A Systematic Literature Review to Compare Clinical Outcomes of Different Surgical Techniques for Second Branchial Cyst Removal

xlomafota13 shared this article with you from Inoreader A Systematic Literature Review to Compare Clinical Outcomes of Different Surgical Techniques for Second Branchial Cyst Removal Via otol rhinol Ann Otol Rhinol Laryngol. 2021 Jun 17:34894211024049. doi: 10.1177/00034894211024049. Online ahead of print. ABSTRACT OBJECTIVE: During the last 2 decades, new treatment methods have been developed for the surgical removal of second branchial cysts which result in less visible scars. The aim of this systematic review is to assess which surgical technique for second branchial arch cyst removal results in the lowest complication and recurrence rates with the highest scar satis faction. METHODS: Two authors systematically reviewed the literature in the Cochrane, PubMed, and EMBASE databases (search date: 1975 to December 2nd, 2020) to identify studies comparing surgical outcomes of second branchial arch cyst removal. Authors appraised selected studies on directness of evidence and risk of bias. Results are reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. RESULTS: Out of the 2442 retrieved articles, 4 articles were included in the current review including a total of 140 operated cysts. Only 2 studies included pre-operatively infected cysts. Follow up ranged from 3 to 24 months. Complication rates ranged from 0 to 27.3% (conventional: [0-10.4%]; endoscopic/retro-auricular: [0-27.3%]). None of the patients presented with postoperative recurrence. Significantly higher scar satisfaction was found in adult patients who underwent endoscopic or retro-auricular hairline incision cyst removal. CONC LUSION: No recurrence of disease occurred during (at least) 3 months of follow up using either conventional surgery or endoscopic/retro-auricular techniques. Although more (temporary) complications occur using endoscopic and retro-auricular techniques, patients report a significantly higher scar satisfaction 3 to 6 months after surgery in comparison to the conventional technique. Future studies are needed to support these findings. PMID:34137276 | DOI:10.1177/00034894211024049 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Presentation and Outcomes of Non-Squamous Cell Carcinoma Sinonasal Malignancies: A National Perspective

xlomafota13 shared this article with you from Inoreader Presentation and Outcomes of Non-Squamous Cell Carcinoma Sinonasal Malignancies: A National Perspective Via otol rhinol Ann Otol Rhinol Laryngol. 2021 Jun 17:34894211024783. doi: 10.1177/00034894211024783. Online ahead of print. ABSTRACT BACKGROUND: Non-squamous cell carcinoma sinonasal malignancies (NSCCSM) are relatively rare. Neoadjuvant radiotherapy and/or chemotherapy (NTx) have been proposed to improve outcomes compared to surgery alone. In this study, we aim to examine the prevalence of NTx utilization and associated outcomes. METHODS: A retrospective study utilizing the National Cancer Database, 2004 to 2015. The study population included adult patients diagnosed with primary NSCCSM. RESULTS: A total of 574 patients were included. The mean age of the study population was 61.7 ± 16.5 years. The median follow-up time was 40.4 months (interquartile range: 15.3-81.3 months). The histopathological diagnoses identified included: (i) 37.0% adenocarcinoma, (ii) 22.8% adenoid cystic carcinoma, (iii) 20.0% mucosal melanoma, (iv) 11.9% esthesioneuroblastoma, and (v) 8.2% sinonasal undifferentiated carcinoma (SNUC). NTx was utilized in 70 (12.20%) of the study population. Patients who received NTx were more likely to have SNUC or esthesioneuroblastoma (P < .01 each) and to have stage III or IV disease (P < .01 each). NTx was most likely to be administrated in a high-volume center [OR: 3.94, 95%CI: (1.47, 10.53), P = .006]. Patients who received NTx had a significantly lower prevalence of positive margin postoperatively [OR: 0.48, 95%CI : (0.26, 0.87), P = .016]. In patients with NSCCSM, negative margin was associated with improved overall survival [HR: 0.55, 95%CI: (0.36, 0.82), P = .004]. CONCLUSIONS: This study provides an epidemiological perspective regarding NSCCSM and related practice patterns and survival outcomes. Neoadjuvant radiotherapy and/or chemotherapy is likely to decrease the risk of positive margin which ultimately could improve survival in this population. PMID:34137285 | DOI:10.1177/00034894211024783 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Extranodal Head and Neck Mantle Cell Lymphoma: Characteristics, Treatment, and Survival

xlomafota13 shared this article with you from Inoreader Extranodal Head and Neck Mantle Cell Lymphoma: Characteristics, Treatment, and Survival Via otol rhinol Ann Otol Rhinol Laryngol. 2021 Jun 17:34894211025171. doi: 10.1177/00034894211025171. Online ahead of print. ABSTRACT OBJECTIVES: To describe disease characteristics and treatment and to analyze survival and mortality for extranodal mantle cell lymphoma (MCL) of the head and neck. METHODS: Patients with extranodal MCL-excluding primary sites in the salivary glands, eye, and adnexa-were identified from the Surveillance, Epidemiology, and End Results (SEER) 18 Registries (2000-2015). Overall survival (OS) and cumulative incidence of MCL and non-MCL mortality were calculated. Factors associated with MCL and non-MCL mortality were analyzed with cause-specific hazard models. RESULTS: Five hundred nine patients met criteria for descriptive analysis and 294 patients met criteria for survival analysis, with a median follow-up of 58 months. The most common sites for MCL were the oropharynx (66.0%), nasopharynx (19.1%), and oral cavity (8.4%). The most common treatment received was chemotherapy alone (48.9%), followed by chemoradiation therapy (16.9%), and radiation therapy alone (10.4%). The proportion of cases diagnosed as early-stage disease ranged from 31% of sinonasal MCLs to 83% of laryngeal MCLs. At 5 years, OS was 63% (95% CI: 57%-69%). There was no significant difference in OS (P = .79), cumulative incidence of MCL mortality (P = .76), or cumulative incidence of non-MCL mortality (P = .98) by anatomic site. Comparing ear ly-stage to late-stage disease, there was no significant difference in OS (P = .38), cumulative incidence of MCL mortality (P = .07), or cumulative incidence of non-MCL mortality (P = .14). Multivariate analysis showed increased hazard of MCL mortality for patients that were older or that presented with stage III or stage IV disease. CONCLUSION: The oropharynx is the most common subsite of head and neck MCLs, followed by the nasopharynx. Primary head and neck MCLs appear to present at an earlier stage than MCLs of other regions. In particular, laryngeal and hypopharyngeal MCLs may present as stage I or II disease. PMID:34137303 | DOI:10.1177/00034894211025171 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Correlation Between Anosmia and Severity Along with Requirement of Tocilizumab in COVID-19 Patients

xlomafota13 shared this article with you from Inoreader Correlation Between Anosmia and Severity Along with Requirement of Tocilizumab in COVID-19 Patients Via Otolaryngology Indian Abstract Anosmia with or without dysgeusia is frequently associated with Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) SARS-CoV-2 infection. SARS-CoV-2 virus affects the olfactory system and thus represents neurotropic and neuro-invasive nature of the virus. We found that tocilizumab's role in reducing mortality in severe covid-19 infection is still questionable and aim of our study was correlation of anosmia and severity of covid-19 infection and requirement of tocilizumab in anosmia patients. To establish relationship between anosmia and severity of COVID-19 infection along with requirement of tocilizumab. This was a retrospective cum prospective cross sectional study done on COVID-19 patients who were admitted in normal COVID-19 ward and intensive care unit of Employee's State Insurance Corporation Hospital, Udaipur and Maharaja Bhupal Hospital of Ravindra Nath Medical College between September 2020 and 15 January 2021 age group of 18 to 92 year s, both sexes. We had asked about anosmia in all COVID-19 positive patients and followed all patients in perspective of severity of disease and tocilizumab. p value < 0.001 of prevalence of anosmia in COVID -19 patients who were isolated at home, admitted in ward and intensive care unit showed that anosmia is inversely related to severity of disease. Tocilizumab has no significant role in decreasing mortality in severe form of disease. Our study indicates that anosmia is related to the mildness of disease and there is no role of tocilizumab in decreasing the mortality in severe form of disease. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Mucormycosis of Paranasal Sinuses of Odontogenic Origin Post COVID19 Infection: A Case Series

xlomafota13 shared this article with you from Inoreader Mucormycosis of Paranasal Sinuses of Odontogenic Origin Post COVID19 Infection: A Case Series Via Otolaryngology Indian Abstract The Severe acute respiratory syndrome and the Middle East respiratory syndromes emerged in 2002 and 2012 respectively. Currently the world is witnessing a global pandemic caused by a novel coronavirus, the severe acute respiratory syndrome coronavirus 2 (SARS CoV- 2) causing the Coronavirus 2019 (COVID-19). Mucormycosis is a fungal infection primarily affecting individuals with an immunocompromised state like diabetes mellitus, malignancies etc. Patients who have or have had COVID-19 infection with pre-existing uncontrolled Type 2 Diabetes mellitus are presumably more vulnerable for emergence of fungal infections cases. This article presents a report of 6 cases with histopathological proven mucormycosis associated with COVID-19 and uncontrolled Diabetes mellitus. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

An Overview of Emergencies in Otorhinolaryngology at a Tertiary Care Centre, Telangana

xlomafota13 shared this article with you from Inoreader An Overview of Emergencies in Otorhinolaryngology at a Tertiary Care Centre, Telangana Via Otolaryngology Indian Abstract Otorhinolaryngology emergencies are a common complaint in the emergency department. These emergencies can occur in all the age groups and can present as a result of infection, trauma, foreign bodies, etc. The most common Ear, Nose and Throat (ENT) emergencies are epistaxis, foreign bodies in ear, nose and throat, stridor, trauma, facial bone fractures etc. Prompt assessment and immediate intervention can save lives and reduce the suffering arising out of these emergencies.The present study focusses on determining the magnitude and pattern, demographic characteristics and outcome of patients with ENT emergencies. A cross sectional study was carried out in the casualty and ENT department of Gandhi Hospital, which is a tertiary care center in Secunderabad, Telangana. The data was collected from June 2014 to May 2018. 2901 patients reported to casualty with ENT emergencies. Around 46.12% of emergencies were of Ear, 34.33% were related to nose and 19.54% were related to throat, neck and others. The most common ENT emergency among pediatric age group was foreign body in ear, nose, throat and aero digestive tract, while the most common ENT emergency in geriatric age group was Stridor. ENT emergencies are increasing in incidence due to increasing burden of road traffic accidents and early detection and institution of appropriate and adequate treatment may be important in preventing the progression of disease and minimizing complications. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Eine Änderung des Rauchverhaltens beeinflusst das Überleben von HNSCC-Patienten

xlomafota13 shared this article with you from Inoreader Eine Änderung des Rauchverhaltens beeinflusst das Überleben von HNSCC-Patienten Via Laryngo-Rhino-Otologie Laryngorhinootologie DOI: 10.1055/a-1509-8851 Einleitung Der Einfluss des Rauchens auf das Überleben bei Patienten mit Kopf-Hals-Karzinomen ist in der Literatur gut belegt. Es gibt nur wenige Daten über Änderungen der Rauchgewohnheiten nach Diagnosestellung. Hier wird die Auswirkung der Reduktion der Rauchquantität im Vergleich zur vollen Entwöhnung auf das Überleben untersucht. Patienten und Methoden Patientenakten und Tumordokumentationen von 643 konsekutiven Kopf-Hals-Karzinom-Fällen des Kopf-Hals-Tumorzentrums der Universitätsklinik Kiel werden retrospektiv ausgewertet: Rauchgewohnheiten vor und nach der Behandlung sowie das Überleben werden dabei ausgewertet. Ergebnisse Eine Änderung des Rauchverhaltens bei der Erstdiagnose des Karzinoms führt zu signifikant positivem Effekt auf die Prognose im Vergleich zu fortgesetztem Rauchen. Es zeigt sich kein Unterschied zwischen Rauchreduktion und Entwöhnung. Dieser Effekt beruht alleinig auf solchen Patienten, die ausschließlich chirurgisch behandelt werden. Lebenslange Nichtraucher weisen einen signifikanten Überlebensvorteil gegenüber aktiven und ehemaligen Rauchern auf, ohne Unterschied zwischen den beiden letztgenannten Gruppen. Schlussfolgerung Der positive Einfluss veränderter Rauchgewohnheiten auf die Prognose verläuft parallel zum negativen direkten Effekt des aktiven Rauchens auf die Therapie, was auf peritumorale Hypoxie mit negativer Auswirkung auf die Wirksamkeit der R(C)T zurückgeführt wird. Der positive Effekt der Rauchverhaltensänderung bei ausschließlicher Chirurgie liegt am ehesten in verminderter perioperativer Komplikation begründet. Patienten sollen ermutigt werden, das Rauchen mit der Krebsdiagnose zumindest zu minimieren. Darüber hinaus sollten ehemalige Raucher für Überlebensschätzungen und Therapieplanung als aktive Raucher betrachtet werden. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Rauchen und Komorbidität ohne Einfluss auf geplante Zieldosis der Radio(chemo)therapie

xlomafota13 shared this article with you from Inoreader Rauchen und Komorbidität ohne Einfluss auf geplante Zieldosis der Radio(chemo)therapie Via Laryngo-Rhino-Otologie Laryngorhinootologie DOI: 10.1055/a-1509-8883 Rauchen verschlechtert die Prognose von Patienten mit HNSCC. Darüber hinaus ist Rauchen mit der Prävalenz von Ko- und Multimorbidität assoziiert, sodass angenommen wird, dass Rauchen nicht per se, sondern Ko-/Multimorbidität die Prognose durch mangelnde Compliance an die Therapie durch z. B. Dosisreduktion der geplanten Therapie verschlechtert. Allerdings sind die Daten zu diesem Thema, insbesondere für HNSCC, derzeit spärlich und widersprüchlich.Patientenakten und Tumordokumentationen von 643 konsekutiven Fällen des Kopf-Hals-Tumorzentrums der Universitätsklinik Kiel wurden retrospektiv ausgewertet. Patientencharakteristiken und Rauchgewohnheiten wurden erfasst und mit Komorbiditäten und Behandlungsverlauf korreliert.Die untersuchten 643 Patientenakten zeigen, dass 113 (17,6 %) Patient*innen nicht, 349 (54,3 %) aktiv und 180 (28 %) vormals geraucht haben. 315 (49 %) sind ausschließl ich chirurgisch therapiert, 121 (18,8 %) mittels Chirurgie + adjuvanter Radio(chemo)therapie (RCT) und 72 (11,2 %) mittels Chirurgie + adjuvanter RT. 111 (17,3 %) erhalten eine primäre RCT und 24 (3,7 %) eine primäre RT. 131 (20,4 %) weisen Ko-/Multimorbidität auf und 512 (79,6 %) nicht. Rauchen (> 10 Pack Years) ist signifikant mit Komorbidität assoziiert (p = 0,002). Allerdings sind Rauchen und Komorbidität, weder allein noch in Kombination, mit dem Erreichen der Zieldosis der RCT korreliert (p > 0,05).Wie erwartet, ist Rauchen signifikant mit Ko-/Multimorbidität verknüpft. Dosisreduktion der R(C)T ist bei aktiven Rauchern und Patienten mit Ko-/Multimorbidität ebenso häufig wie bei Nichtrauchern und Patienten ohne Ko-/Multimorbidität. Rauchen und Ko-/Multimorbidität beeinflussen demnach die Prognose auf andere Weise als durch Beeinträchtigung geplanter Therapieschemata. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Serial step sections at narrow intervals with immunohistochemistry are required for accurate histological assessment of sentinel lymph node biopsy in oral squamous cell carcinoma

xlomafota13 shared this article with you from Inoreader Serial step sections at narrow intervals with immunohistochemistry are required for accurate histological assessment of sentinel lymph node biopsy in oral squamous cell carcinoma Via Head & Neck Abstract Background Sentinel lymph node (SLN) biopsy is an accurate staging modality in early oral squamous cell carcinoma (OSCC), but its accuracy relies on labor-intensive histopathology protocols. We sought to determine whether serial step sections with immunohistochemistry (SSSIHC) at narrow intervals of the entire SLN are required to accurately exclude metastasis. Methods Consecutive SLN biopsies over a 13-year period were retrospectively evaluated. If the index section was negative for carcinoma, the entire SLN was subjected to SSSIHC at 150 μm intervals. The first section level and total number of section levels to contain carcinoma were recorded. Results One hundred and eighteen SLN+ from 90 patients were included. SSSIHC upstaged the nodal status in 19.5% of patients. Metastasis was identified in 16.7% and 10.2% beyond section levels 4 and 6, respectively. Among SLNs requiring SSSIHC, 47.5% contained carcinoma in a single section level. Conclusion SSSIHC of the entire SLN at 150 μm intervals are required to identify occult metastasis in OSCC. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Sound Opportunities: Factors That Impact Referral for Pediatric Cochlear Implant Evaluation

xlomafota13 shared this article with you from Inoreader Sound Opportunities: Factors That Impact Referral for Pediatric Cochlear Implant Evaluation Via The Laryngoscope Objectives/Hypothesis To identify barriers to and opportunities for referral among children who could be considered for cochlear implantation. Study Design Retrospective review. Methods Audiological and medical records were reviewed on all children who had diagnostic or hearing aid care through a statewide healthcare system over 5-year span to identify children who met newly established clinical cochlear implant (CI) referral criteria. Data were collected for 869 potential CI candidates regarding demographic, socio-economic, audiological, medical, and family factors that may influence referral. A binomial logistic regression was completed to investigate the potential contributions of these predictors toward referral for a CI evaluation. Results Children who met traditional candidacy criteria of severe-to-profound bilateral hearing loss were referred at very high rates, while nontraditional candidates were referred less frequently. Factors influencing referral included race, age, insurance source, hearing thresholds, audiologist, physician, and family request. Conclusions Results suggest that bilateral traditional candidates are being referred at high percentages; however, current practices and trends in pediatric cochlear implantation should be shared with families and providers to increase referral rates for nontraditional candidates.  Level of Evidence 3 Laryngoscope, 2021 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A rare case of Hidradenoma of the lower lip

xlomafota13 shared this article with you from Inoreader A rare case of Hidradenoma of the lower lip Via American Journal of Otolaryngology Publication date: Available online 15 June 2021 Source: American Journal of Otolaryngology Author(s): Isabel Park, Esther Lee, Stephanie Barak, Punam G. Thakkar View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.