF leakage, such as headache and even meningitis, can be reduced. CSF leakage could be detected on the basis of correlated clinical symptoms; diagnosis should be based on these symptoms and appropriate imaging studies. However, the diagnosis of CSF leakage remains a challenge, especially if incidental durotomy is unrecognized during surgery; even if incidental durotomy is detected and repaired intraoperatively, the severity of the leakage and quality of the primary dural repair are difficult to evaluate postoperatively. Rapid, inexpensive, and safe methods of detecting CSF-containing samples are currently lacking; hence, the development of a point-of-care test (POCT) method to improve diagnostic efficiency is necessary. We developed a high-sensitivity lateral flow immunoassay with a stacking pad (sLFIA) for quantitative detection of β-trace protein (BTP), a specific CSF marker. The BTP concentration in 39 clinical samples was calculated using a calibration equation for test-line intensity and evaluated by a standard laboratory method. To avoid the hook effect, we diluted each sample prior to testing. The correlation coefficient between the enzyme-linked immunosorbent assay and our BTP sLFIA method was 0.991 A 75-fold sample dilution was applied owing to the hook effect point, identified as 175 ng mL-1. We established an optimal sample-specific cutoff point at a value of 4.0 μg mL-1 for CSF leakage in subfascial drainage samples following spinal posterior decompression. The sensitivity and specificity of the BTP sLFIA method were 90% and 97%, respectively, according to a receiver operating characteristic curve analysis. In addition, clinical samples from patients who underwent primary dural repair intraoperatively were tested, and CSF leakage was successfully diagnosed using our method. Finally, the quantitation of BTP in samples collected daily provided an accurate assessment of the severity of the residual leakage. Our results demonstrate that the BTP sLFIA method possesses the potential to serve as a POCT method for screening and monitoring postoperative CSF leakage. PMID:35151406 | DOI:10.1016/j.aca.2022.339544 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Comparison of outcomes between intracapsular resection and pseudocapsule-based extracapsular resection for pituitary adenoma: a systematic review and meta-analysis

xlomafota13 shared this article with you from Inoreader Comparison of outcomes between intracapsular resection and pseudocapsule-based extracapsular resection for pituitary adenoma: a systematic review and meta-analysis Via leak of cerebrospinal fluid BMC Neurol. 2022 Feb 12;22(1):52. doi: 10.1186/s12883-022-02574-9. ABSTRACT BACKGROUND: Transsphenoidal surgery is the preferred first-line therapy for most pituitary adenoma(PA), and the conventional strategy of treatment is intracapsular resection(IR). The protocol of extracapsular resection(ER), which considers the pseudocapsule as the PA boundary for surgical removal, has also been introduced gradually. In this study, the clinical efficacies and complications were explored and compared between these two procedures. METHODS: A systematic literature review was performed in the PubMed, EMBASE, Web of Science and Cochrane databases. Articles comparing between IR and ER were included. RESULTS: There were 7 studies containing 1768 cases in accordance with the inclusion criteria. Although the meta-analysis showed no significant difference in complete resection, a sensitivity analysis revealed that ER was more conducive to total PA re section than IR. Moreover, we found a significant difference in favor of ER regarding biochemical remission. Furthermore, there was no significant difference in the incidence rate of certain complications, such as hormone deficiency, diabetes insipidus, intraoperative cerebrospinal fluid(CSF) and postoperative CSF leakage. However, a sensitivity analysis suggested that IR decreased the risk of intraoperative CSF leakage. CONCLUSIONS: This meta-analysis unveiled that ER contributed to biochemical remission. To some extent, our results also showed that ER played a positive role in complete resection, but that IR reduced the incidence of intraoperative CSF leakage. However, the available evidence needs to be further authenticated using well-designed prospective, multicenter, randomized controlled clinical trials. PMID:35151259 | DOI:10.1186/s12883-022-02574-9 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

PTH in situ measurement in patients with hyperparathyroidism: single-centre experience of 179 patients

xlomafota13 shared this article with you from Inoreader PTH in situ measurement in patients with hyperparathyroidism: single-centre experience of 179 patients Via oto-rhino-laryngologie Eur J Endocrinol. 2022 Feb 1:EJE-21-1249. doi: 10.1530/EJE-21-1249. Online ahead of print. ABSTRACT CONTEXT: The measurement of PTH in situ (PTHis) by fine-needle aspiration (FNA) is proposed as a tool to preoperatively help localize parathyroid glands detected on ultrasound. However, the accuracy of PTHis is highly variable according to the few available studies. We aimed to develop and validate the PTHis procedure. We assessed the performance of PTHis in a large series of patients with hyperparathyroidism. PATIENTS: The technique setup consisted of PTHis measurement in thyroid samples from patients with thyroid nodules and patients with high circulating PTH levels (tertiary hyperparathyroidism). Consecutive patients were recruited and submitted to ultrasound-guided FNA-PTHis determination. RESULTS: During the method setup, we obtained undetectable PTHis levels in all non-parathyroid tissues after sample dilutions. PTHis was high er in patients with hyperparathyroidism (n=145, 1817±3739 ng/L, range <4.6-31,140) than in those with thyroid or undetermined cervical lesions (n=34, <4.6 ng/mL,p<0.0001). When evaluating PTHis performance in histologically proven samples (158 lesions from 121 patients), PTHis was detectable in 85/97 parathyroid lesions (87%, range 22-31,140 ng/L) and undetectable in all non-parathyroid lesions (n=61,p<0.0001). The specificity and positive predictive value were 100%, and the sensitivity was 87.6%. False-negative lesions (n=12) were smaller (9.4±5.9 mm) and more often consisted of hyperplasias (75%) than true-positive lesions (16.1±8.4 mm and 33%, p=0.009 and p=0.0089, respectively). The method was safe and well tolerated. Four educational cases are also provided. CONCLUSIONS: PTHis determination is a safe and well-tolerated procedure that enhances the specificity of ultrasound-detected lesions. If accurately set up, it confirms the parathyroid origin of uncharac terized cervical lesions. PMID:35167489 | DOI:10.1530/EJE-21-1249 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.